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CHICK:THB

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) THRB (synonyms: C-ERBA-BETA, NR1A2)
Protein Name(s) Thyroid hormone receptor beta

Nuclear receptor subfamily 1 group A member 2

External Links
UniProt P68306
EMBL X17504
M65207
Z50188
PIR S09625
RefSeq NP_990778.2
UniGene Gga.609
ProteinModelPortal P68306
SMR P68306
IntAct P68306
STRING 9031.ENSGALP00000018402
PaxDb P68306
Ensembl ENSGALT00000018423
ENSGALT00000031162
GeneID 396431
KEGG gga:396431
CTD 7068
eggNOG NOG272726
GeneTree ENSGT00760000118837
HOGENOM HOG000010313
HOVERGEN HBG005606
InParanoid P68306
KO K08362
OrthoDB EOG7TBC2V
PhylomeDB P68306
Reactome REACT_258806
NextBio 20816472
PRO PR:P68306
Proteomes UP000000539
ExpressionAtlas P68306
GO GO:0070062
GO:0000790
GO:0031490
GO:0043565
GO:0003707
GO:0070324
GO:0004887
GO:0008270
GO:0008050
GO:0030522
GO:0007621
GO:0000122
GO:0009887
GO:0045944
GO:0008016
GO:0007605
GO:0060509
Gene3D 1.10.565.10
3.30.50.10
InterPro IPR008946
IPR000536
IPR001723
IPR001728
IPR001628
IPR013088
Pfam PF00104
PF00105
PRINTS PR00398
PR00047
PR00546
SMART SM00430
SM00399
SUPFAM SSF48508
PROSITE PS00031
PS51030

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005634

nucleus

PMID:19170125[1]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000138)

Seeded From UniProt

complete

enables

GO:1990837

sequence-specific double-stranded DNA binding

PMID:19170125[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070324

thyroid hormone binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10828

F

Seeded From UniProt

complete

enables

GO:0004879

nuclear receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10828

F

Seeded From UniProt

complete

part_of

GO:0090575

RNA polymerase II transcription factor complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1352462
PANTHER:PTN000637751
UniProtKB:P11473
UniProtKB:P37231
UniProtKB:Q13133

C

Seeded From UniProt

complete

involved_in

GO:0060509

type I pneumocyte differentiation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98742
MGI:MGI:98743
PANTHER:PTN000637753

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
MGI:MGI:104740
MGI:MGI:1352462
MGI:MGI:1352463
MGI:MGI:1352464
MGI:MGI:97747
MGI:MGI:97856
MGI:MGI:97857
MGI:MGI:97858
MGI:MGI:98742
MGI:MGI:98743
PANTHER:PTN000637751
RGD:3371
RGD:3857
RGD:61906
RGD:628831
UniProtKB:O62807
UniProtKB:O75469
UniProtKB:P10276
UniProtKB:P11473
UniProtKB:P37231
UniProtKB:P55055
UniProtKB:Q07869
UniProtKB:Q13133
UniProtKB:Q14994
UniProtKB:Q8JHU1
UniProtKB:Q96RI1
WB:WBGene00000908

P

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104740
PANTHER:PTN000637751

F

Seeded From UniProt

complete

involved_in

GO:0033993

response to lipid

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97747
PANTHER:PTN001941333
RGD:3371

P

Seeded From UniProt

complete

involved_in

GO:0030878

thyroid gland development

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98742
PANTHER:PTN001182181

P

Seeded From UniProt

complete

enables

GO:0030374

nuclear receptor transcription coactivator activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97747
PANTHER:PTN000637751
UniProtKB:O62807
UniProtKB:P37231

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101884
PANTHER:PTN000637751

P

Seeded From UniProt

complete

involved_in

GO:0009887

animal organ morphogenesis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98742
MGI:MGI:98743
PANTHER:PTN000637753

P

Seeded From UniProt

complete

involved_in

GO:0009755

hormone-mediated signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001941333
UniProtKB:P10827

P

Seeded From UniProt

complete

involved_in

GO:0009755

hormone-mediated signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000637753
UniProtKB:P10827

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97856
PANTHER:PTN000637751
RGD:3371
RGD:3534
UniProtKB:P10276
UniProtKB:P10827
UniProtKB:P37231
UniProtKB:Q03181
UniProtKB:Q07869
ZFIN:ZDB-GENE-000210-31

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103076
PANTHER:PTN000637751

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
FB:FBgn0000568
MGI:MGI:101884
MGI:MGI:1346307
MGI:MGI:1352462
MGI:MGI:1352463
MGI:MGI:2444210
MGI:MGI:97747
MGI:MGI:97856
MGI:MGI:97858
MGI:MGI:98742
MGI:MGI:98743
PANTHER:PTN000637751
RGD:3369
RGD:3370
RGD:3371
RGD:3534
RGD:3857
RGD:61909
RGD:621400
RGD:628831
UniProtKB:O62807
UniProtKB:P04625
UniProtKB:P10276
UniProtKB:P10826
UniProtKB:P10827
UniProtKB:P11473
UniProtKB:P13631
UniProtKB:P37231
UniProtKB:P55055
UniProtKB:P68306
UniProtKB:Q07869
UniProtKB:Q13133
UniProtKB:Q14995
WB:WBGene00000908
WB:WBGene00003607
WB:WBGene00004786
ZFIN:ZDB-GENE-990415-263

C

Seeded From UniProt

complete

involved_in

GO:0002154

thyroid hormone mediated signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001182181
ZFIN:ZDB-GENE-990415-263
ZFIN:ZDB-GENE-990415-268

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
PANTHER:PTN000637751
RGD:61906

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
FB:FBgn0015240
MGI:MGI:97856
MGI:MGI:97857
MGI:MGI:97858
PANTHER:PTN000637751
UniProtKB:O75469
UniProtKB:P20393
UniProtKB:Q14994
UniProtKB:Q96RI1
WB:WBGene00004786

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
MGI:MGI:98742
PANTHER:PTN000637751
RGD:628827
UniProtKB:Q96RI1

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101884
MGI:MGI:2449205
MGI:MGI:97747
MGI:MGI:97856
MGI:MGI:97857
MGI:MGI:97858
MGI:MGI:98743
PANTHER:PTN001941333
UniProtKB:P20393
UniProtKB:P37231
UniProtKB:Q07869
WB:WBGene00004786

P

Seeded From UniProt

complete

involved_in

GO:0043401

steroid hormone mediated signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003707

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001723
InterPro:IPR001728

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

enables

GO:0003707

steroid hormone receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001723

F

Seeded From UniProt

complete

enables

GO:0004879

nuclear receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001728

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR001723
InterPro:IPR001728

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR001723
InterPro:IPR001728
InterPro:IPR013088

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR013088

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Lassová, L et al. (2009) Thyroid hormone treatment of cultured chondrocytes mimics in vivo stimulation of collagen X mRNA by increasing BMP 4 expression. J. Cell. Physiol. 219 595-605 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page