GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:15004007
| Citation |
Ohkawara, B, Shirakabe, K, Hyodo-Miura, J, Matsuo, R, Ueno, N, Matsumoto, K and Shibuya, H (2004) Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. Genes Dev. 18:381-6 |
|---|---|
| Abstract |
Transforming growth factor (TGF)-beta-activated kinase 1 (TAK1) and Nemo-like kinase (NLK) function in Xenopus, Drosophila, and Caenorhabditis elegans development. Here we report that serine phosphorylation of STAT3 induced by TAK1-NLK cascade is essential fo TGF-beta-mediated mesoderm induction in Xenopus embryo. Depletion of TAK1, NLK, or STAT3 blocks TGF-beta-mediated mesoderm induction. Coexpression of NLK and STAT3 induces mesoderm by a mechanism that requires serine phosphorylation of STAT3. Activin activates NLK, which in turn directly phosphorylates STAT3. Moreover, depletion of either TAK1 or NLK inhibits endogenous serine phosphorylation of STAT3. These results provide the first evidence that TAK1-NLK-STAT3 cascade participates in TGF-beta-mediated mesoderm induction. |
| Links |
PubMed PMC359392 Online version:10.1101/gad.1166904 |
| Keywords |
Amino Acid Substitution; Animals; Caenorhabditis elegans/enzymology; Carrier Proteins/genetics; DNA-Binding Proteins/genetics; Drosophila/embryology; Embryo, Nonmammalian/physiology; Intracellular Signaling Peptides and Proteins; Mesoderm/physiology; Mitogen-Activated Protein Kinases/genetics; Mutagenesis, Site-Directed; STAT3 Transcription Factor; Trans-Activators/genetics; Transforming Growth Factor beta/physiology; Xenopus/embryology; Xenopus Proteins/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
