HUMAN:VDR

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	VDR (synonyms: NR1I1)
Protein Name(s)	Vitamin D3 receptor VDR 1,25-dihydroxyvitamin D3 receptor Nuclear receptor subfamily 1 group I member 1
External Links
UniProt	P11473
EMBL	J03258 X67482 AF026260 AB002168 AY342401 AK312267 AC004466 AC121338 CH471111 CH471111 BC060832 M65208 AY827087
CCDS	CCDS55820.1 CCDS8757.1
PIR	A28200
RefSeq	NP_000367.1 NP_001017535.1 NP_001017536.1 XP_006719650.1
UniGene	Hs.524368
PDB	1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 3W0A 3W0C 3W0Y 3WGP 4G2I 4ITE 4ITF
PDBsum	1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 3W0A 3W0C 3W0Y 3WGP 4G2I 4ITE 4ITF
DisProt	DP00184
ProteinModelPortal	P11473
SMR	P11473
BioGrid	113264
DIP	DIP-32624N
IntAct	P11473
MINT	MINT-236408
STRING	9606.ENSP00000229022
BindingDB	P11473
ChEMBL	CHEMBL1977
DrugBank	DB01436 DB00146 DB02300 DB00136 DB00169 DB01070 DB00153 DB00910
GuidetoPHARMACOLOGY	605
PhosphoSite	P11473
DMDM	137617
MaxQB	P11473
PaxDb	P11473
PRIDE	P11473
DNASU	7421
Ensembl	ENST00000229022 ENST00000395324 ENST00000549336 ENST00000550325
GeneID	7421
KEGG	hsa:7421
UCSC	uc001rql.3 uc001rqm.3
CTD	7421
GeneCards	GC12M048247
HGNC	HGNC:12679
HPA	CAB004617 HPA047740
MIM	277440 601769 607948
neXtProt	NX_P11473
Orphanet	93160
PharmGKB	PA37301
eggNOG	NOG283526
GeneTree	ENSGT00760000118837
HOGENOM	HOG000220844
HOVERGEN	HBG108655
InParanoid	P11473
KO	K08539
OMA	FCQFRPP
PhylomeDB	P11473
TreeFam	TF316304
Reactome	REACT_15525
SignaLink	P11473
ChiTaRS	VDR
EvolutionaryTrace	P11473
GeneWiki	Calcitriol_receptor
GenomeRNAi	7421
NextBio	29054
PRO	PR:P11473
Proteomes	UP000005640
Bgee	P11473
CleanEx	HS_VDR
ExpressionAtlas	P11473
Genevestigator	P11473
GO	GO:0005654 GO:0005634 GO:0043235 GO:0090575 GO:1902098 GO:0008434 GO:0003677 GO:1902121 GO:0038186 GO:0046965 GO:0043565 GO:0003707 GO:0008270 GO:0038183 GO:0006816 GO:0000902 GO:0006874 GO:0046697 GO:0010467 GO:0050892 GO:0007595 GO:0060745 GO:0008285 GO:0010839 GO:0000122 GO:0045892 GO:0009887 GO:0060058 GO:0010628 GO:0045618 GO:0045944 GO:0010980 GO:0060558 GO:0007165 GO:0001501 GO:0006367 GO:0070561
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR008946 IPR000536 IPR001723 IPR000324 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR00398 PR00047 PR00350
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0046649	lymphocyte activation	PMID:1850412^[1]	ECO:0000270			P		FIG. 7. Western blot analysis of 1,25-(OH)2Ds receptor in activated human lymphocytes.	complete CACAO 3509
	GO:0045670	regulation of osteoclast differentiation	PMID:23149425^[2]	ECO:0000314			P		Fig. 1. 1,25(OH)2D3 inhibits osteoclastogenesis in the human osteoclast precursors from normal peripheral blood (PB)	complete CACAO 6074
enables	GO:0038023	signaling receptor activity	PMID:16549446^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:17823)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[4]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000324 InterPro:IPR001628 InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:D3ZWV0	F		Seeded From UniProt	complete
enables	GO:0046965	retinoid X receptor binding	PMID:28698609^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1902098	calcitriol binding	PMID:28698609^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070561	vitamin D receptor signaling pathway	PMID:28698609^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:28698609^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:17426122^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:17426122^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0070644	vitamin D response element binding	PMID:17426122^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070561	vitamin D receptor signaling pathway	PMID:16549446^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060558	regulation of calcidiol 1-monooxygenase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48281	P		Seeded From UniProt	complete
enables	GO:0046965	retinoid X receptor binding	PMID:17426122^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19793	F		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	PMID:16720713^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010980	positive regulation of vitamin D 24-hydroxylase activity	PMID:16549446^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:16549446^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:17823)	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:16549446^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15589699^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0003700	DNA-binding transcription factor activity	PMID:17426122^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17426122^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:O15528)	Seeded From UniProt	complete
enables	GO:1902121	lithocholic acid binding	PMID:12016314^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1902098	calcitriol binding	PMID:10678179^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1902098	calcitriol binding	PMID:12016314^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17254542^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P02818)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17082781^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P04264)\|has_regulation_target:(UniProtKB:P23490)\|has_regulation_target:(UniProtKB:P20930)	Seeded From UniProt	complete
involved_in	GO:0045618	positive regulation of keratinocyte differentiation	PMID:17082781^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0038186	lithocholic acid receptor activity	PMID:12016314^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0038183	bile acid signaling pathway	PMID:12016314^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(CHEBI:16325)	Seeded From UniProt	complete
involved_in	GO:0010839	negative regulation of keratinocyte proliferation	PMID:17223341^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:17223341^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P04264)\|has_regulation_target:(UniProtKB:P20930)	Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:12016314^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:17082781^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17082781^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	PMID:17223341^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
enables	GO:1902098	calcitriol binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000638069 RGD:3959 UniProtKB:P11473	F		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C		Seeded From UniProt	complete
contributes_to	GO:0070644	vitamin D response element binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000638069 UniProtKB:P11473	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000638069	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000638069	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C		Seeded From UniProt	complete
enables	GO:0005499	vitamin D binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000638069 RGD:3959	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:11891224^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11891224^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P		Seeded From UniProt	complete
involved_in	GO:0060745	mammary gland branching involved in pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	P		Seeded From UniProt	complete
involved_in	GO:0060558	regulation of calcidiol 1-monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	P		Seeded From UniProt	complete
involved_in	GO:0060058	positive regulation of apoptotic process involved in mammary gland involution	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	P		Seeded From UniProt	complete
involved_in	GO:0050892	intestinal absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	P		Seeded From UniProt	complete
involved_in	GO:0007595	lactation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	P		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	F		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48281 ensembl:ENSMUSP00000023119	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000324 InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000324	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000324 InterPro:IPR001628 InterPro:IPR001723	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000324 InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:2849209^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042359	vitamin D metabolic process	Reactome:R-HSA-196791	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-383280	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8963915 Reactome:R-HSA-4546387 Reactome:R-HSA-376419	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yu, XP et al. (1991) Vitamin D receptor expression in human lymphocytes. Signal requirements and characterization by western blots and DNA sequencing. J. Biol. Chem. 266 7588-95 PubMed GONUTS page
↑ Back, SH et al. (2013) TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function. Cell. Mol. Life Sci. 70 1269-84 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Kemmis, CM et al. (2006) Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3. J. Nutr. 136 887-92 PubMed GONUTS page
↑ ^4.0 ^4.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Tamura, M et al. (2017) Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia. Sci Rep 7 5102 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Turunen, MM et al. (2007) Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene. Nucleic Acids Res. 35 2734-47 PubMed GONUTS page
↑ Viganò, P et al. (2006) Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J. Mol. Endocrinol. 36 415-24 PubMed GONUTS page
↑ Eyles, DW et al. (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J. Chem. Neuroanat. 29 21-30 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Makishima, M et al. (2002) Vitamin D receptor as an intestinal bile acid sensor. Science 296 1313-6 PubMed GONUTS page
↑ Rochel, N et al. (2000) The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol. Cell 5 173-9 PubMed GONUTS page
↑ Zella, LA et al. (2007) The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs. Arch. Biochem. Biophys. 460 206-12 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Hawker, NP et al. (2007) Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3. J. Invest. Dermatol. 127 874-80 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Oda, Y et al. (2007) Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation. J. Steroid Biochem. Mol. Biol. 103 776-80 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 ^14.14 ^14.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^15.0 ^15.1 Gonzalez, MM & Carlberg, C (2002) Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. J. Biol. Chem. 277 18501-9 PubMed GONUTS page
↑ Hughes, MR et al. (1988) Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science 242 1702-5 PubMed GONUTS page

[PMID:1850412-1] Yu, XP et al. (1991) Vitamin D receptor expression in human lymphocytes. Signal requirements and characterization by western blots and DNA sequencing. J. Biol. Chem. 266 7588-95 PubMed GONUTS page

[PMID:23149425-2] Back, SH et al. (2013) TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function. Cell. Mol. Life Sci. 70 1269-84 PubMed GONUTS page

[PMID:16549446-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Kemmis, CM et al. (2006) Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3. J. Nutr. 136 887-92 PubMed GONUTS page

[PMID:19274049-4] 4.0 ^4.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:28698609-5] 5.0 ^5.1 ^5.2 ^5.3 Tamura, M et al. (2017) Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia. Sci Rep 7 5102 PubMed GONUTS page

[PMID:17426122-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Turunen, MM et al. (2007) Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene. Nucleic Acids Res. 35 2734-47 PubMed GONUTS page

[PMID:16720713-7] Viganò, P et al. (2006) Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J. Mol. Endocrinol. 36 415-24 PubMed GONUTS page

[PMID:15589699-8] Eyles, DW et al. (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J. Chem. Neuroanat. 29 21-30 PubMed GONUTS page

[PMID:12016314-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Makishima, M et al. (2002) Vitamin D receptor as an intestinal bile acid sensor. Science 296 1313-6 PubMed GONUTS page

[PMID:10678179-10] Rochel, N et al. (2000) The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol. Cell 5 173-9 PubMed GONUTS page

[PMID:17254542-11] Zella, LA et al. (2007) The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs. Arch. Biochem. Biophys. 460 206-12 PubMed GONUTS page

[PMID:17082781-12] 12.0 ^12.1 ^12.2 ^12.3 Hawker, NP et al. (2007) Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3. J. Invest. Dermatol. 127 874-80 PubMed GONUTS page

[PMID:17223341-13] 13.0 ^13.1 ^13.2 Oda, Y et al. (2007) Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation. J. Steroid Biochem. Mol. Biol. 103 776-80 PubMed GONUTS page

[PMID:21873635-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 ^14.14 ^14.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11891224-15] 15.0 ^15.1 Gonzalez, MM & Carlberg, C (2002) Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. J. Biol. Chem. 277 18501-9 PubMed GONUTS page

[PMID:2849209-16] Hughes, MR et al. (1988) Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science 242 1702-5 PubMed GONUTS page

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