MOUSE:PPARD

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ppard (synonyms: Nr1c2, Pparb)
Protein Name(s)	Peroxisome proliferator-activated receptor delta PPAR-delta Nuclear hormone receptor 1 NUC1 Nuclear receptor subfamily 1 group C member 2 Peroxisome proliferator-activated receptor beta PPAR-beta
External Links
UniProt	P35396
EMBL	L28116 U10375 BC070398 U01665
CCDS	CCDS28575.1
PIR	I55442
RefSeq	NP_035275.1 XP_006523922.1 XP_006536796.1
UniGene	Mm.328914
ProteinModelPortal	P35396
SMR	P35396
BioGrid	202319
DIP	DIP-29851N
IntAct	P35396
BindingDB	P35396
ChEMBL	CHEMBL2458
PhosphoSite	P35396
PRIDE	P35396
Ensembl	ENSMUST00000002320
GeneID	19015
KEGG	mmu:19015
UCSC	uc008bqk.1
CTD	5467
MGI	MGI:101884
eggNOG	NOG266867
HOGENOM	HOG000261626
HOVERGEN	HBG106004
InParanoid	P35396
KO	K04504
OMA	MNVPQVE
OrthoDB	EOG7X9G7F
PhylomeDB	P35396
TreeFam	TF316304
Reactome	REACT_226284 REACT_234105 REACT_257268
NextBio	295440
PRO	PR:P35396
Proteomes	UP000000589
Bgee	P35396
CleanEx	MM_PPARD
ExpressionAtlas	P35396
Genevestigator	P35396
GO	GO:0005634 GO:0003677 GO:0008144 GO:0008047 GO:0004879 GO:0070539 GO:0008289 GO:0016501 GO:0046982 GO:0046965 GO:0043565 GO:0003707 GO:0003713 GO:0008270 GO:0060612 GO:0097190 GO:0008366 GO:0030154 GO:0008283 GO:0031589 GO:0009987 GO:0071456 GO:0046697 GO:0007566 GO:0008544 GO:0006635 GO:0015908 GO:0007186 GO:0007507 GO:0030522 GO:0051546 GO:0043616 GO:0006629 GO:0009299 GO:0043066 GO:0030308 GO:0032966 GO:0050680 GO:0050728 GO:0014912 GO:0048662 GO:0000122 GO:0008654 GO:0001890 GO:0043085 GO:0008284 GO:0045684 GO:0032024 GO:0014068 GO:0045893 GO:0045909 GO:0006029 GO:0042127 GO:0045598 GO:0050796 GO:0014823 GO:0009749 GO:0033189 GO:0006776 GO:0042060
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR003074 IPR003075 IPR008946 IPR000536 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR01288 PR01290 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0000790	nuclear chromatin	PMID:20445066^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0000167) coincident_with:(ENSEMBL:ENSMUSG00000093007)	Seeded From UniProt	complete
involved_in	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	PMID:20445066^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000093007)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:20445066^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(ENSEMBL:ENSMUSG00000093007)	Seeded From UniProt	complete
involved_in	GO:0043415	positive regulation of skeletal muscle tissue regeneration	PMID:22040534^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	PMID:22040534^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014842	regulation of skeletal muscle satellite cell proliferation	PMID:22040534^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:22040534^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000288	positive regulation of myoblast proliferation	PMID:22040534^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070539	linoleic acid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03181	F		Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	PMID:14676330^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03181	P		Seeded From UniProt	complete
involved_in	GO:0015908	fatty acid transport	PMID:14676330^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03181	F		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03181	F		Seeded From UniProt	complete
involved_in	GO:0006635	fatty acid beta-oxidation	PMID:14676330^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q03181	F		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352462 PANTHER:PTN000637751 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:Q13133	C		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000638181 RGD:3370	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:104740 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:1352464 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3371 RGD:3857 RGD:61906 RGD:628831 UniProtKB:O62807 UniProtKB:O75469 UniProtKB:P10276 UniProtKB:P11473 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14994 UniProtKB:Q8JHU1 UniProtKB:Q96RI1 WB:WBGene00000908	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637985	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN000637751	F		Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN001941333 RGD:3371	P		Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN001182169 RGD:3371	P		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97747 PANTHER:PTN000637751 UniProtKB:O62807 UniProtKB:P37231	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN000637751	P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000637985 RGD:3371	P		Seeded From UniProt	complete
involved_in	GO:0010887	negative regulation of cholesterol storage	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:P37231 UniProtKB:Q07869	P		Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001941333 UniProtKB:P10827	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN001182169 UniProtKB:Q03181 UniProtKB:Q07869	F		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97856 PANTHER:PTN000637751 RGD:3371 RGD:3534 UniProtKB:P10276 UniProtKB:P10827 UniProtKB:P37231 UniProtKB:Q03181 UniProtKB:Q07869 ZFIN:ZDB-GENE-000210-31	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103076 PANTHER:PTN000637751	P		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104740 PANTHER:PTN001182169 RGD:3369	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0000568 MGI:MGI:101884 MGI:MGI:1346307 MGI:MGI:1352462 MGI:MGI:1352463 MGI:MGI:2444210 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97858 MGI:MGI:98742 MGI:MGI:98743 PANTHER:PTN000637751 RGD:3369 RGD:3370 RGD:3371 RGD:3534 RGD:3857 RGD:61909 RGD:621400 RGD:628831 UniProtKB:O62807 UniProtKB:P04625 UniProtKB:P10276 UniProtKB:P10826 UniProtKB:P10827 UniProtKB:P11473 UniProtKB:P13631 UniProtKB:P37231 UniProtKB:P55055 UniProtKB:P68306 UniProtKB:Q07869 UniProtKB:Q13133 UniProtKB:Q14995 WB:WBGene00000908 WB:WBGene00003607 WB:WBGene00004786 ZFIN:ZDB-GENE-990415-263	C		Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 RGD:3370	F		Seeded From UniProt	complete
	GO:2000288	positive regulation of myoblast proliferation	PMID:22040534^[2]	ECO:0000315			P		Fig. 2BE, and Fig. 3	complete CACAO 2771
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 PANTHER:PTN001182169	F		Seeded From UniProt	complete
	GO:0010628	positive regulation of gene expression	PMID:22040534^[2]	ECO:0000315			P		Fig. 1EF	complete CACAO 2772
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001182169 UniProtKB:Q07869	F		Seeded From UniProt	complete
	GO:0014842	regulation of satellite cell proliferation	PMID:22040534^[2]	ECO:0000315			P		Fig. 2ACD; positive regulation	complete CACAO 2773
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 PANTHER:PTN000637751 RGD:61906	F		Seeded From UniProt	complete
	GO:0045662	negative regulation of myoblast differentiation	PMID:22040534^[2]	ECO:0000315			P		Fig. 2E	complete CACAO 2774
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 FB:FBgn0015240 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 PANTHER:PTN000637751 UniProtKB:O75469 UniProtKB:P20393 UniProtKB:Q14994 UniProtKB:Q96RI1 WB:WBGene00004786	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000546 MGI:MGI:98742 PANTHER:PTN000637751 RGD:628827 UniProtKB:Q96RI1	F		Seeded From UniProt	complete
	GO:0043415	positive regulation of skeletal muscle tissue regeneration	PMID:22040534^[2]	ECO:0000315			P		Fig. 4(A-D)	complete CACAO 2775
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101884 MGI:MGI:2449205 MGI:MGI:97747 MGI:MGI:97856 MGI:MGI:97857 MGI:MGI:97858 MGI:MGI:98743 PANTHER:PTN001941333 UniProtKB:P20393 UniProtKB:P37231 UniProtKB:Q07869 WB:WBGene00004786	P		Seeded From UniProt	complete
	GO:2000288	positive regulation of myoblast proliferation	PMID:22040534^[2]	ECO:0000315			P		Figure 3D, Ppard cKO muscle showed reduced growth rate of myoblasts cells compared to wild type.	complete CACAO 3208
acts_upstream_of_or_within	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03181	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	PMID:24011070^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106918 MGI:MGI:2676890 MGI:MGI:3618742	P	occurs_in:(EMAPA:32688)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
enables	GO:0070539	linoleic acid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03181	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060612	adipose tissue development	PMID:11756685^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386684	P	results_in_development_of:(EMAPA:35112)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051546	keratinocyte migration	PMID:11514592^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3575004	P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050728	negative regulation of inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:14758356^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:10385625^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P28700	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03181	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045684	positive regulation of epidermis development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045598	regulation of fat cell differentiation	PMID:11756685^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386684	P	occurs_in:(EMAPA:19209) results_in_acquisition_of_features_of:(CL:0000136)\|occurs_in(EMAPA:35926) results_in_acquisition_of_features_of:(CL:0000136)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043616	keratinocyte proliferation	PMID:11511099^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3575004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:15380519^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:10866668^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1889516	P	acts_on_population_of:(CL:0000362)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042060	wound healing	PMID:11514592^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3575004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032966	negative regulation of collagen biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032024	positive regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031589	cell-substrate adhesion	PMID:11514592^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3575004	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:16581799^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_acquisition_of_features_of:(CL:0000351)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:16581799^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_acquisition_of_features_of:(CL:0000351)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019395	fatty acid oxidation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014912	negative regulation of smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:16581799^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000351)\|regulates_o_occurs_in:(EMAPA:16042) regulates_o_occurs_in:(CL:0000351)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009299	mRNA transcription	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008654	phospholipid biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008366	axon ensheathment	PMID:10866668^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1889516	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03181	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:11756685^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386684	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03181	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03181	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007566	embryo implantation	PMID:10385625^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03181	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006776	vitamin A metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006629	lipid metabolic process	PMID:16581799^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3623147	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006629	lipid metabolic process	PMID:10866668^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1889516	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006629	lipid metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006029	proteoglycan metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10385625^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	C		Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03181	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3370	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q03181	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8041794^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001890	placenta development	PMID:11756685^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386684	P	results_in_development_of:(EMAPA:16042)\|results_in_development_of:(EMAPA:35689)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001890	placenta development	PMID:11756685^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386684	P	results_in_development_of:(EMAPA:16042)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:8041794^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016501	P		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0030522	intracellular receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004879	P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008047	P		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03181 ensembl:ENSP00000310928	P		Seeded From UniProt	complete
enables	GO:0070539	linoleic acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03181 ensembl:ENSP00000310928	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03181 ensembl:ENSP00000310928	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03181 ensembl:ENSP00000310928	F		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03181 ensembl:ENSP00000310928	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03181 ensembl:ENSP00000310928	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03181 ensembl:ENSP00000310928	P		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03181 ensembl:ENSP00000310928	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q03181 ensembl:ENSP00000310928	F		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	F		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0045684	positive regulation of epidermis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0032966	negative regulation of collagen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0014912	negative regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0009299	mRNA transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0008654	phospholipid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0006776	vitamin A metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
involved_in	GO:0006029	proteoglycan metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	C		Seeded From UniProt	complete
enables	GO:0005504	fatty acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99ND3 ensembl:ENSRNOP00000069522	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003075	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003074 InterPro:IPR003075	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003075	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR003074 InterPro:IPR003075 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:15001550^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046965	retinoid X receptor binding	PMID:15001550^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016501	prostacyclin receptor activity	PMID:10754535^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008047	enzyme activator activity	PMID:14677574^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	PMID:15001550^[15] PMID:10754535^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009987	cellular process	PMID:10866668^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	PMID:10866668^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004879	nuclear receptor activity	PMID:10866668^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Yin, KJ et al. (2010) Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury. J. Neurosci. 30 6398-408 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Angione, AR et al. (2011) PPARδ regulates satellite cell proliferation and skeletal muscle regeneration. Skelet Muscle 1 33 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Tanaka, T et al. (2003) Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc. Natl. Acad. Sci. U.S.A. 100 15924-9 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 ^4.20 ^4.21 ^4.22 ^4.23 ^4.24 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ el Azzouzi, H et al. (2013) The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation. Cell Metab. 18 341-54 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Barak, Y et al. (2002) Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc. Natl. Acad. Sci. U.S.A. 99 303-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Michalik, L et al. (2001) Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J. Cell Biol. 154 799-814 PubMed GONUTS page
↑ Gupta, RA et al. (2004) Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat. Med. 10 245-7 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Lim, H et al. (1999) Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev. 13 1561-74 PubMed GONUTS page
↑ Melis, E et al. (2001) Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development. Biochem. Biophys. Res. Commun. 286 580-6 PubMed GONUTS page
↑ Wang, D et al. (2004) Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 6 285-95 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Peters, JM et al. (2000) Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol. Cell. Biol. 20 5119-28 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Nadra, K et al. (2006) Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Mol. Cell. Biol. 26 3266-81 PubMed GONUTS page
↑ ^14.0 ^14.1 Kliewer, SA et al. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. U.S.A. 91 7355-9 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Lim, HJ et al. (2004) Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells. Endocrinology 145 2886-95 PubMed GONUTS page
↑ ^16.0 ^16.1 Lim, H & Dey, SK () PPAR delta functions as a prostacyclin receptor in blastocyst implantation. Trends Endocrinol. Metab. 11 137-42 PubMed GONUTS page
↑ Wolf, G (2003) The function of the nuclear receptor peroxisome proliferator-activated receptor delta in energy homeostasis. Nutr. Rev. 61 387-90 PubMed GONUTS page

[PMID:20445066-1] 1.0 ^1.1 ^1.2 Yin, KJ et al. (2010) Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury. J. Neurosci. 30 6398-408 PubMed GONUTS page

[PMID:22040534-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Angione, AR et al. (2011) PPARδ regulates satellite cell proliferation and skeletal muscle regeneration. Skelet Muscle 1 33 PubMed GONUTS page

[PMID:14676330-3] 3.0 ^3.1 ^3.2 Tanaka, T et al. (2003) Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc. Natl. Acad. Sci. U.S.A. 100 15924-9 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 ^4.20 ^4.21 ^4.22 ^4.23 ^4.24 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24011070-5] Azzouzi, H et al. (2013) The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation. Cell Metab. 18 341-54 PubMed GONUTS page

[PMID:11756685-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Barak, Y et al. (2002) Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc. Natl. Acad. Sci. U.S.A. 99 303-8 PubMed GONUTS page

[PMID:11514592-7] 7.0 ^7.1 ^7.2 Michalik, L et al. (2001) Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J. Cell Biol. 154 799-814 PubMed GONUTS page

[PMID:14758356-8] Gupta, RA et al. (2004) Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat. Med. 10 245-7 PubMed GONUTS page

[PMID:10385625-9] 9.0 ^9.1 ^9.2 Lim, H et al. (1999) Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev. 13 1561-74 PubMed GONUTS page

[PMID:11511099-10] Melis, E et al. (2001) Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development. Biochem. Biophys. Res. Commun. 286 580-6 PubMed GONUTS page

[PMID:15380519-11] Wang, D et al. (2004) Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 6 285-95 PubMed GONUTS page

[PMID:10866668-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Peters, JM et al. (2000) Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol. Cell. Biol. 20 5119-28 PubMed GONUTS page

[PMID:16581799-13] 13.0 ^13.1 ^13.2 ^13.3 Nadra, K et al. (2006) Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Mol. Cell. Biol. 26 3266-81 PubMed GONUTS page

[PMID:8041794-14] 14.0 ^14.1 Kliewer, SA et al. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. U.S.A. 91 7355-9 PubMed GONUTS page

[PMID:15001550-15] 15.0 ^15.1 ^15.2 Lim, HJ et al. (2004) Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells. Endocrinology 145 2886-95 PubMed GONUTS page

[PMID:10754535-16] 16.0 ^16.1 Lim, H & Dey, SK () PPAR delta functions as a prostacyclin receptor in blastocyst implantation. Trends Endocrinol. Metab. 11 137-42 PubMed GONUTS page

[PMID:14677574-17] Wolf, G (2003) The function of the nuclear receptor peroxisome proliferator-activated receptor delta in energy homeostasis. Nutr. Rev. 61 387-90 PubMed GONUTS page

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MOUSE:PPARD

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