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CHICK:RARB

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) RARB (synonyms: NR1B2)
Protein Name(s) Retinoic acid receptor beta

RAR-beta Nuclear receptor subfamily 1 group B member 2

External Links
UniProt P22448
EMBL X56674
X57341
X57340
X57339
S75943
X59473
S63196
PIR A43786
I51272
S13512
RefSeq NP_990657.1
UniGene Gga.2668
Gga.51498
ProteinModelPortal P22448
SMR P22448
PaxDb P22448
Ensembl ENSGALT00000037748
GeneID 396266
KEGG gga:396266
CTD 5915
eggNOG NOG297448
GeneTree ENSGT00760000118837
HOGENOM HOG000010312
HOVERGEN HBG005606
InParanoid P22448
KO K08528
OMA QEVFVCI
OrthoDB EOG738053
PhylomeDB P22448
TreeFam TF328382
Reactome REACT_258806
NextBio 20816318
PRO PR:P22448
Proteomes UP000000539
GO GO:0005634
GO:0003708
GO:0000977
GO:0003707
GO:0008270
GO:0071729
GO:0048566
GO:0048048
GO:0035116
GO:0002068
GO:0003417
GO:0035108
GO:0035264
GO:0043066
GO:0008285
GO:0032331
GO:0000122
GO:0022008
GO:0003148
GO:0043065
GO:0008284
GO:0045944
GO:0032526
GO:0003406
GO:0021756
GO:0001657
GO:0055012
Gene3D 1.10.565.10
3.30.50.10
InterPro IPR008946
IPR000536
IPR003078
IPR001723
IPR001628
IPR013088
Pfam PF00104
PF00105
PRINTS PR01292
PR00398
PR00047
SMART SM00430
SM00399
SUPFAM SSF48508
PROSITE PS00031
PS51030

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005623

cell

PMID:17706616[1]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001945)

Seeded From UniProt

complete

involved_in

GO:0070660

inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration

PMID:8789806[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:8789806[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002374)

Seeded From UniProt

complete

involved_in

GO:0071729

beak morphogenesis

PMID:1652423[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035108

limb morphogenesis

PMID:7703521[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032526

response to retinoic acid

PMID:1652423[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0090575

RNA polymerase II transcription factor complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1352462
PANTHER:PTN000637751
UniProtKB:P11473
UniProtKB:P37231
UniProtKB:Q13133

C

Seeded From UniProt

complete

involved_in

GO:0071300

cellular response to retinoic acid

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97858
PANTHER:PTN000637903
RGD:1583230
UniProtKB:P10276

P

Seeded From UniProt

complete

involved_in

GO:0060429

epithelium development

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97858
PANTHER:PTN000637903

P

Seeded From UniProt

complete

involved_in

GO:0060349

bone morphogenesis

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97858
PANTHER:PTN000637903

P

Seeded From UniProt

complete

involved_in

GO:0048732

gland development

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97858
PANTHER:PTN000637903

P

Seeded From UniProt

complete

involved_in

GO:0048384

retinoic acid receptor signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97858
PANTHER:PTN000637903
RGD:1583230
RGD:3534
UniProtKB:P10276
UniProtKB:P13631

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
MGI:MGI:104740
MGI:MGI:1352462
MGI:MGI:1352463
MGI:MGI:1352464
MGI:MGI:97747
MGI:MGI:97856
MGI:MGI:97857
MGI:MGI:97858
MGI:MGI:98742
MGI:MGI:98743
PANTHER:PTN000637751
RGD:3371
RGD:3857
RGD:61906
RGD:628831
UniProtKB:O62807
UniProtKB:O75469
UniProtKB:P10276
UniProtKB:P11473
UniProtKB:P37231
UniProtKB:P55055
UniProtKB:Q07869
UniProtKB:Q13133
UniProtKB:Q14994
UniProtKB:Q8JHU1
UniProtKB:Q96RI1
WB:WBGene00000908

P

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104740
PANTHER:PTN000637751

F

Seeded From UniProt

complete

involved_in

GO:0033993

response to lipid

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97747
PANTHER:PTN001941333
RGD:3371

P

Seeded From UniProt

complete

involved_in

GO:0032526

response to retinoic acid

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97856
PANTHER:PTN000637903
UniProtKB:P10276
UniProtKB:P13631
UniProtKB:P22448
ZFIN:ZDB-GENE-980526-284

P

Seeded From UniProt

complete

enables

GO:0030374

nuclear receptor transcription coactivator activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97747
PANTHER:PTN000637751
UniProtKB:O62807
UniProtKB:P37231

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101884
PANTHER:PTN000637751

P

Seeded From UniProt

complete

involved_in

GO:0009755

hormone-mediated signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001941333
UniProtKB:P10827

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97856
PANTHER:PTN000637751
RGD:3371
RGD:3534
UniProtKB:P10276
UniProtKB:P10827
UniProtKB:P37231
UniProtKB:Q03181
UniProtKB:Q07869
ZFIN:ZDB-GENE-000210-31

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103076
PANTHER:PTN000637751

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
FB:FBgn0000568
MGI:MGI:101884
MGI:MGI:1346307
MGI:MGI:1352462
MGI:MGI:1352463
MGI:MGI:2444210
MGI:MGI:97747
MGI:MGI:97856
MGI:MGI:97858
MGI:MGI:98742
MGI:MGI:98743
PANTHER:PTN000637751
RGD:3369
RGD:3370
RGD:3371
RGD:3534
RGD:3857
RGD:61909
RGD:621400
RGD:628831
UniProtKB:O62807
UniProtKB:P04625
UniProtKB:P10276
UniProtKB:P10826
UniProtKB:P10827
UniProtKB:P11473
UniProtKB:P13631
UniProtKB:P37231
UniProtKB:P55055
UniProtKB:P68306
UniProtKB:Q07869
UniProtKB:Q13133
UniProtKB:Q14995
WB:WBGene00000908
WB:WBGene00003607
WB:WBGene00004786
ZFIN:ZDB-GENE-990415-263

C

Seeded From UniProt

complete

involved_in

GO:0001889

liver development

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002377624
RGD:3534

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
PANTHER:PTN000637751
RGD:61906

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
FB:FBgn0015240
MGI:MGI:97856
MGI:MGI:97857
MGI:MGI:97858
PANTHER:PTN000637751
UniProtKB:O75469
UniProtKB:P20393
UniProtKB:Q14994
UniProtKB:Q96RI1
WB:WBGene00004786

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
MGI:MGI:98742
PANTHER:PTN000637751
RGD:628827
UniProtKB:Q96RI1

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101884
MGI:MGI:2449205
MGI:MGI:97747
MGI:MGI:97856
MGI:MGI:97857
MGI:MGI:97858
MGI:MGI:98743
PANTHER:PTN001941333
UniProtKB:P20393
UniProtKB:P37231
UniProtKB:Q07869
WB:WBGene00004786

P

Seeded From UniProt

complete

involved_in

GO:0043401

steroid hormone mediated signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003707

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:F1D8S6
ensembl:ENSP00000332296

C

Seeded From UniProt

complete

involved_in

GO:0048566

embryonic digestive tract development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10826
ensembl:ENSP00000332296

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10826
ensembl:ENSP00000332296

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10826
ensembl:ENSP00000332296

C

Seeded From UniProt

complete

involved_in

GO:0061037

negative regulation of cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0060348

bone development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0055012

ventricular cardiac muscle cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0048048

embryonic eye morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

F

Seeded From UniProt

complete

involved_in

GO:0043068

positive regulation of programmed cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0035264

multicellular organism growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0035116

embryonic hindlimb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0032331

negative regulation of chondrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0022008

neurogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0021756

striatum development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

F

Seeded From UniProt

complete

involved_in

GO:0003417

growth plate cartilage development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0003148

outflow tract septum morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0002068

glandular epithelial cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0001657

ureteric bud development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22605
ensembl:ENSMUSP00000067694

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001723
InterPro:IPR003078

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

enables

GO:0003707

steroid hormone receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001723

F

Seeded From UniProt

complete

enables

GO:0004879

nuclear receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003078

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR001723
InterPro:IPR003078

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR001723
InterPro:IPR003078
InterPro:IPR013088

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR013088

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

involved_in

GO:0048384

retinoic acid receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003078

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Propping, C et al. (2007) Distribution of the cellular retinoic acid binding protein CRABP-I in the developing chick optic tectum. Brain Res. 1168 21-31 PubMed GONUTS page
  2. 2.0 2.1 Lee, KH & Cotanche, DA (1996) Potential role of bFGF and retinoic acid in the regeneration of chicken cochlear hair cells. Hear. Res. 94 1-13 PubMed GONUTS page
  3. 3.0 3.1 Rowe, A et al. (1991) Retinoic acid treatment alters the distribution of retinoic acid receptor-beta transcripts in the embryonic chick face. Development 111 1007-16 PubMed GONUTS page
  4. Smith, SM et al. (1995) Differential expression of retinoic acid receptor-beta isoforms during chick limb ontogeny. Dev. Dyn. 202 54-66 PubMed GONUTS page
  5. 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page