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HUMAN:NR1H2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NR1H2 (synonyms: LXRB, NER, UNR)
Protein Name(s) Oxysterols receptor LXR-beta

Liver X receptor beta Nuclear receptor NER Nuclear receptor subfamily 1 group H member 2 Ubiquitously-expressed nuclear receptor

External Links
UniProt P55055
EMBL U07132
AK290855
AK297978
AC008655
BC007790
BC033500
BC047750
BC074500
U14534
PIR JC4014
RefSeq NP_001243576.1
NP_009052.3
UniGene Hs.432976
PDB 1P8D
1PQ6
1PQ9
1PQC
1UPV
1UPW
3KFC
3L0E
4DK7
4DK8
PDBsum 1P8D
1PQ6
1PQ9
1PQC
1UPV
1UPW
3KFC
3L0E
4DK7
4DK8
ProteinModelPortal P55055
SMR P55055
BioGrid 113222
DIP DIP-53004N
IntAct P55055
MINT MINT-1444220
STRING 9606.ENSP00000253727
BindingDB P55055
ChEMBL CHEMBL4093
GuidetoPHARMACOLOGY 601
PhosphoSite P55055
DMDM 296439251
MaxQB P55055
PaxDb P55055
PRIDE P55055
DNASU 7376
Ensembl ENST00000253727
ENST00000411902
ENST00000593926
GeneID 7376
KEGG hsa:7376
CTD 7376
GeneCards GC19P050879
HGNC HGNC:7965
HPA HPA056838
MIM 600380
neXtProt NX_P55055
PharmGKB PA31750
eggNOG NOG285805
GeneTree ENSGT00760000118837
HOGENOM HOG000220845
HOVERGEN HBG108655
InParanoid P55055
KO K08535
OMA RRYACRG
PhylomeDB P55055
TreeFam TF352167
Reactome REACT_15525
SignaLink P55055
ChiTaRS NR1H2
EvolutionaryTrace P55055
GeneWiki Liver_X_receptor_beta
GenomeRNAi 7376
NextBio 28886
PRO PR:P55055
Proteomes UP000005640
Bgee P55055
CleanEx HS_NR1H2
ExpressionAtlas P55055
Genevestigator P55055
GO GO:0005737
GO:0005654
GO:0005634
GO:0034191
GO:0051117
GO:0003677
GO:0004879
GO:0000978
GO:0001077
GO:0001133
GO:0003707
GO:0008270
GO:0044255
GO:0010467
GO:0010887
GO:0060336
GO:0032369
GO:0010745
GO:0048550
GO:0045892
GO:0032270
GO:0010875
GO:0032376
GO:0045723
GO:0051006
GO:0045944
GO:0010867
GO:2000188
GO:0048384
GO:0006367
Gene3D 1.10.565.10
3.30.50.10
InterPro IPR023257
IPR008946
IPR000536
IPR001723
IPR001628
IPR013088
Pfam PF00104
PF00105
PRINTS PR02034
PR00398
PR00047
SMART SM00430
SM00399
SUPFAM SSF48508
PROSITE PS00031
PS51030

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0003706

ligand-regulated transcription factor activity

PMID:11090131[1]

ECO:0000314

F

Figure 2: Transcriptional activity of LXRbeta increased by presence of synthetic ligands.

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[2]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR000324
InterPro:IPR001628
InterPro:IPR001723

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:D3ZWV0

F

Seeded From UniProt

complete

involved_in

GO:0120163

negative regulation of cold-induced thermogenesis

PMID:21173252[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60644

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:25661920[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051117

ATPase binding

PMID:23931754[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q86UK0

F

Seeded From UniProt

complete

enables

GO:0034191

apolipoprotein A-I receptor binding

PMID:23931754[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O95477

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9013544[6]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:25428)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:9013544[6]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:9013544[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060336

negative regulation of interferon-gamma-mediated signaling pathway

PMID:21268089[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051006

positive regulation of lipoprotein lipase activity

PMID:17186944[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048550

negative regulation of pinocytosis

PMID:17693624[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17186944[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16141411[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045723

positive regulation of fatty acid biosynthetic process

PMID:17186944[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032376

positive regulation of cholesterol transport

PMID:16141411[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032369

negative regulation of lipid transport

PMID:17693624[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032270

positive regulation of cellular protein metabolic process

PMID:17186944[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010887

negative regulation of cholesterol storage

PMID:17693624[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010875

positive regulation of cholesterol efflux

PMID:17186944[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010867

positive regulation of triglyceride biosynthetic process

PMID:17186944[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010745

negative regulation of macrophage derived foam cell differentiation

PMID:17693624[9]

ECO:0000305

curator inference used in manual assertion

GO:0032369

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:12393874[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12393874[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12393874[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042632

cholesterol homeostasis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60644

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20219900[12]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:O95573)

Seeded From UniProt

complete

part_of

GO:0090575

RNA polymerase II transcription factor complex

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1352462
PANTHER:PTN000637751
UniProtKB:P11473
UniProtKB:P37231
UniProtKB:Q13133

C

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1352462
MGI:MGI:1352464
PANTHER:PTN000637752
UniProtKB:Q13133

P

Seeded From UniProt

complete

involved_in

GO:0055088

lipid homeostasis

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1352462
MGI:MGI:1352463
PANTHER:PTN000637752
ZFIN:ZDB-GENE-050410-7

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
MGI:MGI:104740
MGI:MGI:1352462
MGI:MGI:1352463
MGI:MGI:1352464
MGI:MGI:97747
MGI:MGI:97856
MGI:MGI:97857
MGI:MGI:97858
MGI:MGI:98742
MGI:MGI:98743
PANTHER:PTN000637751
RGD:3371
RGD:3857
RGD:61906
RGD:628831
UniProtKB:O62807
UniProtKB:O75469
UniProtKB:P10276
UniProtKB:P11473
UniProtKB:P37231
UniProtKB:P55055
UniProtKB:Q07869
UniProtKB:Q13133
UniProtKB:Q14994
UniProtKB:Q8JHU1
UniProtKB:Q96RI1
WB:WBGene00000908

P

Seeded From UniProt

complete

involved_in

GO:0042632

cholesterol homeostasis

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
MGI:MGI:1352462
MGI:MGI:1352463
MGI:MGI:1352464
PANTHER:PTN000637752
UniProtKB:Q13133

P

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104740
PANTHER:PTN000637751

F

Seeded From UniProt

complete

enables

GO:0030374

nuclear receptor transcription coactivator activity

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97747
PANTHER:PTN000637751
UniProtKB:O62807
UniProtKB:P37231

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101884
PANTHER:PTN000637751

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97856
PANTHER:PTN000637751
RGD:3371
RGD:3534
UniProtKB:P10276
UniProtKB:P10827
UniProtKB:P37231
UniProtKB:Q03181
UniProtKB:Q07869
ZFIN:ZDB-GENE-000210-31

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103076
PANTHER:PTN000637751

P

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000637752
RGD:61909

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
FB:FBgn0000568
MGI:MGI:101884
MGI:MGI:1346307
MGI:MGI:1352462
MGI:MGI:1352463
MGI:MGI:2444210
MGI:MGI:97747
MGI:MGI:97856
MGI:MGI:97858
MGI:MGI:98742
MGI:MGI:98743
PANTHER:PTN000637751
RGD:3369
RGD:3370
RGD:3371
RGD:3534
RGD:3857
RGD:61909
RGD:621400
RGD:628831
UniProtKB:O62807
UniProtKB:P04625
UniProtKB:P10276
UniProtKB:P10826
UniProtKB:P10827
UniProtKB:P11473
UniProtKB:P13631
UniProtKB:P37231
UniProtKB:P55055
UniProtKB:P68306
UniProtKB:Q07869
UniProtKB:Q13133
UniProtKB:Q14995
WB:WBGene00000908
WB:WBGene00003607
WB:WBGene00004786
ZFIN:ZDB-GENE-990415-263

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
PANTHER:PTN000637751
RGD:61906

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
FB:FBgn0015240
MGI:MGI:97856
MGI:MGI:97857
MGI:MGI:97858
PANTHER:PTN000637751
UniProtKB:O75469
UniProtKB:P20393
UniProtKB:Q14994
UniProtKB:Q96RI1
WB:WBGene00004786

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000546
MGI:MGI:98742
PANTHER:PTN000637751
RGD:628827
UniProtKB:Q96RI1

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1352462
MGI:MGI:1352463
MGI:MGI:1352464
PANTHER:PTN000637752
RGD:628831

P

Seeded From UniProt

complete

involved_in

GO:0030522

intracellular receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004879

P

Seeded From UniProt

complete

involved_in

GO:0043401

steroid hormone mediated signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0003707

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001723

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

enables

GO:0003707

steroid hormone receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001723

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR001723

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR001723
InterPro:IPR013088

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628
InterPro:IPR013088

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001628

F

Seeded From UniProt

complete

enables

GO:0004879

nuclear receptor activity

PMID:7926814[14]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:7926814[14]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006367

transcription initiation from RNA polymerase II promoter

Reactome:R-HSA-383280

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-4720432
Reactome:R-HSA-376419

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Schultz, JR et al. (2000) Role of LXRs in control of lipogenesis. Genes Dev. 14 2831-8 PubMed GONUTS page
  2. 2.0 2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  3. Korach-André, M et al. (2011) Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. Proc. Natl. Acad. Sci. U.S.A. 108 403-8 PubMed GONUTS page
  4. Sakurabashi, A et al. (2015) CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase. J. Steroid Biochem. Mol. Biol. 149 80-8 PubMed GONUTS page
  5. 5.0 5.1 Fu, Y et al. (2013) ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metab. 18 225-38 PubMed GONUTS page
  6. 6.0 6.1 6.2 Lehmann, JM et al. (1997) Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272 3137-40 PubMed GONUTS page
  7. Li, N et al. (2011) Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J. Cell. Biochem. 112 675-83 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 Beyea, MM et al. (2007) Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol. J. Biol. Chem. 282 5207-16 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Buono, C et al. (2007) Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL. J. Lipid Res. 48 2411-8 PubMed GONUTS page
  10. 10.0 10.1 Rigamonti, E et al. (2005) Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ. Res. 97 682-9 PubMed GONUTS page
  11. 11.0 11.1 11.2 Mo, J et al. (2002) Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. J. Biol. Chem. 277 50788-94 PubMed GONUTS page
  12. Weedon-Fekjaer, MS et al. (2010) Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells. J. Lipid Res. 51 1886-96 PubMed GONUTS page
  13. 13.00 13.01 13.02 13.03 13.04 13.05 13.06 13.07 13.08 13.09 13.10 13.11 13.12 13.13 13.14 13.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  14. 14.0 14.1 Shinar, DM et al. (1994) NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. Gene 147 273-6 PubMed GONUTS page