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HUMAN:NR1H2
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | NR1H2 (synonyms: LXRB, NER, UNR) | |
Protein Name(s) | Oxysterols receptor LXR-beta
Liver X receptor beta Nuclear receptor NER Nuclear receptor subfamily 1 group H member 2 Ubiquitously-expressed nuclear receptor | |
External Links | ||
UniProt | P55055 | |
EMBL | U07132 AK290855 AK297978 AC008655 BC007790 BC033500 BC047750 BC074500 U14534 | |
PIR | JC4014 | |
RefSeq | NP_001243576.1 NP_009052.3 | |
UniGene | Hs.432976 | |
PDB | 1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 | |
PDBsum | 1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 | |
ProteinModelPortal | P55055 | |
SMR | P55055 | |
BioGrid | 113222 | |
DIP | DIP-53004N | |
IntAct | P55055 | |
MINT | MINT-1444220 | |
STRING | 9606.ENSP00000253727 | |
BindingDB | P55055 | |
ChEMBL | CHEMBL4093 | |
GuidetoPHARMACOLOGY | 601 | |
PhosphoSite | P55055 | |
DMDM | 296439251 | |
MaxQB | P55055 | |
PaxDb | P55055 | |
PRIDE | P55055 | |
DNASU | 7376 | |
Ensembl | ENST00000253727 ENST00000411902 ENST00000593926 | |
GeneID | 7376 | |
KEGG | hsa:7376 | |
CTD | 7376 | |
GeneCards | GC19P050879 | |
HGNC | HGNC:7965 | |
HPA | HPA056838 | |
MIM | 600380 | |
neXtProt | NX_P55055 | |
PharmGKB | PA31750 | |
eggNOG | NOG285805 | |
GeneTree | ENSGT00760000118837 | |
HOGENOM | HOG000220845 | |
HOVERGEN | HBG108655 | |
InParanoid | P55055 | |
KO | K08535 | |
OMA | RRYACRG | |
PhylomeDB | P55055 | |
TreeFam | TF352167 | |
Reactome | REACT_15525 | |
SignaLink | P55055 | |
ChiTaRS | NR1H2 | |
EvolutionaryTrace | P55055 | |
GeneWiki | Liver_X_receptor_beta | |
GenomeRNAi | 7376 | |
NextBio | 28886 | |
PRO | PR:P55055 | |
Proteomes | UP000005640 | |
Bgee | P55055 | |
CleanEx | HS_NR1H2 | |
ExpressionAtlas | P55055 | |
Genevestigator | P55055 | |
GO | GO:0005737 GO:0005654 GO:0005634 GO:0034191 GO:0051117 GO:0003677 GO:0004879 GO:0000978 GO:0001077 GO:0001133 GO:0003707 GO:0008270 GO:0044255 GO:0010467 GO:0010887 GO:0060336 GO:0032369 GO:0010745 GO:0048550 GO:0045892 GO:0032270 GO:0010875 GO:0032376 GO:0045723 GO:0051006 GO:0045944 GO:0010867 GO:2000188 GO:0048384 GO:0006367 | |
Gene3D | 1.10.565.10 3.30.50.10 | |
InterPro | IPR023257 IPR008946 IPR000536 IPR001723 IPR001628 IPR013088 | |
Pfam | PF00104 PF00105 | |
PRINTS | PR02034 PR00398 PR00047 | |
SMART | SM00430 SM00399 | |
SUPFAM | SSF48508 | |
PROSITE | PS00031 PS51030 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0003706 |
ligand-regulated transcription factor activity |
ECO:0000314 |
F |
Figure 2: Transcriptional activity of LXRbeta increased by presence of synthetic ligands. |
complete | |||||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0120163 |
negative regulation of cold-induced thermogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051117 |
ATPase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0034191 |
apolipoprotein A-I receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(NCBI_Gene:25428) |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060336 |
negative regulation of interferon-gamma-mediated signaling pathway |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051006 |
positive regulation of lipoprotein lipase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048550 |
negative regulation of pinocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045723 |
positive regulation of fatty acid biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032376 |
positive regulation of cholesterol transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032369 |
negative regulation of lipid transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032270 |
positive regulation of cellular protein metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010887 |
negative regulation of cholesterol storage |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010875 |
positive regulation of cholesterol efflux |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010867 |
positive regulation of triglyceride biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010745 |
negative regulation of macrophage derived foam cell differentiation |
ECO:0000305 |
curator inference used in manual assertion |
GO:0032369 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042632 |
cholesterol homeostasis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:O95573) |
Seeded From UniProt |
complete | ||
part_of |
GO:0090575 |
RNA polymerase II transcription factor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1352462 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1352462 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0055088 |
lipid homeostasis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1352462 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000546 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042632 |
cholesterol homeostasis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000546 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104740 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0030374 |
nuclear receptor transcription coactivator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97747 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101884 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97856 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103076 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000637752 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000546 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000546 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000546 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000546 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1352462 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030522 |
intracellular receptor signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004879 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043401 |
steroid hormone mediated signaling pathway |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003707 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003707 |
steroid hormone receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004879 |
nuclear receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006367 |
transcription initiation from RNA polymerase II promoter |
Reactome:R-HSA-383280 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-4720432 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Schultz, JR et al. (2000) Role of LXRs in control of lipogenesis. Genes Dev. 14 2831-8 PubMed GONUTS page
- ↑ 2.0 2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ Korach-André, M et al. (2011) Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. Proc. Natl. Acad. Sci. U.S.A. 108 403-8 PubMed GONUTS page
- ↑ Sakurabashi, A et al. (2015) CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase. J. Steroid Biochem. Mol. Biol. 149 80-8 PubMed GONUTS page
- ↑ 5.0 5.1 Fu, Y et al. (2013) ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metab. 18 225-38 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Lehmann, JM et al. (1997) Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272 3137-40 PubMed GONUTS page
- ↑ Li, N et al. (2011) Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J. Cell. Biochem. 112 675-83 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Beyea, MM et al. (2007) Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol. J. Biol. Chem. 282 5207-16 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Buono, C et al. (2007) Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL. J. Lipid Res. 48 2411-8 PubMed GONUTS page
- ↑ 10.0 10.1 Rigamonti, E et al. (2005) Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ. Res. 97 682-9 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Mo, J et al. (2002) Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. J. Biol. Chem. 277 50788-94 PubMed GONUTS page
- ↑ Weedon-Fekjaer, MS et al. (2010) Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells. J. Lipid Res. 51 1886-96 PubMed GONUTS page
- ↑ 13.00 13.01 13.02 13.03 13.04 13.05 13.06 13.07 13.08 13.09 13.10 13.11 13.12 13.13 13.14 13.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 14.0 14.1 Shinar, DM et al. (1994) NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. Gene 147 273-6 PubMed GONUTS page
c
d
n
- GO:0120163 ! negative regulation of cold-induced thermogenesis
- GO:0060336 ! negative regulation of type II interferon-mediated signaling pathway
- GO:0048550 ! negative regulation of pinocytosis
- GO:0032369 ! negative regulation of lipid transport
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0010887 ! negative regulation of cholesterol storage
- GO:0010745 ! negative regulation of macrophage derived foam cell differentiation
- GO:0004879 ! nuclear receptor activity
- GO:0003707 ! nuclear steroid receptor activity
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
o
p
- GO:0045723 ! positive regulation of fatty acid biosynthetic process
- GO:0010867 ! positive regulation of triglyceride biosynthetic process
- GO:0010875 ! positive regulation of cholesterol efflux
- GO:0051006 ! positive regulation of lipoprotein lipase activity
- GO:0032270 ! positive regulation of cellular protein metabolic process
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0032376 ! positive regulation of cholesterol transport
- GO:0045893 ! positive regulation of DNA-templated transcription
- Primates
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