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PMID:10866668
| Citation |
Peters, JM, Lee, SS, Li, W, Ward, JM, Gavrilova, O, Everett, C, Reitman, ML, Hudson, LD and Gonzalez, FJ (2000) Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol. Cell. Biol. 20:5119-28 |
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| Abstract |
To determine the physiological roles of peroxisome proliferator-activated receptor beta (PPARbeta), null mice were constructed by targeted disruption of the ligand binding domain of the murine PPARbeta gene. Homozygous PPARbeta-null term fetuses were smaller than controls, and this phenotype persisted postnatally. Gonadal adipose stores were smaller, and constitutive mRNA levels of CD36 were higher, in PPARbeta-null mice than in controls. In the brain, myelination of the corpus callosum was altered in PPARbeta-null mice. PPARbeta was not required for induction of mRNAs involved in epidermal differentiation induced by O-tetradecanoylphorbol-13-acetate (TPA). The hyperplastic response observed in the epidermis after TPA application was significantly greater in the PPARbeta-null mice than in controls. Inflammation induced by TPA in the skin was lower in wild-type mice fed sulindac than in similarly treated PPARbeta-null mice. These results are the first to provide in vivo evidence of significant roles for PPARbeta in development, myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. |
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| Keywords |
Adipose Tissue/abnormalities; Animals; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Antigens, CD36/genetics; Antigens, CD36/metabolism; Body Constitution/genetics; Body Temperature/genetics; Brain/abnormalities; Brain/pathology; Brain/physiology; Embryonic and Fetal Development/genetics; Fasting; Female; Hyperplasia; Inflammation/chemically induced; Inflammation/drug therapy; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myelin Sheath/metabolism; Receptors, Cytoplasmic and Nuclear/drug effects; Receptors, Cytoplasmic and Nuclear/genetics; Receptors, Cytoplasmic and Nuclear/metabolism; Skin/pathology; Sulindac/pharmacology; Tetradecanoylphorbol Acetate/toxicity; Transcription Factors/drug effects; Transcription Factors/genetics; Transcription Factors/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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