MOUSE:ESR1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Esr1 (synonyms: Esr, Estr, Estra, Nr3a1)
Protein Name(s)	Estrogen receptor ER ER-alpha Estradiol receptor Nuclear receptor subfamily 3 group A member 1
External Links
UniProt	P19785
EMBL	M38651 AK036627 AK041525 AJ276597 AF128221 AF128220
CCDS	CCDS56678.1
PIR	A40061
RefSeq	NP_001289460.1 NP_001289461.1 NP_031982.1 XP_006512496.1 XP_006512497.1 XP_006512498.1
UniGene	Mm.463262 Mm.489063 Mm.9213
ProteinModelPortal	P19785
SMR	P19785
BioGrid	199521
IntAct	P19785
MINT	MINT-2835181
BindingDB	P19785
ChEMBL	CHEMBL3065
GuidetoPHARMACOLOGY	620
PhosphoSite	P19785
UniCarbKB	P19785
PRIDE	P19785
DNASU	13982
Ensembl	ENSMUST00000067086 ENSMUST00000105589 ENSMUST00000105590
GeneID	13982
KEGG	mmu:13982
UCSC	uc007egu.2
CTD	2099
MGI	MGI:1352467
eggNOG	NOG320746
GeneTree	ENSGT00760000118887
HOGENOM	HOG000233468
HOVERGEN	HBG108344
InParanoid	P19785
KO	K08550
OMA	AFYRPNS
OrthoDB	EOG7288S1
PhylomeDB	P19785
TreeFam	TF323751
Reactome	REACT_198574 REACT_234105
NextBio	284854
PRO	PR:P19785
Proteomes	UP000000589
Bgee	P19785
CleanEx	MM_ESR1
ExpressionAtlas	P19785
Genevestigator	P19785
GO	GO:0005737 GO:0005794 GO:0005634 GO:0005886 GO:0003682 GO:0001046 GO:0034056 GO:0038052 GO:0004879 GO:0000978 GO:0001077 GO:0005496 GO:0008134 GO:0008270 GO:0008209 GO:0001547 GO:0016049 GO:0071392 GO:0071391 GO:0002064 GO:0060750 GO:0030518 GO:0008584 GO:0060749 GO:0060745 GO:0010629 GO:0043124 GO:0045839 GO:0043433 GO:0007200 GO:0007204 GO:0048146 GO:0045429 GO:0051000 GO:0010863 GO:0048386 GO:0051091 GO:0045944 GO:0060527 GO:0060523 GO:0042981 GO:0060687 GO:0006355 GO:0060065 GO:0060068
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR008946 IPR000536 IPR024178 IPR001292 IPR024736 IPR001723 IPR001628 IPR013088
Pfam	PF12743 PF00104 PF02159 PF00105
PIRSF	PIRSF500101 PIRSF002527
PRINTS	PR00543 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008406	gonad development	PMID:20005806^[1]	ECO:0000315			P		Figure 1. Postnatal Gonadal Sex Reversal in XX Foxl2 Conditional Mutant Mice	complete CACAO 3404
involved_in	GO:0071392	cellular response to estradiol stimulus	PMID:9448000^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:9448000^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	PMID:25655704^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06211	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03372-3	P		Seeded From UniProt	complete
involved_in	GO:0045839	negative regulation of mitotic nuclear division	PMID:12119130^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03372-3	P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
involved_in	GO:0030518	intracellular steroid hormone receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06211	P		Seeded From UniProt	complete
involved_in	GO:0010863	positive regulation of phospholipase C activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06211	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19797124^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88470	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:20005806^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88470	F		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06211	P		Seeded From UniProt	complete
involved_in	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06211	P		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06211	F		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
part_of	GO:0097550	transcriptional preinitiation complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090209	negative regulation of triglyceride metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071391	cellular response to estrogen stimulus	PMID:17901126^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P	occurs_in:(EMAPA:29915) occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071168	protein localization to chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation	PMID:12021201^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060749	mammary gland alveolus development	PMID:10919287^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P	results_in_development_of:(EMAPA:36566)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060745	mammary gland branching involved in pregnancy	PMID:10919287^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P	has_participant:(EMAPA:35538)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060687	regulation of branching involved in prostate gland morphogenesis	PMID:18755802^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P	regulates_o_occurs_in:(EMAPA:29836)\|regulates_o_occurs_in:(EMAPA:35710)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060687	regulation of branching involved in prostate gland morphogenesis	PMID:15665095^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P	regulates_o_occurs_in:(EMAPA:29836)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	PMID:18535112^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P	has_participant:(EMAPA:19287)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060523	prostate epithelial cord elongation	PMID:18535112^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P	has_participant:(EMAPA:19287)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060068	vagina development	PMID:10976058^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109392	P	results_in_development_of:(EMAPA:18986)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060065	uterus development	PMID:10976058^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109392	P	results_in_development_of:(EMAPA:29915)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060011	Sertoli cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	PMID:12058073^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051000	positive regulation of nitric-oxide synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	PMID:22659029^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048146	positive regulation of fibroblast proliferation	PMID:18755802^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046325	negative regulation of glucose import	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17901126^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P	regulates_o_occurs_in:(EMAPA:29915) regulates_o_occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11544182^[15]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043627	response to estrogen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043523	regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:17901126^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P	occurs_in:(EMAPA:29915) regulates_o_occurs_in:(CL:0000066)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
enables	GO:0042562	hormone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	F		Seeded From UniProt	complete
enables	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	F		Seeded From UniProt	complete
part_of	GO:0035327	transcriptionally active chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034121	regulation of toll-like receptor signaling pathway	PMID:22659029^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P		Seeded From UniProt	complete
enables	GO:0034056	estrogen response element binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032355	response to estradiol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
enables	GO:0031798	type 1 metabotropic glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030520	intracellular estrogen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030518	intracellular steroid hormone receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	C		Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	F		Seeded From UniProt	complete
enables	GO:0017025	TBP-class protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010863	positive regulation of phospholipase C activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:18755802^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P	results_in_development_of:(EMAPA:35761)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008209	androgen metabolic process	PMID:18755802^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P	occurs_in:(EMAPA:35770)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:15322135^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14552897^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32672)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12845704^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17962)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8999954^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18202148^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:29919) part_of:(CL:0000150)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17065319^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17760) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14552897^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32672)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14502087^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32672)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12845704^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17962)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11897499^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17760) part_of:(CL:0000075)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	C		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:15322135^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:24332041^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:96559)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18202148^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:29919) occurs_in:(CL:0000150) has_participant:(MGI:MGI:97250)\|occurs_in(EMAPA:29919) occurs_in:(CL:0000150) has_participant:(MGI:MGI:104556)\|occurs_in(EMAPA:29919) occurs_in:(CL:0000150) has_participant:(MGI:MGI:97567)\|occurs_in(EMAPA:29919) occurs_in:(CL:0000150) has_participant:(MGI:MGI:96837)\|occurs_in(EMAPA:29919) occurs_in:(CL:0000150) has_participant:(MGI:MGI:88313)\|occurs_in(EMAPA:29919) occurs_in:(CL:0000150) has_participant:(MGI:MGI:103189)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002064	epithelial cell development	PMID:18755802^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2150897	P	occurs_in:(EMAPA:35761) results_in_development_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001547	antral ovarian follicle growth	PMID:10976058^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386760	P	occurs_in:(EMAPA:35627)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2581	F		Seeded From UniProt	complete
enables	GO:0001093	TFIIB-class transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P03372	P		Seeded From UniProt	complete
involved_in	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
part_of	GO:0097550	transcriptional preinitiation complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	C		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
involved_in	GO:0071168	protein localization to chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
involved_in	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
part_of	GO:0035327	transcriptionally active chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	C		Seeded From UniProt	complete
enables	GO:0034056	estrogen response element binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	C		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
involved_in	GO:0030520	intracellular estrogen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
enables	GO:0017025	TBP-class protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
enables	GO:0001093	TFIIB-class transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P03372 ensembl:ENSP00000405330	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001292 InterPro:IPR001723 InterPro:IPR024178	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723 InterPro:IPR024178	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001292 InterPro:IPR024178	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001292 InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR024178	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001292 InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088 InterPro:IPR024178	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088 InterPro:IPR024178	F		Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001292	F		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001292	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0754	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Uhlenhaut, NH et al. (2009) Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell 139 1130-42 PubMed GONUTS page
↑ ^2.0 ^2.1 Budhram-Mahadeo, V et al. (1998) POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. Mol. Cell. Biol. 18 1029-41 PubMed GONUTS page
↑ Lindley, LE et al. (2015) The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage. Development 142 893-904 PubMed GONUTS page
↑ Sakazaki, H et al. (2002) Estrogen receptor alpha in mouse splenic lymphocytes: possible involvement in immunity. Toxicol. Lett. 133 221-9 PubMed GONUTS page
↑ Kim, SY et al. (2009) Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha. Endocrinology 150 5085-93 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Yin, Y et al. (2008) Estrogen suppresses uterine epithelial apoptosis by inducing birc1 expression. Mol. Endocrinol. 22 113-25 PubMed GONUTS page
↑ Mueller, SO et al. (2002) Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha. Endocrinology 143 2357-65 PubMed GONUTS page
↑ ^8.0 ^8.1 Bocchinfuso, WP et al. (2000) Induction of mammary gland development in estrogen receptor-alpha knockout mice. Endocrinology 141 2982-94 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Chen, M et al. (2009) Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice. Endocrinology 150 251-9 PubMed GONUTS page
↑ Omoto, Y et al. (2005) Estrogen receptor alpha and imprinting of the neonatal mouse ventral prostate by estrogen. Proc. Natl. Acad. Sci. U.S.A. 102 1484-9 PubMed GONUTS page
↑ ^11.0 ^11.1 Omoto, Y (2008) Estrogen receptor-alpha signaling in growth of the ventral prostate: comparison of neonatal growth and postcastration regrowth. Endocrinology 149 4421-7 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Dupont, S et al. (2000) Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development 127 4277-91 PubMed GONUTS page
↑ Rouleau, N et al. (2002) Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. Mol. Biol. Cell 13 2106-19 PubMed GONUTS page
↑ ^14.0 ^14.1 Cunningham, MA et al. (2012) Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus. Clin. Immunol. 144 1-12 PubMed GONUTS page
↑ Steele-Perkins, G et al. (2001) Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily. Genes Dev. 15 2250-62 PubMed GONUTS page
↑ ^16.0 ^16.1 Khetchoumian, K et al. (2004) TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J. Biol. Chem. 279 48329-41 PubMed GONUTS page
↑ ^17.0 ^17.1 Danilovich, N et al. (2003) Age-related neurodegenerative changes in the central nervous system of estrogen-deficient follitropin receptor knockout mice. Exp. Neurol. 183 559-72 PubMed GONUTS page
↑ ^18.0 ^18.1 Symonds, D et al. (2003) Smad 3 regulates proliferation of the mouse ovarian surface epithelium. Anat Rec A Discov Mol Cell Evol Biol 273 681-6 PubMed GONUTS page
↑ Jiang, MS & Hart, GW (1997) A subpopulation of estrogen receptors are modified by O-linked N-acetylglucosamine. J. Biol. Chem. 272 2421-8 PubMed GONUTS page
↑ ^20.0 ^20.1 Ray, S et al. (2008) Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen. Mol. Endocrinol. 22 1125-40 PubMed GONUTS page
↑ Mussi, P et al. (2006) Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. Proc. Natl. Acad. Sci. U.S.A. 103 16716-21 PubMed GONUTS page
↑ Danilovich, N et al. (2003) The menopausal mouse: a new neural paradigm of a distressing human condition. Neuroreport 14 1617-22 PubMed GONUTS page
↑ Shyamala, G et al. (2002) Cellular expression of estrogen and progesterone receptors in mammary glands: regulation by hormones, development and aging. J. Steroid Biochem. Mol. Biol. 80 137-48 PubMed GONUTS page
↑ Gao, S et al. (2013) NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Cancer Cell 24 725-37 PubMed GONUTS page

[PMID:20005806-1] 1.0 ^1.1 Uhlenhaut, NH et al. (2009) Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell 139 1130-42 PubMed GONUTS page

[PMID:9448000-2] 2.0 ^2.1 Budhram-Mahadeo, V et al. (1998) POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. Mol. Cell. Biol. 18 1029-41 PubMed GONUTS page

[PMID:25655704-3] Lindley, LE et al. (2015) The WNT-controlled transcriptional regulator LBH is required for mammary stem cell expansion and maintenance of the basal lineage. Development 142 893-904 PubMed GONUTS page

[PMID:12119130-4] Sakazaki, H et al. (2002) Estrogen receptor alpha in mouse splenic lymphocytes: possible involvement in immunity. Toxicol. Lett. 133 221-9 PubMed GONUTS page

[PMID:19797124-5] Kim, SY et al. (2009) Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha. Endocrinology 150 5085-93 PubMed GONUTS page

[PMID:17901126-6] 6.0 ^6.1 ^6.2 Yin, Y et al. (2008) Estrogen suppresses uterine epithelial apoptosis by inducing birc1 expression. Mol. Endocrinol. 22 113-25 PubMed GONUTS page

[PMID:12021201-7] Mueller, SO et al. (2002) Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha. Endocrinology 143 2357-65 PubMed GONUTS page

[PMID:10919287-8] 8.0 ^8.1 Bocchinfuso, WP et al. (2000) Induction of mammary gland development in estrogen receptor-alpha knockout mice. Endocrinology 141 2982-94 PubMed GONUTS page

[PMID:18755802-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Chen, M et al. (2009) Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice. Endocrinology 150 251-9 PubMed GONUTS page

[PMID:15665095-10] Omoto, Y et al. (2005) Estrogen receptor alpha and imprinting of the neonatal mouse ventral prostate by estrogen. Proc. Natl. Acad. Sci. U.S.A. 102 1484-9 PubMed GONUTS page

[PMID:18535112-11] 11.0 ^11.1 Omoto, Y (2008) Estrogen receptor-alpha signaling in growth of the ventral prostate: comparison of neonatal growth and postcastration regrowth. Endocrinology 149 4421-7 PubMed GONUTS page

[PMID:10976058-12] 12.0 ^12.1 ^12.2 Dupont, S et al. (2000) Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development 127 4277-91 PubMed GONUTS page

[PMID:12058073-13] Rouleau, N et al. (2002) Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. Mol. Biol. Cell 13 2106-19 PubMed GONUTS page

[PMID:22659029-14] 14.0 ^14.1 Cunningham, MA et al. (2012) Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus. Clin. Immunol. 144 1-12 PubMed GONUTS page

[PMID:11544182-15] Steele-Perkins, G et al. (2001) Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily. Genes Dev. 15 2250-62 PubMed GONUTS page

[PMID:15322135-16] 16.0 ^16.1 Khetchoumian, K et al. (2004) TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J. Biol. Chem. 279 48329-41 PubMed GONUTS page

[PMID:14552897-17] 17.0 ^17.1 Danilovich, N et al. (2003) Age-related neurodegenerative changes in the central nervous system of estrogen-deficient follitropin receptor knockout mice. Exp. Neurol. 183 559-72 PubMed GONUTS page

[PMID:12845704-18] 18.0 ^18.1 Symonds, D et al. (2003) Smad 3 regulates proliferation of the mouse ovarian surface epithelium. Anat Rec A Discov Mol Cell Evol Biol 273 681-6 PubMed GONUTS page

[PMID:8999954-19] Jiang, MS & Hart, GW (1997) A subpopulation of estrogen receptors are modified by O-linked N-acetylglucosamine. J. Biol. Chem. 272 2421-8 PubMed GONUTS page

[PMID:18202148-20] 20.0 ^20.1 Ray, S et al. (2008) Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen. Mol. Endocrinol. 22 1125-40 PubMed GONUTS page

[PMID:17065319-21] Mussi, P et al. (2006) Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. Proc. Natl. Acad. Sci. U.S.A. 103 16716-21 PubMed GONUTS page

[PMID:14502087-22] Danilovich, N et al. (2003) The menopausal mouse: a new neural paradigm of a distressing human condition. Neuroreport 14 1617-22 PubMed GONUTS page

[PMID:11897499-23] Shyamala, G et al. (2002) Cellular expression of estrogen and progesterone receptors in mammary glands: regulation by hormones, development and aging. J. Steroid Biochem. Mol. Biol. 80 137-48 PubMed GONUTS page

[PMID:24332041-24] Gao, S et al. (2013) NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Cancer Cell 24 725-37 PubMed GONUTS page

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