RAT:PPARG

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Pparg (synonyms: Nr1c3)
Protein Name(s)	Peroxisome proliferator-activated receptor gamma PPAR-gamma Nuclear receptor subfamily 1 group C member 3
External Links
UniProt	O88275
EMBL	AF156666 AF156665 AB019561 Y12882 AB011365 AF246457 AF246458
RefSeq	NP_001138838.1 NP_001138839.1 NP_037256.1 XP_006237071.1
UniGene	Rn.23443
ProteinModelPortal	O88275
SMR	O88275
BindingDB	O88275
ChEMBL	CHEMBL4797
PhosphoSite	O88275
PRIDE	O88275
Ensembl	ENSRNOT00000012137 ENSRNOT00000051858
GeneID	25664
KEGG	rno:25664
UCSC	RGD:3371
CTD	5468
RGD	3371
eggNOG	NOG266867
GeneTree	ENSGT00760000119049
HOGENOM	HOG000261626
HOVERGEN	HBG106004
InParanoid	O88275
KO	K08530
OMA	HEEPSNS
OrthoDB	EOG7X9G7F
PhylomeDB	O88275
TreeFam	TF316304
Reactome	REACT_196408 REACT_242509 REACT_260360
NextBio	607577
PRO	PR:O88275
Proteomes	UP000002494
Genevestigator	O88275
GO	GO:0005829 GO:0005634 GO:0048471 GO:0003682 GO:0003677 GO:0008144 GO:0030331 GO:0004879 GO:0030374 GO:0019903 GO:0001012 GO:0001228 GO:0043565 GO:0003700 GO:0003707 GO:0008134 GO:0044212 GO:0008270 GO:0006919 GO:0050873 GO:0045165 GO:0048469 GO:0071455 GO:0032869 GO:0071285 GO:0071380 GO:0071379 GO:0071300 GO:0071306 GO:0030855 GO:0006631 GO:0019395 GO:0042593 GO:0007507 GO:0042953 GO:0015909 GO:0045713 GO:0030224 GO:0002674 GO:0030308 GO:0008285 GO:0010887 GO:0032966 GO:0060336 GO:2000230 GO:0010871 GO:0010891 GO:0048662 GO:0051974 GO:0000122 GO:0031100 GO:0035357 GO:0001890 GO:0043065 GO:0045600 GO:0046321 GO:0048714 GO:0060100 GO:0051091 GO:0045944 GO:0045893 GO:0008217 GO:0045598 GO:0019216 GO:0006357 GO:0060850 GO:0031000 GO:0009409 GO:0036270 GO:0042493 GO:0043627 GO:0035902 GO:0033993 GO:0055098 GO:0009612 GO:1901558 GO:0014070 GO:0010033 GO:0032526 GO:0042594 GO:0033189 GO:0050872
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR003074 IPR003077 IPR008946 IPR000536 IPR022590 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF12577 PF00105
PRINTS	PR01288 PR01291 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:20702579^[1]	ECO:0000314			P	Fig.1	complete CACAO 4620
	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	PMID:20702579^[1]	ECO:0000314			P	Fig.2	complete CACAO 4621
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:20702579^[1]	ECO:0000314			P	Fig.4	complete CACAO 4624
	GO:0043973	histone H3-K4 acetylation	PMID:20702579^[1]	ECO:0000314			P	Fig.5	complete CACAO 4626
	GO:0034968	histone lysine methylation	PMID:20702579^[1]	ECO:0000314			P	Fig.6	complete CACAO 4627
	GO:0001128	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly	PMID:20702579^[1]	ECO:0000314			F	Fig.7	complete CACAO 4628
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P	Seeded From UniProt	complete
involved_in	GO:0010742	macrophage derived foam cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37231	P	Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	F	Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19383491^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19383491^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:19383491^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050872	white fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P	Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P	Seeded From UniProt	complete
involved_in	GO:0060850	regulation of transcription involved in cell fate commitment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P	Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P	Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37231	P	Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O62807	P	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	F	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37231	F	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O62807	F	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	F	Seeded From UniProt	complete
involved_in	GO:2000230	negative regulation of pancreatic stellate cell proliferation	PMID:16202214^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901558	response to metformin	PMID:19000376^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071455	cellular response to hyperoxia	PMID:22444276^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071380	cellular response to prostaglandin E stimulus	PMID:10797535^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071379	cellular response to prostaglandin stimulus	PMID:11936221^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071306	cellular response to vitamin E	PMID:11752099^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	PMID:10797535^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060100	positive regulation of phagocytosis, engulfment	PMID:15940641^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051974	negative regulation of telomerase activity	PMID:16556873^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048714	positive regulation of oligodendrocyte differentiation	PMID:18543250^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:15774612^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0046321	positive regulation of fatty acid oxidation	PMID:18475159^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045598	regulation of fat cell differentiation	PMID:10438514^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:18769493^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:16202214^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	PMID:19157823^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:21451213^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:18846335^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035902	response to immobilization stress	PMID:15820709^[19]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:19251397^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	PMID:18384703^[21]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032966	negative regulation of collagen biosynthetic process	PMID:16202214^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	PMID:18565023^[22]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031000	response to caffeine	PMID:18486259^[23]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	PMID:20689342^[24]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2582	F	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:18600431^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:18600431^[25]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	PMID:17003342^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	PMID:18621767^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:18520050^[28]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:18304850^[29]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	PMID:15572034^[30]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:10438514^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:18594976^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:16556873^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:18600431^[25]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1310749	F	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:15754086^[32]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:16202214^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:10438514^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16247333^[33]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16247333^[33]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16257923^[34]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002674	negative regulation of acute inflammatory response	PMID:18479673^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637985	P	Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F	Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN001941333 RGD:3371	P	Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN001182169 RGD:3371	P	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000638208 UniProtKB:P37231	P	Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000638208 UniProtKB:O62807 UniProtKB:P37231	P	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P	Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000637985 RGD:3371	P	Seeded From UniProt	complete
involved_in	GO:0010887	negative regulation of cholesterol storage	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:P37231 UniProtKB:Q07869	P	Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001941333 UniProtKB:P10827	P	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN001182169 UniProtKB:Q03181 UniProtKB:Q07869	F	Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869	F	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P	Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN001182169 RGD:3369	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C	Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 RGD:3370	F	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN001182169	F	Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:Q07869	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 MGI:MGI:2449205 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98743 PANTHER:PTN001941333 UniProtKB:P20393 UniProtKB:P37231 UniProtKB:Q07869 WB:WBGene00004786	P	Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P	Seeded From UniProt	complete
involved_in	GO:1905563	negative regulation of vascular endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	C	Seeded From UniProt	complete
involved_in	GO:0071404	cellular response to low-density lipoprotein particle stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0061614	pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0060965	negative regulation of gene silencing by miRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
enables	GO:0051393	alpha-actinin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
enables	GO:0050693	LBD domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
enables	GO:0050692	DBD domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0048469	cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
enables	GO:0046965	retinoid X receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0045713	low-density lipoprotein particle receptor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	C	Seeded From UniProt	complete
involved_in	GO:0042953	lipoprotein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
enables	GO:0042277	peptide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
involved_in	GO:0035357	peroxisome proliferator activated receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	C	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
involved_in	GO:0030224	monocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0010891	negative regulation of sequestering of triglyceride	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0010887	negative regulation of cholesterol storage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0010871	negative regulation of receptor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0010745	negative regulation of macrophage derived foam cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0010742	macrophage derived foam cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	C	Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37231 ensembl:ENSP00000287820	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003077	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F	Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F	Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003074 InterPro:IPR003077	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003077	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003077 InterPro:IPR013088	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F	Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	PMID:10438514^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Chia, DJ & Rotwein, P (2010) Defining the epigenetic actions of growth hormone: acute chromatin changes accompany GH-activated gene transcription. Mol. Endocrinol. 24 2038-49 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Du, J et al. (2009) PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons. Biochem. Biophys. Res. Commun. 383 485-90 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Jaster, R et al. () Peroxisome proliferator-activated receptor gamma overexpression inhibits pro-fibrogenic activities of immortalised rat pancreatic stellate cells. J. Cell. Mol. Med. 9 670-82 PubMed GONUTS page
↑ Gao, Y et al. (2008) Metformin regulates osteoblast and adipocyte differentiation of rat mesenchymal stem cells. J. Pharm. Pharmacol. 60 1695-700 PubMed GONUTS page
↑ Zeng, Y et al. (2012) Hyperbaric oxygen preconditioning protects cortical neurons against oxygen-glucose deprivation injury: role of peroxisome proliferator-activated receptor-gamma. Brain Res. 1452 140-50 PubMed GONUTS page
↑ ^6.0 ^6.1 Ershov, AV & Bazan, NG (2000) Photoreceptor phagocytosis selectively activates PPARgamma expression in retinal pigment epithelial cells. J. Neurosci. Res. 60 328-37 PubMed GONUTS page
↑ Hong, JT et al. (2002) Inhibitory effect of peroxisome proliferator-activated receptor gamma agonist on ochratoxin A-induced cytotoxicity and activation of transcription factors in cultured rat embryonic midbrain cells. J. Toxicol. Environ. Health Part A 65 407-18 PubMed GONUTS page
↑ Davies, GF et al. (2002) Unique ability of troglitazone to up-regulate peroxisome proliferator-activated receptor-gamma expression in hepatocytes. J. Pharmacol. Exp. Ther. 300 72-7 PubMed GONUTS page
↑ Shimizu, K et al. (2005) Cytokines and peroxisome proliferator-activated receptor gamma ligand regulate phagocytosis by pancreatic stellate cells. Gastroenterology 128 2105-18 PubMed GONUTS page
↑ ^10.0 ^10.1 Ogawa, D et al. (2006) Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells. Circ. Res. 98 e50-9 PubMed GONUTS page
↑ Leisewitz, AV et al. (2008) A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis. J. Cell. Physiol. 217 367-76 PubMed GONUTS page
↑ Yuan, Z et al. (2005) Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade. Heart 91 1203-8 PubMed GONUTS page
↑ Sugimoto, K et al. (2008) Telmisartan increases fatty acid oxidation in skeletal muscle through a peroxisome proliferator-activated receptor-gamma dependent pathway. J. Hypertens. 26 1209-15 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Guardiola-Diaz, HM et al. (1999) Rat peroxisome proliferator-activated receptors and brown adipose tissue function during cold acclimatization. J. Biol. Chem. 274 23368-77 PubMed GONUTS page
↑ Mansour, MM et al. (2008) Activation of Penile Proadipogenic Peroxisome Proliferator-Activated Receptor gamma with an Estrogen: Interaction with Estrogen Receptor Alpha during Postnatal Development. PPAR Res 2008 651419 PubMed GONUTS page
↑ Palou, M et al. (2010) Regional differences in the expression of genes involved in lipid metabolism in adipose tissue in response to short- and medium-term fasting and refeeding. J. Nutr. Biochem. 21 23-33 PubMed GONUTS page
↑ Miana, M et al. (2011) Effect of eplerenone on hypertension-associated renal damage in rats: potential role of peroxisome proliferator activated receptor gamma (PPAR-γ). J. Physiol. Pharmacol. 62 87-94 PubMed GONUTS page
↑ Yao, Y et al. (2008) Telmisartan but not valsartan inhibits TGF-beta-mediated accumulation of extracellular matrix via activation of PPARgamma. J. Huazhong Univ. Sci. Technol. Med. Sci. 28 543-8 PubMed GONUTS page
↑ García-Bueno, B et al. (2005) Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats. Biol. Psychiatry 57 885-94 PubMed GONUTS page
↑ Duque-Guimarães, DE et al. () Early and prolonged intake of partially hydrogenated fat alters the expression of genes in rat adipose tissue. Nutrition 25 782-9 PubMed GONUTS page
↑ Redonnet, A et al. (2008) Synergic effect of vitamin A and high-fat diet in adipose tissue development and nuclear receptor expression in young rats. Br. J. Nutr. 100 722-30 PubMed GONUTS page
↑ Yamamoto, Y et al. (2008) Role of peroxisome proliferator-activated receptor-gamma (PPARgamma) during liver regeneration in rats. J. Gastroenterol. Hepatol. 23 930-7 PubMed GONUTS page
↑ Gressner, OA et al. (2008) Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. J. Hepatol. 49 758-67 PubMed GONUTS page
↑ Xiang, Q et al. (2010) The role of peroxisome proliferator-activated receptor-gamma and estrogen receptors in genistein-induced regulation of vascular tone in female rat aortas. Pharmacology 86 117-24 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Bao, Y et al. (2008) Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin/NFAT signaling pathway. Mol. Cell. Biochem. 317 189-96 PubMed GONUTS page
↑ Laplante, M et al. (2006) Mechanisms of the depot specificity of peroxisome proliferator-activated receptor gamma action on adipose tissue metabolism. Diabetes 55 2771-8 PubMed GONUTS page
↑ Capobianco, E et al. (2008) Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats. Mol. Hum. Reprod. 14 491-9 PubMed GONUTS page
↑ Zhou, JY et al. (2008) Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Biol. Pharm. Bull. 31 1169-76 PubMed GONUTS page
↑ Zhou, XR et al. (2008) Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance. Growth Horm. IGF Res. 18 361-8 PubMed GONUTS page
↑ Ahdjoudj, S et al. (2005) Transforming growth factor-beta inhibits CCAAT/enhancer-binding protein expression and PPARgamma activity in unloaded bone marrow stromal cells. Exp. Cell Res. 303 138-47 PubMed GONUTS page
↑ Bruck, R et al. (2009) Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor. Dig. Dis. Sci. 54 292-9 PubMed GONUTS page
↑ Steinmetz, M et al. (2005) Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardiac development of the rat. Basic Res. Cardiol. 100 263-9 PubMed GONUTS page
↑ ^33.0 ^33.1 Sato, N et al. (2005) Peroxisome proliferator-activated receptor gamma mediates protection against cyclooxygenase-2-induced gut dysfunction in a rodent model of mesenteric ischemia/reperfusion. Shock 24 462-9 PubMed GONUTS page
↑ Sato, N et al. (2006) Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel. Am. J. Physiol. Gastrointest. Liver Physiol. 290 G616-23 PubMed GONUTS page
↑ Hyong, A et al. (2008) Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents. Brain Res. 1215 218-24 PubMed GONUTS page
↑ ^36.00 ^36.01 ^36.02 ^36.03 ^36.04 ^36.05 ^36.06 ^36.07 ^36.08 ^36.09 ^36.10 ^36.11 ^36.12 ^36.13 ^36.14 ^36.15 ^36.16 ^36.17 ^36.18 ^36.19 ^36.20 ^36.21 ^36.22 ^36.23 ^36.24 ^36.25 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20702579-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Chia, DJ & Rotwein, P (2010) Defining the epigenetic actions of growth hormone: acute chromatin changes accompany GH-activated gene transcription. Mol. Endocrinol. 24 2038-49 PubMed GONUTS page

[PMID:19383491-2] 2.0 ^2.1 ^2.2 Du, J et al. (2009) PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons. Biochem. Biophys. Res. Commun. 383 485-90 PubMed GONUTS page

[PMID:16202214-3] 3.0 ^3.1 ^3.2 ^3.3 Jaster, R et al. () Peroxisome proliferator-activated receptor gamma overexpression inhibits pro-fibrogenic activities of immortalised rat pancreatic stellate cells. J. Cell. Mol. Med. 9 670-82 PubMed GONUTS page

[PMID:19000376-4] Gao, Y et al. (2008) Metformin regulates osteoblast and adipocyte differentiation of rat mesenchymal stem cells. J. Pharm. Pharmacol. 60 1695-700 PubMed GONUTS page

[PMID:22444276-5] Zeng, Y et al. (2012) Hyperbaric oxygen preconditioning protects cortical neurons against oxygen-glucose deprivation injury: role of peroxisome proliferator-activated receptor-gamma. Brain Res. 1452 140-50 PubMed GONUTS page

[PMID:10797535-6] 6.0 ^6.1 Ershov, AV & Bazan, NG (2000) Photoreceptor phagocytosis selectively activates PPARgamma expression in retinal pigment epithelial cells. J. Neurosci. Res. 60 328-37 PubMed GONUTS page

[PMID:11936221-7] Hong, JT et al. (2002) Inhibitory effect of peroxisome proliferator-activated receptor gamma agonist on ochratoxin A-induced cytotoxicity and activation of transcription factors in cultured rat embryonic midbrain cells. J. Toxicol. Environ. Health Part A 65 407-18 PubMed GONUTS page

[PMID:11752099-8] Davies, GF et al. (2002) Unique ability of troglitazone to up-regulate peroxisome proliferator-activated receptor-gamma expression in hepatocytes. J. Pharmacol. Exp. Ther. 300 72-7 PubMed GONUTS page

[PMID:15940641-9] Shimizu, K et al. (2005) Cytokines and peroxisome proliferator-activated receptor gamma ligand regulate phagocytosis by pancreatic stellate cells. Gastroenterology 128 2105-18 PubMed GONUTS page

[PMID:16556873-10] 10.0 ^10.1 Ogawa, D et al. (2006) Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells. Circ. Res. 98 e50-9 PubMed GONUTS page

[PMID:18543250-11] Leisewitz, AV et al. (2008) A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis. J. Cell. Physiol. 217 367-76 PubMed GONUTS page

[PMID:15774612-12] Yuan, Z et al. (2005) Cardioprotective effects of peroxisome proliferator activated receptor gamma activators on acute myocarditis: anti-inflammatory actions associated with nuclear factor kappaB blockade. Heart 91 1203-8 PubMed GONUTS page

[PMID:18475159-13] Sugimoto, K et al. (2008) Telmisartan increases fatty acid oxidation in skeletal muscle through a peroxisome proliferator-activated receptor-gamma dependent pathway. J. Hypertens. 26 1209-15 PubMed GONUTS page

[PMID:10438514-14] 14.0 ^14.1 ^14.2 ^14.3 Guardiola-Diaz, HM et al. (1999) Rat peroxisome proliferator-activated receptors and brown adipose tissue function during cold acclimatization. J. Biol. Chem. 274 23368-77 PubMed GONUTS page

[PMID:18769493-15] Mansour, MM et al. (2008) Activation of Penile Proadipogenic Peroxisome Proliferator-Activated Receptor gamma with an Estrogen: Interaction with Estrogen Receptor Alpha during Postnatal Development. PPAR Res 2008 651419 PubMed GONUTS page

[PMID:19157823-16] Palou, M et al. (2010) Regional differences in the expression of genes involved in lipid metabolism in adipose tissue in response to short- and medium-term fasting and refeeding. J. Nutr. Biochem. 21 23-33 PubMed GONUTS page

[PMID:21451213-17] Miana, M et al. (2011) Effect of eplerenone on hypertension-associated renal damage in rats: potential role of peroxisome proliferator activated receptor gamma (PPAR-γ). J. Physiol. Pharmacol. 62 87-94 PubMed GONUTS page

[PMID:18846335-18] Yao, Y et al. (2008) Telmisartan but not valsartan inhibits TGF-beta-mediated accumulation of extracellular matrix via activation of PPARgamma. J. Huazhong Univ. Sci. Technol. Med. Sci. 28 543-8 PubMed GONUTS page

[PMID:15820709-19] García-Bueno, B et al. (2005) Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats. Biol. Psychiatry 57 885-94 PubMed GONUTS page

[PMID:19251397-20] Duque-Guimarães, DE et al. () Early and prolonged intake of partially hydrogenated fat alters the expression of genes in rat adipose tissue. Nutrition 25 782-9 PubMed GONUTS page

[PMID:18384703-21] Redonnet, A et al. (2008) Synergic effect of vitamin A and high-fat diet in adipose tissue development and nuclear receptor expression in young rats. Br. J. Nutr. 100 722-30 PubMed GONUTS page

[PMID:18565023-22] Yamamoto, Y et al. (2008) Role of peroxisome proliferator-activated receptor-gamma (PPARgamma) during liver regeneration in rats. J. Gastroenterol. Hepatol. 23 930-7 PubMed GONUTS page

[PMID:18486259-23] Gressner, OA et al. (2008) Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. J. Hepatol. 49 758-67 PubMed GONUTS page

[PMID:20689342-24] Xiang, Q et al. (2010) The role of peroxisome proliferator-activated receptor-gamma and estrogen receptors in genistein-induced regulation of vascular tone in female rat aortas. Pharmacology 86 117-24 PubMed GONUTS page

[PMID:18600431-25] 25.0 ^25.1 ^25.2 Bao, Y et al. (2008) Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin/NFAT signaling pathway. Mol. Cell. Biochem. 317 189-96 PubMed GONUTS page

[PMID:17003342-26] Laplante, M et al. (2006) Mechanisms of the depot specificity of peroxisome proliferator-activated receptor gamma action on adipose tissue metabolism. Diabetes 55 2771-8 PubMed GONUTS page

[PMID:18621767-27] Capobianco, E et al. (2008) Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats. Mol. Hum. Reprod. 14 491-9 PubMed GONUTS page

[PMID:18520050-28] Zhou, JY et al. (2008) Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Biol. Pharm. Bull. 31 1169-76 PubMed GONUTS page

[PMID:18304850-29] Zhou, XR et al. (2008) Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance. Growth Horm. IGF Res. 18 361-8 PubMed GONUTS page

[PMID:15572034-30] Ahdjoudj, S et al. (2005) Transforming growth factor-beta inhibits CCAAT/enhancer-binding protein expression and PPARgamma activity in unloaded bone marrow stromal cells. Exp. Cell Res. 303 138-47 PubMed GONUTS page

[PMID:18594976-31] Bruck, R et al. (2009) Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor. Dig. Dis. Sci. 54 292-9 PubMed GONUTS page

[PMID:15754086-32] Steinmetz, M et al. (2005) Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardiac development of the rat. Basic Res. Cardiol. 100 263-9 PubMed GONUTS page

[PMID:16247333-33] 33.0 ^33.1 Sato, N et al. (2005) Peroxisome proliferator-activated receptor gamma mediates protection against cyclooxygenase-2-induced gut dysfunction in a rodent model of mesenteric ischemia/reperfusion. Shock 24 462-9 PubMed GONUTS page

[PMID:16257923-34] Sato, N et al. (2006) Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel. Am. J. Physiol. Gastrointest. Liver Physiol. 290 G616-23 PubMed GONUTS page

[PMID:18479673-35] Hyong, A et al. (2008) Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents. Brain Res. 1215 218-24 PubMed GONUTS page

[PMID:21873635-36] 36.00 ^36.01 ^36.02 ^36.03 ^36.04 ^36.05 ^36.06 ^36.07 ^36.08 ^36.09 ^36.10 ^36.11 ^36.12 ^36.13 ^36.14 ^36.15 ^36.16 ^36.17 ^36.18 ^36.19 ^36.20 ^36.21 ^36.22 ^36.23 ^36.24 ^36.25 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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