CHICK:O73909

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	il-1beta (ECO:0000313 with EMBL:CAA75239.1)
Protein Name(s)	IL-1 beta (ECO:0000313 with EMBL:ABD49198.1) Interleukin-1 beta (ECO:0000313 with EMBL:ACY72339.1) Interleukin-1beta (ECO:0000313 with EMBL:CAA75239.1)
External Links
UniProt	O73909
EMBL	DQ393267 FJ788633 HM179638 Y15006 AJ245728
RefSeq	NP_989855.1
UniGene	Gga.19
PDB	2WRY 3NJ5
PDBsum	2WRY 3NJ5
STRING	9031.ENSGALP00000000737
GeneID	395196
KEGG	gga:395196
CTD	3553
eggNOG	NOG40099
HOGENOM	HOG000246399
HOVERGEN	HBG007328
KO	K04519
OrthoDB	EOG71P2BQ
PhylomeDB	O73909
TreeFam	TF300203
Reactome	REACT_197463 REACT_197474
EvolutionaryTrace	O73909
NextBio	20815286
PRO	PR:O73909
GO	GO:0005615 GO:0030141 GO:0000187 GO:0035690 GO:0071260 GO:0071407 GO:0032602 GO:0019221 GO:0035234 GO:0097192 GO:0001660 GO:0030213 GO:0006955 GO:0032611 GO:0031663 GO:0000165 GO:0070487 GO:0070164 GO:0008285 GO:2001240 GO:0010829 GO:0046627 GO:0050995 GO:0043407 GO:0030593 GO:0045766 GO:0060559 GO:0045080 GO:0031622 GO:0032725 GO:0034116 GO:0032729 GO:0045086 GO:0045410 GO:0032757 GO:0046330 GO:0050996 GO:0051044 GO:0045840 GO:0071639 GO:0035505 GO:0042346 GO:0051092 GO:0045429 GO:0032308 GO:0042102 GO:0045944 GO:0010575 GO:0043491 GO:0050796 GO:0033198 GO:0009743 GO:0030730
InterPro	IPR008996 IPR003294 IPR020877 IPR000975 IPR003502
Pfam	PF00340 PF02394
PRINTS	PR00264 PR01357
SUPFAM	SSF50353
PROSITE	PS00253

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0070417	cellular response to cold	PMID:16150487^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:18343850^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:6208795^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043400	cortisol secretion	PMID:21288573^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:H9H271	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:A3DTN5	C	Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:H9H271	P	Seeded From UniProt	complete
involved_in	GO:0006953	acute-phase response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:A3DTN5	P	Seeded From UniProt	complete
involved_in	GO:0032602	chemokine production	PMID:17275099^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975	F	Seeded From UniProt	complete
enables	GO:0005149	interleukin-1 receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003296 InterPro:IPR003502	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003296	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975 InterPro:IPR020877	C	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975 InterPro:IPR003296 InterPro:IPR003502	P	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000975 InterPro:IPR003296 InterPro:IPR003502	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P	Seeded From UniProt	complete
involved_in	GO:0001660	fever generation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0666	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0001660	fever generation	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000000656	P	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000000656	F	Seeded From UniProt	complete
enables	GO:0005149	interleukin-1 receptor binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000000656	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000000656	C	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:16430960^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032602	chemokine production	PMID:16430960^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032497	detection of lipopolysaccharide	PMID:16430960^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002269	leukocyte activation involved in inflammatory response	PMID:16430960^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002232	leukocyte chemotaxis involved in inflammatory response	PMID:16430960^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001660	fever generation	PMID:16430960^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:19247647^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	PMID:19247647^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019953	sexual reproduction	PMID:18539728^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hangalapura, BN et al. (2006) Cold stress equally enhances in vivo pro-inflammatory cytokine gene expression in chicken lines divergently selected for antibody responses. Dev. Comp. Immunol. 30 503-11 PubMed GONUTS page
↑ Wu, YF et al. (2008) Characterization of interleukin-1beta mRNA expression in chicken macrophages in response to avian reovirus. J. Gen. Virol. 89 1059-68 PubMed GONUTS page
↑ Klasing, KC (1984) Effect of inflammatory agents and interleukin 1 on iron and zinc metabolism. Am. J. Physiol. 247 R901-4 PubMed GONUTS page
↑ Cheng, CS et al. (2011) Structural and functional comparison of cytokine interleukin-1 beta from chicken and human. Mol. Immunol. 48 947-55 PubMed GONUTS page
↑ Wu, YF et al. (2007) Sequence and phylogenetic analysis of interleukin (IL)-1beta-encoding genes of five avian species and structural and functional homology among these IL-1beta proteins. Vet. Immunol. Immunopathol. 116 37-46 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Bar-Shira, E & Friedman, A (2006) Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick. Dev. Comp. Immunol. 30 930-41 PubMed GONUTS page
↑ ^7.0 ^7.1 Downing, T et al. (2009) Contrasting evolution of diversity at two disease-associated chicken genes. Immunogenetics 61 303-14 PubMed GONUTS page
↑ Das, SC et al. (2009) Changes in the expression of interleukin-1beta and lipopolysaccharide-induced TNF factor in the oviduct of laying hens in response to artificial insemination. Reproduction 137 527-36 PubMed GONUTS page

[PMID:16150487-1] Hangalapura, BN et al. (2006) Cold stress equally enhances in vivo pro-inflammatory cytokine gene expression in chicken lines divergently selected for antibody responses. Dev. Comp. Immunol. 30 503-11 PubMed GONUTS page

[PMID:18343850-2] Wu, YF et al. (2008) Characterization of interleukin-1beta mRNA expression in chicken macrophages in response to avian reovirus. J. Gen. Virol. 89 1059-68 PubMed GONUTS page

[PMID:6208795-3] Klasing, KC (1984) Effect of inflammatory agents and interleukin 1 on iron and zinc metabolism. Am. J. Physiol. 247 R901-4 PubMed GONUTS page

[PMID:21288573-4] Cheng, CS et al. (2011) Structural and functional comparison of cytokine interleukin-1 beta from chicken and human. Mol. Immunol. 48 947-55 PubMed GONUTS page

[PMID:17275099-5] Wu, YF et al. (2007) Sequence and phylogenetic analysis of interleukin (IL)-1beta-encoding genes of five avian species and structural and functional homology among these IL-1beta proteins. Vet. Immunol. Immunopathol. 116 37-46 PubMed GONUTS page

[PMID:16430960-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Bar-Shira, E & Friedman, A (2006) Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick. Dev. Comp. Immunol. 30 930-41 PubMed GONUTS page

[PMID:19247647-7] 7.0 ^7.1 Downing, T et al. (2009) Contrasting evolution of diversity at two disease-associated chicken genes. Immunogenetics 61 303-14 PubMed GONUTS page

[PMID:18539728-8] Das, SC et al. (2009) Changes in the expression of interleukin-1beta and lipopolysaccharide-induced TNF factor in the oviduct of laying hens in response to artificial insemination. Reproduction 137 527-36 PubMed GONUTS page

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CHICK:O73909

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