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PMID:12845704
| Citation |
Symonds, D, Tomic, D, Borgeest, C, McGee, E and Flaws, JA (2003) Smad 3 regulates proliferation of the mouse ovarian surface epithelium. Anat Rec A Discov Mol Cell Evol Biol 273:681-6 |
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| Abstract |
Smad 3 is a signaling intermediate for the transforming growth factor beta (TGFbeta) family; however, little is known about the role this protein plays in the regulation of the ovarian surface epithelium (OSE). Using a transgenic mouse model, we found that in the absence of Smad 3 there was a distinct morphological alteration of OSE cells. Wild-type (WT) OSE was flat with thin cells, while Smad 3-deficient (Smad 3 -/-) OSE was thick with plump cuboidal cells. WT OSE had less immunostaining for proliferating cell nuclear antigen (PCNA) and estrogen receptor alpha (ERalpha) than Smad 3 -/- OSE. However, there were no differences in the number of apoptotic cells or Bax and Bcl-2 levels between WT and Smad 3 -/- OSE. Although WT mice had higher levels of serum estradiol than Smad 3 -/- mice, WT and Smad 3 -/- mice had similar levels of progesterone. These data suggest that Smad 3 regulates OSE morphological appearance and proliferation in the absence of high serum estradiol levels or alterations in progesterone levels. |
| Links |
PubMed Online version:10.1002/ar.a.10090 |
| Keywords |
Animals; Apoptosis/genetics; Cell Division/genetics; Cell Size/genetics; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Epithelial Cells/cytology; Epithelial Cells/metabolism; Estradiol/blood; Estrogen Receptor alpha; Female; Mice; Mice, Knockout; Ovary/cytology; Ovary/growth & development; Ovary/metabolism; Progesterone/blood; Proliferating Cell Nuclear Antigen/metabolism; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Receptors, Estrogen/metabolism; Smad3 Protein; Trans-Activators/genetics; Trans-Activators/physiology; bcl-2-Associated X Protein |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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