HUMAN:STAT3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	STAT3 (ECO:0000312 with HGNC:HGNC:11364) (synonyms: APRF (ECO:0000312 with HGNC:HGNC:11364))
Protein Name(s)	Signal transducer and activator of transcription 3 (ECO:0000312 with HGNC:HGNC:11364) Acute-phase response factor
External Links
UniProt	P40763
EMBL	L29277 AJ012463 JB252046 AK291933 AY572796 AC087691 CH471152 BC000627 BC014482 AF029311
CCDS	CCDS32656.1 CCDS32657.1 CCDS59288.1
PIR	A54444
RefSeq	NP_003141.2 NP_644805.1 NP_998827.1 XP_005257673.2 XP_005257674.2 XP_011523447.1 XP_011523448.1
UniGene	Hs.463059
ProteinModelPortal	P40763
SMR	P40763
BioGrid	112651
DIP	DIP-33584N
IntAct	P40763
MINT	MINT-146801
STRING	9606.ENSP00000264657
BindingDB	P40763
ChEMBL	CHEMBL4026
iPTMnet	P40763
PhosphoSite	P40763
BioMuta	STAT3
DMDM	48429227
EPD	P40763
MaxQB	P40763
PaxDb	P40763
PeptideAtlas	P40763
PRIDE	P40763
DNASU	6774
Ensembl	ENST00000264657 ENST00000404395 ENST00000585517 ENST00000588969
GeneID	6774
KEGG	hsa:6774
UCSC	uc002hzl.2
CTD	6774
GeneCards	STAT3
GeneReviews	STAT3
HGNC	HGNC:11364
HPA	CAB003859 CAB068241 CAB068242 HPA001671 HPA058603
MalaCards	STAT3
MIM	102582 147060 615952
neXtProt	NX_P40763
Orphanet	2314
PharmGKB	PA337
eggNOG	KOG3667 ENOG410XPN8
GeneTree	ENSGT00760000119236
HOGENOM	HOG000220792
HOVERGEN	HBG055669
InParanoid	P40763
KO	K04692
OMA	NSMSFAE
OrthoDB	EOG73JKTT
PhylomeDB	P40763
TreeFam	TF318648
Reactome	R-HSA-1059683 R-HSA-1433557 R-HSA-1839117 R-HSA-186763 R-HSA-198745 R-HSA-2559582 R-HSA-2586552 R-HSA-2892247 R-HSA-452723 R-HSA-982772
SignaLink	P40763
ChiTaRS	STAT3
GeneWiki	STAT3
GenomeRNAi	6774
NextBio	26438
PMAP-CutDB	P40763
PRO	PR:P40763
Proteomes	UP000005640
Bgee	P40763
CleanEx	HS_STAT3
ExpressionAtlas	P40763
Genevisible	P40763
GO	GO:0005737 GO:0005829 GO:0005743 GO:0000790 GO:0005654 GO:0005634 GO:0005886 GO:0090575 GO:0031490 GO:0003677 GO:0042802 GO:0046983 GO:0019901 GO:0019903 GO:0000978 GO:0001103 GO:0004879 GO:0004871 GO:0003700 GO:0008134 GO:0044212 GO:0001077 GO:0001228 GO:0006953 GO:0007568 GO:0048708 GO:0008283 GO:0032870 GO:0044320 GO:0071407 GO:0019221 GO:0042755 GO:0097009 GO:0001754 GO:0042593 GO:0060396 GO:0070102 GO:0030522 GO:0007259 GO:0060397 GO:0033210 GO:0006928 GO:0043066 GO:0008285 GO:0045820 GO:0010730 GO:1901215 GO:2001223 GO:0000122 GO:0007399 GO:0048011 GO:0016310 GO:2001171 GO:1902728 GO:0045747 GO:0045944 GO:0045893 GO:0006606 GO:0060019 GO:0051726 GO:0060259 GO:0046902 GO:0040014 GO:0006357 GO:0006355 GO:0042493 GO:0032355 GO:0045471 GO:0044321 GO:0019953 GO:0007165 GO:0035019 GO:0001659 GO:0016032
Gene3D	1.10.238.10 1.10.532.10 1.20.1050.20 2.60.40.630 3.30.505.10
InterPro	IPR011992 IPR008967 IPR000980 IPR001217 IPR013800 IPR015988 IPR013801 IPR012345 IPR013799
PANTHER	PTHR11801
Pfam	PF00017 PF01017 PF02864 PF02865
SMART	SM00252 SM00964
SUPFAM	SSF47655 SSF48092 SSF49417 SSF55550
PROSITE	PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:27050391^[1]	ECO:0000314			P		Figure 4, and from text " collectively, these results suggest that STAT3 directly targets and activates transcription of oocyte-specific genes."	complete CACAO 11579
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001217 InterPro:IPR008967 InterPro:IPR012345 InterPro:IPR013801	F		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:26962683^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P52631	P	regulates_o_occurs_in:(CL:2000043) has_regulation_target:(UniProtKB:Q04206) positively_regulates:(GO:0042226) occurs_in:(CL:2000043)	Seeded From UniProt	complete
involved_in	GO:0045410	positive regulation of interleukin-6 biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P52631	P	regulates_o_occurs_in:(CL:2000043) occurs_in:(CL:2000043)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17360477^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17360477^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:17360477^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14522	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24846175^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:24846175^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:24429361^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000182)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:24429361^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17947,UniProtKB:P49715	F		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	PMID:24429361^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24429361^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49715	P	regulates_transcription_of:(ENSEMBL:ENSG00000108691) occurs_in:(CL:0000182) part_of:(GO:0070102)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24429361^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P17947	P	regulates_transcription_of:(ENSEMBL:ENSG00000108691) occurs_in:(CL:0000182) part_of:(GO:0070102)	Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:23820254^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(RNAcentral:URS000075DE64_9606)	Seeded From UniProt	complete
involved_in	GO:1904685	positive regulation of metalloendopeptidase activity	PMID:23820254^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00003768C5_9606	P	has_regulation_target:(UniProtKB:P08253)\|has_regulation_target:(UniProtKB:P14780)	Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	PMID:28283061^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035278	miRNA mediated inhibition of translation	PMID:23820254^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000122707)	Seeded From UniProt	complete
involved_in	GO:2000637	positive regulation of gene silencing by miRNA	PMID:23820254^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000122707)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23820254^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000110092)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24255059^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(RNAcentral:URS00003768C5_9606) part_of:(GO:0097699) part_of:(GO:0071404)	Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:16835372^[10]	ECO:0000305	curator inference used in manual assertion	GO:0000790	C		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:19390056^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000215417)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19390056^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000184557)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
involved_in	GO:0072540	T-helper 17 cell lineage commitment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:28065600^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16946298^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107) regulates_transcription_of:(ENSEMBL:ENSG00000105697)	Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	PMID:16946298^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:16946298^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0060259	regulation of feeding behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:19390056^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(RNAcentral:URS000075DE64_9606)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17344214^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:17344214^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:17344214^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	PMID:17344214^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	PMID:17344214^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044320	cellular response to leptin stimulus	PMID:17344214^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:17344214^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:16946298^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(UBERON:0002107) has_regulation_target:(ENSEMBL:ENSG00000105697) occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16835372^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000105697) part_of:(GO:0070102)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10336453^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:22984561^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	PMID:16835372^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:16835372^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:16835372^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(ENSEMBL:ENSG00000105697) occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:23066027^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19754877^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61699	P		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	PMID:17324931^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	PMID:12552091^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	PMID:12552091^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060396	growth hormone receptor signaling pathway	PMID:10925297^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17324931^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:17324931^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032870	cellular response to hormone stimulus	PMID:12552091^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:12552091^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	PMID:17324931^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22783022^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22783022^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17324931^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:17324931^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	PMID:22783022^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96ST3	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12444102^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	PMID:12359225^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0060019	radial glial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0048708	astrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0019953	sexual reproduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:12359225^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17706-2	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:15664994^[25]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:15664994^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49715	F		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	PMID:18234692^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:15664994^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18234692^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18234692^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
involved_in	GO:0001754	eye photoreceptor cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:7510216^[27]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25609649^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21988832^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17676033^[30]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001223	negative regulation of neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:2000737	negative regulation of stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:1905564	positive regulation of vascular endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0072540	T-helper 17 cell lineage commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0060259	regulation of feeding behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0060019	radial glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0048708	astrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0045820	negative regulation of glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
involved_in	GO:0042789	mRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0019953	sexual reproduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
involved_in	GO:0001754	eye photoreceptor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
involved_in	GO:2001171	positive regulation of ATP biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:1902728	positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0045410	positive regulation of interleukin-6 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	F		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
enables	GO:0035259	glucocorticoid receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	F		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
enables	GO:0031730	CCR5 chemokine receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
involved_in	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013801	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR008967	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR008967 InterPro:IPR013799 InterPro:IPR013800 InterPro:IPR015988	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR013799 InterPro:IPR013800 InterPro:IPR015988	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:10205054^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007259	receptor signaling pathway via JAK-STAT	PMID:9670957^[32] PMID:15664994^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10205054^[31] PMID:7512451^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:7512451^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:7512451^[33]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:7512451^[33] PMID:8675499^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:8675499^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8848087 Reactome:R-HSA-6788628 Reactome:R-HSA-6788623 Reactome:R-HSA-6788622 Reactome:R-HSA-6788582 Reactome:R-HSA-6788571 Reactome:R-HSA-6786293 Reactome:R-HSA-6786124 Reactome:R-HSA-6786097 Reactome:R-HSA-6786095 Reactome:R-HSA-6786072 Reactome:R-HSA-6784791 Reactome:R-HSA-6784765 Reactome:R-HSA-6784763 Reactome:R-HSA-6784323 Reactome:R-HSA-6784006 Reactome:R-HSA-452515 Reactome:R-HSA-380782 Reactome:R-HSA-1888198 Reactome:R-HSA-1470012 Reactome:R-HSA-1470010 Reactome:R-HSA-1470009 Reactome:R-HSA-1433456 Reactome:R-HSA-1112727 Reactome:R-HSA-1112604 Reactome:R-HSA-1112602 Reactome:R-HSA-1112587 Reactome:R-HSA-1112565 Reactome:R-HSA-1112538 Reactome:R-HSA-9009072 Reactome:R-HSA-9006873 Reactome:R-HSA-9006870 Reactome:R-HSA-8987270 Reactome:R-HSA-8987266 Reactome:R-HSA-8987255 Reactome:R-HSA-8987236 Reactome:R-HSA-8987230 Reactome:R-HSA-8987214 Reactome:R-HSA-8987161 Reactome:R-HSA-8987156 Reactome:R-HSA-8987150 Reactome:R-HSA-8987141 Reactome:R-HSA-8987104 Reactome:R-HSA-8987097 Reactome:R-HSA-8987096 Reactome:R-HSA-8987080 Reactome:R-HSA-8987070 Reactome:R-HSA-8987063 Reactome:R-HSA-8987052 Reactome:R-HSA-8987033 Reactome:R-HSA-8987014 Reactome:R-HSA-8986985 Reactome:R-HSA-8985988 Reactome:R-HSA-8985981 Reactome:R-HSA-8985966 Reactome:R-HSA-8985929 Reactome:R-HSA-8985900 Reactome:R-HSA-8984023 Reactome:R-HSA-8984021 Reactome:R-HSA-8984014 Reactome:R-HSA-8983379 Reactome:R-HSA-8983378 Reactome:R-HSA-8983374 Reactome:R-HSA-8983373 Reactome:R-HSA-8983371 Reactome:R-HSA-8983078 Reactome:R-HSA-8983059 Reactome:R-HSA-8982165 Reactome:R-HSA-8982163 Reactome:R-HSA-8982162 Reactome:R-HSA-8952823 Reactome:R-HSA-8952749 Reactome:R-HSA-8950782 Reactome:R-HSA-8950780 Reactome:R-HSA-8950733 Reactome:R-HSA-8950724 Reactome:R-HSA-8950518 Reactome:R-HSA-8950485 Reactome:R-HSA-8950441 Reactome:R-HSA-8950269 Reactome:R-HSA-8875817 Reactome:R-HSA-8875816 Reactome:R-HSA-8848124	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8987052 Reactome:R-HSA-8985981 Reactome:R-HSA-8983379 Reactome:R-HSA-8950733 Reactome:R-HSA-8950724 Reactome:R-HSA-8848150 Reactome:R-HSA-6788623 Reactome:R-HSA-6786293 Reactome:R-HSA-6784763 Reactome:R-HSA-2895778 Reactome:R-HSA-1470012 Reactome:R-HSA-1112587	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	Reactome:R-HSA-9008059	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070757	interleukin-35-mediated signaling pathway	Reactome:R-HSA-8984722	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070106	interleukin-27-mediated signaling pathway	Reactome:R-HSA-9020956	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	Reactome:R-HSA-1059683	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Reactome:R-HSA-8849474	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038155	interleukin-23-mediated signaling pathway	Reactome:R-HSA-9020933	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038114	interleukin-21-mediated signaling pathway	Reactome:R-HSA-9020958	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038113	interleukin-9-mediated signaling pathway	Reactome:R-HSA-8985947	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038111	interleukin-7-mediated signaling pathway	Reactome:R-HSA-1266695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	Reactome:R-HSA-8983432	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	Reactome:R-HSA-452723	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-8854691 Reactome:R-HSA-6785807 Reactome:R-HSA-6783783	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhao, L et al. (2016) Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep 6 23972 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Shi, J et al. (2016) IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. Cell Death Dis 7 e2133 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Zhang, X et al. (2007) Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. Proc. Natl. Acad. Sci. U.S.A. 104 4060-4 PubMed GONUTS page
↑ ^5.0 ^5.1 Qi, J et al. (2014) β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway. PLoS ONE 9 e98052 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Sarma, NJ et al. (2014) Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis. J. Virol. 88 3733-43 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Lin, HY et al. (2013) STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells. Br. J. Cancer 109 731-8 PubMed GONUTS page
↑ Kim, AR et al. (2017) Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell 168 1053-1064.e15 PubMed GONUTS page
↑ Loyer, X et al. (2014) Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice. Circ. Res. 114 434-43 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Wrighting, DM & Andrews, NC (2006) Interleukin-6 induces hepcidin expression through STAT3. Blood 108 3204-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Brock, M et al. (2009) Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. Circ. Res. 104 1184-91 PubMed GONUTS page
↑ Ma, L et al. (2017) Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. Mol. Cell 65 296-309 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Verga Falzacappa, MV et al. (2007) STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 109 353-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Saxena, NK et al. (2007) leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J. Biol. Chem. 282 13316-25 PubMed GONUTS page
↑ Yamaguchi, T et al. (1999) The role of STAT3 in granulocyte colony-stimulating factor-induced enhancement of neutrophilic differentiation of Me2SO-treated HL-60 cells. GM-CSF inhibits the nuclear translocation of tyrosine-phosphorylated STAT3. J. Biol. Chem. 274 15575-81 PubMed GONUTS page
↑ Kotipatruni, RR et al. (2012) Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma. PLoS ONE 7 e44798 PubMed GONUTS page
↑ Dunkel, Y et al. (2012) STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis. J. Biol. Chem. 287 41667-83 PubMed GONUTS page
↑ Yamagishi, N et al. (2009) Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3. FEBS J. 276 5870-80 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Theiss, AL et al. (2007) Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells. J. Biol. Chem. 282 12804-12 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Leung, KC et al. (2003) Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. Proc. Natl. Acad. Sci. U.S.A. 100 1016-21 PubMed GONUTS page
↑ Ryu, H et al. (2000) Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. J. Immunol. 165 2116-23 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Icardi, L et al. (2012) The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Proc. Natl. Acad. Sci. U.S.A. 109 12058-63 PubMed GONUTS page
↑ Scoles, DR et al. (2002) Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling. Hum. Mol. Genet. 11 3179-89 PubMed GONUTS page
↑ ^24.0 ^24.1 Yamamoto, T et al. (2002) The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. Biochem. Biophys. Res. Commun. 297 811-7 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Numata, A et al. (2005) Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J. Biol. Chem. 280 12621-9 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Muromoto, R et al. (2008) BART is essential for nuclear retention of STAT3. Int. Immunol. 20 395-403 PubMed GONUTS page
↑ Shuai, K et al. (1994) Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76 821-8 PubMed GONUTS page
↑ Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page
↑ Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page
↑ Minegishi, Y et al. (2007) Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature 448 1058-62 PubMed GONUTS page
↑ ^31.0 ^31.1 Nakashima, K et al. (1999) Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284 479-82 PubMed GONUTS page
↑ Mellado, M et al. (1998) The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J. Immunol. 161 805-13 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 Akira, S et al. (1994) Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77 63-71 PubMed GONUTS page
↑ ^34.0 ^34.1 Caldenhoven, E et al. (1996) STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. J. Biol. Chem. 271 13221-7 PubMed GONUTS page

[PMID:27050391-1] Zhao, L et al. (2016) Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep 6 23972 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:26962683-3] Shi, J et al. (2016) IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. Cell Death Dis 7 e2133 PubMed GONUTS page

[PMID:17360477-4] 4.0 ^4.1 ^4.2 Zhang, X et al. (2007) Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. Proc. Natl. Acad. Sci. U.S.A. 104 4060-4 PubMed GONUTS page

[PMID:24846175-5] 5.0 ^5.1 Qi, J et al. (2014) β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway. PLoS ONE 9 e98052 PubMed GONUTS page

[PMID:24429361-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Sarma, NJ et al. (2014) Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis. J. Virol. 88 3733-43 PubMed GONUTS page

[PMID:23820254-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Lin, HY et al. (2013) STAT3 upregulates miR-92a to inhibit RECK expression and to promote invasiveness of lung cancer cells. Br. J. Cancer 109 731-8 PubMed GONUTS page

[PMID:28283061-8] Kim, AR et al. (2017) Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell 168 1053-1064.e15 PubMed GONUTS page

[PMID:24255059-9] Loyer, X et al. (2014) Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice. Circ. Res. 114 434-43 PubMed GONUTS page

[PMID:16835372-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Wrighting, DM & Andrews, NC (2006) Interleukin-6 induces hepcidin expression through STAT3. Blood 108 3204-9 PubMed GONUTS page

[PMID:19390056-11] 11.0 ^11.1 ^11.2 Brock, M et al. (2009) Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. Circ. Res. 104 1184-91 PubMed GONUTS page

[PMID:28065600-12] Ma, L et al. (2017) Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. Mol. Cell 65 296-309 PubMed GONUTS page

[PMID:16946298-13] 13.0 ^13.1 ^13.2 ^13.3 Verga Falzacappa, MV et al. (2007) STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 109 353-8 PubMed GONUTS page

[PMID:17344214-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Saxena, NK et al. (2007) leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J. Biol. Chem. 282 13316-25 PubMed GONUTS page

[PMID:10336453-15] Yamaguchi, T et al. (1999) The role of STAT3 in granulocyte colony-stimulating factor-induced enhancement of neutrophilic differentiation of Me2SO-treated HL-60 cells. GM-CSF inhibits the nuclear translocation of tyrosine-phosphorylated STAT3. J. Biol. Chem. 274 15575-81 PubMed GONUTS page

[PMID:22984561-16] Kotipatruni, RR et al. (2012) Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma. PLoS ONE 7 e44798 PubMed GONUTS page

[PMID:23066027-17] Dunkel, Y et al. (2012) STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis. J. Biol. Chem. 287 41667-83 PubMed GONUTS page

[PMID:19754877-18] Yamagishi, N et al. (2009) Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3. FEBS J. 276 5870-80 PubMed GONUTS page

[PMID:17324931-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Theiss, AL et al. (2007) Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells. J. Biol. Chem. 282 12804-12 PubMed GONUTS page

[PMID:12552091-20] 20.0 ^20.1 ^20.2 ^20.3 Leung, KC et al. (2003) Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. Proc. Natl. Acad. Sci. U.S.A. 100 1016-21 PubMed GONUTS page

[PMID:10925297-21] Ryu, H et al. (2000) Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. J. Immunol. 165 2116-23 PubMed GONUTS page

[PMID:22783022-22] 22.0 ^22.1 ^22.2 Icardi, L et al. (2012) The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Proc. Natl. Acad. Sci. U.S.A. 109 12058-63 PubMed GONUTS page

[PMID:12444102-23] Scoles, DR et al. (2002) Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling. Hum. Mol. Genet. 11 3179-89 PubMed GONUTS page

[PMID:12359225-24] 24.0 ^24.1 Yamamoto, T et al. (2002) The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. Biochem. Biophys. Res. Commun. 297 811-7 PubMed GONUTS page

[PMID:15664994-25] 25.0 ^25.1 ^25.2 ^25.3 Numata, A et al. (2005) Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J. Biol. Chem. 280 12621-9 PubMed GONUTS page

[PMID:18234692-26] 26.0 ^26.1 ^26.2 Muromoto, R et al. (2008) BART is essential for nuclear retention of STAT3. Int. Immunol. 20 395-403 PubMed GONUTS page

[PMID:7510216-27] Shuai, K et al. (1994) Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76 821-8 PubMed GONUTS page

[PMID:25609649-28] Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page

[PMID:21988832-29] Wang, J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. 7 536 PubMed GONUTS page

[PMID:17676033-30] Minegishi, Y et al. (2007) Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature 448 1058-62 PubMed GONUTS page

[PMID:10205054-31] 31.0 ^31.1 Nakashima, K et al. (1999) Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284 479-82 PubMed GONUTS page

[PMID:9670957-32] Mellado, M et al. (1998) The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J. Immunol. 161 805-13 PubMed GONUTS page

[PMID:7512451-33] 33.0 ^33.1 ^33.2 ^33.3 Akira, S et al. (1994) Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell 77 63-71 PubMed GONUTS page

[PMID:8675499-34] 34.0 ^34.1 Caldenhoven, E et al. (1996) STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. J. Biol. Chem. 271 13221-7 PubMed GONUTS page

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