Category:GO:0006919 ! obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process

This GO term has been obsoleted. Do not annotate to it.

id: GO:0006919
name: obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase]
comment: This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase.nThe reason for obsoletion is that this term represents a GO-CAM model.
synonym: "activation of caspase activity" NARROW []
synonym: "activation of metacaspase activity" NARROW []
synonym: "caspase activation" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
replaced_by: GO:2001056 ! positive regulation of cysteine-type endopeptidase activity

AmiGO <GOterm>GO:0006919</GOterm>
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