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PMID:21633715

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Citation

Van Kirk, CA, VanGuilder, HD, Young, M, Farley, JA, Sonntag, WE and Freeman, WM (2011) Age-related alterations in retinal neurovascular and inflammatory transcripts. Mol. Vis. 17:1261-74

Abstract

Vision loss is one of the most common complications of aging, even in individuals with no diagnosed ocular disease. Increasing age induces structural alterations and functional impairments in retinal neurons and microvasculature linked to the activation of proinflammatory signaling pathways. Commonalities between the effects of aging and those observed with diabetes, including visual impairment, vascular dysfunction, and increased inflammatory response, have led to the hypothesis that diabetes-associated pathologies reflect an "advanced aging" phenotype. The goal of this study was to investigate the effects of aging on retinal mRNA expression of neurovascular and inflammatory transcripts previously demonstrated to be regulated with diabetes.

Links

PubMed PMC3103744

Keywords

Aging/metabolism; Animals; Blood Glucose/metabolism; Hybridization, Genetic; Inflammation/genetics; Male; Microcirculation/genetics; Neurons/physiology; RNA, Messenger/metabolism; Rats; Rats, Inbred BN; Rats, Inbred F344; Retina/metabolism; Retinal Vessels/physiology; Reverse Transcriptase Polymerase Chain Reaction

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:STAT3

involved_in

GO:0007568: aging

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:LITAF

involved_in

GO:0007568: aging

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:IC1

involved_in

GO:0007568: aging

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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