HUMAN:NR1H3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NR1H3 (synonyms: LXRA)
Protein Name(s)	Oxysterols receptor LXR-alpha Liver X receptor alpha Nuclear receptor subfamily 1 group H member 3
External Links
UniProt	Q13133
EMBL	U22662 AK290614 AC018410 CH471064 CH471064 CH471064 CH471064 CH471064 CH471064 BC008819 BC041172
CCDS	CCDS44584.1 CCDS44585.1 CCDS7929.1
PIR	I38975
RefSeq	NP_001123573.1 NP_001123574.1 NP_005684.2 XP_005252762.1 XP_005252763.1 XP_005252764.1 XP_005252766.1 XP_005252767.1 XP_005252770.1 XP_006718175.1 XP_006718176.1 XP_006718177.1 XP_006718178.1 XP_006718179.1
UniGene	Hs.438863
PDB	1UHL 3IPQ 3IPS 3IPU
PDBsum	1UHL 3IPQ 3IPS 3IPU
ProteinModelPortal	Q13133
SMR	Q13133
BioGrid	115373
IntAct	Q13133
MINT	MINT-3027136
STRING	9606.ENSP00000342470
BindingDB	Q13133
ChEMBL	CHEMBL2808
GuidetoPHARMACOLOGY	602
PhosphoSite	Q13133
DMDM	23503089
MaxQB	Q13133
PaxDb	Q13133
PRIDE	Q13133
DNASU	10062
Ensembl	ENST00000395397 ENST00000405853 ENST00000407404 ENST00000441012 ENST00000467728
GeneID	10062
KEGG	hsa:10062
UCSC	uc001nek.3 uc001nen.4
CTD	10062
GeneCards	GC11P047269
HGNC	HGNC:7966
HPA	CAB037109 HPA036443
MIM	602423
neXtProt	NX_Q13133
PharmGKB	PA31751
eggNOG	NOG285805
GeneTree	ENSGT00760000118837
HOGENOM	HOG000220845
HOVERGEN	HBG108655
InParanoid	Q13133
KO	K08536
OMA	GRCEMDM
PhylomeDB	Q13133
TreeFam	TF352167
Reactome	REACT_15525
SignaLink	Q13133
EvolutionaryTrace	Q13133
GeneWiki	Liver_X_receptor_alpha
GenomeRNAi	10062
NextBio	38029
PRO	PR:Q13133
Proteomes	UP000005640
Bgee	Q13133
CleanEx	HS_NR1H3
ExpressionAtlas	Q13133
Genevestigator	Q13133
GO	GO:0000790 GO:0005654 GO:0005634 GO:0015485 GO:0003677 GO:0004879 GO:0043565 GO:0003707 GO:0032810 GO:0003713 GO:0044212 GO:0008270 GO:0043277 GO:0071222 GO:0042632 GO:0010467 GO:0030522 GO:0055088 GO:0010887 GO:0050728 GO:0060336 GO:0032369 GO:0043031 GO:0010745 GO:0090188 GO:0048550 GO:0090341 GO:0000122 GO:0032270 GO:0010875 GO:2000189 GO:0032376 GO:0045723 GO:0051006 GO:0010870 GO:0034145 GO:0045944 GO:0045893 GO:0010867 GO:2000188 GO:0042752 GO:0032570 GO:0055092 GO:0006367 GO:0070328
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR023257 IPR008946 IPR000536 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR02034 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0003706	ligand-regulated transcription factor activity	PMID:11090131^[1]	ECO:0000314			F		Figure 2: LXRalpha transcriptional activity greatly induced by synthetic ligands.	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000324 InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR001728	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19481530^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:19481530^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000325	regulation of nuclear receptor transcription coactivator activity	PMID:19481530^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:19481530^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:21173252^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:D3ZWV0	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:25661920^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25661920^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:18511497^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:18511497^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:18511497^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090341	negative regulation of secretion of lysosomal enzymes	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P		Seeded From UniProt	complete
involved_in	GO:0090188	negative regulation of pancreatic juice secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:18511497^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P		Seeded From UniProt	complete
involved_in	GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway	PMID:21268089^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055092	sterol homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P		Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P		Seeded From UniProt	complete
involved_in	GO:0051006	positive regulation of lipoprotein lipase activity	PMID:17186944^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P		Seeded From UniProt	complete
involved_in	GO:0048550	negative regulation of pinocytosis	PMID:17693624^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19229075^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17186944^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18511497^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20837115^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16141411^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045723	positive regulation of fatty acid biosynthetic process	PMID:17186944^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0044212	transcription regulatory region DNA binding	PMID:18511497^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19229075^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043031	negative regulation of macrophage activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P		Seeded From UniProt	complete
involved_in	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	PMID:18511497^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	PMID:16141411^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032376	positive regulation of cholesterol transport	PMID:16141411^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032369	negative regulation of lipid transport	PMID:17693624^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	PMID:17186944^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010887	negative regulation of cholesterol storage	PMID:17693624^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:17186944^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010875	positive regulation of cholesterol efflux	PMID:16141411^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010870	positive regulation of receptor biosynthetic process	PMID:18511497^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010867	positive regulation of triglyceride biosynthetic process	PMID:17693624^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010745	negative regulation of macrophage derived foam cell differentiation	PMID:17693624^[9]	ECO:0000305	curator inference used in manual assertion	GO:0032369	P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:18511497^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z0Y9	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20219900^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O95573)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19628791^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043277	apoptotic cell clearance	PMID:19628791^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0032810	sterol response element binding	PMID:19628791^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352464 PANTHER:PTN000637752 UniProtKB:Q13133	P		Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352463 PANTHER:PTN000637752 ZFIN:ZDB-GENE-050410-7	P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637816	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P		Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 PANTHER:PTN000637752 UniProtKB:Q13133	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000637752 RGD:61909	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 PANTHER:PTN000637752 RGD:628831	P		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7744246^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:7744246^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:7744246^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:7744246^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:18511497^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015485	cholesterol binding	PMID:11090131^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-383280	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-4720446 Reactome:R-HSA-376419	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Schultz, JR et al. (2000) Role of LXRs in control of lipogenesis. Genes Dev. 14 2831-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Jakobsson, T et al. (2009) GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus. Mol. Cell 34 510-8 PubMed GONUTS page
↑ Korach-André, M et al. (2011) Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. Proc. Natl. Acad. Sci. U.S.A. 108 403-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Sakurabashi, A et al. (2015) CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase. J. Steroid Biochem. Mol. Biol. 149 80-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Fontaine, C et al. (2008) The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages. Mol. Endocrinol. 22 1797-811 PubMed GONUTS page
↑ Li, N et al. (2011) Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J. Cell. Biochem. 112 675-83 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Beyea, MM et al. (2007) Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol. J. Biol. Chem. 282 5207-16 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Buono, C et al. (2007) Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL. J. Lipid Res. 48 2411-8 PubMed GONUTS page
↑ ^10.0 ^10.1 Lu, R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J. Lipid Res. 50 1156-64 PubMed GONUTS page
↑ Demeure, O et al. (2011) Regulation of LPCAT3 by LXR. Gene 470 7-11 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Rigamonti, E et al. (2005) Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ. Res. 97 682-9 PubMed GONUTS page
↑ Weedon-Fekjaer, MS et al. (2010) Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells. J. Lipid Res. 51 1886-96 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Rébé, C et al. (2009) Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages. Circ. Res. 105 393-401 PubMed GONUTS page
↑ ^15.00 ^15.01 ^15.02 ^15.03 ^15.04 ^15.05 ^15.06 ^15.07 ^15.08 ^15.09 ^15.10 ^15.11 ^15.12 ^15.13 ^15.14 ^15.15 ^15.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Willy, PJ et al. (1995) LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9 1033-45 PubMed GONUTS page

[PMID:11090131-1] 1.0 ^1.1 Schultz, JR et al. (2000) Role of LXRs in control of lipogenesis. Genes Dev. 14 2831-8 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:19481530-3] 3.0 ^3.1 ^3.2 ^3.3 Jakobsson, T et al. (2009) GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus. Mol. Cell 34 510-8 PubMed GONUTS page

[PMID:21173252-4] Korach-André, M et al. (2011) Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. Proc. Natl. Acad. Sci. U.S.A. 108 403-8 PubMed GONUTS page

[PMID:25661920-5] 5.0 ^5.1 Sakurabashi, A et al. (2015) CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase. J. Steroid Biochem. Mol. Biol. 149 80-8 PubMed GONUTS page

[PMID:18511497-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Fontaine, C et al. (2008) The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages. Mol. Endocrinol. 22 1797-811 PubMed GONUTS page

[PMID:21268089-7] Li, N et al. (2011) Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J. Cell. Biochem. 112 675-83 PubMed GONUTS page

[PMID:17186944-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Beyea, MM et al. (2007) Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol. J. Biol. Chem. 282 5207-16 PubMed GONUTS page

[PMID:17693624-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Buono, C et al. (2007) Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL. J. Lipid Res. 48 2411-8 PubMed GONUTS page

[PMID:19229075-10] 10.0 ^10.1 Lu, R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J. Lipid Res. 50 1156-64 PubMed GONUTS page

[PMID:20837115-11] Demeure, O et al. (2011) Regulation of LPCAT3 by LXR. Gene 470 7-11 PubMed GONUTS page

[PMID:16141411-12] 12.0 ^12.1 ^12.2 ^12.3 Rigamonti, E et al. (2005) Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ. Res. 97 682-9 PubMed GONUTS page

[PMID:20219900-13] Weedon-Fekjaer, MS et al. (2010) Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells. J. Lipid Res. 51 1886-96 PubMed GONUTS page

[PMID:19628791-14] 14.0 ^14.1 ^14.2 Rébé, C et al. (2009) Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages. Circ. Res. 105 393-401 PubMed GONUTS page

[PMID:21873635-15] 15.00 ^15.01 ^15.02 ^15.03 ^15.04 ^15.05 ^15.06 ^15.07 ^15.08 ^15.09 ^15.10 ^15.11 ^15.12 ^15.13 ^15.14 ^15.15 ^15.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7744246-16] 16.0 ^16.1 ^16.2 ^16.3 Willy, PJ et al. (1995) LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9 1033-45 PubMed GONUTS page

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