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Category:GO:0004879 ! nuclear receptor activity

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DAG for GO:0004879id: GO:0004879

name: nuclear receptor activity
namespace: molecular_function
alt_id: GO:0003708
alt_id: GO:0004880
alt_id: GO:0004882
alt_id: GO:0004884
alt_id: GO:0004886
alt_id: GO:0004887
alt_id: GO:0008434
alt_id: GO:0038050
alt_id: GO:0038051
alt_id: GO:0038052
def: "A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus." [GOC:txnOH-2018]
comment: Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'GO:0030374 ; nuclear receptor transcription coactivator activity' or GO:0140536 ; nuclear corepressor activity.
synonym: "1,25-(OH)2D3 receptor activity" NARROW [Wikipedia:Calcitriol]
synonym: "9-cis retinoic acid receptor activity" NARROW []
synonym: "androgen receptor activity" NARROW []
synonym: "calcitriol receptor activity" NARROW []
synonym: "ecdysteroid hormone receptor activity" NARROW []
synonym: "estrogen nuclear receptor activity" NARROW [GOC:bf]
synonym: "glucocorticoid receptor activity" NARROW [GOC:bf]
synonym: "juvenile hormone receptor activity" NARROW []
synonym: "ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT []
synonym: "ligand-dependent nuclear receptor activity" RELATED [GOC:bf]
synonym: "ligand-dependent transcription factor activity" RELATED [GOC:bf]
synonym: "nuclear hormone receptor" NARROW []
synonym: "nuclear receptor activity" RELATED [GOC:bf]
synonym: "retinoic acid receptor activity" NARROW []
synonym: "retinoid-X receptor activity" NARROW [GOC:bf]
synonym: "RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding" NARROW []
synonym: "RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding" NARROW []
synonym: "RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding" EXACT []
synonym: "RXR" NARROW []
synonym: "thyroid hormone receptor activity" NARROW []
synonym: "vitamin A receptor activity" NARROW []
synonym: "vitamin D receptor activity" NARROW []
synonym: "vitamin D3 receptor activity" NARROW [GOC:bf, Wikipedia:Calcitriol_receptor]
is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific
is_a: GO:0038023 ! signaling receptor activity
is_a: GO:0098531 ! ligand-activated transcription factor activity
relationship: part_of: GO:0030522 ! intracellular receptor signaling pathway

AmiGO <GOterm>GO:0004879</GOterm>
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