HUMAN:ESR2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ESR2 (synonyms: ESTRB, NR3A2)
Protein Name(s)	Estrogen receptor beta ER-beta Nuclear receptor subfamily 3 group A member 2
External Links
UniProt	Q92731
EMBL	AB006590 AF051427 AF051428 AF061054 AF061055 AF060555 AF124790 AF047463 AB006589 DQ838582 DQ838583 AY785359 AK292370 AL161756 AL355094 AL359235 CH471061 BC024181 AF191544 X99101 AF074598 AF074599
CCDS	CCDS32096.1 CCDS55920.1 CCDS61469.1 CCDS61470.1 CCDS9762.1
PIR	JC5939 PW0044 S71400
RefSeq	NP_001035365.1 NP_001201831.1 NP_001258805.1 NP_001258806.1 NP_001278641.1 NP_001278652.1 NP_001428.1 XP_006720139.1
UniGene	Hs.660607 Hs.734038 Hs.734416
PDB	1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 1ZAF 2FSZ 2GIU 2I0G 2JJ3 2NV7 2QTU 2YJD 2YLY 2Z4B 3OLL 3OLS 3OMO 3OMP 3OMQ 4J24 4J26
PDBsum	1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 1ZAF 2FSZ 2GIU 2I0G 2JJ3 2NV7 2QTU 2YJD 2YLY 2Z4B 3OLL 3OLS 3OMO 3OMP 3OMQ 4J24 4J26
DisProt	DP00079
ProteinModelPortal	Q92731
SMR	Q92731
BioGrid	108404
DIP	DIP-5966N
IntAct	Q92731
BindingDB	Q92731
ChEMBL	CHEMBL2093866
DrugBank	DB00255 DB00783 DB01196 DB04573 DB04574 DB00481 DB00675 DB01108
GuidetoPHARMACOLOGY	621
PhosphoSite	Q92731
DMDM	6166154
PaxDb	Q92731
PRIDE	Q92731
Ensembl	ENST00000267525 ENST00000341099 ENST00000344288 ENST00000353772 ENST00000358599 ENST00000553796 ENST00000554572 ENST00000555278 ENST00000557772
GeneID	2100
KEGG	hsa:2100
UCSC	uc001xgy.2 uc001xgz.2 uc001xha.1 uc010aqc.1
CTD	2100
GeneCards	GC14M064550
HGNC	HGNC:3468
HPA	CAB022544
MIM	601663
neXtProt	NX_Q92731
PharmGKB	PA27886
eggNOG	NOG271979
GeneTree	ENSGT00760000118887
HOVERGEN	HBG108344
InParanoid	Q92731
KO	K08551
OMA	EPQKSPW
PhylomeDB	Q92731
TreeFam	TF323751
Reactome	REACT_15525
SignaLink	Q92731
EvolutionaryTrace	Q92731
GeneWiki	Estrogen_receptor_beta
GenomeRNAi	2100
NextBio	35517714
PMAP-CutDB	A8K8K5
PRO	PR:Q92731
Proteomes	UP000005640
Bgee	Q92731
ExpressionAtlas	Q92731
Genevestigator	Q92731
GO	GO:0005576 GO:0005739 GO:0005654 GO:0005634 GO:0001046 GO:0003677 GO:0019899 GO:0030284 GO:0034056 GO:0004879 GO:0048019 GO:0003700 GO:0005496 GO:0003707 GO:0003713 GO:0008270 GO:0007420 GO:0007267 GO:0060743 GO:1900116 GO:0010467 GO:0008628 GO:0030520 GO:0060766 GO:0030308 GO:0050680 GO:0000122 GO:0001764 GO:0001541 GO:0051091 GO:0060740 GO:0006355 GO:0007165 GO:0006367 GO:0060065 GO:0060068
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR028355 IPR021064 IPR008946 IPR000536 IPR024178 IPR001723 IPR001628 IPR013088
Pfam	PF12497 PF00104 PF00105
PIRSF	PIRSF500102 PIRSF002527
PRINTS	PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	PMID:21487105^[1]	ECO:0000314			P		Figure 3 details the effects of the introduction of the ER-beta gene into a cell culture already expressing KLF5. Figure 3A shows that the gene product of ER-beta dramatically increases expression of the FOXO1 gene, the expression of which was measured through a direct luciferase assay.	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000324 InterPro:IPR001628 InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	PMID:19126643^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q00175	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20074560^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20074560^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0034056	estrogen response element binding	PMID:19126643^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19126643^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:19126643^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:16469)	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:10681512^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048019	receptor antagonist activity	PMID:9671811^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0034056	estrogen response element binding	PMID:15345745^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(UniProtKB:P24387)	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:11181953^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:12039952^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55345	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62986	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:9671811^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:15345745^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(UniProtKB:P24387)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15345745^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P24387)\|has_regulation_target:(UniProtKB:P24388)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:15024130^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21951318^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92731	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21182203^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92731	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19022902^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92731	F		Seeded From UniProt	complete
involved_in	GO:2000272	negative regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048019	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723 InterPro:IPR024178	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723 InterPro:IPR024178	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024178	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR024178	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088 InterPro:IPR024178	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088 InterPro:IPR024178	F		Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028355	F		Seeded From UniProt	complete
involved_in	GO:0030520	intracellular estrogen receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028355	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	PMID:24033289^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24033289^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0034056	estrogen response element binding	PMID:24033289^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030520	intracellular estrogen receptor signaling pathway	PMID:24033289^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	PMID:24033289^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:8769313^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8769313^[15] PMID:10749889^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:8769313^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	PMID:10749889^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:8769313^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9636657^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030520	intracellular estrogen receptor signaling pathway	PMID:11181953^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030284	estrogen receptor activity	PMID:11181953^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:11181953^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11181953^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	PMID:11181953^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-383280	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9038029 Reactome:R-HSA-8939204 Reactome:R-HSA-8939203 Reactome:R-HSA-8939201 Reactome:R-HSA-376419	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0754	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Nakajima, Y et al. (2011) Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5. Sci Signal 4 ra22 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Chen, M et al. (2009) CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells. Carcinogenesis 30 841-50 PubMed GONUTS page
↑ ^4.0 ^4.1 Koyama, S et al. (2010) Repression of estrogen receptor beta function by putative tumor suppressor DBC1. Biochem. Biophys. Res. Commun. 392 357-62 PubMed GONUTS page
↑ Saville, B et al. (2000) Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements. J. Biol. Chem. 275 5379-87 PubMed GONUTS page
↑ ^6.0 ^6.1 Ogawa, S et al. (1998) Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human. Nucleic Acids Res. 26 3505-12 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 van de Stolpe, A et al. (2004) Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbeta. Mol. Endocrinol. 18 2908-23 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Pettersson, K & Gustafsson, JA (2001) Role of estrogen receptor beta in estrogen action. Annu. Rev. Physiol. 63 165-92 PubMed GONUTS page
↑ Qi, C et al. (2002) Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. J. Biol. Chem. 277 28624-30 PubMed GONUTS page
↑ Yang, SH et al. (2004) Mitochondrial localization of estrogen receptor beta. Proc. Natl. Acad. Sci. U.S.A. 101 4130-5 PubMed GONUTS page
↑ Ivanova, M et al. (2011) Ligand-dependent differences in estrogen receptor beta-interacting proteins identified in lung adenocarcinoma cells corresponds to estrogenic responses. Proteome Sci 9 60 PubMed GONUTS page
↑ Nassa, G et al. (2011) A large set of estrogen receptor β-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei. Proteomics 11 159-65 PubMed GONUTS page
↑ Powell, E & Xu, W (2008) Intermolecular interactions identify ligand-selective activity of estrogen receptor alpha/beta dimers. Proc. Natl. Acad. Sci. U.S.A. 105 19012-7 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Hiroi, R & Handa, RJ (2013) Estrogen receptor-β regulates human tryptophan hydroxylase-2 through an estrogen response element in the 5' untranslated region. J. Neurochem. 127 487-95 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Mosselman, S et al. (1996) ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett. 392 49-53 PubMed GONUTS page
↑ ^16.0 ^16.1 Kahlert, S et al. (2000) Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway. J. Biol. Chem. 275 18447-53 PubMed GONUTS page
↑ Moore, JT et al. (1998) Cloning and characterization of human estrogen receptor beta isoforms. Biochem. Biophys. Res. Commun. 247 75-8 PubMed GONUTS page

[PMID:21487105-1] Nakajima, Y et al. (2011) Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5. Sci Signal 4 ra22 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:19126643-3] 3.0 ^3.1 ^3.2 ^3.3 Chen, M et al. (2009) CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells. Carcinogenesis 30 841-50 PubMed GONUTS page

[PMID:20074560-4] 4.0 ^4.1 Koyama, S et al. (2010) Repression of estrogen receptor beta function by putative tumor suppressor DBC1. Biochem. Biophys. Res. Commun. 392 357-62 PubMed GONUTS page

[PMID:10681512-5] Saville, B et al. (2000) Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements. J. Biol. Chem. 275 5379-87 PubMed GONUTS page

[PMID:9671811-6] 6.0 ^6.1 Ogawa, S et al. (1998) Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human. Nucleic Acids Res. 26 3505-12 PubMed GONUTS page

[PMID:15345745-7] 7.0 ^7.1 ^7.2 van de Stolpe, A et al. (2004) Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbeta. Mol. Endocrinol. 18 2908-23 PubMed GONUTS page

[PMID:11181953-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Pettersson, K & Gustafsson, JA (2001) Role of estrogen receptor beta in estrogen action. Annu. Rev. Physiol. 63 165-92 PubMed GONUTS page

[PMID:12039952-9] Qi, C et al. (2002) Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. J. Biol. Chem. 277 28624-30 PubMed GONUTS page

[PMID:15024130-10] Yang, SH et al. (2004) Mitochondrial localization of estrogen receptor beta. Proc. Natl. Acad. Sci. U.S.A. 101 4130-5 PubMed GONUTS page

[PMID:21951318-11] Ivanova, M et al. (2011) Ligand-dependent differences in estrogen receptor beta-interacting proteins identified in lung adenocarcinoma cells corresponds to estrogenic responses. Proteome Sci 9 60 PubMed GONUTS page

[PMID:21182203-12] Nassa, G et al. (2011) A large set of estrogen receptor β-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei. Proteomics 11 159-65 PubMed GONUTS page

[PMID:19022902-13] Powell, E & Xu, W (2008) Intermolecular interactions identify ligand-selective activity of estrogen receptor alpha/beta dimers. Proc. Natl. Acad. Sci. U.S.A. 105 19012-7 PubMed GONUTS page

[PMID:24033289-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Hiroi, R & Handa, RJ (2013) Estrogen receptor-β regulates human tryptophan hydroxylase-2 through an estrogen response element in the 5' untranslated region. J. Neurochem. 127 487-95 PubMed GONUTS page

[PMID:8769313-15] 15.0 ^15.1 ^15.2 ^15.3 Mosselman, S et al. (1996) ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett. 392 49-53 PubMed GONUTS page

[PMID:10749889-16] 16.0 ^16.1 Kahlert, S et al. (2000) Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway. J. Biol. Chem. 275 18447-53 PubMed GONUTS page

[PMID:9636657-17] Moore, JT et al. (1998) Cloning and characterization of human estrogen receptor beta isoforms. Biochem. Biophys. Res. Commun. 247 75-8 PubMed GONUTS page

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HUMAN:ESR2

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