MOUSE:ANDR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ar (synonyms: Nr3c4)
Protein Name(s)	Androgen receptor Dihydrotestosterone receptor Nuclear receptor subfamily 3 group C member 4
External Links
UniProt	P19091
EMBL	S56585 X53779 M37890 X59592
CCDS	CCDS30294.1
PIR	A35895
RefSeq	NP_038504.1
UniGene	Mm.39005 Mm.394224 Mm.439657
PDB	2QPY
PDBsum	2QPY
ProteinModelPortal	P19091
SMR	P19091
BioGrid	198179
DIP	DIP-41803N
IntAct	P19091
MINT	MINT-151935
BindingDB	P19091
ChEMBL	CHEMBL3056
GuidetoPHARMACOLOGY	628
PhosphoSite	P19091
PRIDE	P19091
DNASU	11835
Ensembl	ENSMUST00000052837
GeneID	11835
KEGG	mmu:11835
UCSC	uc009tuv.1
CTD	367
MGI	MGI:88064
eggNOG	NOG245477
GeneTree	ENSGT00760000118887
HOGENOM	HOG000254783
HOVERGEN	HBG007583
InParanoid	P19091
KO	K08557
OMA	MENYSGP
OrthoDB	EOG7J17Z7
PhylomeDB	P19091
TreeFam	TF350286
Reactome	REACT_234105
EvolutionaryTrace	P19091
NextBio	279763
PRO	PR:P19091
Proteomes	UP000000589
Bgee	P19091
CleanEx	MM_AR
Genevestigator	P19091
GO	GO:0030424 GO:0005737 GO:0030425 GO:0000790 GO:0005634 GO:0005886 GO:0043234 GO:0005497 GO:0004882 GO:0008013 GO:0019899 GO:0004879 GO:0070974 GO:0043565 GO:0003700 GO:0044212 GO:0008270 GO:0060520 GO:0030521 GO:0009987 GO:0060742 GO:0003382 GO:0009566 GO:0001701 GO:0030522 GO:0060599 GO:0033327 GO:0048808 GO:0008584 GO:0019102 GO:0060749 GO:0060571 GO:0035264 GO:0050680 GO:2001237 GO:0045720 GO:0048645 GO:0008284 GO:0043568 GO:0033148 GO:0043410 GO:0051092 GO:0042327 GO:0045944 GO:0045893 GO:0060740 GO:0060736 GO:0051259 GO:0050790 GO:0048638 GO:0090003 GO:0010468 GO:0060685 GO:0003073 GO:0006357 GO:0006355 GO:0048608 GO:0061458 GO:0032868 GO:0072520 GO:0007338 GO:0007283 GO:0060748 GO:0006351
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR001103 IPR008946 IPR000536 IPR001628 IPR013088
Pfam	PF02166 PF00104 PF00105
PRINTS	PR00521 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0071394	cellular response to testosterone stimulus	PMID:18761815^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18761815^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18761815^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	PMID:18761815^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:18761815^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005497	androgen binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:17277772^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8VCD7	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
involved_in	GO:1903076	regulation of protein localization to plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
enables	GO:0070974	POU domain binding	PMID:11997177^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
involved_in	GO:0045720	negative regulation of integrin biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10275	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903076	regulation of protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072520	seminiferous tubule development	PMID:21084446^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1922269	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072520	seminiferous tubule development	PMID:19574395^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071383	cellular response to steroid hormone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061458	reproductive system development	PMID:19574395^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1923802	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060769	positive regulation of epithelial cell proliferation involved in prostate gland development	PMID:11535819^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060749	mammary gland alveolus development	PMID:14676301^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2687199	P	results_in_development_of:(EMAPA:36566)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis	PMID:14676301^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2687199	P	has_participant:(EMAPA:35538)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060742	epithelial cell differentiation involved in prostate gland development	PMID:17652515^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385927,MGI:MGI:2451025	P	occurs_in:(EMAPA:32290) results_in_acquisition_of_features_of:(CL:0000066)\|occurs_in(EMAPA:32290) results_in_acquisition_of_features_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060740	prostate gland epithelium morphogenesis	PMID:17652515^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385927,MGI:MGI:2451025	P	has_participant:(EMAPA:32290)\|has_participant:(EMAPA:32290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060736	prostate gland growth	PMID:17652515^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385927,MGI:MGI:2451025	P	occurs_in:(EMAPA:32290)\|occurs_in:(EMAPA:29836)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060736	prostate gland growth	PMID:17317769^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3716756	P	occurs_in:(EMAPA:29794)\|occurs_in:(EMAPA:35710)\|occurs_in:(EMAPA:29836)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060685	regulation of prostatic bud formation	PMID:12941620^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1099809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060599	lateral sprouting involved in mammary gland duct morphogenesis	PMID:14676301^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2687199	P	has_participant:(EMAPA:35538)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060571	morphogenesis of an epithelial fold	PMID:17652515^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385927,MGI:MGI:2451025	P	has_participant:(EMAPA:32290)\|has_participant:(EMAPA:32290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060520	activation of prostate induction by androgen receptor signaling pathway	PMID:17317769^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3716756	P	occurs_in:(EMAPA:19287)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060406	positive regulation of penile erection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051259	protein complex oligomerization	PMID:18468998^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	PMID:12058073^[12]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:17652515^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385927,MGI:MGI:2451025	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048808	male genitalia morphogenesis	PMID:19282366^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2681507	P	has_participant:(EMAPA:17969)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048645	animal organ formation	PMID:17317769^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3716756	P	results_in_formation_of:(EMAPA:19290)\|results_in_formation_of:(EMAPA:19180)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048638	regulation of developmental growth	PMID:17317769^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3716756	P	regulates_o_occurs_in:(EMAPA:29794)\|regulates_o_occurs_in:(EMAPA:35710)\|regulates_o_occurs_in:(EMAPA:29836)\|regulates_o_occurs_in:(EMAPA:19180)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048608	reproductive structure development	PMID:17317769^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3716756	P	results_in_development_of:(EMAPA:19290)\|results_in_development_of:(EMAPA:19180)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046661	male sex differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045945	positive regulation of transcription by RNA polymerase III	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23487765^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2444354 MGI:MGI:97874	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21427128^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103067	P	has_regulation_target:(MGI:MGI:97538) occurs_in:(CL:0000216) regulates_o_occurs_in:(CL:0000216)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16254014^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:105098	P	has_regulation_target:(MGI:MGI:102849)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17332066^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856319	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21427128^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000216) occurs_in:(CL:0000216) has_regulation_target:(MGI:MGI:97538)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16254014^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045726	positive regulation of integrin biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045720	negative regulation of integrin biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045597	positive regulation of cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	PMID:14676301^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2687199	P	regulates_o_occurs_in:(EMAPA:35538)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:8119157^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	PMID:14676301^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2687199	P	regulates_o_occurs_in:(EMAPA:35538)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042327	positive regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:19574395^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1923802	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033327	Leydig cell differentiation	PMID:19574395^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3717246	P	results_in_acquisition_of_features_of:(CL:0000178)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	PMID:14676301^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2687199	P	regulates_o_occurs_in:(EMAPA:35538)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:18468998^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	C		Seeded From UniProt	complete
enables	GO:0032553	ribonucleotide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030521	androgen receptor signaling pathway	PMID:15660130^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030521	androgen receptor signaling pathway	PMID:15199138^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030521	androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030521	androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019102	male somatic sex determination	PMID:5452809^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856319	P	has_participant:(EMAPA:17972)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019098	reproductive behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014734	skeletal muscle hypertrophy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:17332066^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856319	P	occurs_in:(EMAPA:17972)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009987	cellular process	PMID:12145204^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009566	fertilization	PMID:19574395^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3717246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:21084446^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1922269	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:19574395^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3717246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:17317769^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3716756	P	results_in_development_of:(EMAPA:17972)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:10319319^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856319	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008049	male courtship behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007620	copulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007338	single fertilization	PMID:21084446^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1922269	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:19574395^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3717246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:18403489^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3034098	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:17332066^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856319	P	regulates_o_occurs_in:(EMAPA:17972)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:14576337^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12145204^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006351	transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18468998^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17142810^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12145204^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14576337^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9DAR1	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23786676^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18827067^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32290)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17317769^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32290)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17142810^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15660130^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12801993^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35627) part_of:(CL:0000501)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12145204^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11356695^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32290) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11105903^[31]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32290) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	C		Seeded From UniProt	complete
enables	GO:0005497	androgen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
enables	GO:0005497	androgen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:23786676^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:15199138^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:12145204^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:16254014^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14576337^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12145204^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2147	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003382	epithelial cell morphogenesis	PMID:21084446^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1922269	P	occurs_in:(EMAPA:19290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003073	regulation of systemic arterial blood pressure	PMID:18468998^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101772	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:10319319^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856319	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
enables	GO:0001091	RNA polymerase II general transcription initiation factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10275	P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
involved_in	GO:1903076	regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
involved_in	GO:0071383	cellular response to steroid hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
involved_in	GO:0045945	positive regulation of transcription by RNA polymerase III	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
involved_in	GO:0045726	positive regulation of integrin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
involved_in	GO:0045720	negative regulation of integrin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	C		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	C		Seeded From UniProt	complete
enables	GO:0005497	androgen binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
enables	GO:0001091	RNA polymerase II general transcription initiation factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10275 ensembl:ENSP00000363822	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001103	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001103	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001103	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001103 InterPro:IPR001628	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001103 InterPro:IPR001628 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001103	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0754	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Kang, N et al. (2008) Identification and characterization of a novel thymus aging related protein Rwdd1. Cell. Mol. Immunol. 5 279-85 PubMed GONUTS page
↑ Wissmann, M et al. (2007) Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat. Cell Biol. 9 347-53 PubMed GONUTS page
↑ González, MI et al. (2002) Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct. Mol. Cell. Endocrinol. 190 39-49 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Krutskikh, A et al. (2011) Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia. Endocrinology 152 689-96 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Lim, P et al. (2009) Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis. Endocrinology 150 4755-65 PubMed GONUTS page
↑ Stanbrough, M et al. (2001) Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium. Proc. Natl. Acad. Sci. U.S.A. 98 10823-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Yeh, S et al. (2003) Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor. J. Exp. Med. 198 1899-908 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Wu, CT et al. (2007) Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor. Proc. Natl. Acad. Sci. U.S.A. 104 12679-84 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Simanainen, U et al. (2007) Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function. Endocrinology 148 2264-72 PubMed GONUTS page
↑ Donjacour, AA et al. (2003) FGF-10 plays an essential role in the growth of the fetal prostate. Dev. Biol. 261 39-54 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Lyssand, JS et al. (2008) Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. J. Biol. Chem. 283 18792-800 PubMed GONUTS page
↑ Rouleau, N et al. (2002) Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. Mol. Biol. Cell 13 2106-19 PubMed GONUTS page
↑ Miyagawa, S et al. (2009) Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia. Mol. Endocrinol. 23 871-80 PubMed GONUTS page
↑ Wu, RC et al. (2013) ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways. Proc. Natl. Acad. Sci. U.S.A. 110 4616-21 PubMed GONUTS page
↑ ^15.0 ^15.1 Bagheri-Fam, S et al. (2011) Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome. Hum. Mol. Genet. 20 2213-24 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Khan, OY et al. (2006) Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol. Endocrinol. 20 544-59 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 O'Shaughnessy, PJ et al. (2007) Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. Endocrinology 148 2914-24 PubMed GONUTS page
↑ Asadi, FK et al. (1994) Androgen regulation of gene expression in primary epithelial cells of the mouse kidney. Endocrinology 134 1179-87 PubMed GONUTS page
↑ ^19.0 ^19.1 Terada, K et al. (2005) A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis. EMBO J. 24 611-22 PubMed GONUTS page
↑ ^20.0 ^20.1 Sitz, JH et al. (2004) Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Mol. Cell. Biol. 24 5821-34 PubMed GONUTS page
↑ Lyon, MF & Hawkes, SG (1970) X-linked gene for testicular feminization in the mouse. Nature 227 1217-9 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 Lin, HK et al. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J. 21 4037-48 PubMed GONUTS page
↑ ^23.0 ^23.1 Zimmermann, S et al. (1999) Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol. Endocrinol. 13 681-91 PubMed GONUTS page
↑ Abel, MH et al. (2008) Spermatogenesis and sertoli cell activity in mice lacking sertoli cell receptors for follicle-stimulating hormone and androgen. Endocrinology 149 3279-85 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Jeong, BC et al. (2004) Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase. Mol. Endocrinol. 18 13-25 PubMed GONUTS page
↑ ^26.0 ^26.1 Yong, W et al. (2007) Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. J. Biol. Chem. 282 5026-36 PubMed GONUTS page
↑ ^27.0 ^27.1 Sharma, P et al. (2013) Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. Mol. Cancer 12 67 PubMed GONUTS page
↑ Svensson, J et al. (2008) Liver-derived IGF1 enhances the androgenic response in prostate. J. Endocrinol. 199 489-97 PubMed GONUTS page
↑ Balla, A et al. (2003) Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve. Biol. Reprod. 69 1281-93 PubMed GONUTS page
↑ McPherson, SJ et al. (2001) Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. Endocrinology 142 2458-67 PubMed GONUTS page
↑ Morales, CR et al. () Targeted disruption of the mouse prosaposin gene affects the development of the prostate gland and other male reproductive organs. J. Androl. 21 765-75 PubMed GONUTS page

[PMID:18761815-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Kang, N et al. (2008) Identification and characterization of a novel thymus aging related protein Rwdd1. Cell. Mol. Immunol. 5 279-85 PubMed GONUTS page

[PMID:17277772-2] Wissmann, M et al. (2007) Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat. Cell Biol. 9 347-53 PubMed GONUTS page

[PMID:11997177-3] González, MI et al. (2002) Androgen receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct. Mol. Cell. Endocrinol. 190 39-49 PubMed GONUTS page

[PMID:21084446-4] 4.0 ^4.1 ^4.2 ^4.3 Krutskikh, A et al. (2011) Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia. Endocrinology 152 689-96 PubMed GONUTS page

[PMID:19574395-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Lim, P et al. (2009) Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis. Endocrinology 150 4755-65 PubMed GONUTS page

[PMID:11535819-6] Stanbrough, M et al. (2001) Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium. Proc. Natl. Acad. Sci. U.S.A. 98 10823-8 PubMed GONUTS page

[PMID:14676301-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Yeh, S et al. (2003) Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor. J. Exp. Med. 198 1899-908 PubMed GONUTS page

[PMID:17652515-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Wu, CT et al. (2007) Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor. Proc. Natl. Acad. Sci. U.S.A. 104 12679-84 PubMed GONUTS page

[PMID:17317769-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Simanainen, U et al. (2007) Disruption of prostate epithelial androgen receptor impedes prostate lobe-specific growth and function. Endocrinology 148 2264-72 PubMed GONUTS page

[PMID:12941620-10] Donjacour, AA et al. (2003) FGF-10 plays an essential role in the growth of the fetal prostate. Dev. Biol. 261 39-54 PubMed GONUTS page

[PMID:18468998-11] 11.0 ^11.1 ^11.2 ^11.3 Lyssand, JS et al. (2008) Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. J. Biol. Chem. 283 18792-800 PubMed GONUTS page

[PMID:12058073-12] Rouleau, N et al. (2002) Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. Mol. Biol. Cell 13 2106-19 PubMed GONUTS page

[PMID:19282366-13] Miyagawa, S et al. (2009) Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia. Mol. Endocrinol. 23 871-80 PubMed GONUTS page

[PMID:23487765-14] Wu, RC et al. (2013) ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways. Proc. Natl. Acad. Sci. U.S.A. 110 4616-21 PubMed GONUTS page

[PMID:21427128-15] 15.0 ^15.1 Bagheri-Fam, S et al. (2011) Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome. Hum. Mol. Genet. 20 2213-24 PubMed GONUTS page

[PMID:16254014-16] 16.0 ^16.1 ^16.2 Khan, OY et al. (2006) Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol. Endocrinol. 20 544-59 PubMed GONUTS page

[PMID:17332066-17] 17.0 ^17.1 ^17.2 O'Shaughnessy, PJ et al. (2007) Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. Endocrinology 148 2914-24 PubMed GONUTS page

[PMID:8119157-18] Asadi, FK et al. (1994) Androgen regulation of gene expression in primary epithelial cells of the mouse kidney. Endocrinology 134 1179-87 PubMed GONUTS page

[PMID:15660130-19] 19.0 ^19.1 Terada, K et al. (2005) A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis. EMBO J. 24 611-22 PubMed GONUTS page

[PMID:15199138-20] 20.0 ^20.1 Sitz, JH et al. (2004) Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Mol. Cell. Biol. 24 5821-34 PubMed GONUTS page

[PMID:5452809-21] Lyon, MF & Hawkes, SG (1970) X-linked gene for testicular feminization in the mouse. Nature 227 1217-9 PubMed GONUTS page

[PMID:12145204-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 Lin, HK et al. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J. 21 4037-48 PubMed GONUTS page

[PMID:10319319-23] 23.0 ^23.1 Zimmermann, S et al. (1999) Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol. Endocrinol. 13 681-91 PubMed GONUTS page

[PMID:18403489-24] Abel, MH et al. (2008) Spermatogenesis and sertoli cell activity in mice lacking sertoli cell receptors for follicle-stimulating hormone and androgen. Endocrinology 149 3279-85 PubMed GONUTS page

[PMID:14576337-25] 25.0 ^25.1 ^25.2 Jeong, BC et al. (2004) Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase. Mol. Endocrinol. 18 13-25 PubMed GONUTS page

[PMID:17142810-26] 26.0 ^26.1 Yong, W et al. (2007) Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. J. Biol. Chem. 282 5026-36 PubMed GONUTS page

[PMID:23786676-27] 27.0 ^27.1 Sharma, P et al. (2013) Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. Mol. Cancer 12 67 PubMed GONUTS page

[PMID:18827067-28] Svensson, J et al. (2008) Liver-derived IGF1 enhances the androgenic response in prostate. J. Endocrinol. 199 489-97 PubMed GONUTS page

[PMID:12801993-29] Balla, A et al. (2003) Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve. Biol. Reprod. 69 1281-93 PubMed GONUTS page

[PMID:11356695-30] McPherson, SJ et al. (2001) Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. Endocrinology 142 2458-67 PubMed GONUTS page

[PMID:11105903-31] Morales, CR et al. () Targeted disruption of the mouse prosaposin gene affects the development of the prostate gland and other male reproductive organs. J. Androl. 21 765-75 PubMed GONUTS page

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