MOUSE:NKX31

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nkx3-1 (synonyms: Nkx-3.1, Nkx3a)
Protein Name(s)	Homeobox protein Nkx-3.1 Homeobox protein NK-3 homolog A
External Links
UniProt	P97436
EMBL	U73460 U88542
CCDS	CCDS27237.1
RefSeq	NP_035051.1
UniGene	Mm.3520
ProteinModelPortal	P97436
SMR	P97436
BioGrid	201781
STRING	10090.ENSMUSP00000022646
PhosphoSite	P97436
PRIDE	P97436
Ensembl	ENSMUST00000022646
GeneID	18095
KEGG	mmu:18095
UCSC	uc007umd.1
CTD	4824
MGI	MGI:97352
eggNOG	NOG238786
HOGENOM	HOG000231923
HOVERGEN	HBG006689
InParanoid	P97436
KO	K09348
OMA	GAQRQGG
OrthoDB	EOG7QZG9Z
PhylomeDB	P97436
TreeFam	TF315720
NextBio	293247
PRO	PR:P97436
Proteomes	UP000000589
Bgee	P97436
CleanEx	MM_NKX3-1
ExpressionAtlas	P97436
Genevestigator	P97436
GO	GO:0005622 GO:0005634 GO:0004882 GO:0001047 GO:0008656 GO:0003677 GO:0030284 GO:0030331 GO:0097162 GO:0030295 GO:0043621 GO:0043565 GO:0003700 GO:0008134 GO:0000976 GO:0006919 GO:0030521 GO:0060442 GO:0048754 GO:0035690 GO:0071456 GO:0071347 GO:0071383 GO:0071356 GO:0035907 GO:0060664 GO:0007507 GO:0035260 GO:0008584 GO:0001656 GO:0071850 GO:0008285 GO:0050680 GO:0060770 GO:0071899 GO:0043569 GO:0045930 GO:0045892 GO:0060037 GO:2000836 GO:0010942 GO:0051781 GO:0008284 GO:0043280 GO:0010628 GO:2001244 GO:0045931 GO:0014068 GO:0001934 GO:2001022 GO:0045944 GO:0045893 GO:0030850 GO:0043491 GO:0033574 GO:0007431 GO:0001756 GO:0006366 GO:0001655
Gene3D	1.10.10.60
InterPro	IPR017970 IPR001356 IPR020479 IPR009057
Pfam	PF00046
PRINTS	PR00024
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:18296735^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P63267)	Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	PMID:9621431^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:9621431^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	PMID:9621431^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:2001022	positive regulation of response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:2000836	positive regulation of androgen secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
enables	GO:0097162	MADS box domain binding	PMID:18296735^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q9JM73)	Seeded From UniProt	complete
involved_in	GO:0071899	negative regulation of estrogen receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:0071383	cellular response to steroid hormone stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19597465^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q8BND5) has_regulation_target:(UniProtKB:Q9CQK8) has_regulation_target:(UniProtKB:Q06890)	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:9142502^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	PMID:19597465^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:0035907	dorsal aorta development	PMID:9142502^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	PMID:9142502^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	PMID:9142502^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:9142502^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:18296735^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11831	F		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	PMID:9142502^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001655	urogenital system development	PMID:9142502^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:18296735^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_regulation_target:(UniProtKB:P63267)	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004110 FB:FBgn0004862 FB:FBgn0040318 FB:FBgn0261930 MGI:MGI:108067 MGI:MGI:97347 MGI:MGI:97348 MGI:MGI:97350 PANTHER:PTN000678271 RGD:3866 UniProtKB:A6NCS4 UniProtKB:A6NJ46 UniProtKB:O15522 UniProtKB:P43699 UniProtKB:P52952 UniProtKB:Q99801 WB:WBGene00000445 WB:WBGene00000450	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000576 FB:FBgn0004110 FB:FBgn0004862 MGI:MGI:108015 MGI:MGI:108067 MGI:MGI:1352738 MGI:MGI:97347 MGI:MGI:97350 MGI:MGI:97352 PANTHER:PTN000678271 RGD:1310629 RGD:3866 RGD:620520 RGD:69318 UniProtKB:A6NCS4 UniProtKB:A6NJ46 UniProtKB:O15522 UniProtKB:P43699 UniProtKB:P52952 UniProtKB:Q99801 WB:WBGene00000445	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000576 FB:FBgn0002941 FB:FBgn0004110 FB:FBgn0028993 FB:FBgn0040318 FB:FBgn0261930 MGI:MGI:108015 MGI:MGI:108067 MGI:MGI:1206039 MGI:MGI:1270158 MGI:MGI:1352738 MGI:MGI:1921811 MGI:MGI:97347 MGI:MGI:97348 MGI:MGI:97350 MGI:MGI:97351 PANTHER:PTN000678271 RGD:620520 RGD:69318 UniProtKB:P52952 WB:WBGene00000445 WB:WBGene00000584 ZFIN:ZDB-GENE-030328-42 ZFIN:ZDB-GENE-040718-178 ZFIN:ZDB-GENE-050217-3 ZFIN:ZDB-GENE-070626-1 ZFIN:ZDB-GENE-980526-321 ZFIN:ZDB-GENE-980526-403 ZFIN:ZDB-GENE-990415-179	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000576 FB:FBgn0002941 FB:FBgn0004110 FB:FBgn0004862 FB:FBgn0040318 FB:FBgn0261930 MGI:MGI:108067 MGI:MGI:1206039 MGI:MGI:1352738 MGI:MGI:97347 MGI:MGI:97350 MGI:MGI:97352 PANTHER:PTN000678271 RGD:1308443 RGD:1310629 RGD:3866 RGD:620520 RGD:69318 UniProtKB:F1NC42 UniProtKB:P43699 UniProtKB:P52952 UniProtKB:Q90788 UniProtKB:Q99801 WB:WBGene00000445	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261930 MGI:MGI:108067 MGI:MGI:1352738 MGI:MGI:97347 MGI:MGI:97350 MGI:MGI:97352 PANTHER:PTN000678271 RGD:3866 RGD:69318 UniProtKB:A6NCS4 UniProtKB:O15522 UniProtKB:P43699 UniProtKB:P52952 UniProtKB:Q99801	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108015 MGI:MGI:108067 MGI:MGI:1352738 MGI:MGI:97350 PANTHER:PTN000678271 RGD:69318 UniProtKB:O15522 UniProtKB:P52952 UniProtKB:Q99801	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
enables	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:19258508^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P17936	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:10993896^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007431	salivary gland development	PMID:10906459^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928654	P	results_in_development_of:(EMAPA:35574)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15987773^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32290) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:10993896^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:10993896^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001235	positive regulation of apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001022	positive regulation of response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000836	positive regulation of androgen secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
part_of	GO:0090734	site of DNA damage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071899	negative regulation of estrogen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071850	mitotic cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071383	cellular response to steroid hormone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	PMID:11839815^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3045877	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	PMID:11002344^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928655	P	regulates_o_occurs_in:(EMAPA:29836)\|regulates_o_occurs_in:(EMAPA:35710)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	PMID:10906459^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928654	P	has_participant:(EMAPA:35574)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060442	branching involved in prostate gland morphogenesis	PMID:11002344^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928655	P	has_participant:(EMAPA:29836)\|has_participant:(EMAPA:35710)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060442	branching involved in prostate gland morphogenesis	PMID:10906459^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928654	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060442	branching involved in prostate gland morphogenesis	PMID:10215624^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926960	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051781	positive regulation of cell division	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:11002344^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928655	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048754	branching morphogenesis of an epithelial tube	PMID:11002344^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928655	P	has_participant:(EMAPA:29836)\|has_participant:(EMAPA:35710)\|has_participant:(EMAPA:35643)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10993896^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	PMID:19258508^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043491	protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032880	regulation of protein localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030521	androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q99801	P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:2001235	positive regulation of apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:2001022	positive regulation of response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:2000836	positive regulation of androgen secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
part_of	GO:0090734	site of DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	C		Seeded From UniProt	complete
involved_in	GO:0071899	negative regulation of estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0071850	mitotic cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0071383	cellular response to steroid hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	F		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	F		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	F		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	F		Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	F		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
enables	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	F		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99801 ensembl:ENSP00000370253	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR020479	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
involved_in	GO:0035260	internal genitalia morphogenesis	PMID:9621431^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	PMID:9621431^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001655	urogenital system development	PMID:9621431^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Zhang, Y et al. (2008) Structural and functional analysis of domains mediating interaction between the bagpipe homologue, Nkx3.1 and serum response factor. Exp. Biol. Med. (Maywood) 233 297-309 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Tanaka, M et al. (1998) Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development. Dev. Genet. 22 239-49 PubMed GONUTS page
↑ ^3.0 ^3.1 Song, H et al. (2009) Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis. Oncogene 28 3307-19 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Sciavolino, PJ et al. (1997) Tissue-specific expression of murine Nkx3.1 in the male urogenital system. Dev. Dyn. 209 127-38 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Muhlbradt, E et al. (2009) NKX3.1 activates expression of insulin-like growth factor binding protein-3 to mediate insulin-like growth factor-I signaling and cell proliferation. Cancer Res. 69 2615-22 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Carson, JA et al. (2000) The smooth muscle gamma-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor. J. Biol. Chem. 275 39061-72 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Schneider, A et al. (2000) Targeted disruption of the Nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate. Mech. Dev. 95 163-74 PubMed GONUTS page
↑ Gao, N et al. (2005) Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Development 132 3431-43 PubMed GONUTS page
↑ Abdulkadir, SA et al. (2002) Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol. Cell. Biol. 22 1495-503 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Tanaka, M et al. (2000) Nkx3.1, a murine homolog of Ddrosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands. Dev. Dyn. 219 248-60 PubMed GONUTS page
↑ Bhatia-Gaur, R et al. (1999) Roles for Nkx3.1 in prostate development and cancer. Genes Dev. 13 966-77 PubMed GONUTS page

[PMID:18296735-1] 1.0 ^1.1 ^1.2 ^1.3 Zhang, Y et al. (2008) Structural and functional analysis of domains mediating interaction between the bagpipe homologue, Nkx3.1 and serum response factor. Exp. Biol. Med. (Maywood) 233 297-309 PubMed GONUTS page

[PMID:9621431-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Tanaka, M et al. (1998) Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development. Dev. Genet. 22 239-49 PubMed GONUTS page

[PMID:19597465-3] 3.0 ^3.1 Song, H et al. (2009) Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis. Oncogene 28 3307-19 PubMed GONUTS page

[PMID:9142502-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Sciavolino, PJ et al. (1997) Tissue-specific expression of murine Nkx3.1 in the male urogenital system. Dev. Dyn. 209 127-38 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19258508-6] 6.0 ^6.1 Muhlbradt, E et al. (2009) NKX3.1 activates expression of insulin-like growth factor binding protein-3 to mediate insulin-like growth factor-I signaling and cell proliferation. Cancer Res. 69 2615-22 PubMed GONUTS page

[PMID:10993896-7] 7.0 ^7.1 ^7.2 ^7.3 Carson, JA et al. (2000) The smooth muscle gamma-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor. J. Biol. Chem. 275 39061-72 PubMed GONUTS page

[PMID:10906459-8] 8.0 ^8.1 ^8.2 Schneider, A et al. (2000) Targeted disruption of the Nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate. Mech. Dev. 95 163-74 PubMed GONUTS page

[PMID:15987773-9] Gao, N et al. (2005) Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Development 132 3431-43 PubMed GONUTS page

[PMID:11839815-10] Abdulkadir, SA et al. (2002) Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol. Cell. Biol. 22 1495-503 PubMed GONUTS page

[PMID:11002344-11] 11.0 ^11.1 ^11.2 ^11.3 Tanaka, M et al. (2000) Nkx3.1, a murine homolog of Ddrosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands. Dev. Dyn. 219 248-60 PubMed GONUTS page

[PMID:10215624-12] Bhatia-Gaur, R et al. (1999) Roles for Nkx3.1 in prostate development and cancer. Genes Dev. 13 966-77 PubMed GONUTS page

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MOUSE:NKX31

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