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PMID:11356695

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Citation

McPherson, SJ, Wang, H, Jones, ME, Pedersen, J, Iismaa, TP, Wreford, N, Simpson, ER and Risbridger, GP (2001) Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. Endocrinology 142:2458-67

Abstract

Although androgens are the main steroids controlling the growth of the mammalian prostate, increasing evidence demonstrates that estrogens also regulate prostate development and growth. This study describes the effects of estrogen deficiency using aromatase knockout mice (ArKO) with targeted disruption of the cyp19 gene. Serum and tissue testosterone and 5alpha-dihydrotestosterone as well as serum PRL levels are significantly (P < 0.05) elevated in mature male ArKO mice. Histological, stereological, and immunohistochemical studies demonstrated enlargement of the ventral, anterior, and dorsolateral lobes of the prostate in young and older ArKO mice. Hyperplasia of the epithelial, interstitial, and luminal compartments was identified and associated with up-regulation of androgen receptors. There was no evidence of malignancy as the animals aged (up to 56 weeks). The changes observed in the prostates of ArKO mice were unaffected by maintaining mice on regular or soy-free diets. It is concluded in ArKO mice that, despite the long-term elevation of androgens and PRL, the absence of estrogen in these animals does not result in induction of malignancy in the prostate gland.

Links

PubMed

Keywords

Androgens/blood; Animals; Aromatase/deficiency; Aromatase/genetics; Body Weight; Diet; Diethylstilbestrol/pharmacology; Dihydrotestosterone/blood; Immunohistochemistry; Isoflavones/administration & dosage; Male; Mice; Mice, Knockout; Organ Size/drug effects; Prolactin/blood; Prostate/chemistry; Prostate/pathology; Prostatic Hyperplasia/enzymology; Prostatic Hyperplasia/pathology; Prostatic Neoplasms/etiology; Receptors, Androgen/analysis; Soybeans/chemistry; Testosterone/blood

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:ANDR

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:CP19A

involved_in

GO:0060736: prostate gland growth

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2154536

P

Seeded From UniProt

complete

MOUSE:CP19A

involved_in

GO:0008209: androgen metabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2154536

P

Seeded From UniProt

complete

MOUSE:ANDR

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32290)
  • part_of:(CL:0000066)

Seeded From UniProt

complete


See also

References

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