Category:GO:0004879 ! nuclear receptor activity

name: nuclear receptor activity
namespace: molecular_function
alt_id: GO:0003708
alt_id: GO:0004880
alt_id: GO:0004882
alt_id: GO:0004884
alt_id: GO:0004886
alt_id: GO:0004887
alt_id: GO:0008434
alt_id: GO:0038050
alt_id: GO:0038051
alt_id: GO:0038052
def: "A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus." [GOC:txnOH-2018, PMID:23457262]
comment: Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA.
synonym: "1,25-(OH)2D3 receptor activity" NARROW [Wikipedia:Calcitriol]
synonym: "9-cis retinoic acid receptor activity" NARROW []
synonym: "androgen receptor activity" NARROW []
synonym: "calcitriol receptor activity" NARROW []
synonym: "ecdysteroid hormone receptor activity" NARROW []
synonym: "estrogen nuclear receptor activity" NARROW [GOC:bf]
synonym: "glucocorticoid receptor activity" NARROW [GOC:bf]
synonym: "juvenile hormone receptor activity" NARROW []
synonym: "ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT []
synonym: "ligand-dependent nuclear receptor activity" RELATED [GOC:bf]
synonym: "ligand-dependent transcription factor activity" RELATED [GOC:bf]
synonym: "nuclear hormone receptor" NARROW []
synonym: "retinoic acid receptor activity" NARROW []
synonym: "retinoid-X receptor activity" NARROW [GOC:bf]
synonym: "RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding" NARROW []
synonym: "RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding" NARROW []
synonym: "RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding" EXACT []
synonym: "RXR" NARROW []
synonym: "thyroid hormone receptor activity" NARROW []
synonym: "vitamin A receptor activity" NARROW []
synonym: "vitamin D receptor activity" NARROW []
synonym: "vitamin D3 receptor activity" NARROW [GOC:bf, Wikipedia:Calcitriol_receptor]
is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific
is_a: GO:0038023 ! signaling receptor activity
is_a: GO:0098531 ! ligand-modulated transcription factor activity
relationship: part_of: GO:0030522 ! intracellular receptor signaling pathway

AmiGO <GOterm>GO:0004879</GOterm>
Gene Ontology Home