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PMID:18565023

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Citation

Yamamoto, Y, Ono, T, Dhar, DK, Yamanoi, A, Tachibana, M, Tanaka, T and Nagasue, N (2008) Role of peroxisome proliferator-activated receptor-gamma (PPARgamma) during liver regeneration in rats. J. Gastroenterol. Hepatol. 23:930-7

Abstract

Peroxisome proliferator-activated receptor-gamma (PPARgamma), a member of the nuclear receptor superfamily, is widely expressed in adipocytes and other tissues, including the liver. Several reports have shown that PPARgamma activation induced cell-cycle arrest and apoptosis in tumor cells. We investigated the role of the PPARgamma/ligand system and the effect of the PPARgamma agonist during liver regeneration.

Links

PubMed Online version:10.1111/j.1440-1746.2008.05370.x

Keywords

Animals; Antineoplastic Agents/therapeutic use; Apoptosis/drug effects; Cell Differentiation/drug effects; Cell Proliferation/drug effects; Enzyme-Linked Immunosorbent Assay; Hepatectomy; Hypoglycemic Agents/pharmacology; Liver/cytology; Liver/drug effects; Liver/growth & development; Liver Regeneration/drug effects; Male; Models, Animal; Neoplasms/drug therapy; PPAR gamma/agonists; PPAR gamma/metabolism; Prostaglandin D2/analogs & derivatives; Prostaglandin D2/blood; Rats; Rats, Sprague-Dawley; Thiazolidinediones/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:PPARG

involved_in

GO:0031100: animal organ regeneration

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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