HUMAN:PPARD

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PPARD (synonyms: NR1C2, PPARB)
Protein Name(s)	Peroxisome proliferator-activated receptor delta PPAR-delta NUCI Nuclear hormone receptor 1 NUC1 Nuclear receptor subfamily 1 group C member 2 Peroxisome proliferator-activated receptor beta PPAR-beta
External Links
UniProt	Q03181
EMBL	L07592 AF246303 AF246299 AF246300 AF246301 AF246302 AB307691 AY919140 AK291661 AK296425 AK304878 AK122614 AY442342 AL022721 AL022721 CH471081 BC002715 BC007578 AB099507
CCDS	CCDS4803.1 CCDS4804.1 CCDS54994.1 CCDS54995.1
PIR	A45360
RefSeq	NP_001165289.1 NP_001165290.1 NP_001165291.1 NP_006229.1 NP_803184.1 XP_005249250.1 XP_006715183.1 XP_006715184.1 XP_006715185.1 XP_006715186.1
UniGene	Hs.696032
PDB	1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM
PDBsum	1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 2XYJ 2XYW 2XYX 2ZNP 2ZNQ 3D5F 3DY6 3ET2 3GWX 3GZ9 3OZ0 3PEQ 3SP9 3TKM
ProteinModelPortal	Q03181
SMR	Q03181
BioGrid	111463
IntAct	Q03181
MINT	MINT-1200178
STRING	9606.ENSP00000310928
BindingDB	Q03181
ChEMBL	CHEMBL2111371
DrugBank	DB01393 DB00159 DB00605 DB00374
GuidetoPHARMACOLOGY	594
PhosphoSite	Q03181
DMDM	417522
MaxQB	Q03181
PaxDb	Q03181
PRIDE	Q03181
DNASU	5467
Ensembl	ENST00000311565 ENST00000337400 ENST00000360694 ENST00000418635 ENST00000448077
GeneID	5467
KEGG	hsa:5467
UCSC	uc003okm.3 uc011dtb.2
CTD	5467
GeneCards	GC06P035310
H-InvDB	HIX0165038
HGNC	HGNC:9235
HPA	CAB017635
MIM	600409
neXtProt	NX_Q03181
PharmGKB	PA33557
eggNOG	NOG266867
GeneTree	ENSGT00760000119049
HOGENOM	HOG000261626
HOVERGEN	HBG106004
InParanoid	Q03181
KO	K04504
OMA	MNVPQVE
OrthoDB	EOG7X9G7F
PhylomeDB	Q03181
TreeFam	TF316304
Reactome	REACT_11082 REACT_12528 REACT_15525
SignaLink	Q03181
ChiTaRS	PPARD
EvolutionaryTrace	Q03181
GeneWiki	Peroxisome_proliferator-activated_receptor_delta
GenomeRNAi	5467
NextBio	21160
PRO	PR:Q03181
Proteomes	UP000005640
Bgee	Q03181
CleanEx	HS_PPARD
ExpressionAtlas	Q03181
Genevestigator	Q03181
GO	GO:0005654 GO:0005634 GO:0003677 GO:0008144 GO:0004879 GO:0070539 GO:0008289 GO:0043565 GO:0003700 GO:0003707 GO:0003713 GO:0008270 GO:0060612 GO:0097190 GO:0008366 GO:0030154 GO:0008283 GO:0031589 GO:0071456 GO:0008203 GO:0046697 GO:0007566 GO:0006635 GO:0009062 GO:0015908 GO:0010467 GO:0006091 GO:0006006 GO:0015758 GO:0007507 GO:0030522 GO:0051546 GO:0043616 GO:0006629 GO:0009299 GO:0043066 GO:0030308 GO:0032966 GO:0050680 GO:0050728 GO:0014912 GO:0048662 GO:0000122 GO:0045892 GO:0008654 GO:0008284 GO:0045684 GO:0045600 GO:0032024 GO:0014068 GO:0045893 GO:0045909 GO:0006029 GO:0006357 GO:0014823 GO:0009749 GO:0033189 GO:0006367 GO:0006776 GO:0042060
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR003074 IPR003075 IPR008946 IPR000536 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR01288 PR01290 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006915	apoptotic process	PMID:12909723^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Figure 4. B.	complete CACAO 2452
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003075	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:D3ZWV0	F	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:26504087^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42224	F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35396	C	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35396	F	Seeded From UniProt	complete
involved_in	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35396	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:12909723^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:9113987^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	PMID:11551955^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0070539	linoleic acid binding	PMID:10198642^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12955147^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35396	P	Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	PMID:10991946^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0015908	fatty acid transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35396	P	Seeded From UniProt	complete
involved_in	GO:1904659	glucose transmembrane transport	PMID:15793256^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008366	axon ensheathment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35396	P	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:12955147^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35396	P	Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:10198642^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006635	fatty acid beta-oxidation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35396	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35396	P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	PMID:15793256^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11551955^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:12955147^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12955147^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11551955^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35396	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35396	P	Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000638181 RGD:3370	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637985	P	Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F	Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN001941333 RGD:3371	P	Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN001182169 RGD:3371	P	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P	Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000637985 RGD:3371	P	Seeded From UniProt	complete
involved_in	GO:0010887	negative regulation of cholesterol storage	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:P37231 UniProtKB:Q07869	P	Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001941333 UniProtKB:P10827	P	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN001182169 UniProtKB:Q03181 UniProtKB:Q07869	F	Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869	F	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P	Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN001182169 RGD:3369	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C	Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 RGD:3370	F	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN001182169	F	Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:Q07869	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 MGI:MGI:2449205 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98743 PANTHER:PTN001941333 UniProtKB:P20393 UniProtKB:P37231 UniProtKB:Q07869 WB:WBGene00004786	P	Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004879	P	Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004879	P	Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P	Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003707	P	Seeded From UniProt	complete
involved_in	GO:2000288	positive regulation of myoblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0060612	adipose tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0051546	keratinocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	F	Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0045598	regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0043616	keratinocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0043415	positive regulation of skeletal muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0031589	cell-substrate adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0015908	fatty acid transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0014842	regulation of skeletal muscle satellite cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0008366	axon ensheathment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0006635	fatty acid beta-oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	F	Seeded From UniProt	complete
involved_in	GO:0001890	placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	C	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35396 ensembl:ENSMUSP00000002320	P	Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	F	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0045684	positive regulation of epidermis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0032966	negative regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0014912	negative regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0009299	mRNA transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0008654	phospholipid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0006776	vitamin A metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
involved_in	GO:0006029	proteoglycan metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	C	Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	F	Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003075	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F	Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F	Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003074 InterPro:IPR003075	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003075	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003075 InterPro:IPR013088	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:1333051^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:1333051^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006091	generation of precursor metabolites and energy	PMID:1333051^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	PMID:1333051^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	PMID:11551955^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009062	fatty acid catabolic process	PMID:15192438^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:11847022^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	PMID:15192438^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	PMID:11551955^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006635	fatty acid beta-oxidation	PMID:15192438^[12] PMID:15803109^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-383280	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5634100 Reactome:R-HSA-5422942 Reactome:R-HSA-376419	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Shureiqi, I et al. (2003) The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100 9968-73 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Kotla, S & Rao, GN (2015) Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation. J. Biol. Chem. 290 30306-20 PubMed GONUTS page
↑ Kliewer, SA et al. (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc. Natl. Acad. Sci. U.S.A. 94 4318-23 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Hatae, T et al. (2001) Prostacyclin-dependent apoptosis mediated by PPAR delta. J. Biol. Chem. 276 46260-7 PubMed GONUTS page
↑ ^6.0 ^6.1 Xu, HE et al. (1999) Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol. Cell 3 397-403 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Fu, J et al. (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425 90-3 PubMed GONUTS page
↑ Bastie, C et al. (2000) Alterations of peroxisome proliferator-activated receptor delta activity affect fatty acid-controlled adipose differentiation. J. Biol. Chem. 275 38768-73 PubMed GONUTS page
↑ ^9.0 ^9.1 Krämer, DK et al. (2005) Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta. Diabetes 54 1157-63 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 ^10.19 ^10.20 ^10.21 ^10.22 ^10.23 ^10.24 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Schmidt, A et al. (1992) Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol. Endocrinol. 6 1634-41 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Fredenrich, A & Grimaldi, PA (2004) Roles of peroxisome proliferator-activated receptor delta in skeletal muscle function and adaptation. Curr Opin Clin Nutr Metab Care 7 377-81 PubMed GONUTS page
↑ Bastie, C (2002) [PPARdelta and PPARgamma: roles in fatty acids signalling, implication in tumorigenesis]. Bull Cancer 89 23-8 PubMed GONUTS page
↑ Fredenrich, A & Grimaldi, PA (2005) PPAR delta: an uncompletely known nuclear receptor. Diabetes Metab. 31 23-7 PubMed GONUTS page

[PMID:12909723-1] 1.0 ^1.1 Shureiqi, I et al. (2003) The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100 9968-73 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:26504087-3] Kotla, S & Rao, GN (2015) Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation. J. Biol. Chem. 290 30306-20 PubMed GONUTS page

[PMID:9113987-4] Kliewer, SA et al. (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc. Natl. Acad. Sci. U.S.A. 94 4318-23 PubMed GONUTS page

[PMID:11551955-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Hatae, T et al. (2001) Prostacyclin-dependent apoptosis mediated by PPAR delta. J. Biol. Chem. 276 46260-7 PubMed GONUTS page

[PMID:10198642-6] 6.0 ^6.1 Xu, HE et al. (1999) Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol. Cell 3 397-403 PubMed GONUTS page

[PMID:12955147-7] 7.0 ^7.1 ^7.2 ^7.3 Fu, J et al. (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425 90-3 PubMed GONUTS page

[PMID:10991946-8] Bastie, C et al. (2000) Alterations of peroxisome proliferator-activated receptor delta activity affect fatty acid-controlled adipose differentiation. J. Biol. Chem. 275 38768-73 PubMed GONUTS page

[PMID:15793256-9] 9.0 ^9.1 Krämer, DK et al. (2005) Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta. Diabetes 54 1157-63 PubMed GONUTS page

[PMID:21873635-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 ^10.19 ^10.20 ^10.21 ^10.22 ^10.23 ^10.24 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1333051-11] 11.0 ^11.1 ^11.2 ^11.3 Schmidt, A et al. (1992) Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids. Mol. Endocrinol. 6 1634-41 PubMed GONUTS page

[PMID:15192438-12] 12.0 ^12.1 ^12.2 Fredenrich, A & Grimaldi, PA (2004) Roles of peroxisome proliferator-activated receptor delta in skeletal muscle function and adaptation. Curr Opin Clin Nutr Metab Care 7 377-81 PubMed GONUTS page

[PMID:11847022-13] Bastie, C (2002) [PPARdelta and PPARgamma: roles in fatty acids signalling, implication in tumorigenesis]. Bull Cancer 89 23-8 PubMed GONUTS page

[PMID:15803109-14] Fredenrich, A & Grimaldi, PA (2005) PPAR delta: an uncompletely known nuclear receptor. Diabetes Metab. 31 23-7 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

HUMAN:PPARD

Contents

Annotations

Notes

References

a

c

d

e

f

g

h

i

k

l

m

n

o

p

r

s

t

v

w

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools