GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:PPARG
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Pparg (synonyms: Nr1c3) | |
Protein Name(s) | Peroxisome proliferator-activated receptor gamma
PPAR-gamma Nuclear receptor subfamily 1 group C member 3 | |
External Links | ||
UniProt | P37238 | |
EMBL | U09138 U01664 U01841 U10374 | |
CCDS | CCDS20439.1 CCDS51876.1 | |
PIR | A54101 | |
RefSeq | NP_001120802.1 NP_035276.2 XP_006505803.1 XP_006505804.1 XP_006505805.1 XP_006505806.1 XP_006505807.1 | |
UniGene | Mm.3020 | |
ProteinModelPortal | P37238 | |
SMR | P37238 | |
BioGrid | 202320 | |
DIP | DIP-60435N | |
IntAct | P37238 | |
STRING | 10090.ENSMUSP00000000450 | |
BindingDB | P37238 | |
ChEMBL | CHEMBL2459 | |
PhosphoSite | P37238 | |
PRIDE | P37238 | |
GeneID | 19016 | |
KEGG | mmu:19016 | |
UCSC | uc012eqj.1 | |
CTD | 5468 | |
MGI | MGI:97747 | |
eggNOG | NOG266867 | |
HOGENOM | HOG000261626 | |
HOVERGEN | HBG106004 | |
InParanoid | P37238 | |
KO | K08530 | |
PhylomeDB | P37238 | |
Reactome | REACT_252217 REACT_27166 | |
NextBio | 295444 | |
PRO | PR:P37238 | |
Proteomes | UP000000589 | |
Bgee | P37238 | |
CleanEx | MM_PPARG | |
Genevestigator | P37238 | |
GO | GO:0005737 GO:0005829 GO:0005654 GO:0005634 GO:0050544 GO:0003682 GO:0003677 GO:0004879 GO:0030374 GO:0001012 GO:0001228 GO:0043565 GO:0003700 GO:0003707 GO:0044212 GO:0050699 GO:0008270 GO:0050873 GO:0045165 GO:0071285 GO:0071407 GO:0030855 GO:0045444 GO:0006954 GO:0030522 GO:0015909 GO:0008285 GO:1900077 GO:0001818 GO:0090278 GO:0000122 GO:0045892 GO:0001890 GO:0045600 GO:0045944 GO:0045893 GO:0045598 GO:0060850 GO:0033993 GO:0032526 GO:0050872 | |
Gene3D | 1.10.565.10 3.30.50.10 | |
InterPro | IPR003074 IPR003077 IPR008946 IPR000536 IPR022590 IPR001723 IPR001628 IPR013088 | |
Pfam | PF00104 PF12577 PF00105 | |
PRINTS | PR01288 PR01291 PR00398 PR00047 | |
SMART | SM00430 SM00399 | |
SUPFAM | SSF48508 | |
PROSITE | PS00031 PS51030 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0010742 |
macrophage derived foam cell differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032094 |
response to food |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009416 |
response to light stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0070888 |
E-box binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042752 |
regulation of circadian rhythm |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0150079 |
negative regulation of neuroinflammatory response |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
RNAcentral:URS000024A59E_10090 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903979 |
negative regulation of microglial cell activation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
RNAcentral:URS000024A59E_10090 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1900077 |
negative regulation of cellular response to insulin stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090278 |
negative regulation of peptide hormone secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(UniProtKB:P41159) |
Seeded From UniProt |
complete | ||
enables |
GO:0050544 |
arachidonic acid binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0033993 |
response to lipid |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001818 |
negative regulation of cytokine production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050872 |
white fat cell differentiation |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045600 |
positive regulation of fat cell differentiation |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060850 |
regulation of transcription involved in cell fate commitment |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045600 |
positive regulation of fat cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045600 |
positive regulation of fat cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032526 |
response to retinoic acid |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0030374 |
nuclear receptor transcription coactivator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0030374 |
nuclear receptor transcription coactivator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0090575 |
RNA polymerase II transcription factor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1352462 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000546 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97747 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0038023 |
signaling receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104740 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033993 |
response to lipid |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97747 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033993 |
response to lipid |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97747 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97747 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032526 |
response to retinoic acid |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97747 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0030374 |
nuclear receptor transcription coactivator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97747 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101884 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019216 |
regulation of lipid metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000637985 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010887 |
negative regulation of cholesterol storage |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001182169 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009755 |
hormone-mediated signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001941333 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008289 |
lipid binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104740 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008144 |
drug binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001182169 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97856 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103076 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104740 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000546 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005504 |
fatty acid binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001182169 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101884 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0001103 |
RNA polymerase II repressing transcription factor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001182169 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000546 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000546 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000546 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101884 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0002674 |
negative regulation of acute inflammatory response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0002024 |
diet induced thermogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2651605 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0002021 |
response to dietary excess |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001890 |
placenta development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
results_in_development_of:(EMAPA:16042)|results_in_development_of:(EMAPA:35689) |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
enables |
GO:0001012 |
RNA polymerase II regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:2000230 |
negative regulation of pancreatic stellate cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1905563 |
negative regulation of vascular endothelial cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1905461 |
positive regulation of vascular associated smooth muscle cell apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1904706 |
negative regulation of vascular smooth muscle cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0090575 |
RNA polymerase II transcription factor complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071407 |
cellular response to organic cyclic compound |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071404 |
cellular response to low-density lipoprotein particle stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071285 |
cellular response to lithium ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0061614 |
pri-miRNA transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060965 |
negative regulation of gene silencing by miRNA |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060336 |
negative regulation of interferon-gamma-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060100 |
positive regulation of phagocytosis, engulfment |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0051974 |
negative regulation of telomerase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0051393 |
alpha-actinin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050873 |
brown fat cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
regulates_o_results_in_acquisition_of_features_of:(CL:0000136) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0050872 |
white fat cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
results_in_acquisition_of_features_of:(CL:0000136) |
Seeded From UniProt |
complete | ||
enables |
GO:0050699 |
WW domain binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050699 |
WW domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050693 |
LBD domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0050692 |
DBD domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048714 |
positive regulation of oligodendrocyte differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048662 |
negative regulation of smooth muscle cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048469 |
cell maturation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046965 |
retinoid X receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0046321 |
positive regulation of fatty acid oxidation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:894332 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045713 |
low-density lipoprotein particle receptor biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045598 |
regulation of fat cell differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000353 |
physical interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1337080 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1096393 |
P |
regulates_o_results_in_acquisition_of_features_of:(CL:0000448) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1917649 |
P |
results_in_acquisition_of_features_of:(CL:0000136) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_results_in_acquisition_of_features_of:(CL:0000136) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
results_in_acquisition_of_features_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045165 |
cell fate commitment |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:102784 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045165 |
cell fate commitment |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2651605 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0043621 |
protein self-association |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043537 |
negative regulation of blood vessel endothelial cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043388 |
positive regulation of DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0042953 |
lipoprotein transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0042593 |
glucose homeostasis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042277 |
peptide binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035357 |
peroxisome proliferator activated receptor signaling pathway |
ECO:0000353 |
physical interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035357 |
peroxisome proliferator activated receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0033613 |
activating transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032966 |
negative regulation of collagen biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032869 |
cellular response to insulin stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032526 |
response to retinoic acid |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030855 |
epithelial cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:102784 |
P |
results_in_acquisition_of_features_of:(CL:0000066) |
Seeded From UniProt |
complete | |
enables |
GO:0030374 |
nuclear receptor transcription coactivator activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0030331 |
estrogen receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0030308 |
negative regulation of cell growth |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0030224 |
monocyte differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019903 |
protein phosphatase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0019899 |
enzyme binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0019395 |
fatty acid oxidation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0019216 |
regulation of lipid metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0016525 |
negative regulation of angiogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0015909 |
long-chain fatty acid transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(EMAPA:16042)|occurs_in:(EMAPA:35689) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0010891 |
negative regulation of sequestering of triglyceride |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010887 |
negative regulation of cholesterol storage |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010871 |
negative regulation of receptor biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010745 |
negative regulation of macrophage derived foam cell differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010742 |
macrophage derived foam cell differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010468 |
regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2651605 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2384321 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008270 |
zinc ion binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008217 |
regulation of blood pressure |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008144 |
drug binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007165 |
signal transduction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(MGI:MGI:3029307) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004879 |
nuclear receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3371 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003690 |
double-stranded DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_participant:(MGI:MGI:88038)|has_participant:(MGI:MGI:1916202) |
Seeded From UniProt |
complete | ||
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_participant:(MGI:MGI:88038) |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
|
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043401 |
steroid hormone mediated signaling pathway |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003707 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003707 |
steroid hormone receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004879 |
nuclear receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001628 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001628 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002334) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045444 |
fat cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-MMU-9017440 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0006954 |
inflammatory response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004879 |
nuclear receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048511 |
rhythmic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Wang, N et al. (2008) Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1. Cell Metab. 8 482-91 PubMed GONUTS page
- ↑ 2.0 2.1 Liu, Y et al. (2019) MicroRNA-128 knockout inhibits the development of Alzheimer's disease by targeting PPARγ in mouse models. Eur. J. Pharmacol. 843 134-144 PubMed GONUTS page
- ↑ 3.0 3.1 Buyse, M et al. (2001) Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes. FASEB J. 15 1357-66 PubMed GONUTS page
- ↑ 4.0 4.1 Nagy, L et al. (1998) Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 93 229-40 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Pascual, G et al. (2005) A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 437 759-63 PubMed GONUTS page
- ↑ Bonfield, TL et al. (2008) Peroxisome proliferator-activated receptor-gamma regulates the expression of alveolar macrophage macrophage colony-stimulating factor. J. Immunol. 181 235-42 PubMed GONUTS page
- ↑ 7.0 7.1 Hong, YH et al. (2005) Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis. Mol. Cell. Biochem. 276 133-41 PubMed GONUTS page
- ↑ 8.0 8.1 Ohoka, N et al. (2009) The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression. Mol. Endocrinol. 23 759-71 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Tomaru, T et al. (2006) Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma. Endocrinology 147 377-88 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Grimaldi, B et al. (2010) PER2 controls lipid metabolism by direct regulation of PPARγ. Cell Metab. 12 509-20 PubMed GONUTS page
- ↑ 11.0 11.1 Kawai, M et al. (2010) A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation. Proc. Natl. Acad. Sci. U.S.A. 107 10508-13 PubMed GONUTS page
- ↑ 12.00 12.01 12.02 12.03 12.04 12.05 12.06 12.07 12.08 12.09 12.10 12.11 12.12 12.13 12.14 12.15 12.16 12.17 12.18 12.19 12.20 12.21 12.22 12.23 12.24 12.25 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 Liu, C et al. (2014) PPARγ in vagal neurons regulates high-fat diet induced thermogenesis. Cell Metab. 19 722-30 PubMed GONUTS page
- ↑ 14.0 14.1 Schaiff, WT et al. (2007) Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice. Endocrinology 148 3625-34 PubMed GONUTS page
- ↑ 15.0 15.1 Yamashita-Sugahara, Y et al. (2013) Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor γ target gene that regulates adipogenesis through ceramide synthesis. J. Biol. Chem. 288 4522-37 PubMed GONUTS page
- ↑ 16.0 16.1 Ichida, F et al. (2004) Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J. Biol. Chem. 279 34015-22 PubMed GONUTS page
- ↑ 17.0 17.1 Kliewer, SA et al. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. U.S.A. 91 7355-9 PubMed GONUTS page
- ↑ Bennett, CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J. Biol. Chem. 277 30998-1004 PubMed GONUTS page
- ↑ Vertino, AM et al. (2005) Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol. Biol. Cell 16 2039-48 PubMed GONUTS page
- ↑ 20.0 20.1 Wu, Y & Smas, CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am. J. Physiol. Endocrinol. Metab. 295 E205-15 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 Park, BH et al. (2012) Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ. PLoS ONE 7 e30983 PubMed GONUTS page
- ↑ 22.0 22.1 Rajakumari, S et al. (2013) EBF2 determines and maintains brown adipocyte identity. Cell Metab. 17 562-74 PubMed GONUTS page
- ↑ Ren, G et al. (2016) Expression, regulation and functional assessment of the 80 amino acid Small Adipocyte Factor 1 (Smaf1) protein in adipocytes. Arch. Biochem. Biophys. 590 27-36 PubMed GONUTS page
- ↑ 24.0 24.1 Hong, JH et al. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309 1074-8 PubMed GONUTS page
- ↑ 25.0 25.1 25.2 25.3 Ge, K et al. (2002) Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 417 563-7 PubMed GONUTS page
- ↑ Makowski, L et al. (2005) The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J. Biol. Chem. 280 12888-95 PubMed GONUTS page
- ↑ Fan, M et al. (2004) Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev. 18 278-89 PubMed GONUTS page
- ↑ 28.0 28.1 28.2 Guan, HP et al. (2005) Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev. 19 453-61 PubMed GONUTS page
- ↑ 29.0 29.1 Li, D et al. (2007) Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis. Mol. Endocrinol. 21 2320-33 PubMed GONUTS page
- ↑ 30.0 30.1 30.2 Nofsinger, RR et al. (2008) SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc. Natl. Acad. Sci. U.S.A. 105 20021-6 PubMed GONUTS page
- ↑ Pérez-Mancera, PA et al. (2007) Adipose tissue mass is modulated by SLUG (SNAI2). Hum. Mol. Genet. 16 2972-86 PubMed GONUTS page
- ↑ Bennett, CN et al. (2005) Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc. Natl. Acad. Sci. U.S.A. 102 3324-9 PubMed GONUTS page
- ↑ Tang, QQ et al. (2003) Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc. Natl. Acad. Sci. U.S.A. 100 44-9 PubMed GONUTS page
- ↑ Gray, S et al. (2002) The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J. Biol. Chem. 277 34322-8 PubMed GONUTS page
- ↑ Ross, SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289 950-3 PubMed GONUTS page
- ↑ 36.0 36.1 Drori, S et al. (2005) Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev. 19 362-75 PubMed GONUTS page
- ↑ 37.0 37.1 Beaton, N et al. (2015) TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling. Mol Metab 4 795-810 PubMed GONUTS page
- ↑ Girnun, GD et al. (2002) APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc. Natl. Acad. Sci. U.S.A. 99 13771-6 PubMed GONUTS page
- ↑ 39.0 39.1 Guthmann, F et al. (2004) Phenotype of palmitic acid transport and of signalling in alveolar type II cells from E/H-FABP double-knockout mice: contribution of caveolin-1 and PPARgamma. Biochim. Biophys. Acta 1636 196-204 PubMed GONUTS page
- ↑ 40.0 40.1 40.2 40.3 Shibuya, A et al. (2002) Nitration of PPARgamma inhibits ligand-dependent translocation into the nucleus in a macrophage-like cell line, RAW 264. FEBS Lett. 525 43-7 PubMed GONUTS page
- ↑ Fei, Z et al. (2011) Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. J. Biol. Chem. 286 27761-8 PubMed GONUTS page
- ↑ Dispirito, JR et al. (2013) Pruning of the adipocyte peroxisome proliferator-activated receptor γ cistrome by hematopoietic master regulator PU.1. Mol. Cell. Biol. 33 3354-64 PubMed GONUTS page
- ↑ Patsouris, D et al. (2004) PPARalpha governs glycerol metabolism. J. Clin. Invest. 114 94-103 PubMed GONUTS page
- ↑ 44.0 44.1 Ji, S et al. (2012) O-GlcNAc modification of PPARγ reduces its transcriptional activity. Biochem. Biophys. Res. Commun. 417 1158-63 PubMed GONUTS page
- ↑ Takenaka, Y et al. (2013) A Novel Splicing Variant of Peroxisome Proliferator-Activated Receptor-γ (Pparγ1sv) Cooperatively Regulates Adipocyte Differentiation with Pparγ2. PLoS ONE 8 e65583 PubMed GONUTS page
a
c
- GO:0071404 ! cellular response to low-density lipoprotein particle stimulus
- GO:0071285 ! cellular response to lithium ion
- GO:0032869 ! cellular response to insulin stimulus
- GO:0071407 ! cellular response to organic cyclic compound
- GO:0030154 ! cell differentiation
- GO:0045165 ! cell fate commitment
- GO:0048469 ! cell maturation
- Chordata
- GO:0003682 ! chromatin binding
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005829 ! cytosol
d
- GO:0002024 ! diet induced thermogenesis
- GO:0001227 ! DNA-binding transcription repressor activity, RNA polymerase II-specific
- GO:0003700 ! DNA-binding transcription factor activity
- GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0001228 ! DNA-binding transcription activator activity, RNA polymerase II-specific
- GO:0003677 ! DNA binding
- GO:0050692 ! DNA binding domain binding
- GO:0003690 ! double-stranded DNA binding
e
f
i
l
m
n
- GO:1904706 ! negative regulation of vascular associated smooth muscle cell proliferation
- GO:0030308 ! negative regulation of cell growth
- GO:0010887 ! negative regulation of cholesterol storage
- GO:0008285 ! negative regulation of cell population proliferation
- GO:0010745 ! negative regulation of macrophage derived foam cell differentiation
- GO:0032966 ! negative regulation of collagen biosynthetic process
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0001818 ! negative regulation of cytokine production
- GO:0002674 ! negative regulation of acute inflammatory response
- GO:0048662 ! negative regulation of smooth muscle cell proliferation
- GO:0043537 ! negative regulation of blood vessel endothelial cell migration
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0010891 ! negative regulation of triglyceride storage
- GO:0090278 ! negative regulation of peptide hormone secretion
- GO:1900077 ! negative regulation of cellular response to insulin stimulus
- GO:1903979 ! negative regulation of microglial cell activation
- GO:2000230 ! negative regulation of pancreatic stellate cell proliferation
- GO:0016525 ! negative regulation of angiogenesis
- GO:0150079 ! negative regulation of neuroinflammatory response
- GO:0060336 ! negative regulation of type II interferon-mediated signaling pathway
- GO:0060965 ! negative regulation of miRNA-mediated gene silencing
- GO:1905563 ! negative regulation of vascular endothelial cell proliferation
- GO:0030331 ! nuclear estrogen receptor binding
- GO:0004879 ! nuclear receptor activity
- GO:0046965 ! nuclear retinoid X receptor binding
- GO:0003707 ! nuclear steroid receptor activity
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
o
- GO:0006919 ! obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0008144 ! obsolete drug binding
- GO:0045713 ! obsolete low-density lipoprotein particle receptor biosynthetic process
- GO:0051974 ! obsolete negative regulation of telomerase activity
- GO:0010871 ! obsolete negative regulation of receptor biosynthetic process
- GO:0030374 ! obsolete nuclear receptor coactivator activity
- GO:0008022 ! obsolete protein C-terminus binding
- GO:0043621 ! obsolete protein self-association
- GO:0060850 ! obsolete regulation of transcription involved in cell fate commitment
p
- GO:0042277 ! peptide binding
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0035357 ! peroxisome proliferator activated receptor signaling pathway
- GO:0001890 ! placenta development
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0045600 ! positive regulation of fat cell differentiation
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0048714 ! positive regulation of oligodendrocyte differentiation
- GO:1905461 ! positive regulation of vascular associated smooth muscle cell apoptotic process
- GO:0043065 ! positive regulation of apoptotic process
- GO:0060100 ! positive regulation of phagocytosis, engulfment
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0046321 ! positive regulation of fatty acid oxidation
- GO:0043388 ! positive regulation of DNA binding
- GO:0032991 ! protein-containing complex
- GO:0046982 ! protein heterodimerization activity
- GO:0019903 ! protein phosphatase binding
r
- GO:0045598 ! regulation of fat cell differentiation
- GO:0019216 ! regulation of lipid metabolic process
- GO:0008217 ! regulation of blood pressure
- GO:0006357 ! regulation of transcription by RNA polymerase II
- GO:0006355 ! regulation of DNA-templated transcription
- GO:0042752 ! regulation of circadian rhythm
- GO:0010468 ! regulation of gene expression
- GO:0009416 ! response to light stimulus
- GO:0002021 ! response to dietary excess
- GO:0032094 ! response to food
- GO:0033993 ! response to lipid
- GO:0032526 ! response to retinoic acid
- GO:0048511 ! rhythmic process
- GO:0001103 ! RNA polymerase II repressing transcription factor binding
- GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding
- GO:0001012 ! RNA polymerase II regulatory region DNA binding
- GO:0090575 ! RNA polymerase II transcription regulator complex
- Rodentia
s
t