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PMID:10920384
| Citation |
Kozlova, T and Thummel, CS (2000) Steroid regulation of postembryonic development and reproduction in Drosophila. Trends Endocrinol. Metab. 11:276-80 |
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| Abstract |
Ecdysteroids trigger major developmental transitions in Drosophila, including larval molts and metamorphosis. Recent genetic studies strongly support a role for the Ecdysteroid receptor (EcR)/Ultraspiracle (USP) heterodimer as an ecdysteroid receptor at the onset of metamorphosis, functioning as both a transcriptional activator and repressor in vivo. Genetic analysis also indicates that USP, like its vertebrate homolog retinoid X receptor (RXR), might be involved in regulatory pathways independently of EcR. The ecdysteroid hierarchy was also shown recently to regulate Drosophila oogenesis and reproduction. |
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| Keywords |
Animals; Drosophila/genetics; Drosophila/physiology; Embryonic Development; Reproduction/physiology; Signal Transduction/genetics; Steroids/physiology; Transcription, Genetic/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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