GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:16271724
| Citation |
Napal, L, Marrero, PF and Haro, D (2005) An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A. J. Mol. Biol. 354:751-9 |
|---|---|
| Abstract |
The liver plays a central role in the response to fasting. The hormonal profile in this condition, low insulin, and high concentrations of glucagon in plasma, induce the release of large amounts of fatty acids from adipose tissue. Prolonged starvation can therefore induce a dramatic change in the fatty acid oxidative capacity of liver metabolism. Modulation of gene expression by PPARalpha plays a crucial role in this response. While a major role for PPARalpha in the liver is to produce ketone bodies as fuel through beta-oxidation for peripheral tissues during fast, its participation in the control of CPT1A, the rate-limiting step of the pathway, remains controversial. Using Web-based software (VISTA) combining transcription factor binding site database searches with comparative sequence analyses, we have localized a conserved functional PPAR responsive element downstream of the transcriptional start site of the human CPT1A gene. We have shown that this sequence is fundamental for fatty acids or PGC1-induced transcriptional activation of the CPT1A gene. These results corroborate the hypothesis that PPARalpha regulates the limiting step in the oxidation of fatty acids in liver mitochondria. |
| Links |
PubMed Online version:10.1016/j.jmb.2005.09.097 |
| Keywords |
Amino Acid Sequence; Binding Sites; Carnitine O-Palmitoyltransferase/biosynthesis; Cell Line, Tumor; Computational Biology; Databases, Nucleic Acid; Enzyme Induction; Fatty Acids/metabolism; Fatty Acids/physiology; Humans; Introns; Linoleic Acid/pharmacology; Liver/cytology; Oxidation-Reduction; PPAR alpha/physiology; Response Elements; Transcription Factors/pharmacology; Transfection |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
