GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:21633715
Citation |
Van Kirk, CA, VanGuilder, HD, Young, M, Farley, JA, Sonntag, WE and Freeman, WM (2011) Age-related alterations in retinal neurovascular and inflammatory transcripts. Mol. Vis. 17:1261-74 |
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Abstract |
Vision loss is one of the most common complications of aging, even in individuals with no diagnosed ocular disease. Increasing age induces structural alterations and functional impairments in retinal neurons and microvasculature linked to the activation of proinflammatory signaling pathways. Commonalities between the effects of aging and those observed with diabetes, including visual impairment, vascular dysfunction, and increased inflammatory response, have led to the hypothesis that diabetes-associated pathologies reflect an "advanced aging" phenotype. The goal of this study was to investigate the effects of aging on retinal mRNA expression of neurovascular and inflammatory transcripts previously demonstrated to be regulated with diabetes. |
Links | |
Keywords |
Aging/metabolism; Animals; Blood Glucose/metabolism; Hybridization, Genetic; Inflammation/genetics; Male; Microcirculation/genetics; Neurons/physiology; RNA, Messenger/metabolism; Rats; Rats, Inbred BN; Rats, Inbred F344; Retina/metabolism; Retinal Vessels/physiology; Reverse Transcriptase Polymerase Chain Reaction |
Significance
Annotations
Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|
involved_in |
GO:0007568: aging |
ECO:0000270: expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007568: aging |
ECO:0000270: expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007568: aging |
ECO:0000270: expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Notes
See also
References
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