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PMID:23786676

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Citation

Sharma, P, Knowell, AE, Chinaranagari, S, Komaragiri, S, Nagappan, P, Patel, D, Havrda, MC and Chaudhary, J (2013) Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. Mol. Cancer 12:67

Abstract

Inhibitor of differentiation 4 (Id4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer. Id4 is expressed in the normal prostate where its expression is also regulated by androgens. In this study we investigated the effect of loss of Id4 (Id4-/-) on adult prostate morphology.

Links

PubMed PMC3694449 Online version:10.1186/1476-4598-12-67

Keywords

Animals; Apoptosis; Homeodomain Proteins/metabolism; Humans; Inhibitor of Differentiation Proteins/deficiency; Inhibitor of Differentiation Proteins/metabolism; Male; Mice; Mice, Knockout; PTEN Phosphohydrolase/metabolism; Phenotype; Phosphorylation; Prostate/growth & development; Prostate/pathology; Prostatic Intraepithelial Neoplasia/metabolism; Prostatic Intraepithelial Neoplasia/pathology; Prostatic Neoplasms/metabolism; Prostatic Neoplasms/pathology; Proto-Oncogene Proteins c-akt/metabolism; Receptors, Androgen/metabolism; Transcription Factors/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:KI67

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:ANDR

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:AKT1

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:AKT1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:ID4

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:ID4

involved_in

GO:0060512: prostate gland morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3505549

P

Seeded From UniProt

complete

MOUSE:ID4

involved_in

GO:0060740: prostate gland epithelium morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3505549

P

Seeded From UniProt

complete

MOUSE:ID4

involved_in

GO:0060741: prostate gland stromal morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3505549

P

Seeded From UniProt

complete

MOUSE:ID4

involved_in

GO:0061682: seminal vesicle morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3505549

P

Seeded From UniProt

complete

MOUSE:ID4

involved_in

GO:0010628: positive regulation of gene expression

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3505549

P

Seeded From UniProt

complete

MOUSE:SOX9

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:ANDR

enables

GO:0004879: nuclear receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:ANDR

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:AKT1

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(EMAPA:19287)

Seeded From UniProt

complete

MOUSE:AKT1

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(EMAPA:19287)

Seeded From UniProt

complete

MOUSE:KI67

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

Notes

See also

References

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