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Category:GO:0002224 ! toll-like receptor signaling pathway

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DAG for GO:0002224id: GO:0002224

name: toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
comment: Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
synonym: "TLR signaling pathway" EXACT [ISBN:0781735149]
synonym: "toll-like receptor signalling pathway" EXACT []
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

AmiGO <GOterm>GO:0002224</GOterm>
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