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PMID:15084281
| Citation |
Awasaki, T and Ito, K (2004) Engulfing action of glial cells is required for programmed axon pruning during Drosophila metamorphosis. Curr. Biol. 14:668-77 |
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| Abstract |
Axon pruning is involved in establishment and maintenance of functional neural circuits. During metamorphosis of Drosophila, selective pruning of larval axons is developmentally regulated by ecdysone and caused by local axon degeneration. Previous studies have revealed intrinsic molecular and cellular mechanisms that trigger this pruning process, but how pruning is accomplished remains essentially unknown. |
| Links |
PubMed Online version:10.1016/j.cub.2004.04.001 |
| Keywords |
Alleles; Animals; Axons/metabolism; Axons/physiology; Drosophila/metabolism; Drosophila/physiology; Drosophila Proteins/metabolism; Dynamins/metabolism; Ecdysone/metabolism; Endocytosis/physiology; Gene Expression; Immunohistochemistry; Metamorphosis, Biological/physiology; Motor Neurons, Gamma/metabolism; Mushroom Bodies/innervation; Nerve Degeneration; Neuroglia/metabolism; Neuroglia/physiology; Pupa/metabolism; Pupa/physiology; Receptors, Steroid/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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