MOUSE:NR1H3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nr1h3 (synonyms: Lxra)
Protein Name(s)	Oxysterols receptor LXR-alpha Liver X receptor alpha Nuclear receptor subfamily 1 group H member 3
External Links
UniProt	Q9Z0Y9
EMBL	AJ132599 AJ132600 AJ132601 AF085745 AL691450
CCDS	CCDS16426.1
RefSeq	NP_001171201.1 NP_038867.2 XP_006499229.1 XP_006499230.1 XP_006499231.1
UniGene	Mm.22690
PDB	2ACL 3FAL 3FC6
PDBsum	2ACL 3FAL 3FC6
ProteinModelPortal	Q9Z0Y9
SMR	Q9Z0Y9
BioGrid	204449
IntAct	Q9Z0Y9
ChEMBL	CHEMBL2189152
PhosphoSite	Q9Z0Y9
MaxQB	Q9Z0Y9
PRIDE	Q9Z0Y9
Ensembl	ENSMUST00000002177 ENSMUST00000111354 ENSMUST00000111356
GeneID	22259
KEGG	mmu:22259
UCSC	uc008kvc.2
CTD	10062
MGI	MGI:1352462
eggNOG	NOG285805
GeneTree	ENSGT00760000118837
HOGENOM	HOG000220845
HOVERGEN	HBG108655
InParanoid	Q9Z0Y9
KO	K08536
OMA	HDPLMFP
OrthoDB	EOG7DC25S
TreeFam	TF352167
Reactome	REACT_234105
EvolutionaryTrace	Q9Z0Y9
NextBio	302349
PRO	PR:Q9Z0Y9
Proteomes	UP000000589
Bgee	Q9Z0Y9
CleanEx	MM_NR1H3
ExpressionAtlas	Q9Z0Y9
Genevestigator	Q9Z0Y9
GO	GO:0005634 GO:0090575 GO:0003677 GO:0004879 GO:0000978 GO:0001077 GO:0003700 GO:0003707 GO:0008270 GO:0044255 GO:0071222 GO:0042632 GO:0006633 GO:0030522 GO:0055088 GO:0010887 GO:0050728 GO:0043031 GO:0090188 GO:0045861 GO:0090341 GO:0000122 GO:0045892 GO:0010875 GO:0045944 GO:0045893 GO:2000188 GO:0006355 GO:0055092 GO:0070328
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR023257 IPR008946 IPR000536 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR02034 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010867	positive regulation of triglyceride biosynthetic process	PMID:11090131^[1]	ECO:0000314			P		Figure 3: LXRalpha synthetic agonist T0901317 resulted in the increase in plasma lipid levels in mice.	complete
	GO:0045723	positive regulation of fatty acid biosynthetic process	PMID:11090131^[1]	ECO:0000314			P		Figure 4: Northern blot analysis shows increase in RNA levels of genes involved in fatty acid biosynthesis.	complete
	GO:0045541	negative regulation of cholesterol biosynthetic process	PMID:11090131^[1]	ECO:0000314			P		Figure 4: Northern blot analysis shows a decrease in RNA levels of genes associated with cholesterol biosynthesis when treated with LXR agonist.	complete
	GO:0043193	positive regulation of gene-specific transcription	PMID:11090131^[1]	ECO:0000314			P		Figure 4 and 5: Specific sets of genes are induced upon LXR activation such as ones involved in fatty acid biosynthesis. Other genes such as ones involved in lipid metabolism remain unaffected.	complete
	GO:0032720	negative regulation of tumor necrosis factor production	PMID:12524534^[2]	ECO:0000316		UniProtKB:Q60644	P		Figure 6a This figure shows that in Nr1h3–/–Nr1h2–/– (DKO) mice the expression of TNF-α was enhanced in response to LPS in vivo indicating that Nr1H2 is an inhibitor of TNF. The expression was determined using RT-PCR.	complete
	GO:0045824	negative regulation of innate immune response	PMID:12524534^[2]	ECO:0000314			P		Figure 1: This figure shows that NR1H3 inhibits macrophage responses to bacterial infections. Each part of this figure shows that iNOS and nitrate are inhibited by NR1H3 in different conditions during infection. iNOS and nitrate are important in innate immunity for anti-microbial and anti-tumor activities as well as the oxidative burst of macrophages.	complete
	GO:0050728	negative regulation of inflammatory response	PMID:12524534^[2]	ECO:0000315			P		Figure 3: This figure is a DNA microarray showing the effect of NR1H3 on LPS-induced gene expression in macrophages. Based on changes in gene expression between WT-mice and KO-mice NR1H2 inhibits genes involved in inflammation. In the WT-mice these genes are inhibited, in KO- NR1H2 and KO- NR1H3 mice these genes are partially inhibited, and in DKO mice these genes are not inhibited.	complete
	GO:0043620	regulation of transcription in response to stress	PMID:12524534^[2]	ECO:0000314			P		Figure 5: LXRs antagonize the action of NF-κB on the iNOS and COX-2 promoters. Fig.5a,b,c: Activation of LXRα/RXRα and LXRβ/RXRα inhibits the induction of iNOS and COX-2 gene promoters by LPS and inhibits expression of the reporter containing multiple NF-κB binding sites. Fig.5e,f: The inhibitory effect of LXR on COX-2 promoters is lost when NF-κB activity was blocked by transfection of a dominant-negative IKK or its binding sites mutated.	complete
part_of	GO:0005737	cytoplasm	PMID:27383786^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13133	F		Seeded From UniProt	complete
involved_in	GO:2000325	regulation of nuclear receptor transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:21173252^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q60644	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:27383786^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:17107947^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0004879	nuclear receptor activity	PMID:17107947^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9013544^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:25428)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:9013544^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:9013544^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090341	negative regulation of secretion of lysosomal enzymes	PMID:18806227^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090188	negative regulation of pancreatic juice secretion	PMID:18806227^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21187453^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	PMID:17657314^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	PMID:16325781^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055092	sterol homeostasis	PMID:16325781^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:17657314^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:18806227^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21187453^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16825483^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17107947^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16141411^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11090130^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045861	negative regulation of proteolysis	PMID:18806227^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0044212	transcription regulatory region DNA binding	PMID:17107947^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043031	negative regulation of macrophage activation	PMID:21187453^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:17657314^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0010887	negative regulation of cholesterol storage	PMID:17657314^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:16825483^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21187453^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:18055760^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352464 PANTHER:PTN000637752 UniProtKB:Q13133	P		Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352463 PANTHER:PTN000637752 ZFIN:ZDB-GENE-050410-7	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637816	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 PANTHER:PTN000637752 UniProtKB:Q13133	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000637752 RGD:61909	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 PANTHER:PTN000637752 RGD:628831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000325	regulation of nuclear receptor transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051006	positive regulation of lipoprotein lipase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048550	negative regulation of pinocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61909	F		Seeded From UniProt	complete
enables	GO:0046965	retinoid X receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61909	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12815040^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045723	positive regulation of fatty acid biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044255	cellular lipid metabolic process	PMID:14739254^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	F		Seeded From UniProt	complete
contributes_to	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61909	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043277	apoptotic cell clearance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042632	cholesterol homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
enables	GO:0032810	sterol response element binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032570	response to progesterone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032376	positive regulation of cholesterol transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032369	negative regulation of lipid transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032270	positive regulation of cellular protein metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010887	negative regulation of cholesterol storage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010875	positive regulation of cholesterol efflux	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010870	positive regulation of receptor biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010867	positive regulation of triglyceride biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:14739254^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61909	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14739254^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61909	C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:14739254^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14739254^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15319426^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:107704)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14739254^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13133	C		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	PMID:11090130^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Schultz, JR et al. (2000) Role of LXRs in control of lipogenesis. Genes Dev. 14 2831-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Joseph, SB et al. (2003) Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat. Med. 9 213-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Hsieh, J et al. (2016) TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature 535 303-7 PubMed GONUTS page
↑ Korach-André, M et al. (2011) Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. Proc. Natl. Acad. Sci. U.S.A. 108 403-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Cha, JY & Repa, JJ (2007) The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J. Biol. Chem. 282 743-51 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Lehmann, JM et al. (1997) Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272 3137-40 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Gabbi, C et al. (2008) Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression. Proc. Natl. Acad. Sci. U.S.A. 105 15052-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Hong, C et al. (2011) Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. J. Lipid Res. 52 531-9 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Bradley, MN et al. (2007) Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J. Clin. Invest. 117 2337-46 PubMed GONUTS page
↑ ^10.0 ^10.1 Lund, EG et al. (2006) Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype. Biochem. Pharmacol. 71 453-63 PubMed GONUTS page
↑ ^11.0 ^11.1 Quinet, EM et al. (2006) Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting. Mol. Pharmacol. 70 1340-9 PubMed GONUTS page
↑ Rigamonti, E et al. (2005) Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ. Res. 97 682-9 PubMed GONUTS page
↑ ^13.0 ^13.1 Repa, JJ et al. (2000) Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 14 2819-30 PubMed GONUTS page
↑ Wada, T et al. (2008) Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol. Pharmacol. 73 891-9 PubMed GONUTS page
↑ ^15.00 ^15.01 ^15.02 ^15.03 ^15.04 ^15.05 ^15.06 ^15.07 ^15.08 ^15.09 ^15.10 ^15.11 ^15.12 ^15.13 ^15.14 ^15.15 ^15.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Miyazaki, M et al. (2003) Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J. Biol. Chem. 278 33904-11 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Volle, DH et al. (2004) Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Mol. Endocrinol. 18 888-98 PubMed GONUTS page
↑ Nakamura, K et al. (2004) Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. J. Biol. Chem. 279 45980-9 PubMed GONUTS page

[PMID:11090131-1] 1.0 ^1.1 ^1.2 ^1.3 Schultz, JR et al. (2000) Role of LXRs in control of lipogenesis. Genes Dev. 14 2831-8 PubMed GONUTS page

[PMID:12524534-2] 2.0 ^2.1 ^2.2 ^2.3 Joseph, SB et al. (2003) Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat. Med. 9 213-9 PubMed GONUTS page

[PMID:27383786-3] 3.0 ^3.1 Hsieh, J et al. (2016) TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature 535 303-7 PubMed GONUTS page

[PMID:21173252-4] Korach-André, M et al. (2011) Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. Proc. Natl. Acad. Sci. U.S.A. 108 403-8 PubMed GONUTS page

[PMID:17107947-5] 5.0 ^5.1 ^5.2 ^5.3 Cha, JY & Repa, JJ (2007) The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J. Biol. Chem. 282 743-51 PubMed GONUTS page

[PMID:9013544-6] 6.0 ^6.1 ^6.2 Lehmann, JM et al. (1997) Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272 3137-40 PubMed GONUTS page

[PMID:18806227-7] 7.0 ^7.1 ^7.2 ^7.3 Gabbi, C et al. (2008) Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression. Proc. Natl. Acad. Sci. U.S.A. 105 15052-7 PubMed GONUTS page

[PMID:21187453-8] 8.0 ^8.1 ^8.2 ^8.3 Hong, C et al. (2011) Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. J. Lipid Res. 52 531-9 PubMed GONUTS page

[PMID:17657314-9] 9.0 ^9.1 ^9.2 ^9.3 Bradley, MN et al. (2007) Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J. Clin. Invest. 117 2337-46 PubMed GONUTS page

[PMID:16325781-10] 10.0 ^10.1 Lund, EG et al. (2006) Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype. Biochem. Pharmacol. 71 453-63 PubMed GONUTS page

[PMID:16825483-11] 11.0 ^11.1 Quinet, EM et al. (2006) Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting. Mol. Pharmacol. 70 1340-9 PubMed GONUTS page

[PMID:16141411-12] Rigamonti, E et al. (2005) Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ. Res. 97 682-9 PubMed GONUTS page

[PMID:11090130-13] 13.0 ^13.1 Repa, JJ et al. (2000) Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 14 2819-30 PubMed GONUTS page

[PMID:18055760-14] Wada, T et al. (2008) Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol. Pharmacol. 73 891-9 PubMed GONUTS page

[PMID:21873635-15] 15.00 ^15.01 ^15.02 ^15.03 ^15.04 ^15.05 ^15.06 ^15.07 ^15.08 ^15.09 ^15.10 ^15.11 ^15.12 ^15.13 ^15.14 ^15.15 ^15.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12815040-16] Miyazaki, M et al. (2003) Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J. Biol. Chem. 278 33904-11 PubMed GONUTS page

[PMID:14739254-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Volle, DH et al. (2004) Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Mol. Endocrinol. 18 888-98 PubMed GONUTS page

[PMID:15319426-18] Nakamura, K et al. (2004) Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. J. Biol. Chem. 279 45980-9 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

MOUSE:NR1H3

Contents

Annotations

Notes

References

a

c

d

e

f

g

i

l

m

n

o

p

r

s

t

v

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools