HUMAN:SRBP1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SREBF1 (synonyms: BHLHD1, SREBP1)
Protein Name(s)	Sterol regulatory element-binding protein 1 SREBP-1 Class D basic helix-loop-helix protein 1 bHLHd1 Sterol regulatory element-binding transcription factor 1 Processed sterol regulatory element-binding protein 1
External Links
UniProt	P36956
EMBL	U00968 S66167 S66168 AB373958 AB373959 AC122129 CH471196 CH471196 BC023621 BC026962 BC057388 BC063281 AB209609
CCDS	CCDS11189.1 CCDS32583.1
PIR	A48845
RefSeq	NP_001005291.1 NP_004167.3
UniGene	Hs.592123 Hs.733635
PDB	1AM9
PDBsum	1AM9
ProteinModelPortal	P36956
SMR	P36956
BioGrid	112598
DIP	DIP-331N
IntAct	P36956
MINT	MINT-2803077
STRING	9606.ENSP00000348069
PhosphoSite	P36956
DMDM	166897633
MaxQB	P36956
PaxDb	P36956
PRIDE	P36956
Ensembl	ENST00000261646 ENST00000355815
GeneID	6720
KEGG	hsa:6720
UCSC	uc002grq.2 uc002grs.2 uc010cpq.1
CTD	6720
GeneCards	GC17M017714
HGNC	HGNC:11289
HPA	CAB005406
MIM	184756
neXtProt	NX_P36956
PharmGKB	PA335
eggNOG	NOG242942
GeneTree	ENSGT00390000017651
HOVERGEN	HBG061592
InParanoid	P36956
KO	K07197
OMA	FDPPYAG
PhylomeDB	P36956
TreeFam	TF313894
Reactome	REACT_116145 REACT_118659 REACT_147797 REACT_147904 REACT_27161
SignaLink	P36956
ChiTaRS	SREBF1
EvolutionaryTrace	P36956
GeneWiki	SREBF1
GenomeRNAi	6720
NextBio	26212
PMAP-CutDB	P36956
PRO	PR:P36956
Proteomes	UP000005640
Bgee	P36956
CleanEx	HS_SREBF1
ExpressionAtlas	P36956
Genevestigator	P36956
GO	GO:0005737 GO:0005829 GO:0005783 GO:0005789 GO:0012507 GO:0000139 GO:0016021 GO:0005635 GO:0005654 GO:0005634 GO:0043234 GO:0003682 GO:0003677 GO:0043565 GO:0003700 GO:0032810 GO:0007568 GO:0044255 GO:0071398 GO:0009267 GO:0008203 GO:0007623 GO:0008286 GO:0008610 GO:0006629 GO:0030324 GO:0046676 GO:0000122 GO:0045542 GO:0031065 GO:0045944 GO:0010867 GO:0019217 GO:0003062 GO:0006357 GO:0051591 GO:0042493 GO:0032094 GO:0033762 GO:0009749 GO:0032570 GO:0032526 GO:0044281 GO:0006351
Gene3D	4.10.280.10
InterPro	IPR011598
Pfam	PF00010
SMART	SM00353
SUPFAM	SSF47459
PROSITE	PS50888

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045941	positive regulation of transcription	PMID:20139635^[1]	ECO:0000270			P		Fig.5A	complete
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:12242332^[2]	ECO:0000314			P			complete
involved_in	GO:1903214	regulation of protein targeting to mitochondrion	PMID:24912190^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:1903146	regulation of autophagy of mitochondrion	PMID:24912190^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	PMID:24912190^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9BXM7)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[4]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR011598	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q08874	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:26437365^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000182) regulates_transcription_of:(ENSEMBL:ENSG00000199085)	Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:23610160^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000145214)	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:23610160^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000145214)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23610160^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q13285	P	regulates_transcription_of:(ENSEMBL:ENSG00000145214) part_of:(GO:0071320)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15358760^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0032810	sterol response element binding	PMID:16407292^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:16407292^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56720	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:16407292^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010867	positive regulation of triglyceride biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTN3	P		Seeded From UniProt	complete
involved_in	GO:0008610	lipid biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTN3	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTN3	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WTN3	F		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008047	P		Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	F		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0033762	response to glucagon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	C		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0032094	response to food	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56720 ensembl:ENSRNOP00000050057	F		Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
involved_in	GO:0045542	positive regulation of cholesterol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	F		Seeded From UniProt	complete
involved_in	GO:0042789	mRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
involved_in	GO:0031065	positive regulation of histone deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	F		Seeded From UniProt	complete
involved_in	GO:0019217	regulation of fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	C		Seeded From UniProt	complete
involved_in	GO:0010867	positive regulation of triglyceride biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
involved_in	GO:0008610	lipid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
enables	GO:0008047	enzyme activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	F		Seeded From UniProt	complete
	GO:0032933	SREBP signaling pathway	PMID:27614840^[9]	ECO:0000315			P		Figure 2B. RNA interference-mediated knockdown of (SREBP)-1c reduces expression of sodium/iodide symporter (NIS) in MCF-7 cells.	complete CACAO 12104
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
	GO:0032933	SREBP signaling pathway	PMID:27614840^[9]	ECO:0000314			P		Figure 4B and 4C. nSREBP-1c Transcriptionally Activates the 5′-Flanking Region of hNIS in MCF-7 Cells	complete CACAO 12106
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	F		Seeded From UniProt	complete
involved_in	GO:0003062	regulation of heart rate by chemical signal	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WTN3 ensembl:ENSMUSP00000020846	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024097	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12242332^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:12202038^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12202038^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:24296663^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000182) has_regulation_target:(ENSEMBL:ENSG00000208023) occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:24296663^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000182) regulates_transcription_of:(ENSEMBL:ENSG00000208023)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23610160^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000148795) part_of:(GO:0003376)	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:8156598^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:8156598^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:8156598^[12] Reactome:R-NUL-2317526 Reactome:R-HSA-1368081	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:8156598^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8156598^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045540	regulation of cholesterol biosynthetic process	Reactome:R-HSA-1655829	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	Reactome:R-HSA-400253	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-2065550 Reactome:R-HSA-2065549 Reactome:R-HSA-1655851 Reactome:R-HSA-1655831	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6800052 Reactome:R-HSA-2426164 Reactome:R-HSA-2426163 Reactome:R-HSA-2426162 Reactome:R-HSA-2426161 Reactome:R-HSA-2426160 Reactome:R-HSA-2426157 Reactome:R-HSA-2426156 Reactome:R-HSA-2426155 Reactome:R-HSA-2426154 Reactome:R-HSA-2426153 Reactome:R-HSA-2426152 Reactome:R-HSA-2426151 Reactome:R-HSA-2426150 Reactome:R-HSA-2426148 Reactome:R-HSA-2426147 Reactome:R-HSA-2426146 Reactome:R-HSA-2426144 Reactome:R-HSA-2065966 Reactome:R-HSA-2065539 Reactome:R-HSA-1655831	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-HSA-1655851 Reactome:R-HSA-1655842	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
part_of	GO:0012507	ER to Golgi transport vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0078	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhao, LF et al. (2010) Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. Endocr. J. 57 317-24 PubMed GONUTS page
↑ ^2.0 ^2.1 Yabe, D et al. (2002) Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc. Natl. Acad. Sci. U.S.A. 99 12753-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Ivatt, RM et al. (2014) Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proc. Natl. Acad. Sci. U.S.A. 111 8494-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Goedeke, L et al. (2015) MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels. Nat. Med. 21 1280-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Cai, K & Sewer, MB (2013) cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1. J. Lipid Res. 54 2121-32 PubMed GONUTS page
↑ Zeng, L et al. (2004) Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J. Biol. Chem. 279 48801-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Costet, P et al. (2006) Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. J. Biol. Chem. 281 6211-8 PubMed GONUTS page
↑ ^9.0 ^9.1 Wen, G et al. (2016) Sterol regulatory element-binding proteins are regulators of the sodium/iodide symporter in mammary epithelial cells. J. Dairy Sci. PubMed GONUTS page
↑ ^10.0 ^10.1 Yang, T et al. (2002) Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110 489-500 PubMed GONUTS page
↑ ^11.0 ^11.1 Yang, M et al. (2014) Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake. J. Lipid Res. 55 226-38 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Wang, X et al. (1994) SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77 53-62 PubMed GONUTS page

[PMID:20139635-1] Zhao, LF et al. (2010) Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. Endocr. J. 57 317-24 PubMed GONUTS page

[PMID:12242332-2] 2.0 ^2.1 Yabe, D et al. (2002) Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc. Natl. Acad. Sci. U.S.A. 99 12753-8 PubMed GONUTS page

[PMID:24912190-3] 3.0 ^3.1 ^3.2 Ivatt, RM et al. (2014) Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proc. Natl. Acad. Sci. U.S.A. 111 8494-9 PubMed GONUTS page

[PMID:19274049-4] 4.0 ^4.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:26437365-5] Goedeke, L et al. (2015) MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels. Nat. Med. 21 1280-9 PubMed GONUTS page

[PMID:23610160-6] 6.0 ^6.1 ^6.2 ^6.3 Cai, K & Sewer, MB (2013) cAMP-stimulated transcription of DGKθ requires steroidogenic factor 1 and sterol regulatory element binding protein 1. J. Lipid Res. 54 2121-32 PubMed GONUTS page

[PMID:15358760-7] Zeng, L et al. (2004) Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J. Biol. Chem. 279 48801-7 PubMed GONUTS page

[PMID:16407292-8] 8.0 ^8.1 ^8.2 Costet, P et al. (2006) Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. J. Biol. Chem. 281 6211-8 PubMed GONUTS page

[PMID:27614840-9] 9.0 ^9.1 Wen, G et al. (2016) Sterol regulatory element-binding proteins are regulators of the sodium/iodide symporter in mammary epithelial cells. J. Dairy Sci. PubMed GONUTS page

[PMID:12202038-10] 10.0 ^10.1 Yang, T et al. (2002) Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110 489-500 PubMed GONUTS page

[PMID:24296663-11] 11.0 ^11.1 Yang, M et al. (2014) Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake. J. Lipid Res. 55 226-38 PubMed GONUTS page

[PMID:8156598-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Wang, X et al. (1994) SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77 53-62 PubMed GONUTS page

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