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PMID:18761815
| Citation |
Kang, N, Duan, L, Tang, L, Liu, S, Li, C, Li, Y, Liu, Q, Hu, Y, Cui, L and He, W (2008) Identification and characterization of a novel thymus aging related protein Rwdd1. Cell. Mol. Immunol. 5:279-85 |
|---|---|
| Abstract |
By using DDRT-PCR and EST segment ligation, a novel mouse thymus involution related gene Rwdd1 was identified. The reading frame encoded a protein of 243 amino acid residues which contained an RWD domain at the N terminus. Rwdd1 expression in thymus was decreased in aged and oxidatively stressed mice. It was found to be expressed extensively in thymocytes and thymic epithelial cells. The expression level of Rwdd1 could affect the transactivation activity of androgen receptor (AR) in transiently transfected thymic epithelial cells. However, no direct interaction could be detected by fluorescence resonance energy transfer (FRET) analysis. In conclusion, Rwdd1 is a thymus involution related protein that may indirectly affect AR signaling pathway. |
| Links |
PubMed PMC4651297 Online version:10.1038/cmi.2008.34 |
| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cellular Senescence/physiology; Down-Regulation; Epithelial Cells/metabolism; Fluorescence Resonance Energy Transfer; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Oxidative Stress; Proteins/chemistry; Proteins/genetics; Proteins/metabolism; Receptors, Androgen/metabolism; T-Lymphocytes/metabolism; Thymus Gland/metabolism; Transcriptional Activation; Transfection |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
located_in |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
located_in |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
MOUSE:RWDD1 |
located_in |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
MOUSE:RWDD1 |
involved_in |
GO:0034599: cellular response to oxidative stress |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:RWDD1 |
involved_in |
GO:0030521: androgen receptor signaling pathway |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:RWDD1 |
involved_in |
GO:2000825: positive regulation of androgen receptor activity |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:RWDD1 |
involved_in |
GO:0071394: cellular response to testosterone stimulus |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071394: cellular response to testosterone stimulus |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030521: androgen receptor signaling pathway |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004879: nuclear receptor activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
Notes
See also
References
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