Category:GO:0003713 ! transcription coactivator activity

name: transcription coactivator activity
namespace: molecular_function
alt_id: GO:0001105
def: "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
comment: For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
synonym: "RNA polymerase II transcription co-activator activity" RELATED []
synonym: "RNA polymerase II transcription coactivator activity" RELATED []
synonym: "RNA polymerase II transcription mediator activity" RELATED []
synonym: "transcription co-activator activity" EXACT []
is_a: GO:0003712 ! transcription coregulator activity
relationship: part_of: GO:0045893 ! positive regulation of DNA-templated transcription

AmiGO <GOterm>GO:0003713</GOterm>
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