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PMID:18761815

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Citation

Kang, N, Duan, L, Tang, L, Liu, S, Li, C, Li, Y, Liu, Q, Hu, Y, Cui, L and He, W (2008) Identification and characterization of a novel thymus aging related protein Rwdd1. Cell. Mol. Immunol. 5:279-85

Abstract

By using DDRT-PCR and EST segment ligation, a novel mouse thymus involution related gene Rwdd1 was identified. The reading frame encoded a protein of 243 amino acid residues which contained an RWD domain at the N terminus. Rwdd1 expression in thymus was decreased in aged and oxidatively stressed mice. It was found to be expressed extensively in thymocytes and thymic epithelial cells. The expression level of Rwdd1 could affect the transactivation activity of androgen receptor (AR) in transiently transfected thymic epithelial cells. However, no direct interaction could be detected by fluorescence resonance energy transfer (FRET) analysis. In conclusion, Rwdd1 is a thymus involution related protein that may indirectly affect AR signaling pathway.

Links

PubMed PMC4651297 Online version:10.1038/cmi.2008.34

Keywords

Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cellular Senescence/physiology; Down-Regulation; Epithelial Cells/metabolism; Fluorescence Resonance Energy Transfer; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Oxidative Stress; Proteins/chemistry; Proteins/genetics; Proteins/metabolism; Receptors, Androgen/metabolism; T-Lymphocytes/metabolism; Thymus Gland/metabolism; Transcriptional Activation; Transfection

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:ANDR

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:ANDR

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:RWDD1

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:RWDD1

involved_in

GO:0034599: cellular response to oxidative stress

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:RWDD1

involved_in

GO:0030521: androgen receptor signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:RWDD1

involved_in

GO:2000825: positive regulation of androgen receptor activity

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:RWDD1

involved_in

GO:0071394: cellular response to testosterone stimulus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ANDR

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:ANDR

involved_in

GO:0071394: cellular response to testosterone stimulus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ANDR

part_of

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:ANDR

involved_in

GO:0030521: androgen receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:ANDR

enables

GO:0004879: nuclear receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

Notes

See also

References

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