RAT:LITAF

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Litaf
Protein Name(s)	Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog LPS-induced TNF-alpha factor homolog Estrogen-enhanced transcript protein 1 Eet-1
External Links
UniProt	P0C0T0
EMBL	U53184
RefSeq	NP_001099205.1
UniGene	Rn.6940
PaxDb	P0C0T0
PRIDE	P0C0T0
Ensembl	ENSRNOT00000003412
GeneID	65161
KEGG	rno:65161
UCSC	RGD:69294
CTD	9516
RGD	69294
eggNOG	NOG41852
GeneTree	ENSGT00540000071542
HOGENOM	HOG000039585
HOVERGEN	HBG006272
InParanoid	P0C0T0
OMA	PFCIDAL
OrthoDB	EOG7XH6RR
PhylomeDB	P0C0T0
TreeFam	TF313294
NextBio	614025
PRO	PR:P0C0T0
Proteomes	UP000002494
ExpressionAtlas	P0C0T0
Genevestigator	P0C0T0
GO	GO:0005576 GO:0005794 GO:0005765 GO:0005634 GO:0005886 GO:0004871 GO:0050699 GO:0007568 GO:0006915 GO:0071222 GO:0042347 GO:0043123 GO:0001817 GO:0006355 GO:0006351
InterPro	IPR006629
Pfam	PF10601
SMART	SM00714

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0050663	cytokine secretion	PMID:17475886^[1]	ECO:0000314			P	Figure 7B	complete CACAO 5105
part_of	GO:0098574	cytoplasmic side of lysosomal membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
part_of	GO:0098560	cytoplasmic side of late endosome membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
part_of	GO:0098559	cytoplasmic side of early endosome membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	F	Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	F	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	P	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99732	C	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:21633715^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0098574	cytoplasmic side of lysosomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0098560	cytoplasmic side of late endosome membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0098559	cytoplasmic side of early endosome membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	C	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99732 ensembl:ENSP00000459533	F	Seeded From UniProt	complete
involved_in	GO:1901223	negative regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLJ0 ensembl:ENSMUSP00000023143	P	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLJ0 ensembl:ENSMUSP00000023143	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLJ0 ensembl:ENSMUSP00000023143	P	Seeded From UniProt	complete
involved_in	GO:0001817	regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLJ0 ensembl:ENSMUSP00000023143	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:12467897^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0157	C	Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0151	C	Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ripoll, VM et al. (2007) Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. J. Immunol. 178 6557-66 PubMed GONUTS page
↑ Van Kirk, CA et al. (2011) Age-related alterations in retinal neurovascular and inflammatory transcripts. Mol. Vis. 17 1261-74 PubMed GONUTS page
↑ Hamano, H et al. (2002) Regulation of brain cell environment on neuronal protection: role of TNFalpha in glia cells. Life Sci. 72 565-74 PubMed GONUTS page

[PMID:17475886-1] Ripoll, VM et al. (2007) Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. J. Immunol. 178 6557-66 PubMed GONUTS page

[PMID:21633715-2] Van Kirk, CA et al. (2011) Age-related alterations in retinal neurovascular and inflammatory transcripts. Mol. Vis. 17 1261-74 PubMed GONUTS page

[PMID:12467897-3] Hamano, H et al. (2002) Regulation of brain cell environment on neuronal protection: role of TNFalpha in glia cells. Life Sci. 72 565-74 PubMed GONUTS page

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RAT:LITAF

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