GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

DROME:USP

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) usp (synonyms: Cf1, NR2B4)
Protein Name(s) Protein ultraspiracle

Chorion factor 1 Nuclear receptor subfamily 2 group B member 4 XR2C

External Links
UniProt P20153
EMBL X53417
X52591
AE014298
AL031765
AY069393
X53379
PIR A35872
T13737
RefSeq NP_001259168.1
NP_476781.1
UniGene Dm.25
PDB 1HG4
1R0O
2HAN
PDBsum 1HG4
1R0O
2HAN
ProteinModelPortal P20153
SMR P20153
BioGrid 57709
DIP DIP-645N
IntAct P20153
MINT MINT-824030
STRING 7227.FBpp0070332
ChEMBL CHEMBL2366581
PaxDb P20153
PRIDE P20153
EnsemblMetazoa FBtr0070346
FBtr0333803
GeneID 31165
KEGG dme:Dmel_CG4380
CTD 31165
FlyBase FBgn0003964
eggNOG NOG327099
GeneTree ENSGT00760000118948
InParanoid P20153
KO K14030
OMA KHFLPLD
OrthoDB EOG72RMZ5
PhylomeDB P20153
Reactome REACT_105645
REACT_180268
REACT_180742
REACT_180846
REACT_180981
REACT_181316
REACT_181317
REACT_214173
REACT_214462
REACT_226175
REACT_230364
REACT_236107
REACT_239233
SignaLink P20153
EvolutionaryTrace P20153
GenomeRNAi 31165
NextBio 772247
Proteomes UP000000803
Bgee P20153
ExpressionAtlas P20153
GO GO:0008232
GO:0030425
GO:0008230
GO:0005634
GO:0005700
GO:0003677
GO:0004884
GO:0042562
GO:0005500
GO:0004879
GO:0008289
GO:0046982
GO:0042803
GO:0000976
GO:0008270
GO:0007298
GO:0071390
GO:0048813
GO:0035076
GO:0007281
GO:0030522
GO:0007517
GO:0016319
GO:0045596
GO:0045892
GO:0048666
GO:0016322
GO:0045944
GO:0045893
GO:0035073
GO:0040034
GO:0035075
Gene3D 1.10.565.10
3.30.50.10
InterPro IPR008946
IPR000536
IPR000003
IPR001723
IPR001628
IPR013088
Pfam PF00104
PF00105
PRINTS PR00545
PR00398
PR00047
SMART SM00430
SM00399
SUPFAM SSF48508
PROSITE PS00031
PS51030

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007552

metamorphosis

PMID:23211750[1]

ECO:0000315

P

Figure 5 - Mutants with impaired USP function did not develop through the metamorphosis stage.

complete
CACAO 6602

involved_in

GO:0007552

metamorphosis

PMID:23211750[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:22628309[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P49869

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22628309[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001047

core promoter binding

PMID:22628309[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:22628309[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0008230

ecdysone receptor holocomplex

PMID:22628309[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:22628309[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P34021

F

Seeded From UniProt

complete

involved_in

GO:0071390

cellular response to ecdysone

PMID:19268446[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007281

germ cell development

PMID:21423150[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016322

neuron remodeling

PMID:20027309[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016319

mushroom body development

PMID:20027309[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:19389369[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:18980211[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:18980211[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

PMID:16210248[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0048813

dendrite morphogenesis

PMID:15018941[9]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016322

neuron remodeling

PMID:15084281[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004879

nuclear receptor activity

PMID:11532213[11]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

PMID:11171988[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016322

neuron remodeling

PMID:11163268[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007298

border follicle cell migration

PMID:11163181[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005700

polytene chromosome

PMID:10920384[15]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:8524239[16]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0000546

F

Seeded From UniProt

complete

part_of

GO:0008230

ecdysone receptor holocomplex

PMID:8524239[16]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0000546

C

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:8524239[16]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0000546

F

Seeded From UniProt

complete

contributes_to

GO:0004879

nuclear receptor activity

PMID:8524239[16]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0000546

F

has_input:(CHEBI:23897)

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:7882975[17]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0008232

activator ecdysone receptor complex

PMID:7882975[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0035100

ecdysone binding

PMID:8247157[18]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:1280827[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004879

nuclear receptor activity

PMID:1280827[19]

ECO:0000314

direct assay evidence used in manual assertion

F

has_input:(CHEBI:23897)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:2120114[20]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042594

response to starvation

PMID:25421296[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046620

regulation of organ growth

PMID:25421296[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006697

ecdysone biosynthetic process

PMID:25421296[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042562

hormone binding

PMID:23211750[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035073

pupariation

PMID:23211750[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016319

mushroom body development

PMID:23160410[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035075

response to ecdysone

PMID:21981918[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21981918[23]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21981918[23]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030522

intracellular receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004879

P

Seeded From UniProt

complete

involved_in

GO:0030522

intracellular receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004879

P

Seeded From UniProt

complete

involved_in

GO:0030522

intracellular receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004879

P

Seeded From UniProt

complete

involved_in

GO:0043401

steroid hormone mediated signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003707

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001228

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000003
InterPro:IPR001723

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

enables

GO:0003707

steroid hormone receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000003
InterPro:IPR001723

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000003
InterPro:IPR001628
InterPro:IPR001723

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000003
InterPro:IPR001628
InterPro:IPR001723
InterPro:IPR013088

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000003
InterPro:IPR001628
InterPro:IPR013088

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

involved_in

GO:0040034

regulation of development, heterochronic

PMID:11703937[24]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0008230

ecdysone receptor holocomplex

PMID:11102824[25]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:10920384[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045596

negative regulation of cell differentiation

PMID:10920384[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Jones, G et al. (2013) Ligand binding pocket function of Drosophila USP is necessary for metamorphosis. Gen. Comp. Endocrinol. 182 73-82 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Zoglowek, A et al. (2012) The composite nature of the interaction between nuclear receptors EcR and DHR38. Biol. Chem. 393 457-71 PubMed GONUTS page
  3. ↑ Beck, Y et al. (2009) The ligand-binding domains of the three RXR-USP nuclear receptor types support distinct tissue and ligand specific hormonal responses in transgenic Drosophila. Dev. Biol. 330 1-11 PubMed GONUTS page
  4. ↑ König, A et al. (2011) Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation. EMBO J. 30 1549-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 Lin, S et al. (2009) Nuclear receptor unfulfilled regulates axonal guidance and cell identity of Drosophila mushroom body neurons. PLoS ONE 4 e8392 PubMed GONUTS page
  6. ↑ Bernardi, F et al. (2009) EcR-B1 and Usp nuclear hormone receptors regulate expression of the VM32E eggshell gene during Drosophila oogenesis. Dev. Biol. 328 541-51 PubMed GONUTS page
  7. ↑ 7.0 7.1 Bitra, K & Palli, SR (2009) Interaction of proteins involved in ecdysone and juvenile hormone signal transduction. Arch. Insect Biochem. Physiol. 70 90-105 PubMed GONUTS page
  8. ↑ Kuo, CT et al. (2005) Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling. Proc. Natl. Acad. Sci. U.S.A. 102 15230-5 PubMed GONUTS page
  9. ↑ Grueber, WB & Jan, YN (2004) Dendritic development: lessons from Drosophila and related branches. Curr. Opin. Neurobiol. 14 74-82 PubMed GONUTS page
  10. ↑ Awasaki, T & Ito, K (2004) Engulfing action of glial cells is required for programmed axon pruning during Drosophila metamorphosis. Curr. Biol. 14 668-77 PubMed GONUTS page
  11. ↑ Maglich, JM et al. (2001) Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes. Genome Biol. 2 RESEARCH0029 PubMed GONUTS page
  12. ↑ Clayton, GM et al. (2001) The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation. Proc. Natl. Acad. Sci. U.S.A. 98 1549-54 PubMed GONUTS page
  13. ↑ Lee, T et al. (2000) Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila. Neuron 28 807-18 PubMed GONUTS page
  14. ↑ Bai, J et al. (2000) Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer. Cell 103 1047-58 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 Kozlova, T & Thummel, CS (2000) Steroid regulation of postembryonic development and reproduction in Drosophila. Trends Endocrinol. Metab. 11 276-80 PubMed GONUTS page
  16. ↑ 16.0 16.1 16.2 16.3 Zelhof, AC et al. (1995) Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo. Mol. Cell. Biol. 15 6736-45 PubMed GONUTS page
  17. ↑ 17.0 17.1 Lehmann, M & Korge, G (1995) Ecdysone regulation of the Drosophila Sgs-4 gene is mediated by the synergistic action of ecdysone receptor and SEBP 3. EMBO J. 14 716-26 PubMed GONUTS page
  18. ↑ Yao, TP et al. (1993) Functional ecdysone receptor is the product of EcR and Ultraspiracle genes. Nature 366 476-9 PubMed GONUTS page
  19. ↑ 19.0 19.1 Christianson, AM et al. (1992) DNA binding and heteromerization of the Drosophila transcription factor chorion factor 1/ultraspiracle. Proc. Natl. Acad. Sci. U.S.A. 89 11503-7 PubMed GONUTS page
  20. ↑ Shea, MJ et al. (1990) Proteins that bind to Drosophila chorion cis-regulatory elements: a new C2H2 zinc finger protein and a C2C2 steroid receptor-like component. Genes Dev. 4 1128-40 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 Koyama, T et al. (2014) Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis. Elife 3 PubMed GONUTS page
  22. ↑ Kucherenko, MM et al. (2012) Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain. EMBO J. 31 4511-23 PubMed GONUTS page
  23. ↑ 23.0 23.1 23.2 Johnston, DM et al. (2011) Ecdysone- and NO-mediated gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development. Mol. Cell 44 51-61 PubMed GONUTS page
  24. ↑ Thummel, CS (2001) Molecular mechanisms of developmental timing in C. elegans and Drosophila. Dev. Cell 1 453-65 PubMed GONUTS page
  25. ↑ Buszczak, M & Segraves, WA (2000) Insect metamorphosis: out with the old, in with the new. Curr. Biol. 10 R830-3 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=DROME:USP&oldid=5939617"