CHICK:RARB

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	RARB (synonyms: NR1B2)
Protein Name(s)	Retinoic acid receptor beta RAR-beta Nuclear receptor subfamily 1 group B member 2
External Links
UniProt	P22448
EMBL	X56674 X57341 X57340 X57339 S75943 X59473 S63196
PIR	A43786 I51272 S13512
RefSeq	NP_990657.1
UniGene	Gga.2668 Gga.51498
ProteinModelPortal	P22448
SMR	P22448
PaxDb	P22448
Ensembl	ENSGALT00000037748
GeneID	396266
KEGG	gga:396266
CTD	5915
eggNOG	NOG297448
GeneTree	ENSGT00760000118837
HOGENOM	HOG000010312
HOVERGEN	HBG005606
InParanoid	P22448
KO	K08528
OMA	QEVFVCI
OrthoDB	EOG738053
PhylomeDB	P22448
TreeFam	TF328382
Reactome	REACT_258806
NextBio	20816318
PRO	PR:P22448
Proteomes	UP000000539
GO	GO:0005634 GO:0003708 GO:0000977 GO:0003707 GO:0008270 GO:0071729 GO:0048566 GO:0048048 GO:0035116 GO:0002068 GO:0003417 GO:0035108 GO:0035264 GO:0043066 GO:0008285 GO:0032331 GO:0000122 GO:0022008 GO:0003148 GO:0043065 GO:0008284 GO:0045944 GO:0032526 GO:0003406 GO:0021756 GO:0001657 GO:0055012
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR008946 IPR000536 IPR003078 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR01292 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005623	cell	PMID:17706616^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001945)	Seeded From UniProt	complete
involved_in	GO:0070660	inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration	PMID:8789806^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:8789806^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002374)	Seeded From UniProt	complete
involved_in	GO:0071729	beak morphogenesis	PMID:1652423^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	PMID:7703521^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:1652423^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97858 PANTHER:PTN000637903 RGD:1583230 UniProtKB:P10276	P		Seeded From UniProt	complete
involved_in	GO:0060429	epithelium development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97858 PANTHER:PTN000637903	P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97858 PANTHER:PTN000637903	P		Seeded From UniProt	complete
involved_in	GO:0048732	gland development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97858 PANTHER:PTN000637903	P		Seeded From UniProt	complete
involved_in	GO:0048384	retinoic acid receptor signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97858 PANTHER:PTN000637903 RGD:1583230 RGD:3534 UniProtKB:P10276 UniProtKB:P13631	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F		Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN001941333 RGD:3371	P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637903 UniProtKB:P10276 UniProtKB:P13631 UniProtKB:P22448 ZFIN:ZDB-GENE-980526-284	P		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P		Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001941333 UniProtKB:P10827	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002377624 RGD:3534	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 MGI:MGI:2449205 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98743 PANTHER:PTN001941333 UniProtKB:P20393 UniProtKB:P37231 UniProtKB:Q07869 WB:WBGene00004786	P		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1D8S6 ensembl:ENSP00000332296	C		Seeded From UniProt	complete
involved_in	GO:0048566	embryonic digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10826 ensembl:ENSP00000332296	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10826 ensembl:ENSP00000332296	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10826 ensembl:ENSP00000332296	C		Seeded From UniProt	complete
involved_in	GO:0061037	negative regulation of cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0055012	ventricular cardiac muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0048048	embryonic eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	F		Seeded From UniProt	complete
involved_in	GO:0043068	positive regulation of programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0032331	negative regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0021756	striatum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	F		Seeded From UniProt	complete
involved_in	GO:0003417	growth plate cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0002068	glandular epithelial cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22605 ensembl:ENSMUSP00000067694	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723 InterPro:IPR003078	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003078	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003078	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003078 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
involved_in	GO:0048384	retinoic acid receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003078	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Propping, C et al. (2007) Distribution of the cellular retinoic acid binding protein CRABP-I in the developing chick optic tectum. Brain Res. 1168 21-31 PubMed GONUTS page
↑ ^2.0 ^2.1 Lee, KH & Cotanche, DA (1996) Potential role of bFGF and retinoic acid in the regeneration of chicken cochlear hair cells. Hear. Res. 94 1-13 PubMed GONUTS page
↑ ^3.0 ^3.1 Rowe, A et al. (1991) Retinoic acid treatment alters the distribution of retinoic acid receptor-beta transcripts in the embryonic chick face. Development 111 1007-16 PubMed GONUTS page
↑ Smith, SM et al. (1995) Differential expression of retinoic acid receptor-beta isoforms during chick limb ontogeny. Dev. Dyn. 202 54-66 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 ^5.16 ^5.17 ^5.18 ^5.19 ^5.20 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17706616-1] Propping, C et al. (2007) Distribution of the cellular retinoic acid binding protein CRABP-I in the developing chick optic tectum. Brain Res. 1168 21-31 PubMed GONUTS page

[PMID:8789806-2] 2.0 ^2.1 Lee, KH & Cotanche, DA (1996) Potential role of bFGF and retinoic acid in the regeneration of chicken cochlear hair cells. Hear. Res. 94 1-13 PubMed GONUTS page

[PMID:1652423-3] 3.0 ^3.1 Rowe, A et al. (1991) Retinoic acid treatment alters the distribution of retinoic acid receptor-beta transcripts in the embryonic chick face. Development 111 1007-16 PubMed GONUTS page

[PMID:7703521-4] Smith, SM et al. (1995) Differential expression of retinoic acid receptor-beta isoforms during chick limb ontogeny. Dev. Dyn. 202 54-66 PubMed GONUTS page

[PMID:21873635-5] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 ^5.15 ^5.16 ^5.17 ^5.18 ^5.19 ^5.20 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:RARB

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