MOUSE:PRGR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pgr (synonyms: Nr3c3, Pr)
Protein Name(s)	Progesterone receptor PR Nuclear receptor subfamily 3 group C member 3
External Links
UniProt	Q00175
EMBL	M68915 U12644
PIR	A39596
UniGene	Mm.12798 Mm.437703
ProteinModelPortal	Q00175
SMR	Q00175
IntAct	Q00175
ChEMBL	CHEMBL4969
GuidetoPHARMACOLOGY	627
PhosphoSite	Q00175
PRIDE	Q00175
MGI	MGI:97567
eggNOG	NOG273252
HOGENOM	HOG000290653
HOVERGEN	HBG007583
InParanoid	Q00175
PRO	PR:Q00175
Proteomes	UP000000589
CleanEx	MM_PGR
Genevestigator	Q00175
GO	GO:0005737 GO:0005634 GO:0004879 GO:0043565 GO:0005496 GO:0003707 GO:0008270 GO:0002070 GO:0030879 GO:0001542 GO:0050847 GO:0050678 GO:0006355 GO:0060748
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR008946 IPR000536 IPR000128 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF02161 PF00105
PRINTS	PR00544 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
acts_upstream_of_or_within	GO:1904709	negative regulation of granulosa cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis	PMID:10733525^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857933	P	has_participant:(EMAPA:35538)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060180	female mating behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	PMID:12058073^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06401	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050847	progesterone receptor signaling pathway	PMID:16176985^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050678	regulation of epithelial cell proliferation	PMID:12897242^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674932	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048286	lung alveolus development	PMID:24190884^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3032652	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06401	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	P		Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	C		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	F		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06401	F		Seeded From UniProt	complete
enables	GO:0042562	hormone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042220	response to cocaine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038001	paracrine signaling	PMID:24190884^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3032652	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030879	mammary gland development	PMID:14765981^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857933	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030879	mammary gland development	PMID:12897242^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674932	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06401	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:14681235^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14681235^[7]	ECO:0000305	curator inference used in manual assertion	GO:0006355	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	C		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06401	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:14681235^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	PMID:16176985^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3317	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002070	epithelial cell maturation	PMID:14765981^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857933	P	occurs_in:(EMAPA:17760) results_in_maturation_of:(CL:0000150)\|occurs_in(EMAPA:17760) results_in_maturation_of:(CL:0000167)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001542	ovulation from ovarian follicle	PMID:12897242^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2674932	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06401	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06401	F		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06401 ensembl:ENSP00000325120	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06401 ensembl:ENSP00000325120	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06401 ensembl:ENSP00000325120	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06401 ensembl:ENSP00000325120	F		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06401 ensembl:ENSP00000325120	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06401 ensembl:ENSP00000325120	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06401 ensembl:ENSP00000325120	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000128 InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000128 InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000128	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000128 InterPro:IPR001628 InterPro:IPR001723	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000128 InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000128	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0754	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Brisken, C et al. (2000) Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev. 14 650-4 PubMed GONUTS page
↑ Rouleau, N et al. (2002) Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. Mol. Biol. Cell 13 2106-19 PubMed GONUTS page
↑ ^3.0 ^3.1 Tranguch, S et al. (2005) Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc. Natl. Acad. Sci. U.S.A. 102 14326-31 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Mulac-Jericevic, B et al. (2003) Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc. Natl. Acad. Sci. U.S.A. 100 9744-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Bruno, RD et al. (2014) Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells. J. Cell. Sci. 127 27-32 PubMed GONUTS page
↑ ^6.0 ^6.1 Ismail, PM et al. (2004) Progesterone induction of calcitonin expression in the murine mammary gland. J. Endocrinol. 180 287-95 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Cheon, YP et al. (2004) Induction of cytotoxic T-lymphocyte antigen-2beta, a cysteine protease inhibitor in decidua: a potential regulator of embryo implantation. J. Biol. Chem. 279 10357-63 PubMed GONUTS page

[PMID:10733525-1] Brisken, C et al. (2000) Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev. 14 650-4 PubMed GONUTS page

[PMID:12058073-2] Rouleau, N et al. (2002) Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. Mol. Biol. Cell 13 2106-19 PubMed GONUTS page

[PMID:16176985-3] 3.0 ^3.1 Tranguch, S et al. (2005) Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc. Natl. Acad. Sci. U.S.A. 102 14326-31 PubMed GONUTS page

[PMID:12897242-4] 4.0 ^4.1 ^4.2 Mulac-Jericevic, B et al. (2003) Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc. Natl. Acad. Sci. U.S.A. 100 9744-9 PubMed GONUTS page

[PMID:24190884-5] 5.0 ^5.1 Bruno, RD et al. (2014) Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells. J. Cell. Sci. 127 27-32 PubMed GONUTS page

[PMID:14765981-6] 6.0 ^6.1 Ismail, PM et al. (2004) Progesterone induction of calcitonin expression in the murine mammary gland. J. Endocrinol. 180 287-95 PubMed GONUTS page

[PMID:14681235-7] 7.0 ^7.1 ^7.2 Cheon, YP et al. (2004) Induction of cytotoxic T-lymphocyte antigen-2beta, a cysteine protease inhibitor in decidua: a potential regulator of embryo implantation. J. Biol. Chem. 279 10357-63 PubMed GONUTS page

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MOUSE:PRGR

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