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RAT:ANDR

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Ar (synonyms: Nr3c4)
Protein Name(s) Androgen receptor

Dihydrotestosterone receptor Nuclear receptor subfamily 3 group C member 4

External Links
UniProt P15207
EMBL M20133
M23264
J05454
PIR B40494
RefSeq NP_036634.1
UniGene Rn.9813
PDB 1I37
1I38
1R4I
1XNN
2IHQ
2NW4
3G0W
PDBsum 1I37
1I38
1R4I
1XNN
2IHQ
2NW4
3G0W
ProteinModelPortal P15207
SMR P15207
BioGrid 246396
DIP DIP-5963N
IntAct P15207
STRING 10116.ENSRNOP00000009129
BindingDB P15207
ChEMBL CHEMBL3072
GuidetoPHARMACOLOGY 628
PhosphoSite P15207
PaxDb P15207
PRIDE P15207
Ensembl ENSRNOT00000009129
GeneID 24208
KEGG rno:24208
CTD 367
RGD 2147
eggNOG NOG245477
GeneTree ENSGT00760000118887
HOGENOM HOG000254783
HOVERGEN HBG007583
InParanoid P15207
KO K08557
OrthoDB EOG7J17Z7
PhylomeDB P15207
TreeFam TF350286
Reactome REACT_242509
EvolutionaryTrace P15207
NextBio 602605
PRO PR:P15207
Proteomes UP000002494
Genevestigator P15207
GO GO:0030424
GO:0005737
GO:0030425
GO:0000790
GO:0005634
GO:0005886
GO:0005497
GO:0004882
GO:0050681
GO:0008013
GO:0003677
GO:0004879
GO:0019904
GO:0005102
GO:0043565
GO:0003700
GO:0044212
GO:0008270
GO:0060520
GO:0030521
GO:0071383
GO:0060742
GO:0003382
GO:0001701
GO:0030522
GO:0060599
GO:0033327
GO:0048808
GO:0046661
GO:0019102
GO:0060749
GO:0060571
GO:0035264
GO:0050680
GO:2001237
GO:0045720
GO:0048645
GO:0008284
GO:0043568
GO:0033148
GO:0043410
GO:0051092
GO:0042327
GO:0045944
GO:0045893
GO:0060740
GO:0060736
GO:0050790
GO:0048638
GO:0090003
GO:0060685
GO:0003073
GO:0032868
GO:0072520
GO:0007338
GO:0007283
GO:0060748
GO:0006351
Gene3D 1.10.565.10
3.30.50.10
InterPro IPR001103
IPR008946
IPR000536
IPR001628
IPR013088
Pfam PF02166
PF00104
PF00105
PRINTS PR00521
PR00047
SMART SM00430
SM00399
SUPFAM SSF48508
PROSITE PS00031
PS51030

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0005497

androgen binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

F

Seeded From UniProt

complete

involved_in

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

P

Seeded From UniProt

complete

involved_in

GO:0030522

intracellular receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

P

Seeded From UniProt

complete

enables

GO:0004879

nuclear receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

F

Seeded From UniProt

complete

involved_in

GO:1903076

regulation of protein localization to plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

P

Seeded From UniProt

complete

involved_in

GO:0045720

negative regulation of integrin biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

F

Seeded From UniProt

complete

involved_in

GO:0042327

positive regulation of phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

P

Seeded From UniProt

complete

enables

GO:0008013

beta-catenin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

F

Seeded From UniProt

complete

involved_in

GO:0006351

transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:11875111[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P51843

F

Seeded From UniProt

complete

enables

GO:0004879

nuclear receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10275

C

Seeded From UniProt

complete

involved_in

GO:0071383

cellular response to steroid hormone stimulus

PMID:2341409[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071372

cellular response to follicle-stimulating hormone stimulus

PMID:2502458[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060736

prostate gland growth

PMID:3628973[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060406

positive regulation of penile erection

PMID:21315100[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050681

androgen receptor binding

PMID:9710597[6]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:3583

F

Seeded From UniProt

complete

involved_in

GO:0046661

male sex differentiation

PMID:2341409[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:10385402[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:10385402[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:10385402[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0033574

response to testosterone

PMID:10913783[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032868

response to insulin

PMID:15596216[9]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0032553

ribonucleotide binding

PMID:6193790[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

PMID:10913783[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030521

androgen receptor signaling pathway

PMID:2341409[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

PMID:12865346[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:12865346[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:17223690[12]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:620109

F

Seeded From UniProt

complete

involved_in

GO:0019098

reproductive behavior

PMID:20392832[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014734

skeletal muscle hypertrophy

PMID:7957162[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:25247470[15]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:1559697

F

Seeded From UniProt

complete

involved_in

GO:0008049

male courtship behavior

PMID:15178162[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007620

copulation

PMID:15178162[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

PMID:15347734[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:7643075[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:2341409[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005497

androgen binding

PMID:2341409[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004879

nuclear receptor activity

PMID:2341409[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:3499428[19]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001103

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

enables

GO:0004879

nuclear receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001103

F

Seeded From UniProt

complete

enables

GO:0005496

steroid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001103

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001103
InterPro:IPR001628

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001103
InterPro:IPR001628
InterPro:IPR013088

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR013088

F

Seeded From UniProt

complete

involved_in

GO:0030521

androgen receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001103

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:12865346[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Contributes to

GO:0060737

prostate gland morphogenetic growth

PMID:20599615[20]

ECO:0000314

P

Figure 1A and 2A

complete
CACAO 3501

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0446

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0005496

steroid binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0754

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Holter, E et al. (2002) Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1. Mol. Endocrinol. 16 515-28 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Yarbrough, WG et al. (1990) A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat. J. Biol. Chem. 265 8893-900 PubMed GONUTS page
  3. Blok, LJ et al. (1989) Follicle-stimulating hormone regulates androgen receptor mRNA in Sertoli cells. Mol. Cell. Endocrinol. 63 267-71 PubMed GONUTS page
  4. Moeller, H et al. (1987) Ontogeny of the androgen receptor in rat ventral prostate during sexual development. Res Exp Med (Berl) 187 287-94 PubMed GONUTS page
  5. Bialy, M et al. (2011) Blockade of androgen receptor in the medial amygdala inhibits noncontact erections in male rats. Physiol. Behav. 103 295-301 PubMed GONUTS page
  6. Moilanen, AM et al. (1998) Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Mol. Cell. Biol. 18 5128-39 PubMed GONUTS page
  7. 7.0 7.1 7.2 Aarnisalo, P et al. (1999) Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid-binding domain. Endocrinology 140 3097-105 PubMed GONUTS page
  8. 8.0 8.1 Lynch, CS & Story, AJ () Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity. Physiol. Behav. 69 445-53 PubMed GONUTS page
  9. Shirai, M et al. (2004) Androgen, estrogen, and progesterone receptor gene regulation during diabetic erectile dysfunction and insulin treatment. Urology 64 1244-9 PubMed GONUTS page
  10. Mulder, E et al. (1983) DNA and ribonucleotide binding characteristics of two forms of the androgen receptor from rat prostates. Biochem. Biophys. Res. Commun. 114 1147-53 PubMed GONUTS page
  11. 11.0 11.1 11.2 DonCarlos, LL et al. (2003) Androgen receptor immunoreactivity in forebrain axons and dendrites in the rat. Endocrinology 144 3632-8 PubMed GONUTS page
  12. Ozers, MS et al. (2007) The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay. Biochemistry 46 683-95 PubMed GONUTS page
  13. Kudwa, AE et al. (2010) A selective androgen receptor modulator enhances male-directed sexual preference, proceptive behavior, and lordosis behavior in sexually experienced, but not sexually naive, female rats. Endocrinology 151 2659-68 PubMed GONUTS page
  14. Inoue, K et al. (1994) Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle. Eur J Appl Physiol Occup Physiol 69 88-91 PubMed GONUTS page
  15. Bowers, JM et al. (2014) Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization. Endocrinology 155 4881-94 PubMed GONUTS page
  16. 16.0 16.1 Harding, SM & McGinnis, MY (2004) Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors. Physiol. Behav. 81 671-80 PubMed GONUTS page
  17. Chen, J et al. (2005) A selective androgen receptor modulator for hormonal male contraception. J. Pharmacol. Exp. Ther. 312 546-53 PubMed GONUTS page
  18. Freeman, LM et al. (1995) Distribution of androgen receptor immunoreactivity in the spinal cord of wild-type, androgen-insensitive and gonadectomized male rats. J. Neurobiol. 27 51-9 PubMed GONUTS page
  19. Tsai, YH () Suppression of steroid receptor-chromatin interaction by inhibitors present in ammonium sulfate-fractionated rat testicular androgen receptor preparations. J. Androl. 8 299-306 PubMed GONUTS page
  20. Attardi, BJ et al. (2010) The potent synthetic androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects. J. Steroid Biochem. Mol. Biol. 122 212-8 PubMed GONUTS page