HUMAN:M3K5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAP3K5 (synonyms: ASK1, MAPKKK5, MEKK5)
Protein Name(s)	Mitogen-activated protein kinase kinase kinase 5 Apoptosis signal-regulating kinase 1 ASK-1 MAPK/ERK kinase kinase 5 MEK kinase 5 MEKK 5
External Links
UniProt	Q99683
EMBL	U67156 D84476 AK294507 AL024508 AL121933 AL121933 AL024508 BC054503 BC088829
CCDS	CCDS5179.1
RefSeq	NP_005914.1
UniGene	Hs.186486
PDB	2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE
PDBsum	2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE
ProteinModelPortal	Q99683
SMR	Q99683
BioGrid	110381
DIP	DIP-29516N
IntAct	Q99683
MINT	MINT-99796
STRING	9606.ENSP00000351908
BindingDB	Q99683
ChEMBL	CHEMBL5285
GuidetoPHARMACOLOGY	2080
PhosphoSite	Q99683
DMDM	6685617
MaxQB	Q99683
PaxDb	Q99683
PRIDE	Q99683
DNASU	4217
Ensembl	ENST00000359015
GeneID	4217
KEGG	hsa:4217
UCSC	uc003qhc.3
CTD	4217
GeneCards	GC06M136878
HGNC	HGNC:6857
HPA	CAB007824
MIM	602448
neXtProt	NX_Q99683
PharmGKB	PA30601
eggNOG	COG0515
GeneTree	ENSGT00760000119077
HOVERGEN	HBG006305
InParanoid	Q99683
KO	K04426
OMA	TELHCKK
OrthoDB	EOG7WDN1P
PhylomeDB	Q99683
TreeFam	TF105115
BRENDA	2.7.12.2
Reactome	REACT_169436
SignaLink	Q99683
ChiTaRS	MAP3K5
EvolutionaryTrace	Q99683
GeneWiki	ASK1
GenomeRNAi	4217
NextBio	16633
PRO	PR:Q99683
Proteomes	UP000005640
Bgee	Q99683
CleanEx	HS_MAP3K5
ExpressionAtlas	Q99683
Genevestigator	Q99683
GO	GO:0005829 GO:0005783 GO:1902911 GO:0005524 GO:0008656 GO:0000287 GO:0004709 GO:0042803 GO:0004672 GO:0019903 GO:0006919 GO:0007257 GO:0000186 GO:0097190 GO:0070301 GO:1902170 GO:0045087 GO:0008631 GO:0007254 GO:0000165 GO:0043065 GO:0043280 GO:1901216 GO:0097300 GO:0006468 GO:0002931 GO:0016032
InterPro	IPR025136 IPR011009 IPR000719 IPR017441 IPR013761 IPR002290 IPR008271
Pfam	PF13281 PF00069
SMART	SM00220
SUPFAM	SSF47769 SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11096076^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:11096076^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:11096076^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P47897	F		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	PMID:11096076^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051403	stress-activated MAPK cascade	PMID:11096076^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11096076^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:11096076^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1990604	IRE1-TRAF2-ASK1 complex	PMID:23000344^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:23000344^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	PMID:23000344^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35099	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35099	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35099	P	part_of:(GO:0034976)	Seeded From UniProt	complete
part_of	GO:1990604	IRE1-TRAF2-ASK1 complex	PMID:12050113^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034976)	Seeded From UniProt	complete
part_of	GO:1902911	protein kinase complex	PMID:15983381^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:15983381^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9UER7	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:15983381^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:20674765^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:20674765^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:20674765^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14830	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:11959862^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8K4T5	F		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	PMID:11959862^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:21771788^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:11920685^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	PMID:21771788^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007254	JNK cascade	PMID:21771788^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:17210579^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	PMID:17210579^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:21771788^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	PMID:17210579^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:21771788^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:17210579^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346876 PANTHER:PTN000684887 UniProtKB:Q99683	P		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346876 PANTHER:PTN000684847 RGD:1306565 UniProtKB:O95382 UniProtKB:Q99683	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000172316 UniProtKB:Q99683	F		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684847 UniProtKB:Q99683	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9743501^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19805025^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17937911^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99683	F		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0072577	endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	C		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	F		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
	GO:0002224	toll-like receptor signaling pathway	PMID:26243192^[14]	ECO:0000314			P		Figure 3 and S6 show that M3K5 (reffered to here as ASK1) is required for activation of downstream TLR-dependent signaling proteins	complete CACAO 11202
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZH6 ensembl:ENSRNOP00000051338	P		Seeded From UniProt	complete
	GO:0023014	signal transduction by protein phosphorylation	PMID:26243192^[14]	ECO:0000314			P		Figure 4 shows repression of M3K5 (named here as ASK1) results in lower phosphorylation of downstream signaling molecules	complete CACAO 11213
involved_in	GO:1902170	cellular response to reactive nitrogen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	P		Seeded From UniProt	complete
involved_in	GO:0097300	programmed necrotic cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	P		Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	P		Seeded From UniProt	complete
involved_in	GO:0038066	p38MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	F		Seeded From UniProt	complete
involved_in	GO:0010941	regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	P		Seeded From UniProt	complete
involved_in	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	P		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35099 ensembl:ENSMUSP00000093485	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.25	F		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	PMID:8974401^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	PMID:8974401^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	PMID:8974401^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:8974401^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-3299417 Reactome:R-HSA-3228469 Reactome:R-HSA-3225851	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-NUL-3299417 Reactome:R-HSA-3228469	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Ko, YG et al. (2001) Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J. Biol. Chem. 276 6030-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Zheng, QY et al. (2013) Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. Cell. Signal. 25 206-13 PubMed GONUTS page
↑ Nishitoh, H et al. (2002) ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16 1345-55 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Junn, E et al. (2005) Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc. Natl. Acad. Sci. U.S.A. 102 9691-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Kutuzov, MA et al. (2010) Protein phosphatase with EF-hand domains 2 (PPEF2) is a potent negative regulator of apoptosis signal regulating kinase-1 (ASK1). Int. J. Biochem. Cell Biol. 42 1816-22 PubMed GONUTS page
↑ ^6.0 ^6.1 Zama, T et al. (2002) Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. J. Biol. Chem. 277 23919-26 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Seong, HA et al. (2011) Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9 protein, a zinc finger protein. J. Biol. Chem. 286 31123-35 PubMed GONUTS page
↑ Tobiume, K et al. (2002) Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer. J. Cell. Physiol. 191 95-104 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Takeda, K et al. (2007) Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. J. Biol. Chem. 282 7522-31 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Chang, HY et al. (1998) Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science 281 1860-3 PubMed GONUTS page
↑ Yoon, KW et al. (2009) CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. Proc. Natl. Acad. Sci. U.S.A. 106 17389-94 PubMed GONUTS page
↑ Bunkoczi, G et al. (2007) Structural and functional characterization of the human protein kinase ASK1. Structure 15 1215-26 PubMed GONUTS page
↑ ^14.0 ^14.1 Okazaki, T et al. (2015) The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response. Sci Signal 8 ra78 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Ichijo, H et al. (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275 90-4 PubMed GONUTS page

[PMID:11096076-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Ko, YG et al. (2001) Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J. Biol. Chem. 276 6030-6 PubMed GONUTS page

[PMID:23000344-2] 2.0 ^2.1 ^2.2 Zheng, QY et al. (2013) Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells. Cell. Signal. 25 206-13 PubMed GONUTS page

[PMID:12050113-3] Nishitoh, H et al. (2002) ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 16 1345-55 PubMed GONUTS page

[PMID:15983381-4] 4.0 ^4.1 ^4.2 Junn, E et al. (2005) Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc. Natl. Acad. Sci. U.S.A. 102 9691-6 PubMed GONUTS page

[PMID:20674765-5] 5.0 ^5.1 ^5.2 Kutuzov, MA et al. (2010) Protein phosphatase with EF-hand domains 2 (PPEF2) is a potent negative regulator of apoptosis signal regulating kinase-1 (ASK1). Int. J. Biochem. Cell Biol. 42 1816-22 PubMed GONUTS page

[PMID:11959862-6] 6.0 ^6.1 Zama, T et al. (2002) Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. J. Biol. Chem. 277 23919-26 PubMed GONUTS page

[PMID:21771788-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Seong, HA et al. (2011) Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9 protein, a zinc finger protein. J. Biol. Chem. 286 31123-35 PubMed GONUTS page

[PMID:11920685-8] Tobiume, K et al. (2002) Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer. J. Cell. Physiol. 191 95-104 PubMed GONUTS page

[PMID:17210579-9] 9.0 ^9.1 ^9.2 ^9.3 Takeda, K et al. (2007) Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. J. Biol. Chem. 282 7522-31 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9743501-11] Chang, HY et al. (1998) Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science 281 1860-3 PubMed GONUTS page

[PMID:19805025-12] Yoon, KW et al. (2009) CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. Proc. Natl. Acad. Sci. U.S.A. 106 17389-94 PubMed GONUTS page

[PMID:17937911-13] Bunkoczi, G et al. (2007) Structural and functional characterization of the human protein kinase ASK1. Structure 15 1215-26 PubMed GONUTS page

[PMID:26243192-14] 14.0 ^14.1 Okazaki, T et al. (2015) The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response. Sci Signal 8 ra78 PubMed GONUTS page

[PMID:8974401-15] 15.0 ^15.1 ^15.2 ^15.3 Ichijo, H et al. (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275 90-4 PubMed GONUTS page

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HUMAN:M3K5

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