HUMAN:NKX31

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NKX3-1 (synonyms: NKX3.1, NKX3A)
Protein Name(s)	Homeobox protein Nkx-3.1 Homeobox protein NK-3 homolog A
External Links
UniProt	Q99801
EMBL	U91540 U80669 AF247704 AF249669 AF249670 AF249671 AF249672 BC074863 BC074864
CCDS	CCDS59095.1 CCDS6042.1
RefSeq	NP_001243268.1 NP_006158.2
UniGene	Hs.55999
PDB	2L9R
PDBsum	2L9R
DisProt	DP00683
ProteinModelPortal	Q99801
SMR	Q99801
BioGrid	110888
IntAct	Q99801
STRING	9606.ENSP00000370253
PhosphoSite	Q99801
DMDM	17377578
MaxQB	Q99801
PaxDb	Q99801
PRIDE	Q99801
DNASU	4824
Ensembl	ENST00000380871 ENST00000523261
GeneID	4824
KEGG	hsa:4824
UCSC	uc011kzx.2 uc031tao.1
CTD	4824
GeneCards	GC08M023536
HGNC	HGNC:7838
HPA	HPA025693
MIM	602041
neXtProt	NX_Q99801
PharmGKB	PA31645
eggNOG	NOG238786
GeneTree	ENSGT00760000118779
HOGENOM	HOG000231923
HOVERGEN	HBG006689
InParanoid	Q99801
KO	K09348
OMA	GAQRQGG
OrthoDB	EOG7QZG9Z
PhylomeDB	Q99801
TreeFam	TF315720
SignaLink	Q99801
ChiTaRS	NKX3-1
GeneWiki	NKX3-1
GenomeRNAi	4824
NextBio	18580
PRO	PR:Q99801
Proteomes	UP000005640
Bgee	Q99801
CleanEx	HS_NKX3-1
Genevestigator	Q99801
GO	GO:0005622 GO:0005634 GO:0004882 GO:0001047 GO:0030284 GO:0030331 GO:0042826 GO:0030295 GO:0043621 GO:0000983 GO:0043565 GO:0003700 GO:0008134 GO:0044212 GO:0000976 GO:0006919 GO:0030521 GO:0060442 GO:0048754 GO:0035690 GO:0071456 GO:0071347 GO:0071383 GO:0071356 GO:0035907 GO:0060664 GO:0007507 GO:0008584 GO:0001656 GO:0071850 GO:0007275 GO:0008285 GO:0050680 GO:0060770 GO:0071899 GO:0010629 GO:0043569 GO:0045930 GO:0045892 GO:0060037 GO:2000836 GO:2001235 GO:0010942 GO:0051781 GO:0008284 GO:0043280 GO:0010628 GO:2001244 GO:0045931 GO:0014068 GO:0045860 GO:0001934 GO:2001022 GO:0045944 GO:0045893 GO:0043491 GO:0006355 GO:0033574 GO:0007431 GO:0001756 GO:0043401
Gene3D	1.10.10.60
InterPro	IPR017970 IPR001356 IPR020479 IPR009057
Pfam	PF00046
PRINTS	PR00024
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
NOT	GO:0008284	positive regulation of cell proliferation	PMID:20855495^[1]	ECO:0000315			P		NKX3.1 knockdown impaired proliferation of Jurkat and HSB2 cells (fig S5 a).	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001356 InterPro:IPR009057	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q80Z64	F		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	PMID:20395202^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q13315) happens_during:(GO:0006974)\|has_regulation_target(UniProtKB:Q13535) happens_during:(GO:0006974)\|has_regulation_target(UniProtKB:P16104) happens_during:(GO:0006974)	Seeded From UniProt	complete
part_of	GO:0090734	site of DNA damage	PMID:20395202^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	PMID:20855495^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20855495^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	PMID:20855495^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20855495^[1]	ECO:0000305	curator inference used in manual assertion	GO:0003700	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:20855495^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:20855495^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	PMID:17486276^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001235	positive regulation of apoptotic signaling pathway	PMID:20599703^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001022	positive regulation of response to DNA damage stimulus	PMID:20395202^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000836	positive regulation of androgen secretion	PMID:19886863^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071899	negative regulation of estrogen receptor binding	PMID:18794125^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071850	mitotic cell cycle arrest	PMID:19266349^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:21056661^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071383	cellular response to steroid hormone stimulus	PMID:19886863^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:18757402^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	PMID:18757402^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97436	P		Seeded From UniProt	complete
involved_in	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97436	P		Seeded From UniProt	complete
involved_in	GO:0060442	branching involved in prostate gland morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97436	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97436	P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97436	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19797053^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P63267)	Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	PMID:19266349^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18360715^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10275)\|has_regulation_target:(UniProtKB:P08069)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97436	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18974119^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P49767)	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18360715^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P07288)	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19597465^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O00391)\|has_regulation_target:(UniProtKB:P14091)\|has_regulation_target:(UniProtKB:P35326)\|has_regulation_target:(UniProtKB:P10909)	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18794125^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19263243^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:19780584^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97436	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:19780584^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	PMID:19597465^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:20599703^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P42574)	Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:18974119^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	PMID:18757402^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	has_input:(CHEBI:52717)	Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97436	P		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	PMID:19886863^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	PMID:18794125^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	PMID:18794125^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:20395202^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	PMID:19266349^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:17486276^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10415)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20716579^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q99801)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20599703^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P42574)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:17486276^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q07812)	Seeded From UniProt	complete
enables	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	PMID:19266349^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:19266349^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:17486276^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18360715^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:20716579^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08047	F		Seeded From UniProt	complete
involved_in	GO:0007431	salivary gland development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97436	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:19266349^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:17486276^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:11137288^[18]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19263243^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18757402^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11137288^[18]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:19886863^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11137288^[18]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:20395202^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q13315) happens_during:(GO:2001022)\|has_regulation_target(UniProtKB:Q13535) happens_during:(GO:2001022)\|has_regulation_target(UniProtKB:P16104) happens_during:(GO:2001022)\|has_regulation_target(UniProtKB:O14757) happens_during:(GO:2001022)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:18974119^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P49767)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004110 FB:FBgn0004862 FB:FBgn0040318 FB:FBgn0261930 MGI:MGI:108067 MGI:MGI:97347 MGI:MGI:97348 MGI:MGI:97350 PANTHER:PTN000678271 RGD:3866 UniProtKB:A6NCS4 UniProtKB:A6NJ46 UniProtKB:O15522 UniProtKB:P43699 UniProtKB:P52952 UniProtKB:Q99801 WB:WBGene00000445 WB:WBGene00000450	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000576 FB:FBgn0004110 FB:FBgn0004862 MGI:MGI:108015 MGI:MGI:108067 MGI:MGI:1352738 MGI:MGI:97347 MGI:MGI:97350 MGI:MGI:97352 PANTHER:PTN000678271 RGD:1310629 RGD:3866 RGD:620520 RGD:69318 UniProtKB:A6NCS4 UniProtKB:A6NJ46 UniProtKB:O15522 UniProtKB:P43699 UniProtKB:P52952 UniProtKB:Q99801 WB:WBGene00000445	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000576 FB:FBgn0002941 FB:FBgn0004110 FB:FBgn0028993 FB:FBgn0040318 FB:FBgn0261930 MGI:MGI:108015 MGI:MGI:108067 MGI:MGI:1206039 MGI:MGI:1270158 MGI:MGI:1352738 MGI:MGI:1921811 MGI:MGI:97347 MGI:MGI:97348 MGI:MGI:97350 MGI:MGI:97351 PANTHER:PTN000678271 RGD:620520 RGD:69318 UniProtKB:P52952 WB:WBGene00000445 WB:WBGene00000584 ZFIN:ZDB-GENE-030328-42 ZFIN:ZDB-GENE-040718-178 ZFIN:ZDB-GENE-050217-3 ZFIN:ZDB-GENE-070626-1 ZFIN:ZDB-GENE-980526-321 ZFIN:ZDB-GENE-980526-403 ZFIN:ZDB-GENE-990415-179	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000576 FB:FBgn0002941 FB:FBgn0004110 FB:FBgn0004862 FB:FBgn0040318 FB:FBgn0261930 MGI:MGI:108067 MGI:MGI:1206039 MGI:MGI:1352738 MGI:MGI:97347 MGI:MGI:97350 MGI:MGI:97352 PANTHER:PTN000678271 RGD:1308443 RGD:1310629 RGD:3866 RGD:620520 RGD:69318 UniProtKB:F1NC42 UniProtKB:P43699 UniProtKB:P52952 UniProtKB:Q90788 UniProtKB:Q99801 WB:WBGene00000445	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261930 MGI:MGI:108067 MGI:MGI:1352738 MGI:MGI:97347 MGI:MGI:97350 MGI:MGI:97352 PANTHER:PTN000678271 RGD:3866 RGD:69318 UniProtKB:A6NCS4 UniProtKB:O15522 UniProtKB:P43699 UniProtKB:P52952 UniProtKB:Q99801	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108015 MGI:MGI:108067 MGI:MGI:1352738 MGI:MGI:97350 PANTHER:PTN000678271 RGD:69318 UniProtKB:O15522 UniProtKB:P52952 UniProtKB:Q99801	F		Seeded From UniProt	complete
enables	GO:0097162	MADS box domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	F		Seeded From UniProt	complete
involved_in	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0060442	branching involved in prostate gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	F		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0035907	dorsal aorta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0007431	salivary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	F		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
involved_in	GO:0001655	urogenital system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97436 ensembl:ENSMUSP00000022646	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR020479	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:9537602^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Kusy, S et al. (2010) NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J. Exp. Med. 207 2141-56 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Bowen, C & Gelmann, EP (2010) NKX3.1 activates cellular response to DNA damage. Cancer Res. 70 3089-97 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Wang, P et al. (2007) Expression of Nkx3.1 enhances 17beta-estradiol anti-tumor action in PC3 human prostate cancer cells. Asian J. Androl. 9 353-60 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Pengju, Z et al. (2010) NKX3.1 potentiates TNF-alpha/CHX-induced apoptosis of prostate cancer cells through increasing caspase-3 expression and its activity. Biochem. Biophys. Res. Commun. 398 457-61 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Thomas, MA et al. (2010) Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region. Biochem. J. 425 575-83 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Holmes, KA et al. (2008) Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity. Cancer Res. 68 7380-5 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Wang, P et al. (2009) Nkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cells. Cancer Invest. 27 369-75 PubMed GONUTS page
↑ Mitani, T et al. (2011) Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment. J. Steroid Biochem. Mol. Biol. 123 58-64 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Markowski, MC et al. (2008) Inflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1. Cancer Res. 68 6896-901 PubMed GONUTS page
↑ Sun, Q et al. (2009) Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein. J. Biol. Chem. 284 32582-90 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Possner, M et al. (2008) Functional analysis of NKX3.1 in LNCaP prostate cancer cells by RNA interference. Int. J. Oncol. 32 877-84 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Zhang, H et al. (2008) Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancer. Cancer Res. 68 8770-8 PubMed GONUTS page
↑ ^14.0 ^14.1 Song, H et al. (2009) Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis. Oncogene 28 3307-19 PubMed GONUTS page
↑ ^15.0 ^15.1 Yu, CX et al. (2009) Identification of Sp1-elements in the promoter region of human homeobox gene NKX3.1. Mol. Biol. Rep. 36 2353-60 PubMed GONUTS page
↑ ^16.0 ^16.1 Ju, JH et al. (2009) Interactions of the acidic domain and SRF interacting motifs with the NKX3.1 homeodomain. Biochemistry 48 10601-7 PubMed GONUTS page
↑ ^17.0 ^17.1 Akamatsu, S et al. (2010) A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression. Hum. Mol. Genet. 19 4265-72 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Korkmaz, KS et al. (2000) Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens. Gene 260 25-36 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Prescott, JL et al. (1998) Isolation and androgen regulation of the human homeobox cDNA, NKX3.1. Prostate 35 71-80 PubMed GONUTS page

[PMID:20855495-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Kusy, S et al. (2010) NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J. Exp. Med. 207 2141-56 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:20395202-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Bowen, C & Gelmann, EP (2010) NKX3.1 activates cellular response to DNA damage. Cancer Res. 70 3089-97 PubMed GONUTS page

[PMID:17486276-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Wang, P et al. (2007) Expression of Nkx3.1 enhances 17beta-estradiol anti-tumor action in PC3 human prostate cancer cells. Asian J. Androl. 9 353-60 PubMed GONUTS page

[PMID:20599703-5] 5.0 ^5.1 ^5.2 Pengju, Z et al. (2010) NKX3.1 potentiates TNF-alpha/CHX-induced apoptosis of prostate cancer cells through increasing caspase-3 expression and its activity. Biochem. Biophys. Res. Commun. 398 457-61 PubMed GONUTS page

[PMID:19886863-6] 6.0 ^6.1 ^6.2 ^6.3 Thomas, MA et al. (2010) Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region. Biochem. J. 425 575-83 PubMed GONUTS page

[PMID:18794125-7] 7.0 ^7.1 ^7.2 ^7.3 Holmes, KA et al. (2008) Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity. Cancer Res. 68 7380-5 PubMed GONUTS page

[PMID:19266349-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Wang, P et al. (2009) Nkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cells. Cancer Invest. 27 369-75 PubMed GONUTS page

[PMID:21056661-9] Mitani, T et al. (2011) Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment. J. Steroid Biochem. Mol. Biol. 123 58-64 PubMed GONUTS page

[PMID:18757402-10] 10.0 ^10.1 ^10.2 ^10.3 Markowski, MC et al. (2008) Inflammatory cytokines induce phosphorylation and ubiquitination of prostate suppressor protein NKX3.1. Cancer Res. 68 6896-901 PubMed GONUTS page

[PMID:19797053-11] Sun, Q et al. (2009) Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein. J. Biol. Chem. 284 32582-90 PubMed GONUTS page

[PMID:18360715-12] 12.0 ^12.1 ^12.2 Possner, M et al. (2008) Functional analysis of NKX3.1 in LNCaP prostate cancer cells by RNA interference. Int. J. Oncol. 32 877-84 PubMed GONUTS page

[PMID:18974119-13] 13.0 ^13.1 ^13.2 Zhang, H et al. (2008) Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancer. Cancer Res. 68 8770-8 PubMed GONUTS page

[PMID:19597465-14] 14.0 ^14.1 Song, H et al. (2009) Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis. Oncogene 28 3307-19 PubMed GONUTS page

[PMID:19263243-15] 15.0 ^15.1 Yu, CX et al. (2009) Identification of Sp1-elements in the promoter region of human homeobox gene NKX3.1. Mol. Biol. Rep. 36 2353-60 PubMed GONUTS page

[PMID:19780584-16] 16.0 ^16.1 Ju, JH et al. (2009) Interactions of the acidic domain and SRF interacting motifs with the NKX3.1 homeodomain. Biochemistry 48 10601-7 PubMed GONUTS page

[PMID:20716579-17] 17.0 ^17.1 Akamatsu, S et al. (2010) A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression. Hum. Mol. Genet. 19 4265-72 PubMed GONUTS page

[PMID:11137288-18] 18.0 ^18.1 ^18.2 Korkmaz, KS et al. (2000) Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens. Gene 260 25-36 PubMed GONUTS page

[PMID:21873635-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9537602-20] Prescott, JL et al. (1998) Isolation and androgen regulation of the human homeobox cDNA, NKX3.1. Prostate 35 71-80 PubMed GONUTS page

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HUMAN:NKX31

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