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PMID:21234744
| Citation |
Marroquí, L, Vieira, E, Gonzalez, A, Nadal, A and Quesada, I (2011) Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets. Diabetologia 54:843-51 |
|---|---|
| Abstract |
Leptin, released by adipocytes, can modulate glucose homeostasis through direct actions on pancreatic alpha and beta cells. Although this hormone rapidly regulates alpha cell exocytosis, its long-term effects on glucagon gene expression are currently unknown. |
| Links |
PubMed Online version:10.1007/s00125-010-2024-1 |
| Keywords |
Animals; Blotting, Western; Cell Line; Female; Glucagon/genetics; Glucagon/metabolism; Immunohistochemistry; Islets of Langerhans/drug effects; Islets of Langerhans/metabolism; Leptin/pharmacology; Mice; Mice, Inbred C57BL; RNA, Small Interfering; Reverse Transcriptase Polymerase Chain Reaction |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
MOUSE:LEP |
involved_in |
GO:0001932: regulation of protein phosphorylation |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:LEP |
involved_in |
GO:0000122: negative regulation of transcription by RNA polymerase II |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:LEP |
involved_in |
GO:0007260: tyrosine phosphorylation of STAT protein |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:LEP |
involved_in |
GO:0070093: negative regulation of glucagon secretion |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:LEP |
involved_in |
GO:0046427: positive regulation of receptor signaling pathway via JAK-STAT |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
MOUSE:LEP |
involved_in |
GO:0042307: positive regulation of protein import into nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
located_in |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
located_in |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
MOUSE:GLUC |
located_in |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
See also
References
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