HUMAN:NR1H4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NR1H4 (synonyms: BAR, FXR, HRR1, RIP14)
Protein Name(s)	Bile acid receptor Farnesoid X-activated receptor Farnesol receptor HRR-1 Nuclear receptor subfamily 1 group H member 4 Retinoid X receptor-interacting protein 14 RXR-interacting protein 14
External Links
UniProt	Q96RI1
EMBL	U68233 AF384555 AF478445 AF478446 AK296612 AC010200 CH471054 BC144183 BC144184 BC130573
CCDS	CCDS55873.1 CCDS55874.1 CCDS55875.1 CCDS55876.1 CCDS9078.1
RefSeq	NP_001193906.1 NP_001193907.1 NP_001193908.1 NP_001193921.1 NP_001193922.1 NP_005114.1
UniGene	Hs.282735 Hs.732506
PDB	1OSH 1OSK 3BEJ 3DCT 3DCU 3FLI 3FXV 3GD2 3HC5 3HC6 3L1B 3OKH 3OKI 3OLF 3OMK 3OMM 3OOF 3OOK 3P88 3P89 3RUT 3RUU 3RVF 4II6
PDBsum	1OSH 1OSK 3BEJ 3DCT 3DCU 3FLI 3FXV 3GD2 3HC5 3HC6 3L1B 3OKH 3OKI 3OLF 3OMK 3OMM 3OOF 3OOK 3P88 3P89 3RUT 3RUU 3RVF 4II6
ProteinModelPortal	Q96RI1
SMR	Q96RI1
BioGrid	115296
DIP	DIP-39370N
IntAct	Q96RI1
STRING	9606.ENSP00000315442
BindingDB	Q96RI1
ChEMBL	CHEMBL2047
DrugBank	DB06777
GuidetoPHARMACOLOGY	603
PhosphoSite	Q96RI1
DMDM	46577705
PaxDb	Q96RI1
PRIDE	Q96RI1
DNASU	9971
Ensembl	ENST00000188403 ENST00000392986 ENST00000548884 ENST00000549996 ENST00000551379
GeneID	9971
KEGG	hsa:9971
UCSC	uc001ths.2 uc001tht.2
CTD	9971
GeneCards	GC12P100867
HGNC	HGNC:7967
HPA	HPA047699
MIM	603826
neXtProt	NX_Q96RI1
Orphanet	69665
PharmGKB	PA31752
eggNOG	NOG302915
GeneTree	ENSGT00760000118837
HOVERGEN	HBG108655
InParanoid	Q96RI1
KO	K08537
OMA	MKPAKGV
OrthoDB	EOG7DC25S
PhylomeDB	Q96RI1
TreeFam	TF316304
Reactome	REACT_11041 REACT_11042 REACT_11048 REACT_11054 REACT_116145 REACT_13812 REACT_15525 REACT_267716
SignaLink	Q96RI1
EvolutionaryTrace	Q96RI1
GeneWiki	Farnesoid_X_receptor
GenomeRNAi	9971
NextBio	37658
PRO	PR:Q96RI1
Proteomes	UP000005640
Bgee	Q96RI1
CleanEx	HS_NR1H4
ExpressionAtlas	Q96RI1
Genevestigator	Q96RI1
GO	GO:0005719 GO:0005654 GO:0032052 GO:0038181 GO:1902122 GO:0003690 GO:0004879 GO:0016922 GO:0042277 GO:0000978 GO:0001077 GO:0000980 GO:0003705 GO:0001190 GO:0043565 GO:0003700 GO:0003707 GO:0004887 GO:0003713 GO:0003714 GO:0008270 GO:0008206 GO:1903413 GO:0071417 GO:0048565 GO:0010467 GO:0038185 GO:0030522 GO:0070858 GO:0000122 GO:0001080 GO:2001250 GO:2000213 GO:0045944 GO:0070857 GO:0006109 GO:0090181 GO:0034255 GO:0009749 GO:0032496 GO:0007165 GO:0006367
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR008946 IPR000536 IPR001723 IPR001728 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR00398 PR00047 PR00546
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000324 InterPro:IPR001628 InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:D3ZWV0	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:20447400^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	PMID:20447400^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:20447400^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035356	cellular triglyceride homeostasis	PMID:20447400^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904468	negative regulation of tumor necrosis factor secretion	PMID:21242261^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902714	negative regulation of interferon-gamma secretion	PMID:21242261^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072615	interleukin-17 secretion	PMID:21242261^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:21242261^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034142	toll-like receptor 4 signaling pathway	PMID:19864602^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010988	regulation of low-density lipoprotein particle clearance	PMID:12660231^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034971	histone H3-R17 methylation	PMID:15471871^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038183	bile acid signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60641	P		Seeded From UniProt	complete
involved_in	GO:1905695	positive regulation of phosphatidic acid biosynthetic process	PMID:23767959^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0038183)	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:23767959^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(ENSEMBL:ENSG00000145214)	Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:23767959^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000145214)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23767959^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000145214) part_of:(GO:0038183)	Seeded From UniProt	complete
involved_in	GO:2000213	positive regulation of glutamate metabolic process	PMID:21757002^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60641	P		Seeded From UniProt	complete
involved_in	GO:0071417	cellular response to organonitrogen compound	PMID:21757002^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60641	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21757002^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034255	regulation of urea metabolic process	PMID:21757002^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60641	P		Seeded From UniProt	complete
enables	GO:0032052	bile acid binding	PMID:21757002^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60641	F	has_direct_input:(CHEBI:16755)	Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60641	P		Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:21757002^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:21757002^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60641	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21757002^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:21757002^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001080	nitrogen catabolite activation of transcription from RNA polymerase II promoter	PMID:21757002^[8]	ECO:0000305	curator inference used in manual assertion	GO:0071417	P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:21757002^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21757002^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60641	P		Seeded From UniProt	complete
enables	GO:1902122	chenodeoxycholic acid binding	PMID:10334992^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070858	negative regulation of bile acid biosynthetic process	PMID:10334992^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:12815072^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0038185	intracellular bile acid receptor signaling pathway	PMID:10334992^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038181	bile acid receptor activity	PMID:10334992^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:28834)	Seeded From UniProt	complete
enables	GO:0038181	bile acid receptor activity	PMID:10334992^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:16325)	Seeded From UniProt	complete
enables	GO:0038181	bile acid receptor activity	PMID:10334992^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:16755)	Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352464 PANTHER:PTN000637752 UniProtKB:Q13133	P		Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352463 PANTHER:PTN000637752 ZFIN:ZDB-GENE-050410-7	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352464 PANTHER:PTN001182124	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 PANTHER:PTN000637752 UniProtKB:Q13133	P		Seeded From UniProt	complete
involved_in	GO:0038183	bile acid signaling pathway	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352464 PANTHER:PTN001182124	P		Seeded From UniProt	complete
enables	GO:0038181	bile acid receptor activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182124 RGD:628831 UniProtKB:Q96RI1	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F		Seeded From UniProt	complete
enables	GO:0032052	bile acid binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352464 PANTHER:PTN001182124 RGD:628831	F		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000637752 RGD:61909	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 PANTHER:PTN000637752 RGD:628831	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:24211198^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P		Seeded From UniProt	complete
involved_in	GO:2001250	positive regulation of ammonia assimilation cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:2000213	positive regulation of glutamate metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:1904179	positive regulation of adipose tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0071638	negative regulation of monocyte chemotactic protein-1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0071417	cellular response to organonitrogen compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
enables	GO:0046965	retinoid X receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	F		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0038183	bile acid signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0034255	regulation of urea metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0034162	toll-like receptor 9 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0032703	negative regulation of interleukin-2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0032692	negative regulation of interleukin-1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
enables	GO:0032052	bile acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	F		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0008206	bile acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0007043	cell-cell junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	F		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60641 ensembl:ENSMUSP00000100933	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723 InterPro:IPR001728	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001728	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR001728	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR001728 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:26888176^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:26888176^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038183	bile acid signaling pathway	PMID:23767959^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038181	bile acid receptor activity	PMID:23767959^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:10334993^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:10334992^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:10334992^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9223286^[15] PMID:10334992^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090181	regulation of cholesterol metabolic process	PMID:21757002^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070857	regulation of bile acid biosynthetic process	PMID:21757002^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0032052	bile acid binding	PMID:21757002^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016922	nuclear receptor binding	PMID:21757002^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0015721	bile acid and bile salt transport	Reactome:R-HSA-159418	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-383280	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5340251 Reactome:R-HSA-5340195 Reactome:R-HSA-4755419 Reactome:R-HSA-376419	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Popescu, IR et al. (2010) The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity. FEBS Lett. 584 2845-51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gadaleta, RM et al. (2011) Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 60 463-72 PubMed GONUTS page
↑ Vavassori, P et al. (2009) The bile acid receptor FXR is a modulator of intestinal innate immunity. J. Immunol. 183 6251-61 PubMed GONUTS page
↑ Anisfeld, AM et al. (2003) Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor. J. Biol. Chem. 278 20420-8 PubMed GONUTS page
↑ Ananthanarayanan, M et al. (2004) Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. J. Biol. Chem. 279 54348-57 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Cai, K & Sewer, MB (2013) Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes. Biochem. J. 454 267-74 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 ^8.13 ^8.14 ^8.15 Renga, B et al. (2011) The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate. Biochim. Biophys. Acta 1812 1522-31 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 Makishima, M et al. (1999) Identification of a nuclear receptor for bile acids. Science 284 1362-5 PubMed GONUTS page
↑ Holt, JA et al. (2003) Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev. 17 1581-91 PubMed GONUTS page
↑ ^11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 ^11.15 ^11.16 ^11.17 ^11.18 ^11.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Li, L et al. (2013) Farnesoid X receptor up-regulates expression of lipid transfer inhibitor protein in liver cells and mice. Biochem. Biophys. Res. Commun. 441 880-5 PubMed GONUTS page
↑ ^13.0 ^13.1 Gomez-Ospina, N et al. (2016) Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. Nat Commun 7 10713 PubMed GONUTS page
↑ Parks, DJ et al. (1999) Bile acids: natural ligands for an orphan nuclear receptor. Science 284 1365-8 PubMed GONUTS page
↑ Zavacki, AM et al. (1997) Activation of the orphan receptor RIP14 by retinoids. Proc. Natl. Acad. Sci. U.S.A. 94 7909-14 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:20447400-2] 2.0 ^2.1 ^2.2 ^2.3 Popescu, IR et al. (2010) The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity. FEBS Lett. 584 2845-51 PubMed GONUTS page

[PMID:21242261-3] 3.0 ^3.1 ^3.2 ^3.3 Gadaleta, RM et al. (2011) Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 60 463-72 PubMed GONUTS page

[PMID:19864602-4] Vavassori, P et al. (2009) The bile acid receptor FXR is a modulator of intestinal innate immunity. J. Immunol. 183 6251-61 PubMed GONUTS page

[PMID:12660231-5] Anisfeld, AM et al. (2003) Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor. J. Biol. Chem. 278 20420-8 PubMed GONUTS page

[PMID:15471871-6] Ananthanarayanan, M et al. (2004) Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. J. Biol. Chem. 279 54348-57 PubMed GONUTS page

[PMID:23767959-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Cai, K & Sewer, MB (2013) Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes. Biochem. J. 454 267-74 PubMed GONUTS page

[PMID:21757002-8] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 ^8.13 ^8.14 ^8.15 Renga, B et al. (2011) The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate. Biochim. Biophys. Acta 1812 1522-31 PubMed GONUTS page

[PMID:10334992-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 ^9.8 Makishima, M et al. (1999) Identification of a nuclear receptor for bile acids. Science 284 1362-5 PubMed GONUTS page

[PMID:12815072-10] Holt, JA et al. (2003) Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev. 17 1581-91 PubMed GONUTS page

[PMID:21873635-11] 11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 ^11.15 ^11.16 ^11.17 ^11.18 ^11.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24211198-12] Li, L et al. (2013) Farnesoid X receptor up-regulates expression of lipid transfer inhibitor protein in liver cells and mice. Biochem. Biophys. Res. Commun. 441 880-5 PubMed GONUTS page

[PMID:26888176-13] 13.0 ^13.1 Gomez-Ospina, N et al. (2016) Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. Nat Commun 7 10713 PubMed GONUTS page

[PMID:10334993-14] Parks, DJ et al. (1999) Bile acids: natural ligands for an orphan nuclear receptor. Science 284 1365-8 PubMed GONUTS page

[PMID:9223286-15] Zavacki, AM et al. (1997) Activation of the orphan receptor RIP14 by retinoids. Proc. Natl. Acad. Sci. U.S.A. 94 7909-14 PubMed GONUTS page

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