HUMAN:THB

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	THRB (synonyms: ERBA2, NR1A2, THR1)
Protein Name(s)	Thyroid hormone receptor beta Nuclear receptor subfamily 1 group A member 2 c-erbA-2 c-erbA-beta
External Links
UniProt	P10828
EMBL	M26747 X04707 AK096628 AC012087 AC093927 AC098971 AC099054 AC112217 CH471055 BC106929 BC106930 AY286465 AY286466 AY286467 AY286468 AY286469 AY286470 AY286471 X74497
CCDS	CCDS2641.1
PIR	A25237 S40152
RefSeq	NP_000452.2 NP_001121648.1 NP_001121649.1 NP_001239563.1 XP_005265477.1 XP_005265478.1 XP_005265480.1 XP_005265481.1 XP_005265482.1 XP_006713380.1 XP_006713381.1
UniGene	Hs.187861
PDB	1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC
PDBsum	1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC
ProteinModelPortal	P10828
SMR	P10828
BioGrid	112924
DIP	DIP-5991N
IntAct	P10828
MINT	MINT-1508903
STRING	9606.ENSP00000348827
BindingDB	P10828
ChEMBL	CHEMBL1947
DrugBank	DB00509 DB00451 DB00279 DB01583
GuidetoPHARMACOLOGY	589
PhosphoSite	P10828
DMDM	586092
MaxQB	P10828
PaxDb	P10828
PRIDE	P10828
DNASU	7068
Ensembl	ENST00000280696 ENST00000356447 ENST00000396671 ENST00000415021 ENST00000416420 ENST00000447875
GeneID	7068
KEGG	hsa:7068
UCSC	uc003ccx.4
CTD	7068
GeneCards	GC03M024158
HGNC	HGNC:11799
HPA	CAB002008 CAB002009
MIM	145650 188570 190160 274300
neXtProt	NX_P10828
Orphanet	3221 97927 165994
PharmGKB	PA36508
eggNOG	NOG272726
GeneTree	ENSGT00760000118837
HOGENOM	HOG000010313
HOVERGEN	HBG005606
InParanoid	P10828
KO	K08362
OMA	PLFLEMF
OrthoDB	EOG7TBC2V
PhylomeDB	P10828
TreeFam	TF328382
Reactome	REACT_15525
SignaLink	P10828
ChiTaRS	THRB
EvolutionaryTrace	P10828
GeneWiki	Thyroid_hormone_receptor_beta
GenomeRNAi	7068
NextBio	27637
PRO	PR:P10828
Proteomes	UP000005640
Bgee	P10828
CleanEx	HS_THRB
ExpressionAtlas	P10828
Genevestigator	P10828
GO	GO:0070062 GO:0000790 GO:0005654 GO:0005634 GO:0031490 GO:0003677 GO:0019899 GO:0043565 GO:0003700 GO:0003707 GO:0070324 GO:0004887 GO:0003714 GO:0008270 GO:0008050 GO:0010467 GO:0030522 GO:0007621 GO:0000122 GO:0009887 GO:0045944 GO:0008016 GO:0007605 GO:0006367 GO:0006351 GO:0060509
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR008946 IPR000536 IPR001723 IPR001728 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR00398 PR00047 PR00546
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR001728	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:D3ZWV0	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:1618799^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070324	thyroid hormone binding	PMID:15466465^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:12039952^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55345	F	Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:15466465^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C	Seeded From UniProt	complete
involved_in	GO:0060509	type I pneumocyte differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637753	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P	Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F	Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN001941333 RGD:3371	P	Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98742 PANTHER:PTN001182181	P	Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637753	P	Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001941333 UniProtKB:P10827	P	Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000637753 UniProtKB:P10827	P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C	Seeded From UniProt	complete
involved_in	GO:0002154	thyroid hormone mediated signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182181 ZFIN:ZDB-GENE-990415-263 ZFIN:ZDB-GENE-990415-268	P	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 MGI:MGI:2449205 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98743 PANTHER:PTN001941333 UniProtKB:P20393 UniProtKB:P37231 UniProtKB:Q07869 WB:WBGene00004786	P	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P	Seeded From UniProt	complete
involved_in	GO:0097474	retinal cone cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
involved_in	GO:0060509	type I pneumocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
involved_in	GO:0046549	retinal cone cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
involved_in	GO:0042480	negative regulation of eye photoreceptor cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	F	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
involved_in	GO:0008050	female courtship behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
involved_in	GO:0007621	negative regulation of female receptivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	C	Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	C	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37242 ensembl:ENSMUSP00000022304	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723 InterPro:IPR001728	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F	Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F	Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001728	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR001728	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR001728 InterPro:IPR013088	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F	Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	PMID:1618799^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:1618799^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:1618799^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:1618799^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:1618799^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-383280	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-4719448 Reactome:R-HSA-4719424 Reactome:R-HSA-376419	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Nagaya, T et al. (1992) Thyroid hormone receptor mutants that cause resistance to thyroid hormone. Evidence for receptor competition for DNA sequences in target genes. J. Biol. Chem. 267 13014-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Sandler, B et al. (2004) Thyroxine-thyroid hormone receptor interactions. J. Biol. Chem. 279 55801-8 PubMed GONUTS page
↑ Qi, C et al. (2002) Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. J. Biol. Chem. 277 28624-30 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 ^5.16 ^5.17 ^5.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:1618799-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Nagaya, T et al. (1992) Thyroid hormone receptor mutants that cause resistance to thyroid hormone. Evidence for receptor competition for DNA sequences in target genes. J. Biol. Chem. 267 13014-9 PubMed GONUTS page

[PMID:15466465-3] 3.0 ^3.1 Sandler, B et al. (2004) Thyroxine-thyroid hormone receptor interactions. J. Biol. Chem. 279 55801-8 PubMed GONUTS page

[PMID:12039952-4] Qi, C et al. (2002) Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. J. Biol. Chem. 277 28624-30 PubMed GONUTS page

[PMID:21873635-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 ^5.16 ^5.17 ^5.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:THB

Contents

Annotations

Notes

References

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