HUMAN:PPARG

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PPARG (synonyms: NR1C3)
Protein Name(s)	Peroxisome proliferator-activated receptor gamma PPAR-gamma Nuclear receptor subfamily 1 group C member 3
External Links
UniProt	P37231
EMBL	U79012 U63415 D83233 L40904 AB005526 X90563 X90563 DQ356894 BT007281 AK290581 AB451337 AB451486 AY157024 AC090947 AC091492 AC093174 CH471055 BC006811
CCDS	CCDS2609.1 CCDS2610.2
PIR	JC4859 PC4290 PC4429
RefSeq	NP_005028.4 NP_056953.2 NP_619725.2 NP_619726.2 XP_006713271.1
UniGene	Hs.162646
PDB	1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZEO 1ZGY 2ATH 2F4B 2FVJ 2G0G 2G0H 2GTK 2HFP 2HWQ 2HWR 2I4J 2I4P 2I4Z 2OM9 2P4Y 2POB 2PRG 2Q59 2Q5P 2Q5S 2Q61 2Q6R 2Q6S 2Q8S 2QMV 2VSR 2VST 2VV0 2VV1 2VV2 2VV3 2VV4 2XKW 2YFE 2ZK0 2ZK1 2ZK2 2ZK3 2ZK4 2ZK5 2ZK6 2ZNO 2ZVT 3ADS 3ADT 3ADU 3ADV 3ADW 3ADX 3AN3 3AN4 3B0Q 3B0R 3B1M 3B3K 3BC5 3CDP 3CDS 3CS8 3CWD 3D6D 3DZU 3DZY 3E00 3ET0 3ET3 3FEJ 3FUR 3G9E 3GBK 3H0A 3HO0 3HOD 3IA6 3K8S 3KMG 3LMP 3NOA 3OSI 3OSW 3PBA 3PO9 3PRG 3QT0 3R5N 3R8A 3R8I 3S9S 3SZ1 3T03 3TY0 3U9Q 3V9T 3V9V 3V9Y 3VJH 3VJI 3VN2 3VSO 3VSP 3WJ4 3WJ5 4A4V 4A4W 4E4K 4E4Q 4EM9 4EMA 4F9M 4FGY 4HEE 4JAZ 4JL4 4L96 4L98 4O8F 4PRG
PDBsum	1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZEO 1ZGY 2ATH 2F4B 2FVJ 2G0G 2G0H 2GTK 2HFP 2HWQ 2HWR 2I4J 2I4P 2I4Z 2OM9 2P4Y 2POB 2PRG 2Q59 2Q5P 2Q5S 2Q61 2Q6R 2Q6S 2Q8S 2QMV 2VSR 2VST 2VV0 2VV1 2VV2 2VV3 2VV4 2XKW 2YFE 2ZK0 2ZK1 2ZK2 2ZK3 2ZK4 2ZK5 2ZK6 2ZNO 2ZVT 3ADS 3ADT 3ADU 3ADV 3ADW 3ADX 3AN3 3AN4 3B0Q 3B0R 3B1M 3B3K 3BC5 3CDP 3CDS 3CS8 3CWD 3D6D 3DZU 3DZY 3E00 3ET0 3ET3 3FEJ 3FUR 3G9E 3GBK 3H0A 3HO0 3HOD 3IA6 3K8S 3KMG 3LMP 3NOA 3OSI 3OSW 3PBA 3PO9 3PRG 3QT0 3R5N 3R8A 3R8I 3S9S 3SZ1 3T03 3TY0 3U9Q 3V9T 3V9V 3V9Y 3VJH 3VJI 3VN2 3VSO 3VSP 3WJ4 3WJ5 4A4V 4A4W 4E4K 4E4Q 4EM9 4EMA 4F9M 4FGY 4HEE 4JAZ 4JL4 4L96 4L98 4O8F 4PRG
DisProt	DP00718
ProteinModelPortal	P37231
SMR	P37231
BioGrid	111464
DIP	DIP-35528N
IntAct	P37231
BindingDB	P37231
ChEMBL	CHEMBL2095162
DrugBank	DB01014 DB01393 DB01067 DB01050 DB00159 DB00328 DB00244 DB01252 DB00731 DB01132 DB00912 DB00412 DB00795 DB00966
GuidetoPHARMACOLOGY	595
PhosphoSite	P37231
DMDM	13432234
MaxQB	P37231
PaxDb	P37231
PRIDE	P37231
DNASU	5468
Ensembl	ENST00000287820 ENST00000309576 ENST00000396999 ENST00000397010 ENST00000397012 ENST00000397015
GeneID	5468
KEGG	hsa:5468
UCSC	uc003bwr.3
CTD	5468
GeneCards	GC03P012328
HGNC	HGNC:9236
HPA	CAB004282
MIM	137800 601487 601665 604367 606641 609338
neXtProt	NX_P37231
Orphanet	79083 251579 251576
PharmGKB	PA281
eggNOG	NOG266867
GeneTree	ENSGT00760000119049
HOVERGEN	HBG106004
InParanoid	P37231
KO	K08530
OMA	HEEPSNS
PhylomeDB	P37231
TreeFam	TF316304
Reactome	REACT_116145 REACT_15525 REACT_27161
SignaLink	P37231
ChiTaRS	PPARG
EvolutionaryTrace	P37231
GeneWiki	Peroxisome_proliferator-activated_receptor_gamma
GenomeRNAi	5468
NextBio	21164
PRO	PR:P37231
Proteomes	UP000005640
Bgee	P37231
ExpressionAtlas	P37231
Genevestigator	P37231
GO	GO:0005829 GO:0005654 GO:0005634 GO:0048471 GO:0090575 GO:0033613 GO:0050544 GO:0003682 GO:0003677 GO:0008144 GO:0019899 GO:0004879 GO:0030374 GO:0004955 GO:0046965 GO:0001012 GO:0001228 GO:0043565 GO:0003700 GO:0003707 GO:0044212 GO:0008270 GO:0006919 GO:0050873 GO:0045165 GO:0048469 GO:0071455 GO:0032869 GO:0071285 GO:0071380 GO:0071300 GO:0071306 GO:0030855 GO:0019395 GO:0007186 GO:0010467 GO:0042593 GO:0007507 GO:0045087 GO:0055088 GO:0006629 GO:0042953 GO:0015909 GO:0045713 GO:0030224 GO:0002674 GO:0030308 GO:0010887 GO:0032966 GO:0060336 GO:0010745 GO:2000230 GO:0010871 GO:0010891 GO:0048662 GO:0051974 GO:0000122 GO:0045892 GO:0031100 GO:0035357 GO:0001890 GO:0045600 GO:0046321 GO:0048714 GO:0060100 GO:0051091 GO:0045944 GO:0045893 GO:0008217 GO:0060694 GO:0060850 GO:0031000 GO:0009409 GO:0036270 GO:0043627 GO:0035902 GO:0033993 GO:0055098 GO:0009612 GO:1901558 GO:0007584 GO:0032526 GO:0042594 GO:0033189 GO:0007165 GO:0006367 GO:0050872
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR003074 IPR003077 IPR008946 IPR000536 IPR022590 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF12577 PF00105
PRINTS	PR01288 PR01291 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003077	F		Seeded From UniProt	complete
involved_in	GO:1905563	negative regulation of vascular endothelial cell proliferation	PMID:24960162^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002012)	Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	PMID:24960162^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002012)	Seeded From UniProt	complete
involved_in	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	PMID:28522568^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002591)	Seeded From UniProt	complete
involved_in	GO:1905563	negative regulation of vascular endothelial cell proliferation	PMID:24244514^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_division_of:(CL:1001568)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:D3ZWV0	F		Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	PMID:28522568^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	acts_on_population_of:(CL:0002591)	Seeded From UniProt	complete
involved_in	GO:0060965	negative regulation of gene silencing by miRNA	PMID:28522568^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000284190) occurs_in:(CL:0002591)	Seeded From UniProt	complete
involved_in	GO:0061614	pri-miRNA transcription by RNA polymerase II	PMID:28566713^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000284231) occurs_in:(CL:0000071)\|regulates_transcription_of(ENSEMBL:ENSG00000208005) occurs_in:(CL:0000071)	Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	PMID:28566713^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0001525) part_of:(GO:0006954)	Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:28566713^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000071) part_of:(GO:0006954)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:26504087^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42224	F		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:19043829^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042277	peptide binding	PMID:19043829^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:19043829^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:19043829^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:19043829^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:P19793	F		Seeded From UniProt	complete
enables	GO:0050692	DBD domain binding	PMID:19043829^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P19793) has_direct_input:(UniProtKB:P37231)	Seeded From UniProt	complete
enables	GO:0050693	LBD domain binding	PMID:19043829^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P19793)	Seeded From UniProt	complete
enables	GO:0046965	retinoid X receptor binding	PMID:19043829^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19793	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19043829^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	PMID:19043829^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:P19793	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19043829^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:P19793	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:19043829^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:50122)	Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:19043829^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P19793)	Seeded From UniProt	complete
involved_in	GO:0010742	macrophage derived foam cell differentiation	PMID:26504087^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051393	alpha-actinin binding	PMID:22351778^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43707	F		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	F		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:9568716^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060694	regulation of cholesterol transporter activity	PMID:17611579^[10]	ECO:0000305	curator inference used in manual assertion	GO:0045944	P		Seeded From UniProt	complete
involved_in	GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway	PMID:21268089^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071404	cellular response to low-density lipoprotein particle stimulus	PMID:9568716^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:18293083^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050544	arachidonic acid binding	PMID:9568715^[13]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	F		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:20622039^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002012)	Seeded From UniProt	complete
involved_in	GO:0048469	cell maturation	PMID:9568716^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046965	retinoid X receptor binding	PMID:9568715^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20622039^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17611579^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12700342^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9568715^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
involved_in	GO:0045713	low-density lipoprotein particle receptor biosynthetic process	PMID:9568716^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:18293083^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	F		Seeded From UniProt	complete
contributes_to	GO:0043565	sequence-specific DNA binding	PMID:9568716^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042953	lipoprotein transport	PMID:9568716^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:10622252^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035357	peroxisome proliferator activated receptor signaling pathway	PMID:20622039^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002591)	Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:9568715^[13]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	PMID:10622252^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:10622252^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
involved_in	GO:0030224	monocyte differentiation	PMID:9568716^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0015909	long-chain fatty acid transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
involved_in	GO:0010891	negative regulation of sequestering of triglyceride	PMID:12700342^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010887	negative regulation of cholesterol storage	PMID:19114110^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010871	negative regulation of receptor biosynthetic process	PMID:12700342^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010745	negative regulation of macrophage derived foam cell differentiation	PMID:19114110^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010745	negative regulation of macrophage derived foam cell differentiation	PMID:12700342^[15]	ECO:0000305	curator inference used in manual assertion	GO:0010891	P		Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	PMID:10622252^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:9113987^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:10622252^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:9568716^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:18293083^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9568716^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:10622252^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9568715^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	F		Seeded From UniProt	complete
involved_in	GO:0001890	placenta development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12700342^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
involved_in	GO:0050872	white fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
involved_in	GO:0060850	regulation of transcription involved in cell fate commitment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16239304^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:16239304^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:16239304^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:12039952^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55345	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37238	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16239304^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637985	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F		Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN001941333 RGD:3371	P		Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN001182169 RGD:3371	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000638208 UniProtKB:P37231	P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000638208 UniProtKB:O62807 UniProtKB:P37231	P		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000637985 RGD:3371	P		Seeded From UniProt	complete
involved_in	GO:0010887	negative regulation of cholesterol storage	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:P37231 UniProtKB:Q07869	P		Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001941333 UniProtKB:P10827	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN001182169 UniProtKB:Q03181 UniProtKB:Q07869	F		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN001182169 RGD:3369	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C		Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 RGD:3370	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN001182169	F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:Q07869	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 MGI:MGI:2449205 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98743 PANTHER:PTN001941333 UniProtKB:P20393 UniProtKB:P37231 UniProtKB:Q07869 WB:WBGene00004786	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25609649^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P37231	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004955	P		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P		Seeded From UniProt	complete
involved_in	GO:2000230	negative regulation of pancreatic stellate cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:1901558	response to metformin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0071455	cellular response to hyperoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0071380	cellular response to prostaglandin E stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0071379	cellular response to prostaglandin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0071306	cellular response to vitamin E	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0060100	positive regulation of phagocytosis, engulfment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0051974	negative regulation of telomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	C		Seeded From UniProt	complete
involved_in	GO:0046321	positive regulation of fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0045598	regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	F		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0035902	response to immobilization stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0032966	negative regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0031000	response to caffeine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	F		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	F		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	F		Seeded From UniProt	complete
involved_in	GO:0002674	negative regulation of acute inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88275 ensembl:ENSRNOP00000012137	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003077	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003074 InterPro:IPR003077	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003077	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003077 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17937915^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P37231-1	F		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	PMID:10973253^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:9568716^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:9113987^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:17145956^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004955	prostaglandin receptor activity	PMID:9568715^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050872	white fat cell differentiation	PMID:12588810^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-383280	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8944099 Reactome:R-HSA-381262 Reactome:R-HSA-376419	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 Bertero, T et al. (2014) Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J. Clin. Invest. 124 3514-28 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Green, DE et al. (2017) Peroxisome proliferator-activated receptor-γ enhances human pulmonary artery smooth muscle cell apoptosis through microRNA-21 and programmed cell death 4. Am. J. Physiol. Lung Cell Mol. Physiol. 313 L371-L383 PubMed GONUTS page
↑ Kang, BY et al. (2013) Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature. PLoS ONE 8 e79503 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Lee, A et al. (2017) A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis. Sci Rep 7 2528 PubMed GONUTS page
↑ ^6.0 ^6.1 Kotla, S & Rao, GN (2015) Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation. J. Biol. Chem. 290 30306-20 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 Chandra, V et al. (2008) Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature 456 350-6 PubMed GONUTS page
↑ Khurana, S et al. (2012) Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors. J. Biol. Chem. 287 12027-35 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 ^9.9 Tontonoz, P et al. (1998) PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93 241-52 PubMed GONUTS page
↑ ^10.0 ^10.1 Jiang, YJ et al. (2008) PPAR and LXR activators regulate ABCA12 expression in human keratinocytes. J. Invest. Dermatol. 128 104-9 PubMed GONUTS page
↑ Li, N et al. (2011) Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J. Cell. Biochem. 112 675-83 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Bonofiglio, D et al. (2009) Peroxisome proliferator-activated receptor gamma activates fas ligand gene promoter inducing apoptosis in human breast cancer cells. Breast Cancer Res. Treat. 113 423-34 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Nagy, L et al. (1998) Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 93 229-40 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Falcetti, E et al. (2010) Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 182 1161-70 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Haraguchi, G et al. (2003) PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor. J. Lipid Res. 44 1224-31 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Barroso, I et al. () Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 402 880-3 PubMed GONUTS page
↑ ^17.0 ^17.1 Mei, CL et al. (2009) Chlamydia pneumoniae induces macrophage-derived foam cell formation via PPAR alpha and PPAR gamma-dependent pathways. Cell Biol. Int. 33 301-8 PubMed GONUTS page
↑ ^18.0 ^18.1 Kliewer, SA et al. (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc. Natl. Acad. Sci. U.S.A. 94 4318-23 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Tomaru, T et al. (2006) Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma. Endocrinology 147 377-88 PubMed GONUTS page
↑ Qi, C et al. (2002) Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. J. Biol. Chem. 277 28624-30 PubMed GONUTS page
↑ ^21.00 ^21.01 ^21.02 ^21.03 ^21.04 ^21.05 ^21.06 ^21.07 ^21.08 ^21.09 ^21.10 ^21.11 ^21.12 ^21.13 ^21.14 ^21.15 ^21.16 ^21.17 ^21.18 ^21.19 ^21.20 ^21.21 ^21.22 ^21.23 ^21.24 ^21.25 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page
↑ Bruning, JB et al. (2007) Partial agonists activate PPARgamma using a helix 12 independent mechanism. Structure 15 1258-71 PubMed GONUTS page
↑ Altshuler, D et al. (2000) The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 26 76-80 PubMed GONUTS page
↑ Berruyer, C et al. (2006) Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. J. Exp. Med. 203 2817-27 PubMed GONUTS page
↑ Puigserver, P & Spiegelman, BM (2003) Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr. Rev. 24 78-90 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:24960162-2] 2.0 ^2.1 Bertero, T et al. (2014) Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J. Clin. Invest. 124 3514-28 PubMed GONUTS page

[PMID:28522568-3] 3.0 ^3.1 ^3.2 Green, DE et al. (2017) Peroxisome proliferator-activated receptor-γ enhances human pulmonary artery smooth muscle cell apoptosis through microRNA-21 and programmed cell death 4. Am. J. Physiol. Lung Cell Mol. Physiol. 313 L371-L383 PubMed GONUTS page

[PMID:24244514-4] Kang, BY et al. (2013) Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature. PLoS ONE 8 e79503 PubMed GONUTS page

[PMID:28566713-5] 5.0 ^5.1 ^5.2 Lee, A et al. (2017) A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis. Sci Rep 7 2528 PubMed GONUTS page

[PMID:26504087-6] 6.0 ^6.1 Kotla, S & Rao, GN (2015) Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation. J. Biol. Chem. 290 30306-20 PubMed GONUTS page

[PMID:19043829-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 Chandra, V et al. (2008) Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature 456 350-6 PubMed GONUTS page

[PMID:22351778-8] Khurana, S et al. (2012) Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors. J. Biol. Chem. 287 12027-35 PubMed GONUTS page

[PMID:9568716-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 ^9.9 Tontonoz, P et al. (1998) PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93 241-52 PubMed GONUTS page

[PMID:17611579-10] 10.0 ^10.1 Jiang, YJ et al. (2008) PPAR and LXR activators regulate ABCA12 expression in human keratinocytes. J. Invest. Dermatol. 128 104-9 PubMed GONUTS page

[PMID:21268089-11] Li, N et al. (2011) Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J. Cell. Biochem. 112 675-83 PubMed GONUTS page

[PMID:18293083-12] 12.0 ^12.1 ^12.2 Bonofiglio, D et al. (2009) Peroxisome proliferator-activated receptor gamma activates fas ligand gene promoter inducing apoptosis in human breast cancer cells. Breast Cancer Res. Treat. 113 423-34 PubMed GONUTS page

[PMID:9568715-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Nagy, L et al. (1998) Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 93 229-40 PubMed GONUTS page

[PMID:20622039-14] 14.0 ^14.1 ^14.2 Falcetti, E et al. (2010) Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 182 1161-70 PubMed GONUTS page

[PMID:12700342-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Haraguchi, G et al. (2003) PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor. J. Lipid Res. 44 1224-31 PubMed GONUTS page

[PMID:10622252-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Barroso, I et al. () Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 402 880-3 PubMed GONUTS page

[PMID:19114110-17] 17.0 ^17.1 Mei, CL et al. (2009) Chlamydia pneumoniae induces macrophage-derived foam cell formation via PPAR alpha and PPAR gamma-dependent pathways. Cell Biol. Int. 33 301-8 PubMed GONUTS page

[PMID:9113987-18] 18.0 ^18.1 Kliewer, SA et al. (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc. Natl. Acad. Sci. U.S.A. 94 4318-23 PubMed GONUTS page

[PMID:16239304-19] 19.0 ^19.1 ^19.2 ^19.3 Tomaru, T et al. (2006) Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma. Endocrinology 147 377-88 PubMed GONUTS page

[PMID:12039952-20] Qi, C et al. (2002) Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. J. Biol. Chem. 277 28624-30 PubMed GONUTS page

[PMID:21873635-21] 21.00 ^21.01 ^21.02 ^21.03 ^21.04 ^21.05 ^21.06 ^21.07 ^21.08 ^21.09 ^21.10 ^21.11 ^21.12 ^21.13 ^21.14 ^21.15 ^21.16 ^21.17 ^21.18 ^21.19 ^21.20 ^21.21 ^21.22 ^21.23 ^21.24 ^21.25 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25609649-22] Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page

[PMID:17937915-23] Bruning, JB et al. (2007) Partial agonists activate PPARgamma using a helix 12 independent mechanism. Structure 15 1258-71 PubMed GONUTS page

[PMID:10973253-24] Altshuler, D et al. (2000) The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 26 76-80 PubMed GONUTS page

[PMID:17145956-25] Berruyer, C et al. (2006) Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. J. Exp. Med. 203 2817-27 PubMed GONUTS page

[PMID:12588810-26] Puigserver, P & Spiegelman, BM (2003) Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr. Rev. 24 78-90 PubMed GONUTS page

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