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PMID:10754535
| Citation |
Lim, H and Dey, SK PPAR delta functions as a prostacyclin receptor in blastocyst implantation. Trends Endocrinol. Metab. 11:137-42 |
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| Abstract |
Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone superfamily, are the target of extensive investigation because of their role in various pathophysiological processes. Recently, a novel biological function of PPAR delta, a less studied member of the family, was observed in the mouse. Evidence suggests that cyclooxygenase 2-derived prostacyclin mediates blastocyst implantation via this receptor. In this review, this new function of PPAR delta in implantation is highlighted, and future directions to investigate its mechanism of action are discussed. |
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| Keywords |
Animals; Blastocyst/physiology; Embryo Implantation/physiology; Prostaglandins/physiology; Receptors, Cell Surface/physiology; Receptors, Cytoplasmic and Nuclear/physiology; Receptors, Epoprostenol; Receptors, Prostaglandin/physiology; Signal Transduction/physiology; Transcription Factors/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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