RAT:STAT3

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Stat3
Protein Name(s)	Signal transducer and activator of transcription 3
External Links
UniProt	P52631
EMBL	X91810 BC087025
RefSeq	NP_036879.1
UniGene	Rn.10247
ProteinModelPortal	P52631
SMR	P52631
BioGrid	247196
DIP	DIP-44909N
MINT	MINT-1529438
STRING	10116.ENSRNOP00000026760
ChEMBL	CHEMBL1764933
PhosphoSite	P52631
PaxDb	P52631
PRIDE	P52631
Ensembl	ENSRNOT00000026760
GeneID	25125
KEGG	rno:25125
CTD	6774
RGD	3772
eggNOG	NOG303257
GeneTree	ENSGT00760000119236
HOGENOM	HOG000220792
HOVERGEN	HBG055669
InParanoid	P52631
KO	K04692
OMA	NKESHAT
OrthoDB	EOG73JKTT
PhylomeDB	P52631
TreeFam	TF318648
Reactome	REACT_195025 REACT_195204 REACT_196425 REACT_198628 REACT_199244 REACT_206819 REACT_212185 REACT_228003 REACT_234852
NextBio	605521
PRO	PR:P52631
Proteomes	UP000002494
Genevestigator	P52631
GO	GO:0005737 GO:0005829 GO:0005743 GO:0005739 GO:0005634 GO:0005886 GO:0005509 GO:0031730 GO:0003677 GO:0035259 GO:0004879 GO:0046983 GO:0019901 GO:0043565 GO:0003700 GO:0004871 GO:0008134 GO:0044212 GO:0006953 GO:0007568 GO:0048708 GO:0008283 GO:0042755 GO:0001754 GO:0042593 GO:0070102 GO:0007259 GO:0060397 GO:0060548 GO:0008285 GO:0045820 GO:0010730 GO:1901215 GO:2001223 GO:0016310 GO:2001171 GO:1902728 GO:0045747 GO:0045944 GO:0045893 GO:0006606 GO:0060019 GO:0046902 GO:0040014 GO:0006357 GO:0034097 GO:0042493 GO:0032355 GO:0045471 GO:0014070 GO:0010033 GO:0043434 GO:0019953 GO:0019827 GO:0001659
Gene3D	1.10.238.10 1.10.532.10 1.20.1050.20 2.60.40.630 3.30.505.10
InterPro	IPR011992 IPR008967 IPR000980 IPR001217 IPR013800 IPR015988 IPR013801 IPR012345 IPR013799
PANTHER	PTHR11801
Pfam	PF00017 PF01017 PF02864 PF02865
SMART	SM00252 SM00964
SUPFAM	SSF47655 SSF48092 SSF49417 SSF55550
PROSITE	PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0090184	positive regulation of kidney development	PMID:20624457^[1]	ECO:0000314			P		Although both STAT1 and STAT3 are present in adult rat kidney, little phosphorylated STAT1 and STAT3 can be detected indicating that they are not activated once development ceases (Fig 1 A)	complete
involved_in	GO:0045410	positive regulation of interleukin-6 biosynthetic process	PMID:29702085^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P16599	P	regulates_o_occurs_in:(CL:2000043) occurs_in:(CL:2000043)	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:29702085^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P16599	P	regulates_o_occurs_in:(CL:2000043) has_regulation_target:(UniProtKB:Q7TQN4) positively_regulates:(GO:0042226) occurs_in:(CL:2000043)	Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
involved_in	GO:0072540	T-helper 17 cell lineage commitment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0060259	regulation of feeding behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	F		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0044320	cellular response to leptin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0060019	radial glial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0048708	astrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0019953	sexual reproduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P40763	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:23271731^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	F		Seeded From UniProt	complete
involved_in	GO:0001754	eye photoreceptor cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42227	P		Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	PMID:22284190^[4]	ECO:0006042	cell fractionation evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	PMID:22284190^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	PMID:22284190^[4]	ECO:0000279	western blot evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:22284190^[4]	ECO:0006054	pharmacological assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:22284190^[4]	ECO:0006052	RNAi evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:22284190^[4]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:22284190^[4]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:22284190^[4]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:22284190^[4]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:22284190^[4]	ECO:0006054	pharmacological assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:22284190^[4]	ECO:0006052	RNAi evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:22284190^[4]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:22284190^[4]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:22284190^[4]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0098685)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:22284190^[4]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:22284190^[4]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(GO:0098685)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:22284190^[4]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:22284190^[4]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098685)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:10891587^[5]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:10891587^[5]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:10891587^[5]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:2001171	positive regulation of ATP biosynthetic process	PMID:23590160^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902728	positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	PMID:23869758^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:23884942^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:19450559^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	PMID:23590160^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:17916759^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:16648019^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	PMID:17911393^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:18031608^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035259	glucocorticoid receptor binding	PMID:20155810^[14]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2741	F		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:18270592^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:17916759^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031730	CCR5 chemokine receptor binding	PMID:14674010^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620596	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:18339648^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	PMID:23590160^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:17916759^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:23608221^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:22426029^[19]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620913	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19289167^[20]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:21633715^[21]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	PMID:8530402^[22]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:23271731^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:23895834^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17353091^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18230613^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16648019^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8530402^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	PMID:19414010^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	PMID:19414010^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000637	positive regulation of gene silencing by miRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:1904685	positive regulation of metalloendopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0060396	growth hormone receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0044320	cellular response to leptin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
involved_in	GO:0035278	miRNA mediated inhibition of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0032870	cellular response to hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P40763 ensembl:ENSP00000264657	C		Seeded From UniProt	complete
involved_in	GO:2001223	negative regulation of neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:2000737	negative regulation of stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:1905564	positive regulation of vascular endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0072540	T-helper 17 cell lineage commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0060259	regulation of feeding behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0060019	radial glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0048708	astrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0045820	negative regulation of glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
involved_in	GO:0042789	mRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0019953	sexual reproduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
involved_in	GO:0001754	eye photoreceptor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42227 ensembl:ENSMUSP00000120152	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013801	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR008967	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR008967 InterPro:IPR013799 InterPro:IPR013800 InterPro:IPR015988	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001217 InterPro:IPR013799 InterPro:IPR013800 InterPro:IPR015988	P		Seeded From UniProt	complete
involved_in	GO:0007259	receptor signaling pathway via JAK-STAT	PMID:8530402^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:8530402^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-RNO-198717	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wang, H et al. (2010) STAT1 activation regulates proliferation and differentiation of renal progenitors. Cell. Signal. 22 1717-26 PubMed GONUTS page
↑ ^2.0 ^2.1 Matsumoto, J et al. (2018) TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways. Brain Res. 1692 34-44 PubMed GONUTS page
↑ ^3.0 ^3.1 Tammineni, P et al. (2013) The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. J. Biol. Chem. 288 4723-32 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 Nicolas, CS et al. (2012) The Jak/STAT pathway is involved in synaptic plasticity. Neuron 73 374-90 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Murata, S et al. (2000) Occurrence of a transcription factor, signal transducer and activators of transcription 3 (Stat3), in the postsynaptic density of the rat brain. Brain Res. Mol. Brain Res. 78 80-90 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Boengler, K et al. (2013) The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation. Curr. Pharm. Des. 19 6890-5 PubMed GONUTS page
↑ Kurosaka, M & Machida, S (2013) Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting. Cell Prolif. 46 365-73 PubMed GONUTS page
↑ Sehara, Y et al. (2013) Survivin Is a transcriptional target of STAT3 critical to estradiol neuroprotection in global ischemia. J. Neurosci. 33 12364-74 PubMed GONUTS page
↑ Barry, SP et al. (2009) STAT3 deletion sensitizes cells to oxidative stress. Biochem. Biophys. Res. Commun. 385 324-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Chen, JR et al. (2008) Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade. J. Pharmacol. Exp. Ther. 324 50-9 PubMed GONUTS page
↑ ^11.0 ^11.1 Robinson, K et al. (2006) Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J. J. Am. Coll. Surg. 202 788-96 PubMed GONUTS page
↑ Anhê, GF et al. (2007) Signal transducer and activator of transcription 3-regulated sarcoendoplasmic reticulum Ca2+-ATPase 2 expression by prolactin and glucocorticoids is involved in the adaptation of insulin secretory response during the peripartum period. J. Endocrinol. 195 17-27 PubMed GONUTS page
↑ Shi, YH et al. (2007) Fluvastatin inhibits activation of JAK and STAT proteins in diabetic rat glomeruli and mesangial cells under high glucose conditions. Acta Pharmacol. Sin. 28 1938-46 PubMed GONUTS page
↑ Arambasić, J et al. (2010) Association of the glucocorticoid receptor with STAT3, C/EBPbeta, and the hormone-responsive element within the rat haptoglobin gene promoter during the acute phase response. IUBMB Life 62 227-36 PubMed GONUTS page
↑ Alten, JA et al. (2008) Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PLoS ONE 3 e1605 PubMed GONUTS page
↑ Shahrara, S et al. (2003) Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis. Arthritis Rheum. 48 3568-83 PubMed GONUTS page
↑ Suleman, N et al. (2008) Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning. Cardiovasc. Res. 79 127-33 PubMed GONUTS page
↑ Chung, H et al. (2013) Multiple signaling pathways mediate ghrelin-induced proliferation of hippocampal neural stem cells. J. Endocrinol. 218 49-59 PubMed GONUTS page
↑ Ma, H et al. (2012) Association of Stat3 with HSF1 plays a critical role in G-CSF-induced cardio-protection against ischemia/reperfusion injury. J. Mol. Cell. Cardiol. 52 1282-90 PubMed GONUTS page
↑ Torres, L et al. (2009) In vivo GSH depletion induces c-myc expression by modulation of chromatin protein complexes. Free Radic. Biol. Med. 46 1534-42 PubMed GONUTS page
↑ Van Kirk, CA et al. (2011) Age-related alterations in retinal neurovascular and inflammatory transcripts. Mol. Vis. 17 1261-74 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 Ripperger, JA et al. (1995) Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. J. Biol. Chem. 270 29998-30006 PubMed GONUTS page
↑ Zhang, M et al. (2013) [Change of cardiac mitochondrial STAT3 activity in rats with selenium deficiency and its relation with myocardial injury]. Nan Fang Yi Ke Da Xue Xue Bao 33 967-71 PubMed GONUTS page
↑ Mütze, J et al. (2007) Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration. Neurosci. Lett. 417 286-91 PubMed GONUTS page
↑ Romeo, GR & Kazlauskas, A (2008) Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. J. Biol. Chem. 283 9595-605 PubMed GONUTS page
↑ ^26.0 ^26.1 Lv, N et al. (2009) JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp. Cell Res. 315 2064-71 PubMed GONUTS page

[PMID:20624457-1] Wang, H et al. (2010) STAT1 activation regulates proliferation and differentiation of renal progenitors. Cell. Signal. 22 1717-26 PubMed GONUTS page

[PMID:29702085-2] 2.0 ^2.1 Matsumoto, J et al. (2018) TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways. Brain Res. 1692 34-44 PubMed GONUTS page

[PMID:23271731-3] 3.0 ^3.1 Tammineni, P et al. (2013) The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. J. Biol. Chem. 288 4723-32 PubMed GONUTS page

[PMID:22284190-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 Nicolas, CS et al. (2012) The Jak/STAT pathway is involved in synaptic plasticity. Neuron 73 374-90 PubMed GONUTS page

[PMID:10891587-5] 5.0 ^5.1 ^5.2 Murata, S et al. (2000) Occurrence of a transcription factor, signal transducer and activators of transcription 3 (Stat3), in the postsynaptic density of the rat brain. Brain Res. Mol. Brain Res. 78 80-90 PubMed GONUTS page

[PMID:23590160-6] 6.0 ^6.1 ^6.2 Boengler, K et al. (2013) The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation. Curr. Pharm. Des. 19 6890-5 PubMed GONUTS page

[PMID:23869758-7] Kurosaka, M & Machida, S (2013) Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting. Cell Prolif. 46 365-73 PubMed GONUTS page

[PMID:23884942-8] Sehara, Y et al. (2013) Survivin Is a transcriptional target of STAT3 critical to estradiol neuroprotection in global ischemia. J. Neurosci. 33 12364-74 PubMed GONUTS page

[PMID:19450559-9] Barry, SP et al. (2009) STAT3 deletion sensitizes cells to oxidative stress. Biochem. Biophys. Res. Commun. 385 324-9 PubMed GONUTS page

[PMID:17916759-10] 10.0 ^10.1 ^10.2 Chen, JR et al. (2008) Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade. J. Pharmacol. Exp. Ther. 324 50-9 PubMed GONUTS page

[PMID:16648019-11] 11.0 ^11.1 Robinson, K et al. (2006) Peptide YY attenuates STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J. J. Am. Coll. Surg. 202 788-96 PubMed GONUTS page

[PMID:17911393-12] Anhê, GF et al. (2007) Signal transducer and activator of transcription 3-regulated sarcoendoplasmic reticulum Ca2+-ATPase 2 expression by prolactin and glucocorticoids is involved in the adaptation of insulin secretory response during the peripartum period. J. Endocrinol. 195 17-27 PubMed GONUTS page

[PMID:18031608-13] Shi, YH et al. (2007) Fluvastatin inhibits activation of JAK and STAT proteins in diabetic rat glomeruli and mesangial cells under high glucose conditions. Acta Pharmacol. Sin. 28 1938-46 PubMed GONUTS page

[PMID:20155810-14] Arambasić, J et al. (2010) Association of the glucocorticoid receptor with STAT3, C/EBPbeta, and the hormone-responsive element within the rat haptoglobin gene promoter during the acute phase response. IUBMB Life 62 227-36 PubMed GONUTS page

[PMID:18270592-15] Alten, JA et al. (2008) Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PLoS ONE 3 e1605 PubMed GONUTS page

[PMID:14674010-16] Shahrara, S et al. (2003) Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis. Arthritis Rheum. 48 3568-83 PubMed GONUTS page

[PMID:18339648-17] Suleman, N et al. (2008) Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning. Cardiovasc. Res. 79 127-33 PubMed GONUTS page

[PMID:23608221-18] Chung, H et al. (2013) Multiple signaling pathways mediate ghrelin-induced proliferation of hippocampal neural stem cells. J. Endocrinol. 218 49-59 PubMed GONUTS page

[PMID:22426029-19] Ma, H et al. (2012) Association of Stat3 with HSF1 plays a critical role in G-CSF-induced cardio-protection against ischemia/reperfusion injury. J. Mol. Cell. Cardiol. 52 1282-90 PubMed GONUTS page

[PMID:19289167-20] Torres, L et al. (2009) In vivo GSH depletion induces c-myc expression by modulation of chromatin protein complexes. Free Radic. Biol. Med. 46 1534-42 PubMed GONUTS page

[PMID:21633715-21] Van Kirk, CA et al. (2011) Age-related alterations in retinal neurovascular and inflammatory transcripts. Mol. Vis. 17 1261-74 PubMed GONUTS page

[PMID:8530402-22] 22.0 ^22.1 ^22.2 ^22.3 Ripperger, JA et al. (1995) Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. J. Biol. Chem. 270 29998-30006 PubMed GONUTS page

[PMID:23895834-23] Zhang, M et al. (2013) [Change of cardiac mitochondrial STAT3 activity in rats with selenium deficiency and its relation with myocardial injury]. Nan Fang Yi Ke Da Xue Xue Bao 33 967-71 PubMed GONUTS page

[PMID:17353091-24] Mütze, J et al. (2007) Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration. Neurosci. Lett. 417 286-91 PubMed GONUTS page

[PMID:18230613-25] Romeo, GR & Kazlauskas, A (2008) Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. J. Biol. Chem. 283 9595-605 PubMed GONUTS page

[PMID:19414010-26] 26.0 ^26.1 Lv, N et al. (2009) JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp. Cell Res. 315 2064-71 PubMed GONUTS page

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RAT:STAT3

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