HUMAN:PPARA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PPARA (synonyms: NR1C1, PPAR)
Protein Name(s)	Peroxisome proliferator-activated receptor alpha PPAR-alpha Nuclear receptor subfamily 1 group C member 1
External Links
UniProt	Q07869
EMBL	L02932 S74349 Y07619 AB307690 EU650667 EU395809 CR456547 AK289821 CR457435 AY206718 AL049856 AL078611 Z94161 CH471138
CCDS	CCDS33669.1
PIR	A49289 I56603
RefSeq	NP_001001928.1 NP_005027.2 XP_005261710.1 XP_005261712.1 XP_005261713.1 XP_005261714.1 XP_006724332.1 XP_006724333.1
UniGene	Hs.103110 Hs.710044
PDB	1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR
PDBsum	1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR
ProteinModelPortal	Q07869
SMR	Q07869
BioGrid	111461
DIP	DIP-241N
IntAct	Q07869
MINT	MINT-232229
STRING	9606.ENSP00000262735
BindingDB	Q07869
ChEMBL	CHEMBL239
DrugBank	DB01393 DB00636 DB01039 DB01241 DB00328
GuidetoPHARMACOLOGY	593
PhosphoSite	Q07869
DMDM	3041727
PaxDb	Q07869
PRIDE	Q07869
DNASU	5465
Ensembl	ENST00000262735 ENST00000402126 ENST00000407236
GeneID	5465
KEGG	hsa:5465
UCSC	uc003bgw.1
CTD	5465
GeneCards	GC22P046546
HGNC	HGNC:9232
MIM	170998
neXtProt	NX_Q07869
PharmGKB	PA280
eggNOG	NOG266867
GeneTree	ENSGT00760000119049
HOGENOM	HOG000261626
HOVERGEN	HBG106004
InParanoid	Q07869
KO	K07294
OMA	NNNPPFV
PhylomeDB	Q07869
TreeFam	TF316304
Reactome	REACT_111118 REACT_116145 REACT_118659 REACT_118713 REACT_118789 REACT_147904 REACT_15525 REACT_19241 REACT_200608 REACT_24941 REACT_267716 REACT_27161
SignaLink	Q07869
ChiTaRS	PPARA
EvolutionaryTrace	Q07869
GeneWiki	Peroxisome_proliferator-activated_receptor_alpha
GenomeRNAi	5465
NextBio	21152
PRO	PR:Q07869
Proteomes	UP000005640
Bgee	Q07869
CleanEx	HS_PPARA
ExpressionAtlas	Q07869
Genevestigator	Q07869
GO	GO:0005654 GO:0005634 GO:0003677 GO:0008144 GO:0004879 GO:0008289 GO:0000978 GO:0001078 GO:0001077 GO:0001103 GO:0001190 GO:0043565 GO:0003700 GO:0003707 GO:0031624 GO:0008270 GO:0035095 GO:0044255 GO:0032922 GO:0070166 GO:0008544 GO:0006631 GO:0015908 GO:0010467 GO:0007507 GO:0030522 GO:0006629 GO:0042157 GO:0032099 GO:0045776 GO:0010887 GO:0045820 GO:0010745 GO:1901215 GO:0032091 GO:0010871 GO:0010891 GO:0000122 GO:2000678 GO:0032000 GO:0046321 GO:0045722 GO:0045944 GO:0045893 GO:0072366 GO:0042752 GO:0072363 GO:0072369 GO:0001666 GO:0032868 GO:0044281 GO:0006367 GO:0042060
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR003074 IPR003076 IPR008946 IPR000536 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR01288 PR01289 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003076	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:D3ZWV0	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:26504087^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24639097^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000525)\|part_of:(CL:0000523)	Seeded From UniProt	complete
involved_in	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	PMID:21636785^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000062716)	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21636785^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0034616) occurs_in:(CL:0000071)	Seeded From UniProt	complete
involved_in	GO:1903038	negative regulation of leukocyte cell-cell adhesion	PMID:21636785^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0034616)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9748239^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:335)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:9748239^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:9748239^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:9748239^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9748239^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:335)	Seeded From UniProt	complete
involved_in	GO:0072369	regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter	PMID:19955185^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072366	regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter	PMID:19955185^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072363	regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter	PMID:19955185^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046321	positive regulation of fatty acid oxidation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23204	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19955185^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20837115^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045820	negative regulation of glycolytic process	PMID:19955185^[6]	ECO:0000305	curator inference used in manual assertion	GO:0072363	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23204	F		Seeded From UniProt	complete
enables	GO:0031624	ubiquitin conjugating enzyme binding	PMID:19955185^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63279	F		Seeded From UniProt	complete
involved_in	GO:0010891	negative regulation of sequestering of triglyceride	PMID:12700342^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010887	negative regulation of cholesterol storage	PMID:19114110^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010871	negative regulation of receptor biosynthetic process	PMID:12700342^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010745	negative regulation of macrophage derived foam cell differentiation	PMID:19114110^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010745	negative regulation of macrophage derived foam cell differentiation	PMID:12700342^[8]	ECO:0000305	curator inference used in manual assertion	GO:0010891	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:9113987^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:19955185^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	PMID:19955185^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:19955185^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23204	F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	PMID:19955185^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75376	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12700342^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12955147^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23204	P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23204	P		Seeded From UniProt	complete
involved_in	GO:0032099	negative regulation of appetite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23204	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:12955147^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:12955147^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:12955147^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002515155 UniProtKB:Q07869	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637985	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F		Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN001941333 RGD:3371	P		Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN001182169 RGD:3371	P		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000637985 RGD:3371	P		Seeded From UniProt	complete
involved_in	GO:0010887	negative regulation of cholesterol storage	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:P37231 UniProtKB:Q07869	P		Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001941333 UniProtKB:P10827	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN001182169 UniProtKB:Q03181 UniProtKB:Q07869	F		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN001182169 RGD:3369	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C		Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 RGD:3370	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN001182169	F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:Q07869	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 MGI:MGI:2449205 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98743 PANTHER:PTN001941333 UniProtKB:P20393 UniProtKB:P37231 UniProtKB:Q07869 WB:WBGene00004786	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003707	P		Seeded From UniProt	complete
involved_in	GO:0070166	enamel mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	P		Seeded From UniProt	complete
involved_in	GO:0046321	positive regulation of fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	P		Seeded From UniProt	complete
involved_in	GO:0045722	positive regulation of gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	F		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	F		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	P		Seeded From UniProt	complete
involved_in	GO:0032099	negative regulation of appetite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	P		Seeded From UniProt	complete
involved_in	GO:0008544	epidermis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	F		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23204 ensembl:ENSMUSP00000105049	F		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	P		Seeded From UniProt	complete
enables	GO:0097371	MDM2/MDM4 family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	F		Seeded From UniProt	complete
involved_in	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	P		Seeded From UniProt	complete
enables	GO:0051525	NFAT protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	F		Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	F		Seeded From UniProt	complete
involved_in	GO:0042157	lipoprotein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	P		Seeded From UniProt	complete
involved_in	GO:0035095	behavioral response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	P		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	P		Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	F		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	P		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	P		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37230 ensembl:ENSRNOP00000038651	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003076	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003074 InterPro:IPR003076	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003076	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003076 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	PMID:10377439^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:9792666^[14] PMID:7684926^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:10860941^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032000	positive regulation of fatty acid beta-oxidation	PMID:16271724^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0015908	fatty acid transport	PMID:16271724^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16271724^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	Reactome:R-HSA-400206	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-383280	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-4341070 Reactome:R-HSA-400204 Reactome:R-HSA-400183 Reactome:R-HSA-400143 Reactome:R-HSA-376419	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Kotla, S & Rao, GN (2015) Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation. J. Biol. Chem. 290 30306-20 PubMed GONUTS page
↑ Zhao, C et al. (2014) MicroRNA-518d regulates PPARα protein expression in the placentas of females with gestational diabetes mellitus. Mol Med Rep 9 2085-90 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Zhou, J et al. (2011) MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc. Natl. Acad. Sci. U.S.A. 108 10355-60 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Vu-Dac, N et al. (1998) The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates. J. Biol. Chem. 273 25713-20 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Pourcet, B et al. (2010) SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR. J. Biol. Chem. 285 5983-92 PubMed GONUTS page
↑ Demeure, O et al. (2011) Regulation of LPCAT3 by LXR. Gene 470 7-11 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Haraguchi, G et al. (2003) PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor. J. Lipid Res. 44 1224-31 PubMed GONUTS page
↑ ^9.0 ^9.1 Mei, CL et al. (2009) Chlamydia pneumoniae induces macrophage-derived foam cell formation via PPAR alpha and PPAR gamma-dependent pathways. Cell Biol. Int. 33 301-8 PubMed GONUTS page
↑ Kliewer, SA et al. (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc. Natl. Acad. Sci. U.S.A. 94 4318-23 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Fu, J et al. (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425 90-3 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 ^12.18 ^12.19 ^12.20 ^12.21 ^12.22 ^12.23 ^12.24 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Leone, TC et al. (1999) A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc. Natl. Acad. Sci. U.S.A. 96 7473-8 PubMed GONUTS page
↑ Costet, P et al. (1998) Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J. Biol. Chem. 273 29577-85 PubMed GONUTS page
↑ Sher, T et al. (1993) cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 32 5598-604 PubMed GONUTS page
↑ Rodríguez, C et al. (2000) Differences in the formation of PPARalpha-RXR/acoPPRE complexes between responsive and nonresponsive species upon fibrate administration. Mol. Pharmacol. 58 185-93 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Napal, L et al. (2005) An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A. J. Mol. Biol. 354 751-9 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:26504087-2] Kotla, S & Rao, GN (2015) Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation. J. Biol. Chem. 290 30306-20 PubMed GONUTS page

[PMID:24639097-3] Zhao, C et al. (2014) MicroRNA-518d regulates PPARα protein expression in the placentas of females with gestational diabetes mellitus. Mol Med Rep 9 2085-90 PubMed GONUTS page

[PMID:21636785-4] 4.0 ^4.1 ^4.2 Zhou, J et al. (2011) MicroRNA-21 targets peroxisome proliferators-activated receptor-alpha in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc. Natl. Acad. Sci. U.S.A. 108 10355-60 PubMed GONUTS page

[PMID:9748239-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Vu-Dac, N et al. (1998) The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates. J. Biol. Chem. 273 25713-20 PubMed GONUTS page

[PMID:19955185-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Pourcet, B et al. (2010) SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR. J. Biol. Chem. 285 5983-92 PubMed GONUTS page

[PMID:20837115-7] Demeure, O et al. (2011) Regulation of LPCAT3 by LXR. Gene 470 7-11 PubMed GONUTS page

[PMID:12700342-8] 8.0 ^8.1 ^8.2 ^8.3 Haraguchi, G et al. (2003) PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor. J. Lipid Res. 44 1224-31 PubMed GONUTS page

[PMID:19114110-9] 9.0 ^9.1 Mei, CL et al. (2009) Chlamydia pneumoniae induces macrophage-derived foam cell formation via PPAR alpha and PPAR gamma-dependent pathways. Cell Biol. Int. 33 301-8 PubMed GONUTS page

[PMID:9113987-10] Kliewer, SA et al. (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc. Natl. Acad. Sci. U.S.A. 94 4318-23 PubMed GONUTS page

[PMID:12955147-11] 11.0 ^11.1 ^11.2 ^11.3 Fu, J et al. (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425 90-3 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 ^12.18 ^12.19 ^12.20 ^12.21 ^12.22 ^12.23 ^12.24 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10377439-13] Leone, TC et al. (1999) A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc. Natl. Acad. Sci. U.S.A. 96 7473-8 PubMed GONUTS page

[PMID:9792666-14] Costet, P et al. (1998) Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J. Biol. Chem. 273 29577-85 PubMed GONUTS page

[PMID:7684926-15] Sher, T et al. (1993) cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 32 5598-604 PubMed GONUTS page

[PMID:10860941-16] Rodríguez, C et al. (2000) Differences in the formation of PPARalpha-RXR/acoPPRE complexes between responsive and nonresponsive species upon fibrate administration. Mol. Pharmacol. 58 185-93 PubMed GONUTS page

[PMID:16271724-17] 17.0 ^17.1 ^17.2 Napal, L et al. (2005) An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A. J. Mol. Biol. 354 751-9 PubMed GONUTS page

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HUMAN:PPARA

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