GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
RAT:ANDR
Contents
Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
Gene Name(s) | Ar (synonyms: Nr3c4) | |
Protein Name(s) | Androgen receptor
Dihydrotestosterone receptor Nuclear receptor subfamily 3 group C member 4 | |
External Links | ||
UniProt | P15207 | |
EMBL | M20133 M23264 J05454 | |
PIR | B40494 | |
RefSeq | NP_036634.1 | |
UniGene | Rn.9813 | |
PDB | 1I37 1I38 1R4I 1XNN 2IHQ 2NW4 3G0W | |
PDBsum | 1I37 1I38 1R4I 1XNN 2IHQ 2NW4 3G0W | |
ProteinModelPortal | P15207 | |
SMR | P15207 | |
BioGrid | 246396 | |
DIP | DIP-5963N | |
IntAct | P15207 | |
STRING | 10116.ENSRNOP00000009129 | |
BindingDB | P15207 | |
ChEMBL | CHEMBL3072 | |
GuidetoPHARMACOLOGY | 628 | |
PhosphoSite | P15207 | |
PaxDb | P15207 | |
PRIDE | P15207 | |
Ensembl | ENSRNOT00000009129 | |
GeneID | 24208 | |
KEGG | rno:24208 | |
CTD | 367 | |
RGD | 2147 | |
eggNOG | NOG245477 | |
GeneTree | ENSGT00760000118887 | |
HOGENOM | HOG000254783 | |
HOVERGEN | HBG007583 | |
InParanoid | P15207 | |
KO | K08557 | |
OrthoDB | EOG7J17Z7 | |
PhylomeDB | P15207 | |
TreeFam | TF350286 | |
Reactome | REACT_242509 | |
EvolutionaryTrace | P15207 | |
NextBio | 602605 | |
PRO | PR:P15207 | |
Proteomes | UP000002494 | |
Genevestigator | P15207 | |
GO | GO:0030424 GO:0005737 GO:0030425 GO:0000790 GO:0005634 GO:0005886 GO:0005497 GO:0004882 GO:0050681 GO:0008013 GO:0003677 GO:0004879 GO:0019904 GO:0005102 GO:0043565 GO:0003700 GO:0044212 GO:0008270 GO:0060520 GO:0030521 GO:0071383 GO:0060742 GO:0003382 GO:0001701 GO:0030522 GO:0060599 GO:0033327 GO:0048808 GO:0046661 GO:0019102 GO:0060749 GO:0060571 GO:0035264 GO:0050680 GO:2001237 GO:0045720 GO:0048645 GO:0008284 GO:0043568 GO:0033148 GO:0043410 GO:0051092 GO:0042327 GO:0045944 GO:0045893 GO:0060740 GO:0060736 GO:0050790 GO:0048638 GO:0090003 GO:0060685 GO:0003073 GO:0032868 GO:0072520 GO:0007338 GO:0007283 GO:0060748 GO:0006351 | |
Gene3D | 1.10.565.10 3.30.50.10 | |
InterPro | IPR001103 IPR008946 IPR000536 IPR001628 IPR013088 | |
Pfam | PF02166 PF00104 PF00105 | |
PRINTS | PR00521 PR00047 | |
SMART | SM00430 SM00399 | |
SUPFAM | SSF48508 | |
PROSITE | PS00031 PS51030 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0005497 |
androgen binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001237 |
negative regulation of extrinsic apoptotic signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030522 |
intracellular receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004879 |
nuclear receptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1903076 |
regulation of protein localization to plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045720 |
negative regulation of integrin biosynthetic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042327 |
positive regulation of phosphorylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008013 |
beta-catenin binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006351 |
transcription, DNA-templated |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004879 |
nuclear receptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071383 |
cellular response to steroid hormone stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071372 |
cellular response to follicle-stimulating hormone stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060736 |
prostate gland growth |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060406 |
positive regulation of penile erection |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0050681 |
androgen receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:3583 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046661 |
male sex differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0033574 |
response to testosterone |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032868 |
response to insulin |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0032553 |
ribonucleotide binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032355 |
response to estradiol |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030521 |
androgen receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030425 |
dendrite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030424 |
axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:620109 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019098 |
reproductive behavior |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0014734 |
skeletal muscle hypertrophy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:1559697 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008049 |
male courtship behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007620 |
copulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005497 |
androgen binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004879 |
nuclear receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004879 |
nuclear receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005496 |
steroid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030521 |
androgen receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Contributes to |
GO:0060737 |
prostate gland morphogenetic growth |
ECO:0000314 |
P |
Figure 1A and 2A |
complete | ||||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005496 |
steroid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Holter, E et al. (2002) Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1. Mol. Endocrinol. 16 515-28 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Yarbrough, WG et al. (1990) A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat. J. Biol. Chem. 265 8893-900 PubMed GONUTS page
- ↑ Blok, LJ et al. (1989) Follicle-stimulating hormone regulates androgen receptor mRNA in Sertoli cells. Mol. Cell. Endocrinol. 63 267-71 PubMed GONUTS page
- ↑ Moeller, H et al. (1987) Ontogeny of the androgen receptor in rat ventral prostate during sexual development. Res Exp Med (Berl) 187 287-94 PubMed GONUTS page
- ↑ Bialy, M et al. (2011) Blockade of androgen receptor in the medial amygdala inhibits noncontact erections in male rats. Physiol. Behav. 103 295-301 PubMed GONUTS page
- ↑ Moilanen, AM et al. (1998) Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Mol. Cell. Biol. 18 5128-39 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Aarnisalo, P et al. (1999) Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain. Endocrinology 140 3097-105 PubMed GONUTS page
- ↑ 8.0 8.1 Lynch, CS & Story, AJ () Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity. Physiol. Behav. 69 445-53 PubMed GONUTS page
- ↑ Shirai, M et al. (2004) Androgen, estrogen, and progesterone receptor gene regulation during diabetic erectile dysfunction and insulin treatment. Urology 64 1244-9 PubMed GONUTS page
- ↑ Mulder, E et al. (1983) DNA and ribonucleotide binding characteristics of two forms of the androgen receptor from rat prostates. Biochem. Biophys. Res. Commun. 114 1147-53 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 DonCarlos, LL et al. (2003) Androgen receptor immunoreactivity in forebrain axons and dendrites in the rat. Endocrinology 144 3632-8 PubMed GONUTS page
- ↑ Ozers, MS et al. (2007) The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay. Biochemistry 46 683-95 PubMed GONUTS page
- ↑ Kudwa, AE et al. (2010) A selective androgen receptor modulator enhances male-directed sexual preference, proceptive behavior, and lordosis behavior in sexually experienced, but not sexually naive, female rats. Endocrinology 151 2659-68 PubMed GONUTS page
- ↑ Inoue, K et al. (1994) Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle. Eur J Appl Physiol Occup Physiol 69 88-91 PubMed GONUTS page
- ↑ Bowers, JM et al. (2014) Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization. Endocrinology 155 4881-94 PubMed GONUTS page
- ↑ 16.0 16.1 Harding, SM & McGinnis, MY (2004) Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors. Physiol. Behav. 81 671-80 PubMed GONUTS page
- ↑ Chen, J et al. (2005) A selective androgen receptor modulator for hormonal male contraception. J. Pharmacol. Exp. Ther. 312 546-53 PubMed GONUTS page
- ↑ Freeman, LM et al. (1995) Distribution of androgen receptor immunoreactivity in the spinal cord of wild-type, androgen-insensitive and gonadectomized male rats. J. Neurobiol. 27 51-9 PubMed GONUTS page
- ↑ Tsai, YH () Suppression of steroid receptor-chromatin interaction by inhibitors present in ammonium sulfate-fractionated rat testicular androgen receptor preparations. J. Androl. 8 299-306 PubMed GONUTS page
- ↑ Attardi, BJ et al. (2010) The potent synthetic androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects. J. Steroid Biochem. Mol. Biol. 122 212-8 PubMed GONUTS page
c
d
g
m
n
- GO:0045720 ! negative regulation of integrin biosynthetic process
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway
- GO:0050681 ! nuclear androgen receptor binding
- GO:0000790 ! nuclear chromatin
- GO:0004879 ! nuclear receptor activity
- GO:0005634 ! nucleus
p
- GO:0060406 ! positive regulation of penile erection
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0042327 ! positive regulation of phosphorylation
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0051092 ! positive regulation of NF-kappaB transcription factor activity
- GO:0060736 ! prostate gland growth
- GO:0060737 ! prostate gland morphogenetic growth
- GO:0019904 ! protein domain specific binding
r
- Rattus
- Rattus norvegicus
- GO:1903076 ! regulation of protein localization to plasma membrane
- GO:0006355 ! regulation of DNA-templated transcription
- GO:0019098 ! reproductive behavior
- GO:0033574 ! response to testosterone
- GO:0032868 ! response to insulin
- GO:0032355 ! response to estradiol
- GO:0032553 ! ribonucleotide binding
- Rodentia
s
t