HUMAN:TAF1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TAF1 (synonyms: BA2R, CCG1, CCGS, TAF2A)
Protein Name(s)	Transcription initiation factor TFIID subunit 1 Cell cycle gene 1 protein TBP-associated factor 250 kDa p250 Transcription initiation factor TFIID 250 kDa subunit TAF(II)250 TAFII-250 TAFII250
External Links
UniProt	P21675
EMBL	D90359 X07024 AB300418 AY623109 AL590762 AL590763 AB209316 AJ549247 AJ549248 AJ549249 AJ549250 AJ555148 AJ555149 AM711892 AM711893 AM711894 AM711895
CCDS	CCDS14412.1 CCDS35325.1 CCDS69783.1
PIR	A40262
RefSeq	NP_001273003.1 NP_004597.2 NP_620278.1 XP_005262354.1
UniGene	Hs.158560
PDB	1EQF 3AAD 3UV4 3UV5
PDBsum	1EQF 3AAD 3UV4 3UV5
ProteinModelPortal	P21675
SMR	P21675
BioGrid	112735
DIP	DIP-147N
IntAct	P21675
MINT	MINT-1211825
PhosphoSite	P21675
DMDM	115942
MaxQB	P21675
PaxDb	P21675
PRIDE	P21675
Ensembl	ENST00000276072 ENST00000373790 ENST00000423759
GeneID	6872
KEGG	hsa:6872
UCSC	uc004dzt.4 uc004dzu.4 uc004dzv.4
CTD	6872
GeneCards	GC0XP070586
GeneReviews	TAF1
HGNC	HGNC:11535
HPA	CAB016283 HPA001075
MIM	313650 314250
neXtProt	NX_P21675
Orphanet	53351
PharmGKB	PA36310
eggNOG	COG5076
GeneTree	ENSGT00390000012659
HOVERGEN	HBG050223
InParanoid	P21675
KO	K03125
OMA	CLSDDEX
OrthoDB	EOG7QNVK2
PhylomeDB	P21675
TreeFam	TF313573
Reactome	REACT_1655 REACT_1851 REACT_2089 REACT_22107 REACT_6233 REACT_6253 REACT_6332 REACT_834
EvolutionaryTrace	P21675
GeneWiki	TAF1
GenomeRNAi	6872
NextBio	26827
PRO	PR:P21675
Proteomes	UP000005640
Bgee	P21675
Genevestigator	P21675
GO	GO:0071339 GO:0005654 GO:0005634 GO:0005669 GO:0005524 GO:0004402 GO:0070577 GO:0002039 GO:0004674 GO:0043565 GO:0017025 GO:0003713 GO:0008134 GO:0007049 GO:0006974 GO:0006352 GO:0010467 GO:0016573 GO:0018105 GO:0018107 GO:0032436 GO:0045944 GO:0060261 GO:0046777 GO:0051123 GO:0006368 GO:0006366 GO:0006367 GO:0016032
Gene3D	1.10.1100.10 1.20.920.10
InterPro	IPR001487 IPR018359 IPR011177 IPR009067 IPR022591
Pfam	PF00439 PF12157 PF09247
PIRSF	PIRSF003047
PRINTS	PR00503
SMART	SM00297
SUPFAM	SSF47055 SSF47370
PROSITE	PS00633 PS50014

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:24289924^[1]	ECO:0000305	curator inference used in manual assertion	GO:0010768 GO:1903026	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:25412659^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15545	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P27782	F		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	PMID:24927529^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	PMID:17237821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q00987)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:17237821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000135679)\|regulates_expression_of:(ENSEMBL:ENSG00000124762)\|regulates_expression_of:(ENSEMBL:ENSG00000087088)	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:18548200^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:Q00987)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:18548200^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q00987)	Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:20181722^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P10275)	Seeded From UniProt	complete
enables	GO:0061631	ubiquitin conjugating enzyme activity	PMID:20181722^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P10275)	Seeded From UniProt	complete
involved_in	GO:0036369	transcription factor catabolic process	PMID:20181722^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P10275) part_of:(GO:0071383)	Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	PMID:20181722^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P10275) part_of:(GO:0071383) part_of:(GO:0000209)	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:20181722^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000825	positive regulation of androgen receptor activity	PMID:20181722^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0071383) has_regulation_target:(UniProtKB:P10275)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:20181722^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071383) coincident_with:(ENSEMBL:ENSG00000142515) coincident_with:(SO:0001668)\|exists_during(GO:0071383) coincident_with:(ENSEMBL:ENSG00000142515) coincident_with:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	PMID:20181722^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10275	F	part_of:(GO:0071383) occurs_at:(SO:0001668) positively_regulates:(GO:0004879)\|part_of(GO:0071383) occurs_at:(SO:0000165) positively_regulates:(GO:0004879)	Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	PMID:26637982^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q1LYC2	P	occurs_in:(UBERON:0000922)	Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	PMID:27007846^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	causally_upstream_of:(GO:0071318)	Seeded From UniProt	complete
involved_in	GO:0010768	negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	PMID:24289924^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000124762)\|regulates_transcription_of:(ENSEMBL:ENSG00000205076)	Seeded From UniProt	complete
involved_in	GO:0071318	cellular response to ATP	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0034644)	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(GO:0005634)	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(ENSEMBL:ENSG00000124762) coincident_with:(SO:0001668) exists_during:(GO:0034644)\|exists_during:(GO:0034644) coincident_with:(SO:0000315)\|coincident_with:(ENSEMBL:ENSG00000205076) exists_during:(GO:0034644)\|exists_during:(GO:0034644) coincident_with:(ENSEMBL:ENSG00000170855)\|exists_during(GO:0034644) coincident_with:(ENSEMBL:ENSG00000196576)\|exists_during(GO:0034644) coincident_with:(ENSEMBL:ENSG00000130766)\|exists_during(GO:0034644) coincident_with:(ENSEMBL:ENSG00000063660)\|exists_during(GO:0034644) coincident_with:(ENSEMBL:ENSG00000198625)\|exists_during(GO:0034644) coincident_with:(ENSEMBL:ENSG00000177595)	Seeded From UniProt	complete
involved_in	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P04637) happens_during:(GO:0018107)	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P04637) occurs_at:(SO:0000170) occurs_in:(GO:0005634)\|has_input(UniProtKB:P35269) occurs_in:(GO:0005634)	Seeded From UniProt	complete
enables	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	PMID:24289924^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12498690^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005730	nucleolus	PMID:12498690^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:17237821^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q00987) has_regulation_target:(UniProtKB:P04637)	Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:17237821^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q00987)	Seeded From UniProt	complete
involved_in	GO:1905524	negative regulation of protein autoubiquitination	PMID:17237821^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q00987)	Seeded From UniProt	complete
contributes_to	GO:0061628	H3K27me3 modified histone binding	PMID:24927529^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15545	F		Seeded From UniProt	complete
NOT\|enables	GO:0004402	histone acetyltransferase activity	PMID:24927529^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
NOT\|enables	GO:1905502	acetyl-CoA binding	PMID:24927529^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060260	regulation of transcription initiation from RNA polymerase II promoter	PMID:24927529^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016251	RNA polymerase II general transcription initiation factor activity	PMID:25412659^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q15545	F	has_input:(ENSEMBL:ENSG00000110092)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:25412659^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15545	F	positively_regulates:(GO:0008283)	Seeded From UniProt	complete
involved_in	GO:0045943	positive regulation of transcription by RNA polymerase I	PMID:12498690^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P17480,UniProtKB:Q15572	P		Seeded From UniProt	complete
colocalizes_with	GO:0005654	nucleoplasm	PMID:12498690^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070577	lysine-acetylated histone binding	PMID:17996705^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51123	P		Seeded From UniProt	complete
involved_in	GO:0051123	RNA polymerase II preinitiation complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51123	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:8625415^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9660973^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q60544	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17996705^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51123	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51123	F		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:15053879^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:15053879^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:8625415^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017025	TBP-class protein binding	PMID:9660973^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P53360	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:8625415^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35269	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:15053879^[13]	ECO:0000305	curator inference used in manual assertion	GO:0032436	P		Seeded From UniProt	complete
involved_in	GO:0006352	DNA-templated transcription, initiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51123	P		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	PMID:8625415^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:15053879^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:17996705^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:15053879^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
part_of	GO:0071339	MLL1 complex	PMID:15960975^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8625415^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	PMID:8980232^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010355 PANTHER:PTN000356981 UniProtKB:P21675 WB:WBGene00006382	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010355 PANTHER:PTN000356981	F		Seeded From UniProt	complete
enables	GO:0017025	TBP-class protein binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000356981 SGD:S000003506 UniProtKB:P21675 UniProtKB:Q8IZX4	F		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010355 PANTHER:PTN000356981 PomBase:SPAC2G11.14 SGD:S000003506 UniProtKB:P21675	C		Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336878 PANTHER:PTN000356981 SGD:S000003506 UniProtKB:P21675	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:15053879^[13]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	PMID:14580349^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004402	P		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004402	P		Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004402	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011177	F		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011177	C		Seeded From UniProt	complete
involved_in	GO:0006352	DNA-templated transcription, initiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011177	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011177	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:25412659^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005669	transcription factor TFIID complex	PMID:25412659^[2] PMID:12498690^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902806	regulation of cell cycle G1/S phase transition	PMID:12498690^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:15053879^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-75953 Reactome:R-HSA-73779	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	Reactome:R-HSA-73857	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9613497 Reactome:R-HSA-9613494 Reactome:R-HSA-75949 Reactome:R-HSA-75873 Reactome:R-HSA-75869 Reactome:R-HSA-75866 Reactome:R-HSA-75864 Reactome:R-HSA-75862 Reactome:R-HSA-75861 Reactome:R-HSA-75856 Reactome:R-HSA-75850 Reactome:R-HSA-75095 Reactome:R-HSA-73946 Reactome:R-HSA-6805399 Reactome:R-HSA-109639 Reactome:R-HSA-109638 Reactome:R-HSA-109637 Reactome:R-HSA-109636	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0012	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Wu, Y et al. (2014) Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. Mol. Cell 53 63-74 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Wang, H et al. (2014) Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. Cell Res. 24 1433-44 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Bhattacharya, S et al. (2014) Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Proc. Natl. Acad. Sci. U.S.A. 111 9103-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Allende-Vega, N et al. (2007) Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53. Oncogene 26 4234-42 PubMed GONUTS page
↑ ^5.0 ^5.1 Allende-Vega, N et al. (2008) Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2. Mol. Cell. Biochem. 316 99-106 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Tavassoli, P et al. (2010) TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains. Mol. Endocrinol. 24 696-708 PubMed GONUTS page
↑ O'Rawe, JA et al. (2015) TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations. Am. J. Hum. Genet. 97 922-32 PubMed GONUTS page
↑ Louder, RK et al. (2016) Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Nature 531 604-9 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Lin, CY et al. (2002) The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF. Curr. Biol. 12 2142-6 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Li, AG et al. (2007) An acetylation switch in p53 mediates holo-TFIID recruitment. Mol. Cell 28 408-21 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Dikstein, R et al. (1996) TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74. Cell 84 781-90 PubMed GONUTS page
↑ ^12.0 ^12.1 O'Brien, T & Tjian, R (1998) Functional analysis of the human TAFII250 N-terminal kinase domain. Mol. Cell 1 905-11 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Li, HH et al. (2004) Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. Mol. Cell 13 867-78 PubMed GONUTS page
↑ Dou, Y et al. (2005) Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell 121 873-85 PubMed GONUTS page
↑ Mizzen, CA et al. (1996) The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. Cell 87 1261-70 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Guermah, M et al. (2003) The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Mol. Cell 12 991-1001 PubMed GONUTS page

[PMID:24289924-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Wu, Y et al. (2014) Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. Mol. Cell 53 63-74 PubMed GONUTS page

[PMID:25412659-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Wang, H et al. (2014) Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. Cell Res. 24 1433-44 PubMed GONUTS page

[PMID:24927529-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Bhattacharya, S et al. (2014) Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Proc. Natl. Acad. Sci. U.S.A. 111 9103-8 PubMed GONUTS page

[PMID:17237821-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Allende-Vega, N et al. (2007) Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53. Oncogene 26 4234-42 PubMed GONUTS page

[PMID:18548200-5] 5.0 ^5.1 Allende-Vega, N et al. (2008) Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2. Mol. Cell. Biochem. 316 99-106 PubMed GONUTS page

[PMID:20181722-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Tavassoli, P et al. (2010) TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains. Mol. Endocrinol. 24 696-708 PubMed GONUTS page

[PMID:26637982-7] O'Rawe, JA et al. (2015) TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations. Am. J. Hum. Genet. 97 922-32 PubMed GONUTS page

[PMID:27007846-8] Louder, RK et al. (2016) Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Nature 531 604-9 PubMed GONUTS page

[PMID:12498690-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Lin, CY et al. (2002) The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF. Curr. Biol. 12 2142-6 PubMed GONUTS page

[PMID:17996705-10] 10.0 ^10.1 ^10.2 Li, AG et al. (2007) An acetylation switch in p53 mediates holo-TFIID recruitment. Mol. Cell 28 408-21 PubMed GONUTS page

[PMID:8625415-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Dikstein, R et al. (1996) TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74. Cell 84 781-90 PubMed GONUTS page

[PMID:9660973-12] 12.0 ^12.1 O'Brien, T & Tjian, R (1998) Functional analysis of the human TAFII250 N-terminal kinase domain. Mol. Cell 1 905-11 PubMed GONUTS page

[PMID:15053879-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Li, HH et al. (2004) Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. Mol. Cell 13 867-78 PubMed GONUTS page

[PMID:15960975-14] Dou, Y et al. (2005) Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell 121 873-85 PubMed GONUTS page

[PMID:8980232-15] Mizzen, CA et al. (1996) The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. Cell 87 1261-70 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14580349-17] Guermah, M et al. (2003) The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Mol. Cell 12 991-1001 PubMed GONUTS page

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