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PMID:24211198

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Citation

Li, L, Liu, H, Peng, J, Wang, Y, Zhang, Y, Dong, J, Liu, X, Guo, D and Jiang, Y (2013) Farnesoid X receptor up-regulates expression of lipid transfer inhibitor protein in liver cells and mice. Biochem. Biophys. Res. Commun. 441:880-5

Abstract

Apolipoprotein F is a component protein mainly secreted by liver and resides on several lipoprotein classes. It can inhibit lipids transfer between different lipoproteins. FXR is a member of the nuclear receptor superfamily which is also highly expressed in the liver. It modulates bile acids synthesis and lipids metabolism by transcriptional regulation. We aimed to determine whether apoF can be regulated by FXR. The FXR agonist Chenodeoxycholic acid (CDCA) and GW4064 both can activate the expression of apoF in liver cell lines and in C57/BL6 mouse liver. This is dependent on the binding of FXR to the FXR element ER1 (-2904 to -2892 bp) in the apoF gene promoter. Taken together, we have identified apoF as likely another target gene of FXR.

Links

PubMed Online version:10.1016/j.bbrc.2013.10.156

Keywords

Animals; Apolipoproteins/genetics; Chenodeoxycholic Acid/pharmacology; Gene Expression Regulation; Hep G2 Cells; Humans; Isoxazoles/pharmacology; Liver/metabolism; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear/agonists; Receptors, Cytoplasmic and Nuclear/metabolism; Up-Regulation

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:NR1H4

acts_upstream_of_or_within

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:16846)
  • regulates_o_occurs_in:(EMAPA:16846)
  • has_input:(MGI:MGI:104593)

Seeded From UniProt

complete

HUMAN:NR1H4

enables

GO:0001228: DNA-binding transcription activator activity, RNA polymerase II-specific

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

Notes

See also

References

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