Category:GO:0097190 ! apoptotic signaling pathway

name: apoptotic signaling pathway
namespace: biological_process
alt_id: GO:0008624
def: "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis]
comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
synonym: "apoptotic signalling pathway" EXACT [GOC:mah]
synonym: "induction of apoptosis by extracellular signals" EXACT []
is_a: GO:0007165 ! signal transduction
relationship: part_of: GO:0006915 ! apoptotic process

AmiGO <GOterm>GO:0097190</GOterm>
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