MOUSE:STAT3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Stat3 (synonyms: Aprf)
Protein Name(s)	Signal transducer and activator of transcription 3 Acute-phase response factor
External Links
UniProt	P42227
EMBL	L29278 U08378 U06922 U30709 AF246978 AY299489 AY299490 AL591466 AL591466 BC003806
CCDS	CCDS25440.1 CCDS25441.1 CCDS48934.1
PIR	I49508
RefSeq	NP_998824.1 NP_998825.1
UniGene	Mm.249934 Mm.473190
PDB	1BG1 3CWG 4E68 4ZIA
PDBsum	1BG1 3CWG 4E68 4ZIA
ProteinModelPortal	P42227
SMR	P42227
BioGrid	203523
DIP	DIP-442N
IntAct	P42227
MINT	MINT-4135802
STRING	10090.ENSMUSP00000120152
BindingDB	P42227
ChEMBL	CHEMBL5402
MoonProt	P42227
iPTMnet	P42227
PhosphoSite	P42227
EPD	P42227
MaxQB	P42227
PaxDb	P42227
PRIDE	P42227
Ensembl	ENSMUST00000092671 ENSMUST00000103114 ENSMUST00000127638
GeneID	20848
UCSC	uc007lmp.1 uc007lmq.1
CTD	6774
MGI	MGI:103038
eggNOG	KOG3667 ENOG410XPN8
GeneTree	ENSGT00760000119236
HOGENOM	HOG000220792
HOVERGEN	HBG055669
InParanoid	P42227
OMA	NSMSFAE
OrthoDB	EOG73JKTT
PhylomeDB	P42227
TreeFam	TF318648
Reactome	R-MMU-1059683 R-MMU-1433557 R-MMU-186763 R-MMU-2586551
ChiTaRS	Stat3
EvolutionaryTrace	P42227
NextBio	299623
PRO	PR:P42227
Proteomes	UP000000589
Bgee	P42227
ExpressionAtlas	P42227
Genevisible	P42227
GO	GO:0005737 GO:0005829 GO:0005743 GO:0000790 GO:0005654 GO:0005634 GO:0005886 GO:0090575 GO:0031490 GO:0003677 GO:0042802 GO:0046983 GO:0019901 GO:0019903 GO:0000978 GO:0001103 GO:0004879 GO:0000981 GO:0043565 GO:0004871 GO:0003700 GO:0008134 GO:0044212 GO:0001077 GO:0001228 GO:0006953 GO:0007568 GO:0048708 GO:0008283 GO:0071345 GO:0032870 GO:0044320 GO:0071407 GO:0019221 GO:0042755 GO:0097009 GO:0001754 GO:0042593 GO:0060396 GO:0070102 GO:0030522 GO:0007259 GO:0060397 GO:0033210 GO:0043066 GO:0008285 GO:0045820 GO:0010730 GO:1901215 GO:2001223 GO:0016310 GO:2001171 GO:1902728 GO:0045747 GO:0045944 GO:0045893 GO:0006606 GO:0060019 GO:0051726 GO:0060259 GO:0046902 GO:0040014 GO:0006355 GO:0042493 GO:0032355 GO:0045471 GO:0044321 GO:0019953 GO:0019827 GO:0001659 GO:0006366
Gene3D	1.10.238.10 1.10.532.10 1.20.1050.20 2.60.40.630 3.30.505.10
InterPro	IPR011992 IPR008967 IPR000980 IPR001217 IPR013800 IPR015988 IPR013801 IPR012345 IPR013799
PANTHER	PTHR11801
Pfam	PF00017 PF01017 PF02864 PF02865
SMART	SM00252 SM00964
SUPFAM	SSF47655 SSF48092 SSF49417 SSF55550
PROSITE	PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:27050391^[1]	ECO:0000314			C		Figure 5C shows immunostaining of STAT3 in the nucleus.	complete CACAO 11580
Colocalizes with	GO:0005737	cytoplasm	PMID:22761423^[2]	ECO:0000316		UniProtKB:Q9R1E0 UniProtKB:Q9WVH4	C		Organism: Mus musculus Protein: Stat3 // Stat3 with FOXO1 and FOXO3a // Foxo1 and Foxo3 Figure 1: "STAT3 co-localized and interacted with pFoxO1 and pFoxO3a in the cytoplasm of activated T cells."	complete CACAO 12864
	GO:0005737	cytoplasm	PMID:22761423^[2]	ECO:0000314			C		Organism: Mus musculus Protein STAT3// Stat3 Figure 1 shows the protein localizes in the cytoplasm.	complete CACAO 12865
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:20546595^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002548) regulates_transcription_of:(ENSEMBL:ENSMUSG00000065455)	Seeded From UniProt	complete
involved_in	GO:1905564	positive regulation of vascular endothelial cell proliferation	PMID:26505789^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	acts_on_population_of:(CL:0010006)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:26505789^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0010006)	Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24255059^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P35951	P	has_regulation_target:(RNAcentral:URS0000329B12_10090) occurs_in:(UBERON:0001508)	Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	PMID:16825198^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:16825198^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	PMID:16825198^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:28065600^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072540	T-helper 17 cell lineage commitment	PMID:28065600^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:28065600^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:28065600^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:28065600^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	PMID:12594516^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	PMID:12594516^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:12594516^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	PMID:12594516^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060259	regulation of feeding behavior	PMID:12594516^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0044320	cellular response to leptin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	PMID:8923468^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21234744^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21234744^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0060019	radial glial cell differentiation	PMID:15156153^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048708	astrocyte differentiation	PMID:15156153^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:23401489^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	PMID:15156153^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:15004007^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O54949	F		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:15664994^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	PMID:23401489^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:15664994^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15156153^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15156153^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001223	negative regulation of neuron migration	PMID:23321696^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1918021 MGI:MGI:95789	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001171	positive regulation of ATP biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000737	negative regulation of stem cell differentiation	PMID:25335925^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000637	positive regulation of gene silencing by miRNA	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904685	positive regulation of metalloendopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902728	positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099527	postsynapse to nucleus signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	C		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	PMID:19414010^[17]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P52631	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071345	cellular response to cytokine stimulus	PMID:19414010^[17]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P52631	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070102	interleukin-6-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060396	growth hormone receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051726	regulation of cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:11579100^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42225 UniProtKB:P42227	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046902	regulation of mitochondrial membrane permeability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20530874^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1933533	P	has_regulation_target:(MGI:MGI:96562) has_regulation_target:(MGI:MGI:96561) regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16801560^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96787	P	regulates_o_occurs_in:(CL:0000352) has_regulation_target:(MGI:MGI:1919200)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24843164^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19666510^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:107364)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15659653^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15096606^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11579100^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045820	negative regulation of glycolytic process	PMID:22891351^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045410	positive regulation of interleukin-6 biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044321	response to leptin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044320	cellular response to leptin stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:16801560^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000352) has_input:(MGI:MGI:1919200)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042789	mRNA transcription by RNA polymerase II	PMID:26026268^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042755	eating behavior	PMID:15070774^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2451328	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:15070774^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2451328	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040014	regulation of multicellular organism growth	PMID:15070774^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2451328	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035278	miRNA mediated inhibition of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
enables	GO:0035259	glucocorticoid receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034097	response to cytokine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032870	cellular response to hormone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032355	response to estradiol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
enables	GO:0031730	CCR5 chemokine receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	F		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019953	sexual reproduction	PMID:15070774^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2451328	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:20720539^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010507	negative regulation of autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:22891351^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:15659653^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	acts_on_population_of:(CL:0000100)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	PMID:11579100^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12826573^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16047)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19796622^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15749075^[31]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17386) part_of:(CL:0000039)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15096606^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12746441^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12634107^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24211183^[34]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17528)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22891351^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16801560^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15659653^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000100)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15096606^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12826573^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16047)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12634107^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15659653^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15096606^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12746441^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11579100^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3772	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001754	eye photoreceptor cell differentiation	PMID:15207851^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17168) results_in_acquisition_of_features_of:(CL:0000604)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001659	temperature homeostasis	PMID:15070774^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:2451328	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:26026268^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:15096606^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P40763	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23434585^[36]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17463090^[37]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
involved_in	GO:2000637	positive regulation of gene silencing by miRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:1904685	positive regulation of metalloendopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0060396	growth hormone receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0044320	cellular response to leptin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
involved_in	GO:0035278	miRNA mediated inhibition of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0032870	cellular response to hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
involved_in	GO:2001171	positive regulation of ATP biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:1902728	positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0045410	positive regulation of interleukin-6 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	F		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
enables	GO:0035259	glucocorticoid receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	F		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
enables	GO:0031730	CCR5 chemokine receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
involved_in	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	P		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52631 ensembl:ENSRNOP00000026760	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013801	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR008967	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR008967 InterPro:IPR013799 InterPro:IPR013800 InterPro:IPR015988	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR013799 InterPro:IPR013800 InterPro:IPR015988	P		Seeded From UniProt	complete
involved_in	GO:0007259	receptor signaling pathway via JAK-STAT	PMID:15664994^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-8982998 Reactome:R-MMU-8950442 Reactome:R-MMU-2730598 Reactome:R-MMU-2730597 Reactome:R-MMU-2671877 Reactome:R-MMU-2671854 Reactome:R-MMU-2671836 Reactome:R-MMU-1169206 Reactome:R-MMU-1169142	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-2730598	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0011	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhao, L et al. (2016) Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep 6 23972 PubMed GONUTS page
↑ ^2.0 ^2.1 Oh, HM et al. (2012) STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells. J. Biol. Chem. 287 30436-43 PubMed GONUTS page
↑ Choy, MK et al. (2010) High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure. Genome Med 2 37 PubMed GONUTS page
↑ ^4.0 ^4.1 Zhang, Y et al. () Mmu-miR-351 attenuates the survival of cardiac arterial endothelial cells through targeting STAT3 in the atherosclerotic mice. Biochem. Biophys. Res. Commun. 468 300-5 PubMed GONUTS page
↑ Loyer, X et al. (2014) Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice. Circ. Res. 114 434-43 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Gonzalez, RR et al. (2006) Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). J. Biol. Chem. 281 26320-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Ma, L et al. (2017) Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. Mol. Cell 65 296-309 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Bates, SH et al. (2003) STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421 856-9 PubMed GONUTS page
↑ Yi, W et al. (1996) Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase. Mol. Endocrinol. 10 1425-43 PubMed GONUTS page
↑ ^10.0 ^10.1 Marroquí, L et al. (2011) Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets. Diabetologia 54 843-51 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Kamakura, S et al. (2004) Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat. Cell Biol. 6 547-54 PubMed GONUTS page
↑ ^12.0 ^12.1 Choi, SM et al. (2013) Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia. J. Exp. Med. 210 551-61 PubMed GONUTS page
↑ Ohkawara, B et al. (2004) Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. Genes Dev. 18 381-6 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Numata, A et al. (2005) Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J. Biol. Chem. 280 12621-9 PubMed GONUTS page
↑ Larco, DO et al. (2013) The metabolite GnRH-(1-5) inhibits the migration of immortalized GnRH neurons. Endocrinology 154 783-95 PubMed GONUTS page
↑ Shen, J et al. (2015) Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling. Stem Cells 33 661-73 PubMed GONUTS page
↑ ^17.0 ^17.1 Lv, N et al. (2009) JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp. Cell Res. 315 2064-71 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Turkson, J et al. (2001) Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J. Biol. Chem. 276 45443-55 PubMed GONUTS page
↑ De Domenico, I et al. (2010) Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J. Clin. Invest. 120 2395-405 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Suzuki, A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 103 10294-9 PubMed GONUTS page
↑ Ortiz, B et al. (2014) Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis. Proc. Natl. Acad. Sci. U.S.A. 111 8149-54 PubMed GONUTS page
↑ Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Hao, A et al. (2005) The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities. Mol. Biol. Cell 16 1569-83 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 Fu, AK et al. (2004) Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proc. Natl. Acad. Sci. U.S.A. 101 6728-33 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Couto, JP et al. (2012) STAT3 negatively regulates thyroid tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 109 E2361-70 PubMed GONUTS page
↑ ^26.0 ^26.1 Ren, F et al. (2015) Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP. FEBS Lett. 589 1890-6 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 ^27.4 Gao, Q et al. (2004) Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc. Natl. Acad. Sci. U.S.A. 101 4661-6 PubMed GONUTS page
↑ Kagey, MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 430-5 PubMed GONUTS page
↑ ^29.0 ^29.1 Fedorcsák, P & Storeng, R (2003) Effects of leptin and leukemia inhibitory factor on preimplantation development and STAT3 signaling of mouse embryos in vitro. Biol. Reprod. 69 1531-8 PubMed GONUTS page
↑ ^30.0 ^30.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ Murphy, K et al. (2005) Expression of Stat3 in germ cells of developing and adult mouse ovaries and testes. Gene Expr. Patterns 5 475-82 PubMed GONUTS page
↑ ^32.0 ^32.1 Ma, J et al. (2003) A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation. J. Biol. Chem. 278 29252-60 PubMed GONUTS page
↑ ^33.0 ^33.1 Zhang, SS et al. (2003) Expression and activation of STAT proteins during mouse retina development. Exp. Eye Res. 76 421-31 PubMed GONUTS page
↑ Kumari, S et al. (2013) Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity 39 899-911 PubMed GONUTS page
↑ Ozawa, Y et al. (2004) Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina. Mol. Cell. Neurosci. 26 258-70 PubMed GONUTS page
↑ Nkansah, E et al. (2013) Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. FEBS Lett. 587 833-9 PubMed GONUTS page
↑ Siddiquee, K et al. (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc. Natl. Acad. Sci. U.S.A. 104 7391-6 PubMed GONUTS page

[PMID:27050391-1] Zhao, L et al. (2016) Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep 6 23972 PubMed GONUTS page

[PMID:22761423-2] 2.0 ^2.1 Oh, HM et al. (2012) STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells. J. Biol. Chem. 287 30436-43 PubMed GONUTS page

[PMID:20546595-3] Choy, MK et al. (2010) High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure. Genome Med 2 37 PubMed GONUTS page

[PMID:26505789-4] 4.0 ^4.1 Zhang, Y et al. () Mmu-miR-351 attenuates the survival of cardiac arterial endothelial cells through targeting STAT3 in the atherosclerotic mice. Biochem. Biophys. Res. Commun. 468 300-5 PubMed GONUTS page

[PMID:24255059-5] Loyer, X et al. (2014) Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice. Circ. Res. 114 434-43 PubMed GONUTS page

[PMID:16825198-6] 6.0 ^6.1 ^6.2 Gonzalez, RR et al. (2006) Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). J. Biol. Chem. 281 26320-8 PubMed GONUTS page

[PMID:28065600-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Ma, L et al. (2017) Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation. Mol. Cell 65 296-309 PubMed GONUTS page

[PMID:12594516-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Bates, SH et al. (2003) STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421 856-9 PubMed GONUTS page

[PMID:8923468-9] Yi, W et al. (1996) Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase. Mol. Endocrinol. 10 1425-43 PubMed GONUTS page

[PMID:21234744-10] 10.0 ^10.1 Marroquí, L et al. (2011) Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets. Diabetologia 54 843-51 PubMed GONUTS page

[PMID:15156153-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Kamakura, S et al. (2004) Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat. Cell Biol. 6 547-54 PubMed GONUTS page

[PMID:23401489-12] 12.0 ^12.1 Choi, SM et al. (2013) Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia. J. Exp. Med. 210 551-61 PubMed GONUTS page

[PMID:15004007-13] Ohkawara, B et al. (2004) Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. Genes Dev. 18 381-6 PubMed GONUTS page

[PMID:15664994-14] 14.0 ^14.1 ^14.2 Numata, A et al. (2005) Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J. Biol. Chem. 280 12621-9 PubMed GONUTS page

[PMID:23321696-15] Larco, DO et al. (2013) The metabolite GnRH-(1-5) inhibits the migration of immortalized GnRH neurons. Endocrinology 154 783-95 PubMed GONUTS page

[PMID:25335925-16] Shen, J et al. (2015) Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling. Stem Cells 33 661-73 PubMed GONUTS page

[PMID:19414010-17] 17.0 ^17.1 Lv, N et al. (2009) JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp. Cell Res. 315 2064-71 PubMed GONUTS page

[PMID:11579100-18] 18.0 ^18.1 ^18.2 ^18.3 Turkson, J et al. (2001) Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J. Biol. Chem. 276 45443-55 PubMed GONUTS page

[PMID:20530874-19] De Domenico, I et al. (2010) Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J. Clin. Invest. 120 2395-405 PubMed GONUTS page

[PMID:16801560-20] 20.0 ^20.1 ^20.2 Suzuki, A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 103 10294-9 PubMed GONUTS page

[PMID:24843164-21] Ortiz, B et al. (2014) Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis. Proc. Natl. Acad. Sci. U.S.A. 111 8149-54 PubMed GONUTS page

[PMID:19666510-22] Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page

[PMID:15659653-23] 23.0 ^23.1 ^23.2 ^23.3 Hao, A et al. (2005) The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities. Mol. Biol. Cell 16 1569-83 PubMed GONUTS page

[PMID:15096606-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 Fu, AK et al. (2004) Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity. Proc. Natl. Acad. Sci. U.S.A. 101 6728-33 PubMed GONUTS page

[PMID:22891351-25] 25.0 ^25.1 ^25.2 Couto, JP et al. (2012) STAT3 negatively regulates thyroid tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 109 E2361-70 PubMed GONUTS page

[PMID:26026268-26] 26.0 ^26.1 Ren, F et al. (2015) Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP. FEBS Lett. 589 1890-6 PubMed GONUTS page

[PMID:15070774-27] 27.0 ^27.1 ^27.2 ^27.3 ^27.4 Gao, Q et al. (2004) Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc. Natl. Acad. Sci. U.S.A. 101 4661-6 PubMed GONUTS page

[PMID:20720539-28] Kagey, MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 430-5 PubMed GONUTS page

[PMID:12826573-29] 29.0 ^29.1 Fedorcsák, P & Storeng, R (2003) Effects of leptin and leukemia inhibitory factor on preimplantation development and STAT3 signaling of mouse embryos in vitro. Biol. Reprod. 69 1531-8 PubMed GONUTS page

[PMID:19796622-30] 30.0 ^30.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:15749075-31] Murphy, K et al. (2005) Expression of Stat3 in germ cells of developing and adult mouse ovaries and testes. Gene Expr. Patterns 5 475-82 PubMed GONUTS page

[PMID:12746441-32] 32.0 ^32.1 Ma, J et al. (2003) A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation. J. Biol. Chem. 278 29252-60 PubMed GONUTS page

[PMID:12634107-33] 33.0 ^33.1 Zhang, SS et al. (2003) Expression and activation of STAT proteins during mouse retina development. Exp. Eye Res. 76 421-31 PubMed GONUTS page

[PMID:24211183-34] Kumari, S et al. (2013) Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity 39 899-911 PubMed GONUTS page

[PMID:15207851-35] Ozawa, Y et al. (2004) Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina. Mol. Cell. Neurosci. 26 258-70 PubMed GONUTS page

[PMID:23434585-36] Nkansah, E et al. (2013) Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. FEBS Lett. 587 833-9 PubMed GONUTS page

[PMID:17463090-37] Siddiquee, K et al. (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc. Natl. Acad. Sci. U.S.A. 104 7391-6 PubMed GONUTS page

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