MOUSE:GCR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nr3c1 (synonyms: Grl, Grl1)
Protein Name(s)	Glucocorticoid receptor GR Nuclear receptor subfamily 3 group C member 1
External Links
UniProt	P06537
EMBL	X04435 X13358 X13359
PIR	A25691
UniGene	Mm.129481
PDB	3MNE 3MNO 3MNP
PDBsum	3MNE 3MNO 3MNP
ProteinModelPortal	P06537
SMR	P06537
DIP	DIP-11N
IntAct	P06537
MINT	MINT-152096
BindingDB	P06537
ChEMBL	CHEMBL3144
GuidetoPHARMACOLOGY	625
PhosphoSite	P06537
MaxQB	P06537
PaxDb	P06537
PRIDE	P06537
MGI	MGI:95824
eggNOG	NOG270250
HOGENOM	HOG000037950
HOVERGEN	HBG007583
InParanoid	P06537
Reactome	REACT_198620 REACT_24972
ChiTaRS	Nr3c1
EvolutionaryTrace	P06537
PRO	PR:P06537
Proteomes	UP000000589
CleanEx	MM_NR3C1
Genevestigator	P06537
GO	GO:0005737 GO:0005829 GO:0005622 GO:0016020 GO:0005739 GO:0005634 GO:0003677 GO:0004883 GO:0046983 GO:0043565 GO:0003700 GO:0005496 GO:0008270 GO:0030325 GO:0016568 GO:0008211 GO:0042921 GO:0060603 GO:0042711 GO:1900170 GO:0043525 GO:0031946 GO:0006111 GO:0006355 GO:0006351
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR001409 IPR008946 IPR000536 IPR001723 IPR001628 IPR013088
Pfam	PF02155 PF00104 PF00105
PRINTS	PR00528 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0042921	glucocorticoid receptor signaling pathway	PMID:25510864^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000182)	Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:25510864^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000065498) occurs_in:(CL:0000182) part_of:(GO:0042921)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:27686098^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:20371704^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q2NL51	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04150	C		Seeded From UniProt	complete
enables	GO:1990239	steroid hormone binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04150	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	PMID:17081986^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9Z2S7)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
enables	GO:1990239	steroid hormone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	P		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071385	cellular response to glucocorticoid stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071383	cellular response to steroid hormone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060603	mammary gland duct morphogenesis	PMID:12198239^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857745	P	has_participant:(EMAPA:17760)\|has_participant:(EMAPA:35538)	Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048096	chromatin-mediated maintenance of transcription	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:7883868^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046685	response to arsenic-containing substance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:7883868^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	PMID:10744634^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P	occurs_in:(EMAPA:19037)	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043116	negative regulation of vascular permeability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042921	glucocorticoid receptor signaling pathway	PMID:7628695^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857745	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042921	glucocorticoid receptor signaling pathway	PMID:10224232^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042921	glucocorticoid receptor signaling pathway	PMID:15199138^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042711	maternal behavior	PMID:23071095^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1924378 MGI:MGI:97762	P		Seeded From UniProt	complete
enables	GO:0042562	hormone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	C		Seeded From UniProt	complete
enables	GO:0032183	SUMO binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031946	regulation of glucocorticoid biosynthetic process	PMID:7628695^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857745	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031914	negative regulation of synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030325	adrenal gland development	PMID:7628695^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857745	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:9237103^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000542)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014049	positive regulation of glutamate secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010906	regulation of glucose metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008211	glucocorticoid metabolic process	PMID:10509797^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857745	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:10224232^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006351	transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006338	chromatin remodeling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006111	regulation of gluconeogenesis	PMID:7628695^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857745	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:7914432^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7914432^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15870285^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11555636^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	C		Seeded From UniProt	complete
colocalizes_with	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	C		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
enables	GO:0004883	glucocorticoid receptor activity	PMID:9237103^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:18767) occurs_in:(CL:0000542)\|occurs_in:(EMAPA:32834) occurs_in:(CL:0000542)\|occurs_in:(EMAPA:18768) occurs_in:(CL:0000542)	Seeded From UniProt	complete
enables	GO:0004883	glucocorticoid receptor activity	PMID:7914432^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004883	glucocorticoid receptor activity	PMID:15199138^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15870285^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
enables	GO:0001047	core promoter binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
enables	GO:0001012	RNA polymerase II regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04150	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001409 InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0004883	glucocorticoid receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001409	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001409	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001409 InterPro:IPR001628 InterPro:IPR001723	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001409 InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
involved_in	GO:0042921	glucocorticoid receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001409	P		Seeded From UniProt	complete
involved_in	GO:0043402	glucocorticoid mediated signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001409	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900170	negative regulation of glucocorticoid mediated signaling pathway	PMID:20660300^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20660300^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20660300^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9625700 Reactome:R-MMU-9009091	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0754	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 de Guia, RM et al. (2015) microRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis. EMBO J. 34 344-60 PubMed GONUTS page
↑ Okabe, T et al. (2016) REV-ERBα influences the stability and nuclear localization of the glucocorticoid receptor. J. Cell. Sci. 129 4143-4154 PubMed GONUTS page
↑ Spokoini, R et al. (2010) Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. Mol. Endocrinol. 24 1136-50 PubMed GONUTS page
↑ Lin, DY et al. (2006) Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol. Cell 24 341-54 PubMed GONUTS page
↑ Kingsley-Kallesen, M et al. (2002) The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development. Mol. Endocrinol. 16 2008-18 PubMed GONUTS page
↑ ^6.0 ^6.1 Jaskoll, T et al. () Glucocorticoids, TGF-beta, and embryonic mouse salivary gland morphogenesis. J. Craniofac. Genet. Dev. Biol. 14 217-30 PubMed GONUTS page
↑ Almeida, OF et al. (2000) Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J. 14 779-90 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Cole, TJ et al. (1995) Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 9 1608-21 PubMed GONUTS page
↑ ^9.0 ^9.1 Pazirandeh, A et al. (1999) Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. FASEB J. 13 893-901 PubMed GONUTS page
↑ ^10.0 ^10.1 Sitz, JH et al. (2004) Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Mol. Cell. Biol. 24 5821-34 PubMed GONUTS page
↑ Martyn, AC et al. (2012) Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct. Mol. Cell. Biol. 32 5140-50 PubMed GONUTS page
↑ ^12.0 ^12.1 Van Houten, N et al. (1997) Elevated expression of Bcl-2 and Bcl-x by intestinal intraepithelial lymphocytes: resistance to apoptosis by glucocorticoids and irradiation. Int. Immunol. 9 945-53 PubMed GONUTS page
↑ Cole, TJ et al. (1999) The glucocorticoid receptor is essential for maintaining basal and dexamethasone-induced repression of the murine corticosteroid-binding globulin gene. Mol. Cell. Endocrinol. 154 29-36 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Tomomura, M et al. (1994) Abnormal gene expression and regulation in the liver of jvs mice with systemic carnitine deficiency. Biochim. Biophys. Acta 1226 307-14 PubMed GONUTS page
↑ ^15.0 ^15.1 Ki, SH et al. (2005) Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Mol. Cell. Biol. 25 4150-65 PubMed GONUTS page
↑ Sutherland, HG et al. (2001) Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum. Mol. Genet. 10 1995-2011 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Hinds, TD Jr et al. (2010) Discovery of glucocorticoid receptor-beta in mice with a role in metabolism. Mol. Endocrinol. 24 1715-27 PubMed GONUTS page

[PMID:25510864-1] 1.0 ^1.1 de Guia, RM et al. (2015) microRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis. EMBO J. 34 344-60 PubMed GONUTS page

[PMID:27686098-2] Okabe, T et al. (2016) REV-ERBα influences the stability and nuclear localization of the glucocorticoid receptor. J. Cell. Sci. 129 4143-4154 PubMed GONUTS page

[PMID:20371704-3] Spokoini, R et al. (2010) Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. Mol. Endocrinol. 24 1136-50 PubMed GONUTS page

[PMID:17081986-4] Lin, DY et al. (2006) Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol. Cell 24 341-54 PubMed GONUTS page

[PMID:12198239-5] Kingsley-Kallesen, M et al. (2002) The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development. Mol. Endocrinol. 16 2008-18 PubMed GONUTS page

[PMID:7883868-6] 6.0 ^6.1 Jaskoll, T et al. () Glucocorticoids, TGF-beta, and embryonic mouse salivary gland morphogenesis. J. Craniofac. Genet. Dev. Biol. 14 217-30 PubMed GONUTS page

[PMID:10744634-7] Almeida, OF et al. (2000) Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J. 14 779-90 PubMed GONUTS page

[PMID:7628695-8] 8.0 ^8.1 ^8.2 ^8.3 Cole, TJ et al. (1995) Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 9 1608-21 PubMed GONUTS page

[PMID:10224232-9] 9.0 ^9.1 Pazirandeh, A et al. (1999) Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. FASEB J. 13 893-901 PubMed GONUTS page

[PMID:15199138-10] 10.0 ^10.1 Sitz, JH et al. (2004) Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Mol. Cell. Biol. 24 5821-34 PubMed GONUTS page

[PMID:23071095-11] Martyn, AC et al. (2012) Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct. Mol. Cell. Biol. 32 5140-50 PubMed GONUTS page

[PMID:9237103-12] 12.0 ^12.1 Van Houten, N et al. (1997) Elevated expression of Bcl-2 and Bcl-x by intestinal intraepithelial lymphocytes: resistance to apoptosis by glucocorticoids and irradiation. Int. Immunol. 9 945-53 PubMed GONUTS page

[PMID:10509797-13] Cole, TJ et al. (1999) The glucocorticoid receptor is essential for maintaining basal and dexamethasone-induced repression of the murine corticosteroid-binding globulin gene. Mol. Cell. Endocrinol. 154 29-36 PubMed GONUTS page

[PMID:7914432-14] 14.0 ^14.1 ^14.2 Tomomura, M et al. (1994) Abnormal gene expression and regulation in the liver of jvs mice with systemic carnitine deficiency. Biochim. Biophys. Acta 1226 307-14 PubMed GONUTS page

[PMID:15870285-15] 15.0 ^15.1 Ki, SH et al. (2005) Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Mol. Cell. Biol. 25 4150-65 PubMed GONUTS page

[PMID:11555636-16] Sutherland, HG et al. (2001) Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum. Mol. Genet. 10 1995-2011 PubMed GONUTS page

[PMID:20660300-17] 17.0 ^17.1 ^17.2 Hinds, TD Jr et al. (2010) Discovery of glucocorticoid receptor-beta in mice with a role in metabolism. Mol. Endocrinol. 24 1715-27 PubMed GONUTS page

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